Reduced Estradiol-Induced Vasodilation and Poly-(ADP-Ribose) Polymerase (PARP) Activity in the Aortas of Rats with Experimental Polycystic Ovary Syndrome (PCOS)
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{"title"=>"Reduced Estradiol-Induced Vasodilation and Poly-(ADP-Ribose) Polymerase (PARP) Activity in the Aortas of Rats with Experimental Polycystic Ovary Syndrome (PCOS)", "type"=>"journal", "authors"=>[{"first_name"=>"Gabriella", "last_name"=>"Masszi", "scopus_author_id"=>"15820934300"}, {"first_name"=>"Eszter Maria", "last_name"=>"Horvath", "scopus_author_id"=>"56015033900"}, {"first_name"=>"Robert", "last_name"=>"Tarszabo", "scopus_author_id"=>"55376320700"}, {"first_name"=>"Rita", "last_name"=>"Benko", "scopus_author_id"=>"56015000000"}, {"first_name"=>"Agnes", "last_name"=>"Novak", "scopus_author_id"=>"55375283500"}, {"first_name"=>"Anna", "last_name"=>"Buday", "scopus_author_id"=>"36466173400"}, {"first_name"=>"Anna Maria", "last_name"=>"Tokes", "scopus_author_id"=>"6602836947"}, {"first_name"=>"Gyorgy L.", "last_name"=>"Nadasy", "scopus_author_id"=>"7004875386"}, {"first_name"=>"Peter", "last_name"=>"Hamar", "scopus_author_id"=>"6701787850"}, {"first_name"=>"Zoltán", "last_name"=>"Benyó", "scopus_author_id"=>"7003461451"}, {"first_name"=>"Szabolcs", "last_name"=>"Varbiro", "scopus_author_id"=>"6601975960"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"368601742", "sgr"=>"84875410764", "doi"=>"10.1371/journal.pone.0055589", "scopus"=>"2-s2.0-84875410764", "isbn"=>"1932-6203", "pmid"=>"23555555"}, "id"=>"b89bf5e9-4e36-3b1b-be6b-0af7f707c773", "abstract"=>"Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism and insulin resistance, both of which have been connected to atherosclerosis. Indeed, an increased risk of clinical manifestations of arterial vascular diseases has been described in PCOS. On the other hand endothelial dysfunction can be detected early on, before atherosclerosis develops. Thus we assumed that vascular dysfunction is also related directly to the hormonal imbalance rather than to its metabolic consequences. To detect early functional changes, we applied a novel rodent model of PCOS: rats were either sham operated or hyperandrogenism was achieved by implanting subcutaneous pellets of dihydrotestosterone (DHT). After ten weeks, myograph measurements were performed on isolated aortic rings. Previously we described an increased contractility to norepinephrine (NE). Here we found a reduced immediate relaxation to estradiol treatment in pre-contracted aortic rings from hyperandrogenic rats. Although the administration of vitamin D3 along with DHT reduced responsiveness to NE, it did not restore relaxation to estradiol. Poly-(ADP-ribose) polymerase (PARP) activity was assessed by poly-ADP-ribose immunostaining. Increased PAR staining in ovaries and circulating leukocytes from DHT rats showed enhanced DNA damage, which was reduced by concomitant vitamin D3 treatment. Surprisingly, PAR staining was reduced in both the endothelium and vascular smooth muscle cells of the aorta rings from hyperandrogenic rats. Thus in the early phase of PCOS, vascular tone is already shifted towards vasoconstriction, characterized by reduced vasorelaxation and vascular dysfunction is concomitant with altered PARP activity. Based on our findings, PARP inhibitors might have a future perspective in restoring metabolic disorders in PCOS.", "link"=>"http://www.mendeley.com/research/reduced-estradiolinduced-vasodilation-polyadpribose-polymerase-parp-activity-aortas-rats-experimenta", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>3, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/997658"], "description"=>"<p>Ovaries, aortas and circulating leukocytes were isolated from animals exposed to the three treatments (control, DHT, DHT+ D<sub>3</sub>) as described previously. PAR immunohistochemistry was performed. Representative images were taken. PAR staining was augmented in ovaries and leukocytes, however was reduced in both the endothelial and the muscular layer of the aortas in the DHT animals. Vitamin D<sub>3</sub> reduced the augmented staining detected in ovaries and leukocytes, but did not alter the staining in the aortas. It is notable that the DHT treatment induced the morphological changes typical in PCOS.