Quantitative Comparison of PET and Bremsstrahlung SPECT for Imaging the In Vivo Yttrium-90 Microsphere Distribution after Liver Radioembolization
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{"title"=>"Quantitative Comparison of PET and Bremsstrahlung SPECT for Imaging the In Vivo Yttrium-90 Microsphere Distribution after Liver Radioembolization", "type"=>"journal", "authors"=>[{"first_name"=>"Mattijs", "last_name"=>"Elschot", "scopus_author_id"=>"36117605600"}, {"first_name"=>"Bart J.", "last_name"=>"Vermolen", "scopus_author_id"=>"56629284200"}, {"first_name"=>"Marnix G.E.H.", "last_name"=>"Lam", "scopus_author_id"=>"8949022700"}, {"first_name"=>"Bart", "last_name"=>"de Keizer", "scopus_author_id"=>"6506602636"}, {"first_name"=>"Maurice A.A.J.", "last_name"=>"van den Bosch", "scopus_author_id"=>"36946952500"}, {"first_name"=>"Hugo W.A.M.", "last_name"=>"de Jong", "scopus_author_id"=>"7102715206"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84873529250", "pui"=>"368304321", "doi"=>"10.1371/journal.pone.0055742", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "sgr"=>"84873529250", "pmid"=>"23405207"}, "id"=>"bc4c4929-d750-3e13-aef9-fccd50fbddfd", "abstract"=>"BACKGROUND: After yttrium-90 ((90)Y) microsphere radioembolization (RE), evaluation of extrahepatic activity and liver dosimetry is typically performed on (90)Y Bremsstrahlung SPECT images. Since these images demonstrate a low quantitative accuracy, (90)Y PET has been suggested as an alternative. The aim of this study is to quantitatively compare SPECT and state-of-the-art PET on the ability to detect small accumulations of (90)Y and on the accuracy of liver dosimetry.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: SPECT/CT and PET/CT phantom data were acquired using several acquisition and reconstruction protocols, including resolution recovery and Time-Of-Flight (TOF) PET. Image contrast and noise were compared using a torso-shaped phantom containing six hot spheres of various sizes. The ability to detect extra- and intrahepatic accumulations of activity was tested by quantitative evaluation of the visibility and unique detectability of the phantom hot spheres. Image-based dose estimates of the phantom were compared to the true dose. For clinical illustration, the SPECT and PET-based estimated liver dose distributions of five RE patients were compared. At equal noise level, PET showed higher contrast recovery coefficients than SPECT. The highest contrast recovery coefficients were obtained with TOF PET reconstruction including resolution recovery. All six spheres were consistently visible on SPECT and PET images, but PET was able to uniquely detect smaller spheres than SPECT. TOF PET-based estimates of the dose in the phantom spheres were more accurate than SPECT-based dose estimates, with underestimations ranging from 45% (10-mm sphere) to 11% (37-mm sphere) for PET, and 75% to 58% for SPECT, respectively. The differences between TOF PET and SPECT dose-estimates were supported by the patient data.\\n\\nCONCLUSIONS/SIGNIFICANCE: In this study we quantitatively demonstrated that the image quality of state-of-the-art PET is superior over Bremsstrahlung SPECT for the assessment of the (90)Y microsphere distribution after radioembolization.", "link"=>"http://www.mendeley.com/research/quantitative-comparison-pet-bremsstrahlung-spect-imaging-vivo-yttrium90-microsphere-distribution-aft", "reader_count"=>87, "reader_count_by_academic_status"=>{"Unspecified"=>7, "Professor > Associate Professor"=>7, "Librarian"=>1, "Student > Doctoral Student"=>6, "Researcher"=>13, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>2, "Other"=>11, "Student > Master"=>17, "Student > Bachelor"=>1, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>7, "Professor > Associate Professor"=>7, "Librarian"=>1, "Student > Doctoral Student"=>6, "Researcher"=>13, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>2, "Other"=>11, "Student > Master"=>17, "Student > Bachelor"=>1, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>9, "Unspecified"=>9, "Nursing and Health Professions"=>1, "Mathematics"=>2, "Medicine and Dentistry"=>34, "Arts and Humanities"=>1, "Design"=>1, "Business, Management and Accounting"=>1, "Physics and Astronomy"=>28, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Engineering"=>{"Engineering"=>9}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>34}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>28}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>9}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>1}, "group_count"=>7}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/483059", "https://ndownloader.figshare.com/files/483061", "https://ndownloader.figshare.com/files/483064", "https://ndownloader.figshare.com/files/483068"], "description"=>"<div><h3>Background</h3><p>After yttrium-90 (<sup>90</sup>Y) microsphere radioembolization (RE), evaluation of extrahepatic activity and liver dosimetry is typically performed on <sup>90</sup>Y Bremsstrahlung SPECT images. Since these images demonstrate a low quantitative accuracy, <sup>90</sup>Y PET has been suggested as an alternative. The aim of this study is to quantitatively compare SPECT and state-of-the-art PET on the ability to detect small accumulations of <sup>90</sup>Y and on the accuracy of liver dosimetry.