Human Prostate Side Population Cells Demonstrate Stem Cell Properties in Recombination with Urogenital Sinus Mesenchyme
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{"title"=>"Human Prostate Side Population Cells Demonstrate Stem Cell Properties in Recombination with Urogenital Sinus Mesenchyme", "type"=>"journal", "authors"=>[{"first_name"=>"Barbara A.", "last_name"=>"Foster", "scopus_author_id"=>"7202824418"}, {"first_name"=>"Kalyan J.", "last_name"=>"Gangavarapu", "scopus_author_id"=>"24832670200"}, {"first_name"=>"Grinu", "last_name"=>"Mathew", "scopus_author_id"=>"57197397432"}, {"first_name"=>"Gissou", "last_name"=>"Azabdaftari", "scopus_author_id"=>"7801423376"}, {"first_name"=>"Carl D.", "last_name"=>"Morrison", "scopus_author_id"=>"7201898006"}, {"first_name"=>"Austin", "last_name"=>"Miller", "scopus_author_id"=>"57201541114"}, {"first_name"=>"Wendy J.", "last_name"=>"Huss", "scopus_author_id"=>"6603539478"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368246846", "sgr"=>"84873149792", "issn"=>"19326203", "pmid"=>"23383057", "scopus"=>"2-s2.0-84873149792", "doi"=>"10.1371/journal.pone.0055062"}, "id"=>"a8850272-fa89-363d-85d5-4756c2afb8b3", "abstract"=>"Stem cell enrichment provides a tool to examine prostate stem cells obtained from benign and malignant tissue. Functional assays can enrich stem cells based on common stem cell phenotypes, such as high ATP binding cassette (ABC) transporter mediated efflux of Hoechst substrates (side population assay). This functional assay is based upon mechanisms that protect cells from environmental insult thus contributing to the survival and protection of the stem cell population. We have isolated and analyzed cells digested from twelve clinical prostate specimens based on the side population assay. Prostate stem cell properties of the isolated cells were tested by serial recombination with rat urogenital mesenchyme. Recombinants with side population cells demonstrate an increase in the frequency of human ductal growth and the number of glands per recombinant when compared to recombinants with non-side population cells. Isolated cells were capable of prostatic growth for up to three generations in the recombination assay with as little as 125 sorted prostate cells. The ability to reproducibly use cells isolated by fluorescence activated cell sorting from human prostate tissue is an essential step to a better understanding of human prostate stem cell biology. ABC transporter G2 (ABCG2) was expressed in recombinants from side population cells indicating the side population cells have self-renewal properties. Epithelial cell differentiation of recombinants was determined by immunohistochemical analysis for expression of the basal, luminal, and neuroendocrine markers, p63, androgen receptor, prostate specific antigen, and chromogranin A, respectively. Thus, the ABCG2 expressing side population demonstrates multipotency and self-renewal properties indicating stem cells are within this population.", "link"=>"http://www.mendeley.com/research/human-prostate-side-population-cells-demonstrate-stem-cell-properties-recombination-urogenital-sinus", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/480873", "https://ndownloader.figshare.com/files/480874", "https://ndownloader.figshare.com/files/480875", "https://ndownloader.figshare.com/files/480877"], "description"=>"<div><p>Stem cell enrichment provides a tool to examine prostate stem cells obtained from benign and malignant tissue. Functional assays can enrich stem cells based on common stem cell phenotypes, such as high ATP binding cassette (ABC) transporter mediated efflux of Hoechst substrates (side population assay). This functional assay is based upon mechanisms that protect cells from environmental insult thus contributing to the survival and protection of the stem cell population. We have isolated and analyzed cells digested from twelve clinical prostate specimens based on the side population assay. Prostate stem cell properties of the isolated cells were tested by serial recombination with rat urogenital mesenchyme. Recombinants with side population cells demonstrate an increase in the frequency of human ductal growth and the number of glands per recombinant when compared to recombinants with non-side population cells. Isolated cells were capable of prostatic growth for up to three generations in the recombination assay with as little as 125 sorted prostate cells. The ability to reproducibly use cells isolated by fluorescence activated cell sorting from human prostate tissue is an essential step to a better understanding of human prostate stem cell biology. ABC transporter G2 (ABCG2) was expressed in recombinants from side population cells indicating the side population cells have self-renewal properties. Epithelial cell differentiation of recombinants was determined by immunohistochemical analysis for expression of the basal, luminal, and neuroendocrine markers, p63, androgen receptor, prostate specific antigen, and chromogranin A, respectively. Thus, the ABCG2 expressing side population demonstrates multipotency and self-renewal properties indicating stem cells are within this population.