MicroRNA-182-5p Promotes Cell Invasion and Proliferation by Down Regulating FOXF2, RECK and MTSS1 Genes in Human Prostate Cancer
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{"title"=>"MicroRNA-182-5p Promotes Cell Invasion and Proliferation by Down Regulating FOXF2, RECK and MTSS1 Genes in Human Prostate Cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Hiroshi", "last_name"=>"Hirata", "scopus_author_id"=>"7202342771"}, {"first_name"=>"Koji", "last_name"=>"Ueno", "scopus_author_id"=>"23468272400"}, {"first_name"=>"Varahram", "last_name"=>"Shahryari", "scopus_author_id"=>"26030059000"}, {"first_name"=>"Guoren", "last_name"=>"Deng", "scopus_author_id"=>"7101931985"}, {"first_name"=>"Yuichiro", "last_name"=>"Tanaka", "scopus_author_id"=>"55736241300"}, {"first_name"=>"Z. Laura", "last_name"=>"Tabatabai", "scopus_author_id"=>"6506319141"}, {"first_name"=>"Yuji", "last_name"=>"Hinoda", "scopus_author_id"=>"7102787850"}, {"first_name"=>"Rajvir", "last_name"=>"Dahiya", "scopus_author_id"=>"7102833652"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84873850704", "issn"=>"19326203", "pui"=>"368227194", "sgr"=>"84873850704", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23383207", "doi"=>"10.1371/journal.pone.0055502"}, "id"=>"42823a96-d8a8-3d74-abd9-3d79c56dad5b", "abstract"=>"Recently miR-182 has been reported to be over-expressed in prostate cancer (PC) tissues, however detailed functional analysis of miR-182-5p has not been carried out. The purpose of this study was to: 1. analyze the function of miR-182-5p in prostate cancer, 2. assess its usefulness as a tumor marker, 3. identify miR-182-5p target genes in PC, 4. investigate the potential for miR-182-5p inhibitor to be used in PC treatment. Initially we found that miR-182-5p expression was significantly higher in prostate cancer tissues and cell lines compared to normal prostate tissues and cells. Moreover high miR-182-5p expression was associated with shorter overall survival in PC patients. To study the functional significance of miR-182-5p, we knocked down miR-182-5p with miR-182-5p inhibitor. After miR-182-5p knock-down, prostate cancer cell proliferation, migration and invasion were decreased. We identified FOXF2, RECK and MTSS1 as potential target genes of miR-182-5p using several algorithms which was confirmed by 3'UTR luciferase assay and Western analysis. Knock-down of miR-182-5p also significantly decreased in vivo prostate tumor growth. In conclusion this is the first report documenting that over-expression of miR-182-5p is associated with prostate cancer progression and potentially useful as a prognostic biomarker. Also knock down of miR-182-5p in order to increase expression of tumor suppressor genes FOXF2, RECK and MTSS1 may be of therapeutic benefit in prostate cancer treatment.", "link"=>"http://www.mendeley.com/research/microrna1825p-promotes-cell-invasion-proliferation-down-regulating-foxf2-reck-mtss1-genes-human-pros", "reader_count"=>43, "reader_count_by_academic_status"=>{"Researcher"=>12, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>4, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>6}, "reader_count_by_user_role"=>{"Researcher"=>12, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>4, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>9, "Agricultural and Biological Sciences"=>22, "Medicine and Dentistry"=>5, "Neuroscience"=>1, "Social Sciences"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Iran"=>1, "Germany"=>1}, "group_count"=>1}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/498931"], "description"=>"<p>A. Relative miR-182-5p expression [each tumor tissue (T)/normal prostate tissue (N)] based on real time PCR results, B. Association between miR-182-5p expression and clinic-pathological parameters (age at diagnosis, pT, Gleason score, PSA failure and overall survival) in prostate cancer tissues based on q-PCR results. C. Kaplan-Meier plots of over-all survival after radical prostatectomy.</p>", "links"=>[], "tags"=>["prostate", "cancer", "tissues", "clinic-pathological", "parameters"], "article_id"=>169434, "categories"=>["Cancer", "Cell Biology", "Biophysics", "Mathematics", "Molecular Biology"], "users"=>["Hiroshi Hirata", "Koji Ueno", "Varahram Shahryari", "Guoren Deng", "Yuichiro Tanaka", "Z. Laura Tabatabai", "Yuji Hinoda", "Rajvir Dahiya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055502.g001", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miR_182_5p_expression_in_human_prostate_cancer_tissues_and_normal_prostate_tissues_and_association_with_clinic_pathological_parameters_q_PCR_/169434", "title"=>"miR-182-5p expression in human prostate cancer tissues and normal prostate tissues and association with clinic-pathological parameters (q-PCR).