</p> <h3>Methodology/Principal Findings</h3><p>SPECT/CT and PET/CT phantom data were acquired using several acquisition and reconstruction protocols, including resolution recovery and Time-Of-Flight (TOF) PET. Image contrast and noise were compared using a torso-shaped phantom containing six hot spheres of various sizes. The ability to detect extra- and intrahepatic accumulations of activity was tested by quantitative evaluation of the visibility and unique detectability of the phantom hot spheres. Image-based dose estimates of the phantom were compared to the true dose. For clinical illustration, the SPECT and PET-based estimated liver dose distributions of five RE patients were compared. At equal noise level, PET showed higher contrast recovery coefficients than SPECT. The highest contrast recovery coefficients were obtained with TOF PET reconstruction including resolution recovery. All six spheres were consistently visible on SPECT and PET images, but PET was able to uniquely detect smaller spheres than SPECT. TOF PET-based estimates of the dose in the phantom spheres were more accurate than SPECT-based dose estimates, with underestimations ranging from 45% (10-mm sphere) to 11% (37-mm sphere) for PET, and 75% to 58% for SPECT, respectively. The differences between TOF PET and SPECT dose-estimates were supported by the patient data.</p> <h3>Conclusions/Significance</h3><p>In this study we quantitatively demonstrated that the image quality of state-of-the-art PET is superior over Bremsstrahlung SPECT for the assessment of the <sup>90</sup>Y microsphere distribution after radioembolization.</p> </div>", "links"=>[], "tags"=>["quantitative", "bremsstrahlung", "spect", "imaging", "vivo", "yttrium-90", "microsphere", "radioembolization"], "article_id"=>155980, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.s001", "https://dx.doi.org/10.1371/journal.pone.0055742.s002", "https://dx.doi.org/10.1371/journal.pone.0055742.s003", "https://dx.doi.org/10.1371/journal.pone.0055742.s004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Quantitative_Comparison_of_PET_and_Bremsstrahlung_SPECT_for_Imaging_the_In_Vivo_Yttrium_90_Microsphere_Distribution_after_Liver_Radioembolization__/155980", "title"=>"Quantitative Comparison of PET and Bremsstrahlung SPECT for Imaging the In Vivo Yttrium-90 Microsphere Distribution after Liver Radioembolization", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-02-06 01:39:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/493833"], "description"=>"<p>Contrast recovery as a function of sphere diameter for all reconstruction methods.</p>", "links"=>[], "tags"=>["diameter", "reconstruction"], "article_id"=>164357, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Contrast_recovery_as_a_function_of_sphere_diameter_for_all_reconstruction_methods_/164357", "title"=>"Contrast recovery as a function of sphere diameter for all reconstruction methods.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:12:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/493924"], "description"=>"<p>Contrast recovery and image noise in the 22-mm sphere for all reconstruction methods (A), the slice through the center of the SPECT volume (iterative+PSF) (B), the slice through the center of the PET volume (iterative+PSF+TOF) (C), and the slice through the center of the PET volume (iterative+PSF+TOF) reconstructed with SPECT-like noise level (D). All images were linearly window-leveled from 0 to 4 times the mean intensity in the background ROI. The boundaries of the central lung insert, the six hot sphere ROIs, and the background ROI are illustrated by the red lines and the 22-mm sphere is indicated by the arrow.</p>", "links"=>[], "tags"=>["spect"], "article_id"=>164444, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PET_and_SPECT_contrast_recovery_and_image_noise_/164444", "title"=>"PET and SPECT contrast recovery and image noise.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:14:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/494030"], "description"=>"<p>The activity concentration in the hot spheres was 2.4 MBq ml<sup>−1</sup> for both the images without (rows 1–3) and with background activity (rows 4–6). In the 1<sup>st</sup> and 4<sup>th</sup> row, the SPECT+PSF (1<sup>st</sup> and 3<sup>rd</sup> column) and PET+PSF+TOF (2<sup>nd</sup> and 4<sup>th</sup> column) slices are overlaid with the location of the visible phantom spheres (red). In rows 2, 3, 5 and 6 a background slice is overlaid with the location of false positive regions. For illustrative reasons, only the largest false positive ROIs are shown (red: 10 mm; green: 13 mm; blue: 17 mm; yellow: 22 mm; purple: 37 mm). Clustered ROIs with connecting center voxels are represented by the ROI with the highest υ<sub>TEST-FP</sub> value.