</p> </div>", "links"=>[], "tags"=>["prostate", "cells", "properties", "recombination", "urogenital", "sinus", "mesenchyme"], "article_id"=>155214, "categories"=>["Cancer", "Biochemistry", "Developmental Biology"], "users"=>["Barbara A. Foster", "Kalyan J. Gangavarapu", "Grinu Mathew", "Gissou Azabdaftari", "Carl D. Morrison", "Austin Miller", "Wendy J. Huss"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055062.s001", "https://dx.doi.org/10.1371/journal.pone.0055062.s002", "https://dx.doi.org/10.1371/journal.pone.0055062.s003", "https://dx.doi.org/10.1371/journal.pone.0055062.s004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Human_Prostate_Side_Population_Cells_Demonstrate_Stem_Cell_Properties_in_Recombination_with_Urogenital_Sinus_Mesenchyme__/155214", "title"=>"Human Prostate Side Population Cells Demonstrate Stem Cell Properties in Recombination with Urogenital Sinus Mesenchyme", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-31 01:26:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/497031"], "description"=>"<p>A) First generation recombinant (H&E staining) generated with 1000 side population cells isolated from 9NT, micro-dissected piece of the recombinant and new rUGM used for serial recombination, and second generation growth (H&E staining and IHC analysis). B) First generation recombinant (H&E staining) generated with 400 non-side population cells isolated from 9NT, micro-dissected piece of the recombinant and new rUGM used for serial recombination, and second generation growth (H&E staining and IHC analysis). Ruler scale = mm; Scale bar = 50 µm.</p>", "links"=>[], "tags"=>["recombination"], "article_id"=>167547, "categories"=>["Cancer", "Biochemistry", "Developmental Biology"], "users"=>["Barbara A. Foster", "Kalyan J. Gangavarapu", "Grinu Mathew", "Gissou Azabdaftari", "Carl D. Morrison", "Austin Miller", "Wendy J. Huss"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055062.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serial_Recombination_with_new_rUGM_/167547", "title"=>"Serial Recombination with new rUGM.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-31 02:05:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/497228"], "description"=>"<p>A) Live cells are identified and gated based on 7AAD staining and a plot of forward scatter (FSC) vs. side scatter (SSC). B) Cells gated in (A) are plotted and gated as viable singlets based on FSC-Width (FSC-W) vs. FSC-Height (FSC-H). C,E,G,I,K,M,O,Q,S) The gated viable singlets (B) are plotted in a double scatter plot between red (650 nm) and blue (450/40 nm) emission and are isolated based upon efflux of DCV. D,F,H,J,L,N,P,R,T) ABCG2-mediated DCV efflux is inhibited in the presence of FTC to establish where the side population (SP) and non-side population (NSP) gates should be placed. Purple: viable single cells; Green: NSP; Blue: SP.</p>", "links"=>[], "tags"=>["specimens", "dcv"], "article_id"=>167738, "categories"=>["Cancer", "Biochemistry", "Developmental Biology"], "users"=>["Barbara A. Foster", "Kalyan J. Gangavarapu", "Grinu Mathew", "Gissou Azabdaftari", "Carl D. Morrison", "Austin Miller", "Wendy J. Huss"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055062.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FACS_isolation_of_the_side_population_in_human_clinical_specimens_based_upon_DCV_efflux_/167738", "title"=>"FACS isolation of the side population in human clinical specimens based upon DCV efflux.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-31 02:08:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/497336"], "description"=>"<p>A) The percentage of recombinants with human ductal growth in the first generation with equal number of sorted cells side population n = 51 and non-sided population n = 52, analyzed by Fisher’s Exact two-sided test p = 0.017. B) The number of glands in recombinants with equal number of sorted cells derived from side population n = 19 and non-side population n = 6 was quantitated and analyzed by Exact Wilcoxon test p = 0.041. C) The percentage of recombinants with human ductal growth in the first generation with representative number of cells side population n = 42 and non-side population n = 45, analyzed by Fisher’s Exact two-sided test p = 1.000. D) The number of glands in recombinants with representative number of cells derived from side population n = 10 and non-side population n = 9 was quantitated and analyzed by Exact Wilcoxon test p = 0.161. E) Kaplan-Meier plot of recombinant survival rate in multiple generations, Logrank test p = 0.2692.