</p>", "links"=>[], "tags"=>["staining", "reduced", "endothelium", "cells", "aortas"], "article_id"=>659873, "categories"=>["Chemistry", "Cell Biology", "Physiology", "Mathematics"], "users"=>["Gabriella Masszi", "Eszter Maria Horvath", "Robert Tarszabo", "Rita Benkő", "Agnes Novak", "Anna Buday", "Anna-Mária Tőkés", "Gyorgy L. Nadasy", "Peter Hamar", "Zoltán Benyó", "Szabolcs Varbiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055589.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PAR_staining_is_reduced_in_both_the_endothelium_and_the_smooth_muscle_cells_of_aortas_in_PCOS_/659873", "title"=>"PAR staining is reduced in both the endothelium and the smooth muscle cells of aortas in PCOS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-27 09:54:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/997665"], "description"=>"<p>Slides from <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055589#pone-0055589-g002\" target=\"_blank\">Figure 2</a>. were evaluated using a 10-graded scale (PAR score) as described in Methods. Results from ovaries (A), circulating leukocytes (B), vascular endothelium (C) and vascular smooth muscle cells (D) are presented. <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055589#pone-0055589-g003\" target=\"_blank\">Figure 3</a>. A, B: Control vs. DHT (# = p<0.05), DHT vs. DHT+ D<sub>3</sub> (± = p<0.05). <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055589#pone-0055589-g003\" target=\"_blank\">Figure 3</a>. C, D: Control vs. DHT, and Control vs. DHT+ D<sub>3</sub> (# = p<0.05).</p>", "links"=>[], "tags"=>["confirmed", "par", "staining", "intensities"], "article_id"=>659876, "categories"=>["Chemistry", "Cell Biology", "Physiology", "Mathematics"], "users"=>["Gabriella Masszi", "Eszter Maria Horvath", "Robert Tarszabo", "Rita Benkő", "Agnes Novak", "Anna Buday", "Anna-Mária Tőkés", "Gyorgy L. Nadasy", "Peter Hamar", "Zoltán Benyó", "Szabolcs Varbiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055589.g003", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Statistical_analysis_confirmed_the_significant_changes_in_PAR_staining_intensities_in_the_three_experimental_groups_/659876", "title"=>"Statistical analysis confirmed the significant changes in PAR staining intensities in the three experimental groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-27 09:55:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/997655"], "description"=>"<p>Rats were treated with DHT for 70 days +/− vitamin D<sub>3</sub> when they were sacrificed and aorta rings were isolated for myography studies. Specimens were first precontracted with norepinephrine (5×10<sup>−8</sup> M) and then treated with two different doses of estradiol as shown. Vasodilation is expressed as a percentage of difference between maximally contracted and maximally dilated tone of the vessels according to the following equation (percentage =  (tension after norepinephrine-tension after estradiol)/(tension after norepinephrine-baseline tension) * 100). The difference between control and DHT (# = p<0.01) or control vs. DHT+ D<sub>3</sub> animals (+ = p<0.01) were both significant. The difference between DHT and DHT+ D<sub>3</sub> was not significant.</p>", "links"=>[], "tags"=>["vasorelaxation", "weaker"], "article_id"=>659870, "categories"=>["Chemistry", "Cell Biology", "Physiology", "Mathematics"], "users"=>["Gabriella Masszi", "Eszter Maria Horvath", "Robert Tarszabo", "Rita Benkő", "Agnes Novak", "Anna Buday", "Anna-Mária Tőkés", "Gyorgy L. Nadasy", "Peter Hamar", "Zoltán Benyó", "Szabolcs Varbiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055589.g001", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estradiol_dependent_vasorelaxation_is_weaker_in_experimental_PCOS_/659870", "title"=>"Estradiol dependent vasorelaxation is weaker in experimental PCOS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-27 09:54:03"}

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Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[273, 476, 611, 714, 821, 911, 1005, 1103, 1201, 1287, 1388, 1478, 1557]}]}
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