</p>", "links"=>[], "tags"=>["visibility", "detectability"], "article_id"=>164554, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Visualization_of_the_visibility_and_unique_detectability_results_/164554", "title"=>"Visualization of the visibility and unique detectability results.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:15:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/494135"], "description"=>"<p>CDVH of the phantom background ROI and the ROI of the 37-mm diameter sphere. The presented doses were not corrected for PVE.</p>", "links"=>[], "tags"=>["oncology", "Gastroenterology and hepatology", "radiology and medical imaging"], "article_id"=>164650, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phantom_dosimetry_/164650", "title"=>"Phantom dosimetry.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:17:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/494251"], "description"=>"<p>The CDVH of the whole liver (WL), low-dose (LD) and high-dose (HD) ROIs of patient 2 (A), a transversal slice through the SPECT-based dose map, fused with CT (B), and the same transversal slice through the PET-based dose map (C). The boundary of the high-dose ROI is depicted by the green line.</p>", "links"=>[], "tags"=>["oncology", "Gastroenterology and hepatology", "radiology and medical imaging"], "article_id"=>164767, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_2_dosimetry_/164767", "title"=>"Patient 2 dosimetry.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/494334"], "description"=>"<p>The mean dose (Gy) in the low-dose ROI (LD) and the high-dose ROI (HD) are given for all patients.</p>", "links"=>[], "tags"=>["oncology", "Gastroenterology and hepatology", "radiology and medical imaging"], "article_id"=>164857, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_dosimetry_/164857", "title"=>"Patient dosimetry.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:20:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/494377"], "description"=>"<p>The uncorrected mean dose (Gy) in the 6 hot sphere ROIs and the background ROI (BKG), followed by the mean dose corrected for PVE in brackets (spheres only). The TRUE dose represents the actual dose in the phantom.</p>", "links"=>[], "tags"=>["oncology", "Gastroenterology and hepatology", "radiology and medical imaging"], "article_id"=>164899, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phantom_dosimetry_/164899", "title"=>"Phantom dosimetry.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:21:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/494426"], "description"=>"<p>Phantom experiments.</p>", "links"=>[], "tags"=>["oncology", "Gastroenterology and hepatology", "radiology and medical imaging"], "article_id"=>164937, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phantom_experiments_/164937", "title"=>"Phantom experiments.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:22:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/494457"], "description"=>"<p>The extra- and intrahepatic activity distribution is represented by hot spheres in a cold and warm background, respectively. For each image, the diameters (mm) of the first ‘mean-based’ visible and uniquely detectable spheres are given, followed by the diameters of the ‘median-based’ results in brackets. ‘X’ means that none of the spheres were uniquely detectable.</p>", "links"=>[], "tags"=>["intrahepatic", "visibility"], "article_id"=>164976, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Extra_and_intrahepatic_visibility_and_unique_detectibility_/164976", "title"=>"Extra- and intrahepatic visibility and unique detectibility.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:22:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/494505"], "description"=>"a<p>Primary disease: CRC = colorectal carcinoma; NPC = nasopharyngeal carcinoma; MC = mammary carcinoma; HCC = hepatocellular carcinoma.</p>b<p>Lobes treated: W = whole liver treatment; L = left lobar treatment.</p>c<p>V<sub>L</sub> = treated liver volume (ml).</p>d<p>V<sub>T</sub> = volume of tumours in treated liver volume (ml).</p>e<p>A<sub>A</sub> = Activity administered to the patient, at time of administration (MBq).</p>f<p>A<sub>S</sub> = Activity at time of SPECT acquisition (MBq).</p>g<p>A<sub>P</sub> = Activity at time of PET acquisition (MBq).</p>", "links"=>[], "tags"=>["oncology", "Gastroenterology and hepatology", "radiology and medical imaging"], "article_id"=>165022, "categories"=>["Cancer", "Chemistry", "Cell Biology"], "users"=>["Mattijs Elschot", "Bart J. Vermolen", "Marnix G. E. H. Lam", "Bart de Keizer", "Maurice A. A. J. van den Bosch", "Hugo W. A. M. de Jong"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0055742.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_and_treatment_characteristics_/165022", "title"=>"Patient and treatment characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:23:42"}

PMC Usage Stats | Further Information

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Relative Metric

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