Glucose 6P Binds and Activates HlyIIR to Repress Bacillus cereus Haemolysin hlyII Gene Expression
Publication Date
February 06, 2013
Journal
PLOS ONE
Authors
Elisabeth Guillemet, Seav Ly Tran, Céline Cadot, Didier Rognan, et al
Volume
8
Issue
2
Pages
e55085
DOI
https://dx.plos.org/10.1371/journal.pone.0055085
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0055085
Scopus
84873535287
Mendeley
http://www.mendeley.com/research/glucose-6p-binds-activates-hlyiir-repress-bacillus-cereus-haemolysin-hlyii-gene-expression
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Mendeley | Further Information

{"title"=>"Glucose 6P Binds and Activates HlyIIR to Repress Bacillus cereus Haemolysin HlyII Gene Expression", "type"=>"journal", "authors"=>[{"first_name"=>"Elisabeth", "last_name"=>"Guillemet", "scopus_author_id"=>"55299582100"}, {"first_name"=>"Seav Ly", "last_name"=>"Tran", "scopus_author_id"=>"35560040100"}, {"first_name"=>"Céline", "last_name"=>"Cadot", "scopus_author_id"=>"35557899000"}, {"first_name"=>"Didier", "last_name"=>"Rognan", "scopus_author_id"=>"7004226067"}, {"first_name"=>"Didier", "last_name"=>"Lereclus", "scopus_author_id"=>"7005147819"}, {"first_name"=>"Nalini", "last_name"=>"Ramarao", "scopus_author_id"=>"8684032800"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368304254", "scopus"=>"2-s2.0-84873535287", "pmid"=>"23405113", "doi"=>"10.1371/journal.pone.0055085", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "sgr"=>"84873535287"}, "id"=>"1cb4846a-e524-355e-abd0-9fa652436bd7", "abstract"=>"Bacillus cereus is a Gram-positive spore-forming bacterium causing food poisoning and serious opportunistic infections. These infections are characterized by bacterial accumulation despite the recruitment of phagocytic cells. We have previously shown that B. cereus Haemolysin II (HlyII) induces macrophage cell death by apoptosis. In this work, we investigated the regulation of the hlyII gene. We show that HlyIIR, the negative regulator of hlyII expression in B. cereus, is especially active during the early bacterial growth phase. We demonstrate that glucose 6P directly binds to HlyIIR and enhances its activity at a post-transcriptional level. Glucose 6P activates HlyIIR, increasing its capacity to bind to its DNA-box located upstream of the hlyII gene, inhibiting its expression. Thus, hlyII expression is modulated by the availability of glucose. As HlyII induces haemocyte and macrophage death, two cell types that play a role in the sequestration of nutrients upon infection, HlyII may induce host cell death to allow the bacteria to gain access to carbon sources that are essential components for bacterial growth.", "link"=>"http://www.mendeley.com/research/glucose-6p-binds-activates-hlyiir-repress-bacillus-cereus-haemolysin-hlyii-gene-expression", "reader_count"=>8, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>3, "Sports and Recreations"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "group_count"=>0}

Scopus | Further Information

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