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:17:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/499178"], "description"=>"<p>Two prostate cancer cell lines (PC-3 and DU145) were transiently transfected with either miR-182-5p inhibitor or miR-negative control (miR-NC-inhibitor). A. Relative miR-182-5p expression (miR-NC inhibitor or miR-182-5p inhibitor transfected PC cells), B. Cell viability assay (miR-NC inhibitor or miR-182-5p inhibitor transfected PC cells), C. Invasion assay, D. Wound healing assay (24 hours). Error bars represent±S.D. (standard deviation).</p>", "links"=>[], "tags"=>["mir-182-5p", "prostate", "cancer", "cells"], "article_id"=>169690, "categories"=>["Cancer", "Cell Biology", "Biophysics", "Mathematics", "Molecular Biology"], "users"=>["Hiroshi Hirata", "Koji Ueno", "Varahram Shahryari", "Guoren Deng", "Yuichiro Tanaka", "Z. Laura Tabatabai", "Yuji Hinoda", "Rajvir Dahiya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055502.g003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_miR_182_5p_knock_down_on_prostate_cancer_cells_PC_3_DU145_/169690", "title"=>"Effect of miR-182-5p knock down on prostate cancer cells (PC-3, DU145).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:18:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/499579"], "description"=>"<p>A. FOXF2 protein expression (si-NC or si-FOXF2 transfected PC cells). B. Cell viability assay (si-NC or si-FOXF2 transfected PC cells). C. Invasion assay, D. Wound healing assay (8 hours), Error bars represent±S.D. (standard deviation).</p>", "links"=>[], "tags"=>["foxf2", "knockdown", "prostate", "cancer", "cells"], "article_id"=>170087, "categories"=>["Cancer", "Cell Biology", "Biophysics", "Mathematics", "Molecular Biology"], "users"=>["Hiroshi Hirata", "Koji Ueno", "Varahram Shahryari", "Guoren Deng", "Yuichiro Tanaka", "Z. Laura Tabatabai", "Yuji Hinoda", "Rajvir Dahiya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055502.g007", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_FOXF2_knockdown_on_prostate_cancer_cells_PC_3_DU145_/170087", "title"=>"Effect of FOXF2 knockdown on prostate cancer cells (PC-3, DU145).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:20:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/499669"], "description"=>"<p>Primer sequences used for plasmid construction.</p>", "links"=>[], "tags"=>["sequences", "plasmid"], "article_id"=>170183, "categories"=>["Cancer", "Cell Biology", "Biophysics", "Mathematics", "Molecular Biology"], "users"=>["Hiroshi Hirata", "Koji Ueno", "Varahram Shahryari", "Guoren Deng", "Yuichiro Tanaka", "Z. Laura Tabatabai", "Yuji Hinoda", "Rajvir Dahiya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055502.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primer_sequences_used_for_plasmid_construction_/170183", "title"=>"Primer sequences used for plasmid construction.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 16:21:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/499465"], "description"=>"<p>At 24 hours after transfection of either pCMV6-empty, pCMV6-RECK or pCMV6-MTSS1 into prostate cancer cells (PC-3 and DU 145), RECK and MTSS1 expression levels were verified by real time RT-PCR (A) and Western analysis (B) C. Cell viability assay, D. Invasion assay, E. Wound healing assay, Error bars represent±S.D. (standard deviation).</p>", "links"=>[], "tags"=>["reck", "mtss1", "over-expression", "prostate", "cancer"], "article_id"=>169972, "categories"=>["Cancer", "Cell Biology", "Biophysics", "Mathematics", "Molecular Biology"], "users"=>["Hiroshi Hirata", "Koji Ueno", "Varahram Shahryari", "Guoren Deng", "Yuichiro Tanaka", "Z. Laura Tabatabai", "Yuji Hinoda", "Rajvir Dahiya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055502.g006", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_RECK_and_MTSS1_over_expression_on_prostate_cancer_cell_function_/169972", "title"=>"Effect of RECK and MTSS1 over-expression on prostate cancer cell function.