</p>", "links"=>[], "tags"=>["recombinants", "non-side"], "article_id"=>167852, "categories"=>["Cancer", "Biochemistry", "Developmental Biology"], "users"=>["Barbara A. Foster", "Kalyan J. Gangavarapu", "Grinu Mathew", "Gissou Azabdaftari", "Carl D. Morrison", "Austin Miller", "Wendy J. Huss"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055062.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ductal_Growth_of_Recombinants_from_Side_and_Non_Side_Population_Cells_/167852", "title"=>"Ductal Growth of Recombinants from Side and Non-Side Population Cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-31 02:10:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/497542"], "description"=>"<p>Nonconsecutive serial sections of a recombinant derived from 250 side population cells from specimen NT6+ rUGM were stained. A) H&E staining, box represents area examined at higher power in D–H; B) p63 IHC; C) AR IHC; D) PSA IHC; E) ABCG2 IHC; F) Chromogranin A (ChrA) IHC arrows indicate positive cells; G) telomere (Telo) detection by FISH; and H) DAPI staining. B-H) Scale bar, 10 µm.</p>", "links"=>[], "tags"=>["differentiation", "markers"], "article_id"=>168063, "categories"=>["Cancer", "Biochemistry", "Developmental Biology"], "users"=>["Barbara A. Foster", "Kalyan J. Gangavarapu", "Grinu Mathew", "Gissou Azabdaftari", "Carl D. Morrison", "Austin Miller", "Wendy J. Huss"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055062.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_Differentiation_Markers_in_Recombinants_/168063", "title"=>"Expression of Differentiation Markers in Recombinants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-31 02:14:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/497682"], "description"=>"*<p>Grafts not analyzed due to host animal death. ND: Not Determined because the recombinant did not demonstrate visible ductal growth upon micro-dissection.</p>", "links"=>[], "tags"=>["ductal", "recombinants", "sorted"], "article_id"=>168199, "categories"=>["Cancer", "Biochemistry", "Developmental Biology"], "users"=>["Barbara A. Foster", "Kalyan J. Gangavarapu", "Grinu Mathew", "Gissou Azabdaftari", "Carl D. Morrison", "Austin Miller", "Wendy J. Huss"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055062.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Incidence_of_human_ductal_growth_in_recombinants_with_equal_number_of_sorted_cells_/168199", "title"=>"Incidence of human ductal growth in recombinants with equal number of sorted cells.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-31 02:16:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/497723"], "description"=>"*<p>Grafts not analyzed due to host animal death. ND: Not Determined because the recombinant did not demonstrate visible ductual growth upon micro-dissection.</p>**<p>There was a 33-fold ratio between non-side and side population cells isolated, however due to the number of cells isolated only a 25-fold ratio was possible for the recombinants from this specimen.</p>", "links"=>[], "tags"=>["ductal", "recombinants", "sorted"], "article_id"=>168238, "categories"=>["Cancer", "Biochemistry", "Developmental Biology"], "users"=>["Barbara A. Foster", "Kalyan J. Gangavarapu", "Grinu Mathew", "Gissou Azabdaftari", "Carl D. Morrison", "Austin Miller", "Wendy J. Huss"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055062.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Incidence_of_human_ductal_growth_in_recombinants_with_representative_number_of_sorted_cells_/168238", "title"=>"Incidence of human ductal growth in recombinants with representative number of sorted cells.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-31 02:17:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/497767"], "description"=>"<p>NT: Histologically non-tumor areas from radical prostatectomies. T: Histologically tumor areas from radical prostatectomies. B: Benign prostate specimens from cystoprostatectomies.</p>", "links"=>[], "tags"=>["non-side", "gated", "viable", "cells", "specimens", "benign", "prostate", "cancer"], "article_id"=>168273, "categories"=>["Cancer", "Biochemistry", "Developmental Biology"], "users"=>["Barbara A. Foster", "Kalyan J. Gangavarapu", "Grinu Mathew", "Gissou Azabdaftari", "Carl D. Morrison", "Austin Miller", "Wendy J. Huss"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055062.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_percentage_of_total_side_population_SP_and_non_side_population_NSP_gated_relative_to_total_viable_cells_in_tissue_specimens_from_human_benign_prostate_and_prostate_cancer_specimens_/168273", "title"=>"The percentage of total side population (SP) and non-side population (NSP) gated relative to total viable cells in tissue specimens from human benign prostate and prostate cancer specimens.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-31 02:17:53"}

PMC Usage Stats | Further Information

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Relative Metric

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