Frequency of Thyroid Dysfunctions during Interferon Alpha Treatment of Single and Combination Therapy in Hepatitis C Virus-Infected Patients: A Systematic Review Based Analysis
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{"title"=>"Frequency of Thyroid Dysfunctions during Interferon Alpha Treatment of Single and Combination Therapy in Hepatitis C Virus-Infected Patients: A Systematic Review Based Analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Chandrasekharan", "last_name"=>"Nair Kesavachandran", "scopus_author_id"=>"55577535300"}, {"first_name"=>"Frank", "last_name"=>"Haamann", "scopus_author_id"=>"6602956998"}, {"first_name"=>"Albert", "last_name"=>"Nienhaus", "scopus_author_id"=>"6701531558"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368253984", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0055364", "scopus"=>"2-s2.0-84873269405", "pmid"=>"23383326", "sgr"=>"84873269405"}, "id"=>"be0e4d35-daa6-3109-a081-4d9c5d725178", "abstract"=>"BACKGROUND: Thyroid dysfunction is the commonest endocrinopathy associated with HCV infection due to interferon-based treatment. This comprehensive and systematic review presents the available evidence for newly developed thyroid antibodies and dysfunctions during interferon treatment (both single and combination) in HCV patients.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: This systematic review was conducted in accordance with the PRISMA guidelines. The data generated were used to analyze the risk for thyroid dysfunctions during interferon (IFN) treatment in HCV patients. There was a wide range in the incidence of newly developed thyroid dysfunctions and thyroid antibodies in HCV patients during IFN treatment (both single and combination). The wide range of incidence also denoted the possibility of factors other than IFN treatment for thyroid-related abnormalities in HCV patients. These other factors include HCV viral factors, genetic predisposition, environmental factors, and patho-physiological factors. Variations in IFN dosage, treatment duration of IFN, definition/criteria followed in each study for thyroid dysfunction and irregular thyroid function testing during treatment in different studies influence the outcome of the single studies and jeopardise the validity of a pooled risk estimate of side effects of thyroid dysfunction. Importantly, reports differ as to whether the thyroid-related side effects disappear totally after withdrawal of the IFN treatment.\\n\\nCONCLUSIONS/SIGNIFICANCE: The present review shows that there is a wide range in the incidence of newly developed thyroid dysfunctions and thyroid antibodies in IFN treated HCV patients. This is a comprehensive attempt to collate relevant data from 56 publications across several nations about IFN (both mono and combination therapy) related thyroid dysfunction among HCV patients. The role of each factor in causing thyroid dysfunctions in HCV patients treated with IFN should be analyzed in detail in future studies, for a better understanding of the problem and sounder clinical management of the disease.", "link"=>"http://www.mendeley.com/research/frequency-thyroid-dysfunctions-during-interferon-alpha-treatment-single-combination-therapy-hepatiti-2", "reader_count"=>7, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Postgraduate"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Postgraduate"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>4, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/496228"], "description"=>"<p>Identification, screening, eligibility and inclusion of data sources for the study.</p>", "links"=>[], "tags"=>["eligibility", "inclusion", "sources"], "article_id"=>166746, "categories"=>["Chemistry", "Biotechnology", "Infectious Diseases", "Immunology"], "users"=>["Chandrasekharan Nair Kesavachandran", "Frank Haamann", "Albert Nienhaus"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055364.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Identification_screening_eligibility_and_inclusion_of_data_sources_for_the_study_/166746", "title"=>"Identification, screening, eligibility and inclusion of data sources for the study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:02:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/496340"], "description"=>"<p>Differences in definition of thyroid dysfunction/positive for thyroid autoantibody given in method section of some of the publications.</p>", "links"=>[], "tags"=>["thyroid", "autoantibody"], "article_id"=>166860, "categories"=>["Chemistry", "Biotechnology", "Infectious Diseases", "Immunology"], "users"=>["Chandrasekharan Nair Kesavachandran", "Frank Haamann", "Albert Nienhaus"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055364.t003", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differences_in_definition_of_thyroid_dysfunction_positive_for_thyroid_autoantibody_given_in_method_section_of_some_of_the_publications_/166860", "title"=>"Differences in definition of thyroid dysfunction/positive for thyroid autoantibody given in method section of some of the publications.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 16:03:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/496382"], "description"=>"<p>Abbreviations and symbols in Table: RIBA, Ribavirin; IIT, Interferon induced thyroiditis M/F, male/female ratio; NR, not reported; Tab: thyroid antibodies;</p>*<p>Children and adolescent (2–17 yrs); <sup>**</sup>Children between 8–19 years; <sup>***</sup>Although remaining within the reference interval. TSH was reported as increasing during therapy in this study;</p>a<p>although 6 cases showed thyrotropin outcome profile variation during treatment, all recovered at the end of the study;</p><p><a href=\"mailto:@3\" target=\"_blank\">@3</a> patients show initial higher TSH from the normal range, but all patients including 3 patients had normal thyroid functions at the end of 36 months;</p><p><a href=\"mailto:@@Tabs\" target=\"_blank\">@@Tabs</a> were elevated at the time of therapy cessation;</p>#<p>Case report; <sup>##</sup>Out of 1292 patients and 13 studies.</p>", "links"=>[], "tags"=>["developed", "thyroid", "antibodies", "autoimmune", "iit", "non-autoimmune", "patients", "hepatitis", "treated"], "article_id"=>166889, "categories"=>["Chemistry", "Biotechnology", "Infectious Diseases", "Immunology"], "users"=>["Chandrasekharan Nair Kesavachandran", "Frank Haamann", "Albert Nienhaus"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055364.t002", "stats"=>{"downloads"=>9, "page_views"=>48, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Frequency_of_newly_developed_thyroid_antibodies_and_clinical_thyroid_Disease_Including_Autoimmune_IIT_and_Non_Autoimmune_IIT_in_Patients_with_Hepatitis_C_Infection_treated_with_combination_therapy_IFN_945_pegylated_or_non_pegylated_Ribavirin_or_Levovirin/166889", "title"=>"Frequency of newly developed thyroid antibodies and clinical thyroid Disease (Including Autoimmune IIT and Non-Autoimmune IIT) in Patients with Hepatitis C Infection treated with combination therapy (IFN α (pegylated or non-pegylated+Ribavirin or Levovirin) treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 16:03:12"}

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Relative Metric

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