Peroxisome Proliferator-Activated Receptor-γ Agonist 15d-Prostaglandin J2 Mediates Neuronal Autophagy after Cerebral Ischemia-Reperfusion Injury
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{"title"=>"Peroxisome Proliferator-Activated Receptor-γ Agonist 15d-Prostaglandin J2 Mediates Neuronal Autophagy after Cerebral Ischemia-Reperfusion Injury", "type"=>"journal", "authors"=>[{"first_name"=>"Feng", "last_name"=>"Xu", "scopus_author_id"=>"57061343100"}, {"first_name"=>"Jian", "last_name"=>"Li", "scopus_author_id"=>"57196157998"}, {"first_name"=>"Wei", "last_name"=>"Ni", "scopus_author_id"=>"57196506172"}, {"first_name"=>"Yi wen", "last_name"=>"Shen", "scopus_author_id"=>"7404768168"}, {"first_name"=>"Xiao ping", "last_name"=>"Zhang", "scopus_author_id"=>"54786126300"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"368187608", "sgr"=>"84872845566", "doi"=>"10.1371/journal.pone.0055080", "scopus"=>"2-s2.0-84872845566", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23372817"}, "id"=>"8defcf78-a40a-3127-bbbd-78bced98807c", "abstract"=>"Peroxisome proliferator-activated receptor-γ (PPAR-γ) has recently emerged as potential therapeutic agents for cerebral ischemia-reperfusion (I/R) injury because of anti-neuronal apoptotic actions. However, whether PPAR-γ activation mediates neuronal autophagy in such conditions remains unclear. Therefore, in this study, we investigated the role of PPAR-γ agonist 15-PGJ(2) on neuronal autophagy induced by I/R. The expression of autophagic-related protein in ischemic cortex such as LC3-II, Beclin 1, cathepsin-B and LAMP1 increased significantly after cerebral I/R injury. Furthermore, increased punctate LC3 labeling and cathepsin-B staining occurred in neurons. Treatment with PPAR-γ agonist 15d-PGJ(2) decreased not only autophagic-related protein expression in ischemic cortex, but also immunoreactivity of LC3 and cathepsin-B in neurons. Autophagic inhibitor 3-methyladenine (3-MA) decreased LC3-II levels, reduced the infarct volume, and mimicked some protective effect of 15d-PGJ(2) against cerebral I/R injury. These results indicate that PPAR-γ agonist 15d-PGJ(2) exerts neuroprotection by inhibiting neuronal autophagy after cerebral I/R injury. Although the molecular mechanisms underlying PPAR-γ agonist in mediating neuronal autophagy remain to be determined, neuronal autophagy may be a new target for PPAR-γ agonist treatment in cerebral I/R injury.", "link"=>"http://www.mendeley.com/research/peroxisome-proliferatoractivated-receptor%CE%B3-agonist-15dprostaglandin-j2-mediates-neuronal-autophagy-a", "reader_count"=>14, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/501163"], "description"=>"<p>15-PGJ<sub>2</sub> (1, 10, 50 pg) was administered icv immediately before reperfusion. (A) Five consecutive TTC-stained coronal brain slices arranged in cranial to caudal order 24 h after I/R. The white brain area represents infracted tissue. Infarct volume (B), neurological deficits (C) was measured 24 h after I/R. <sup>#</sup>p<0.05 versus I/R group.</p>", "links"=>[], "tags"=>["cerebral"], "article_id"=>171687, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Feng Xu", "Jian Li", "Wei Ni", "Yi-wen Shen", "Xiao-ping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055080.g007", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neuroprotective_effects_of_15_PGJ_2_against_cerebral_I_R_injury_/171687", "title"=>"Neuroprotective effects of 15-PGJ<sub>2</sub> against cerebral I/R injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:29:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/500693"], "description"=>"<p>(A) In sham-operated animals, cortical cells displayed diffuse and weak staining for LC3 in the cytosol. After I/R, intense LC3 staining appeared granular in the cytosol of cortical cells. Double staining for LC3 (green) and NeuN (red) showed that increase in LC3 punctate labeling occurred in cortical neurons. (B) In sham-operated animals, cortical cells displayed fine, granular, and perinuclear cathepsin-B staining. After I/R, cathepin-B granules became progressively larger and irregular, and the granular pattern was finally replaced with diffuse cytoplasmic staining. Double staining for cathepsin-B (green) and NeuN (red) showed that increased expression of cathepsin-B occurred mainly in neurons. Bar = 20 µm.</p>", "links"=>[], "tags"=>["lc3", "cathepsin", "neurons", "cerebral"], "article_id"=>171212, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Feng Xu", "Jian Li", "Wei Ni", "Yi-wen Shen", "Xiao-ping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055080.g003", "stats"=>{"downloads"=>13, "page_views"=>173, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemistry_for_LC3_and_cathepsin_B_in_neurons_after_cerebral_I_R_injury_/171212", "title"=>"Immunohistochemistry for LC3 and cathepsin B in neurons after cerebral I/R injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:27:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/500924"], "description"=>"<p>The expression of LC3-II, Beclin 1, cathepisin-B, and LAMP1 expression significantly increased at 12 h after reperfusion. Treatment with 15-PGJ<sub>2</sub> at 1 to 50 pg significantly decreased LC3-II, Beclin 1, cathepisin-B, and LAMP1 expression after I/R injury. Optical density of respective protein bands were analyzed with Sigma Scan Pro 5 and normalized to the loading control (β-actin). <sup>#</sup>p<0.05 versus I/R group.