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:20:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/499374"], "description"=>"<p>A. Time record of tumor size in miR-NC and miR-182-5p inhibitor xenografts. B. Relative miR-182-5p expression at injection of cells and harvest of xenografts. Error bars represent ±S.D. (standard deviation). MiR-182-5p expression was significantly lower in the miR-182-5p inhibitor group. C. Typical gross appearance of nude mouse tumors in control and miR-182-5p inhibitor groups. D. Expression of FOXF2, RECK and MTSS1 protein in tumor xenografts.</p>", "links"=>[], "tags"=>["mir-182-5p", "knockdown", "pc3"], "article_id"=>169884, "categories"=>["Cancer", "Cell Biology", "Biophysics", "Mathematics", "Molecular Biology"], "users"=>["Hiroshi Hirata", "Koji Ueno", "Varahram Shahryari", "Guoren Deng", "Yuichiro Tanaka", "Z. Laura Tabatabai", "Yuji Hinoda", "Rajvir Dahiya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055502.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inhibition_of_in_vivo_tumor_growth_by_miR_182_5p_knockdown_in_PC3_cells_/169884", "title"=>"Inhibition of <i>in vivo</i> tumor growth by miR-182-5p knockdown in PC3 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:19:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/499287"], "description"=>"<p>A. FOXF2, RECK and MTSS1 3’UTR position and complementary miR-182-5p sequence. B. 3’UTR Luciferase assay (miR-NC and miR-182-5p precursor), Error bars represent±S.D. (standard deviation). C. Protein expression of FOXF2, RECK, MTSS1, MMP-2 and beta-tubulin in miR-NC inhibitor or miR-182-5p inhibitor transfected prostate cancer cells (PC-3, DU145).</p>", "links"=>[], "tags"=>["binds", "utr", "reck", "mtss1", "mrnas", "down-regulates"], "article_id"=>169788, "categories"=>["Cancer", "Cell Biology", "Biophysics", "Mathematics", "Molecular Biology"], "users"=>["Hiroshi Hirata", "Koji Ueno", "Varahram Shahryari", "Guoren Deng", "Yuichiro Tanaka", "Z. Laura Tabatabai", "Yuji Hinoda", "Rajvir Dahiya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055502.g004", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miR_182_5p_binds_to_the_3_8217_UTR_of_FOXF2_RECK_and_MTSS1_mRNAs_and_down_regulates_expression_/169788", "title"=>"miR-182-5p binds to the 3’ UTR of FOXF2, RECK and MTSS1 mRNAs and down-regulates expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:19:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/499063"], "description"=>"<p>A. The expression of miR-182-5p was significantly higher in three prostate cancer cell lines compared to a normal prostate cell line (RWPE-1), B. Relative miR-182-5p expression (miR-NC or miR-182-5p precursor transfected RWPE-1 cells), B. cell viability assay (miR-NC or miR-182-5p precursor transfected RWPE-1 cells), C. Wound healing assay (miR-NC or miR-182-5p precursor transfected RWPE-1 cells). Error bars represent ±S.D. (standard deviation).</p>", "links"=>[], "tags"=>["mir-182-5p", "lines", "overexpression", "prostate", "cells"], "article_id"=>169569, "categories"=>["Cancer", "Cell Biology", "Biophysics", "Mathematics", "Molecular Biology"], "users"=>["Hiroshi Hirata", "Koji Ueno", "Varahram Shahryari", "Guoren Deng", "Yuichiro Tanaka", "Z. Laura Tabatabai", "Yuji Hinoda", "Rajvir Dahiya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055502.g002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_miR_182_5p_in_cell_lines_and_effect_of_miR_182_5p_overexpression_on_normal_prostate_cells_RWPE_1_/169569", "title"=>"Expression of miR-182-5p in cell lines and effect of miR-182-5p overexpression on normal prostate cells (RWPE-1).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:17:55"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
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  • {"unique-ip"=>"32", "full-text"=>"39", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
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  • {"unique-ip"=>"22", "full-text"=>"15", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"31", "full-text"=>"28", "pdf"=>"24", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
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  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
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  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
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Relative Metric

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