Frailty, HIV Infection, and Mortality in an Aging Cohort of Injection Drug Users
Publication Date
January 31, 2013
Journal
PLOS ONE
Authors
Damani A. Piggott, Abimereki D. Muzaale, Shruti H. Mehta, Todd T. Brown, et al
Volume
8
Issue
1
Pages
e54910
DOI
https://dx.plos.org/10.1371/journal.pone.0054910
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0054910
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23382997
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561408
Europe PMC
http://europepmc.org/abstract/MED/23382997
Web of Science
000314610600049
Scopus
84873100763
Mendeley
http://www.mendeley.com/research/frailty-hiv-infection-mortality-aging-cohort-injection-drug-users
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Mendeley | Further Information

{"title"=>"Frailty, HIV Infection, and Mortality in an Aging Cohort of Injection Drug Users", "type"=>"journal", "authors"=>[{"first_name"=>"Damani A.", "last_name"=>"Piggott", "scopus_author_id"=>"6602653595"}, {"first_name"=>"Abimereki D.", "last_name"=>"Muzaale", "scopus_author_id"=>"35739114000"}, {"first_name"=>"Shruti H.", "last_name"=>"Mehta", "scopus_author_id"=>"7401670716"}, {"first_name"=>"Todd T.", "last_name"=>"Brown", "scopus_author_id"=>"7404319468"}, {"first_name"=>"Kushang V.", "last_name"=>"Patel", "scopus_author_id"=>"7402235062"}, {"first_name"=>"Sean X.", "last_name"=>"Leng", "scopus_author_id"=>"7003330618"}, {"first_name"=>"Gregory D.", "last_name"=>"Kirk", "scopus_author_id"=>"35454021400"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84873100763", "pui"=>"368246859", "doi"=>"10.1371/journal.pone.0054910", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84873100763", "pmid"=>"23382997"}, "id"=>"0ec3685f-bc55-300b-a8b1-df0d1743a0e3", "abstract"=>"BACKGROUND: Frailty is associated with morbidity and premature mortality among elderly HIV-uninfected adults, but the determinants and consequences of frailty in HIV-infected populations remain unclear. We evaluated the correlates of frailty, and the impact of frailty on mortality in a cohort of aging injection drug users (IDUs)., METHODS: Frailty was assessed using standard criteria among HIV-infected and uninfected IDUs in 6-month intervals from 2005 to 2008. Generalized linear mixed-model analyses assessed correlates of frailty. Cox proportional hazards models estimated risk for all-cause mortality., RESULTS: Of 1230 participants at baseline, the median age was 48 years and 29% were HIV-infected; the frailty prevalence was 12.3%. In multivariable analysis of 3,365 frailty measures, HIV-infected IDUs had an increased likelihood of frailty (OR, 1.66; 95% CI, 1.24-2.21) compared to HIV-uninfected IDUs; the association was strongest (OR, 2.37; 95% CI, 1.62-3.48) among HIV-infected IDUs with advanced HIV disease (CD4<350 cells/mm3 and detectable HIV RNA). No significant association was seen with less advanced disease. Sociodemographic factors, comorbidity, depressive symptoms, and prescription drug abuse were also independently associated with frailty. Mortality risk was increased with frailty alone (HR 2.63, 95% CI, 1.23-5.66), HIV infection alone (HR 3.29, 95% CI, 1.85-5.88), and being both HIV-infected and frail (HR, 7.06; 95%CI 3.49-14.3)., CONCLUSION: Frailty was strongly associated with advanced HIV disease, but IDUs with well-controlled HIV had a similar prevalence to HIV-uninfected IDUs. Frailty was independently associated with mortality, with a marked increase in mortality risk for IDUs with both frailty and HIV infection.", "link"=>"http://www.mendeley.com/research/frailty-hiv-infection-mortality-aging-cohort-injection-drug-users", "reader_count"=>52, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>12, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>4, "Other"=>5, "Student > Master"=>6, "Student > Bachelor"=>7, "Lecturer > Senior Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>12, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>4, "Other"=>5, "Student > Master"=>6, "Student > Bachelor"=>7, "Lecturer > Senior Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>4, "Mathematics"=>2, "Medicine and Dentistry"=>29, "Agricultural and Biological Sciences"=>5, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>2, "Social Sciences"=>4, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>29}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>4}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Turkey"=>1}, "group_count"=>5}