</p>", "links"=>[], "tags"=>["autophagic-related", "ischemic", "cortex", "cerebral"], "article_id"=>171440, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Feng Xu", "Jian Li", "Wei Ni", "Yi-wen Shen", "Xiao-ping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055080.g005", "stats"=>{"downloads"=>15, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_15_PGJ_2_treatment_on_autophagic_related_protein_expression_in_ischemic_cortex_after_cerebral_I_R_injury_/171440", "title"=>"Effect of 15-PGJ<sub>2</sub> treatment on autophagic-related protein expression in ischemic cortex after cerebral I/R injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:28:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/500572"], "description"=>"<p>The level of LC3-II and Beclin 1 in ischemic cortex increased significantly from 6 to 24 h after reperfusion, with a maximal induction at 12 h. The expression of active cathepsin-B and LAMP1 in ischemic cortex increased significantly from 6 to 12 h after reperfusion, with a maximal induction at 12 h. Optical density of respective protein bands were analyzed with Sigma Scan Pro 5 and normalized to the loading control (β-actin). *p<0.05 versus sham group.</p>", "links"=>[], "tags"=>["blot", "autophagic-related", "cerebral"], "article_id"=>171092, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Feng Xu", "Jian Li", "Wei Ni", "Yi-wen Shen", "Xiao-ping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055080.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_Blot_analysis_of_autophagic_related_protein_expression_after_cerebral_I_R_injury_/171092", "title"=>"Western Blot analysis of autophagic-related protein expression after cerebral I/R injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:26:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/501063"], "description"=>"<p>Double staining showed that LC3 punctate labeling and cathepsin-B immunoreactivity increased in neurons compared with sham-operated animals at 12 h after I/R injury. 15-PGJ2 at 50 pg effectively blocked the activation of autophagy as evidence by inhibiting immunoreactivity of LC3 (A) and cathepsin-B (B). Bar = 20 µm.</p>", "links"=>[], "tags"=>["lc3", "cathepsin-b", "immunoreactivity", "cerebral"], "article_id"=>171576, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Feng Xu", "Jian Li", "Wei Ni", "Yi-wen Shen", "Xiao-ping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055080.g006", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_15_PGJ_2_treatment_on_LC3_and_cathepsin_B_immunoreactivity_after_cerebral_I_R_injury_/171576", "title"=>"Effect of 15-PGJ<sub>2</sub> treatment on LC3 and cathepsin-B immunoreactivity after cerebral I/R injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:28:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/500802"], "description"=>"<p>(A) The level of PPAR-γ in ischemic cortex was higher than control in a time-dependent manner. (B) 15-PGJ<sub>2</sub> upregulated PPAR-γ expression in ischemic cortex in a concentration-dependent manner. *p<0.05 versus sham group, <sup>#</sup>p<0.05 versus I/R group.</p>", "links"=>[], "tags"=>["cortex", "cerebral"], "article_id"=>171322, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Feng Xu", "Jian Li", "Wei Ni", "Yi-wen Shen", "Xiao-ping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055080.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PPAR_947_protein_expression_in_cortex_after_cerebral_I_R_injury_/171322", "title"=>"PPAR-γ protein expression in cortex after cerebral I/R injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:27:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/501252"], "description"=>"<p>3-MA (60 µg) solutions were injected icv immediately before reperfusion. (A) The changes of LC3 after the treatment of 3-MA. 3-MA significantly decreased LC3-II levels at 24 h after I/R. Effect of 3-MA on infarct volumes (B) and neurological deficits (C). 3-MA significantly reduced the infarct volume, and ameliorate the neurological symptoms at 24 h after I/R. <sup>#</sup>p<0.05 versus I/R group.</p>", "links"=>[], "tags"=>["3-mehtyladenine", "cerebral"], "article_id"=>171771, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Feng Xu", "Jian Li", "Wei Ni", "Yi-wen Shen", "Xiao-ping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055080.g008", "stats"=>{"downloads"=>13, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protective_effects_of_3_mehtyladenine_3_MA_following_cerebral_I_R_injury_/171771", "title"=>"Protective effects of 3-mehtyladenine (3-MA) following cerebral I/R injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:30:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/500465"], "description"=>"<p>(A) N, nucleus; Broad arrows represent autophagosomes; Narrow arrows represent mitochondria. (B) Quantitative analysis of the nubmeber of autophagosomes. Three animals in each group and 10 fields for each animal were examined. *p<0.05 versus sham group.</p>", "links"=>[], "tags"=>["micrographs", "morphological", "changes", "cortical", "neurons", "cerebral"], "article_id"=>170975, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Feng Xu", "Jian Li", "Wei Ni", "Yi-wen Shen", "Xiao-ping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055080.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Electron_micrographs_of_morphological_changes_of_cortical_neurons_after_cerebral_I_R_injury_/170975", "title"=>"Electron micrographs of morphological changes of cortical neurons after cerebral I/R injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:25:39"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Medicine and health sciences/Critical care and emergency medicine", "average_usage"=>[232, 415, 550, 654, 763, 861, 963, 1070, 1169, 1253, 1343, 1442, 1502]}, {"subject_area"=>"/Medicine and health sciences/Neurology", "average_usage"=>[271, 485, 617, 733, 835, 933, 1026, 1115, 1207, 1294, 1386, 1475, 1543]}]}
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