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/496122"], "description"=>"<p>Kaplan Meier Survival Curve Estimates for 1230 ALIVE Participants from July 2005 to December 2008. Frail- participants had a frailty score of 0–2; Frail+ participants had a frailty score of 3–5.</p>", "links"=>[], "tags"=>["frailty", "hiv"], "article_id"=>166640, "categories"=>["Physiology", "Medicine", "Mental Health", "Infectious Diseases"], "users"=>["Damani A. Piggott", "Abimereki D. Muzaale", "Shruti H. Mehta", "Todd T. Brown", "Kushang V. Patel", "Sean X. Leng", "Gregory D. Kirk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054910.g002", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_by_Frailty_and_HIV_Status_in_the_ALIVE_cohort_/166640", "title"=>"Survival by Frailty and HIV Status in the ALIVE cohort.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-31 01:50:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/496206"], "description"=>"<p>Abbreviations: HAART, highly active antiretroviral therapy; IQR, interquartile range; y, years; Hazardous alcohol use, score of ≥8 on the AUDIT; Depressive symptoms, score of ≥21 on the CES-D.</p>a<p>Data are no. (%) of participants, unless otherwise indicated.</p>b<p>Reflect characteristics within the previous 6 months.</p>c<p>Reflect characteristics within the prior year.</p>d<p>Diabetes, Hypertension, Cerebrovascular accident, Cardiovascular disease, Renal disease, Chronic obstructive pulmonary disease, Cancer, Obesity, Liver disease.</p>", "links"=>[], "tags"=>["1230", "3365", "hiv"], "article_id"=>166722, "categories"=>["Physiology", "Medicine", "Mental Health", "Infectious Diseases"], "users"=>["Damani A. Piggott", "Abimereki D. Muzaale", "Shruti H. Mehta", "Todd T. Brown", "Kushang V. Patel", "Sean X. Leng", "Gregory D. Kirk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054910.t001", "stats"=>{"downloads"=>3, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_1230_ALIVE_Participants_at_3365_Study_Visits_by_HIV_Status_a_/166722", "title"=>"Characteristics of 1230 ALIVE Participants at 3365 Study Visits, by HIV Status<sup>a</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-31 01:52:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/496287"], "description"=>"<p>Abbreviations : HAART, highly active antiretroviral therapy; VL, HIV viral load; UD, undetectable, <50 HIV RNA copies/ml; Hazardous alcohol use, score of ≥8 on the AUDIT; Depressive symptoms, score of ≥21 on the CES-D.</p><p>– Not included in final model/not significant in adjusted analyses.</p>a<p>Data are given as unadjusted and adjusted odds ratios (95% confidence interval).</p>b<p>Adjusted for age, gender, race, education, marital status, prescription drug abuse, depressive symptoms, # comorbid conditions and HIV status.</p>c<p>Adjusted for age, gender, race, education, marital status, prescription drug abuse, depressive symptoms, and # comorbid conditions.</p>d<p>Reflect characteristics within the previous 6 months.</p>e<p>Reflect characteristics within the prior year.</p>f<p>Diabetes, Hypertension, Cerebrovascular accident, Cardiovascular disease, Renal disease, Chronic obstructive pulmonary disease, Cancer, Obesity, Liver disease.</p>", "links"=>[], "tags"=>["frailty", "prefrailty", "3365"], "article_id"=>166804, "categories"=>["Physiology", "Medicine", "Mental Health", "Infectious Diseases"], "users"=>["Damani A. Piggott", "Abimereki D. Muzaale", "Shruti H. Mehta", "Todd T. Brown", "Kushang V. Patel", "Sean X. Leng", "Gregory D. Kirk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054910.t002", "stats"=>{"downloads"=>9, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Factors_Associated_with_Frailty_and_Prefrailty_among_3365_ALIVE_Study_Person_Visits_a_/166804", "title"=>"Factors Associated with Frailty and Prefrailty among 3365 ALIVE Study Person-Visits<sup>a</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-31 01:53:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/480850"], "description"=>"<div><h3>Background</h3><p>Frailty is associated with morbidity and premature mortality among elderly HIV-uninfected adults, but the determinants and consequences of frailty in HIV-infected populations remain unclear. We evaluated the correlates of frailty, and the impact of frailty on mortality in a cohort of aging injection drug users (IDUs).</p> <h3>Methods</h3><p>Frailty was assessed using standard criteria among HIV-infected and uninfected IDUs in 6-month intervals from 2005 to 2008. Generalized linear mixed-model analyses assessed correlates of frailty. Cox proportional hazards models estimated risk for all-cause mortality.</p> <h3>Results</h3><p>Of 1230 participants at baseline, the median age was 48 years and 29% were HIV-infected; the frailty prevalence was 12.3%. In multivariable analysis of 3,365 frailty measures, HIV-infected IDUs had an increased likelihood of frailty (OR, 1.66; 95% CI, 1.24–2.21) compared to HIV-uninfected IDUs; the association was strongest (OR, 2.37; 95% CI, 1.62–3.48) among HIV-infected IDUs with advanced HIV disease (CD4<350 cells/mm3 and detectable HIV RNA). No significant association was seen with less advanced disease. Sociodemographic factors, comorbidity, depressive symptoms, and prescription drug abuse were also independently associated with frailty. Mortality risk was increased with frailty alone (HR 2.63, 95% CI, 1.23–5.66), HIV infection alone (HR 3.29, 95% CI, 1.85–5.88), and being both HIV-infected and frail (HR, 7.06; 95%CI 3.49–14.3).</p> <h3>Conclusion</h3><p>Frailty was strongly associated with advanced HIV disease, but IDUs with well-controlled HIV had a similar prevalence to HIV-uninfected IDUs. Frailty was independently associated with mortality, with a marked increase in mortality risk for IDUs with both frailty and HIV infection.</p> </div>", "links"=>[], "tags"=>["hiv", "aging", "cohort", "injection", "users"], "article_id"=>155206, "categories"=>["Physiology", "Medicine", "Mental Health", "Infectious Diseases"], "users"=>["Damani A. Piggott", "Abimereki D. Muzaale", "Shruti H. Mehta", "Todd T. Brown", "Kushang V. Patel", "Sean X. Leng", "Gregory D. Kirk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054910", "stats"=>{"downloads"=>0, "page_views"=>39, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Frailty_HIV_Infection_and_Mortality_in_an_Aging_Cohort_of_Injection_Drug_Users__/155206", "title"=>"Frailty, HIV Infection, and Mortality in an Aging Cohort of Injection Drug Users", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-31 01:26:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/496052"], "description"=>"<p>Kaplan Meier Survival Curve Estimates for 1230 ALIVE Participants from July 2005 to December 2008. Robust participants had a frailty score of 0; prefrail participants had a frailty score of 1–2; frail participants had a frailty score of 3–5.</p>", "links"=>[], "tags"=>["frailty"], "article_id"=>166568, "categories"=>["Physiology", "Medicine", "Mental Health", "Infectious Diseases"], "users"=>["Damani A. Piggott", "Abimereki D. Muzaale", "Shruti H. Mehta", "Todd T. Brown", "Kushang V. Patel", "Sean X. Leng", "Gregory D. Kirk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054910.g001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_by_Frailty_Status_in_the_ALIVE_cohort_/166568", "title"=>"Survival by Frailty Status in the ALIVE cohort.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-31 01:49:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/496245"], "description"=>"a<p>Data are given as unadjusted and adjusted hazard ratios (95% confidence interval).</p>b<p>Adjusted for age, gender, race, education, # comorbid conditions, HIV status and frailty status.</p>c<p>Adjusted for age, gender, race, education and # comorbid conditions.</p>d<p>Robust participants had a frailty score of 0; prefrail participants had a frailty score of 1–2; frail participants had a frailty score of 3–5; nonfrail participants had a frailty score of 0–2.</p>", "links"=>[], "tags"=>["frailty", "hiv"], "article_id"=>166762, "categories"=>["Physiology", "Medicine", "Mental Health", "Infectious Diseases"], "users"=>["Damani A. Piggott", "Abimereki D. Muzaale", "Shruti H. Mehta", "Todd T. Brown", "Kushang V. Patel", "Sean X. Leng", "Gregory D. Kirk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054910.t003", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mortality_Risk_associated_with_Frailty_and_HIV_among_ALIVE_Participants_a_/166762", "title"=>"Mortality Risk associated with Frailty and HIV among ALIVE Participants<sup>a</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-31 01:52:42"}

PMC Usage Stats | Further Information

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Relative Metric

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