Cyclooxgenase-2 Inhibiting Perfluoropoly (Ethylene Glycol) Ether Theranostic Nanoemulsions—In Vitro Study
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{"title"=>"Cyclooxgenase-2 Inhibiting Perfluoropoly (Ethylene Glycol) Ether Theranostic Nanoemulsions-In Vitro Study", "type"=>"journal", "authors"=>[{"first_name"=>"Sravan Kumar", "last_name"=>"Patel", "scopus_author_id"=>"55585956600"}, {"first_name"=>"Yang", "last_name"=>"Zhang", "scopus_author_id"=>"55586884200"}, {"first_name"=>"John A.", "last_name"=>"Pollock", "scopus_author_id"=>"7203035306"}, {"first_name"=>"Jelena M.", "last_name"=>"Janjic", "scopus_author_id"=>"6602742460"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84873587480", "doi"=>"10.1371/journal.pone.0055802", "pui"=>"368311208", "pmid"=>"23409048", "scopus"=>"2-s2.0-84873587480", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"810b6e75-5707-38e1-ab78-f7159be90bd2", "abstract"=>"Cylcooxgenase-2 (COX-2) expressing macrophages, constituting a major portion of tumor mass, are involved in several pro-tumorigenic mechanisms. In addition, macrophages are actively recruited by the tumor and represent a viable target for anticancer therapy. COX-2 specific inhibitor, celecoxib, apart from its anticancer properties was shown to switch macrophage phenotype from tumor promoting to tumor suppressing. Celecoxib has low aqueous solubility, which may limit its tumor inhibiting effect. As opposed to oral administration, we propose that maximum anticancer effect may be achieved by nanoemulsion mediated intravenous delivery. Here we report multifunctional celecoxib nanoemulsions that can be imaged by both near-infrared fluorescence (NIRF) and (19)F magnetic resonance. Celecoxib loaded nanoemulsions showed a dose dependent uptake in mouse macrophages as measured by (19)F NMR and NIRF signal intensities of labeled cells. Dramatic inhibition of intracellular COX-2 enzyme was observed in activated macrophages upon nanoemulsion uptake. COX-2 enzyme inhibition was statistically equivalent between free drug and drug loaded nanoemulsion. However, nanoemulsion mediated drug delivery may be advantageous, helping to avoid systemic exposure to celecoxib and related side effects. Dual molecular imaging signatures of the presented nanoemulsions allow for future in vivo monitoring of the labeled macrophages and may help in examining the role of macrophage COX-2 inhibition in inflammation-cancer interactions. These features strongly support the future use of the presented nanoemulsions as anti-COX-2 theranostic nanomedicine with possible anticancer applications.", "link"=>"http://www.mendeley.com/research/cyclooxgenase2-inhibiting-perfluoropoly-ethylene-glycol-ether-theranostic-nanoemulsionsin-vitro-stud", "reader_count"=>27, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>5, "Neuroscience"=>2, "Arts and Humanities"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Chemical Engineering"=>1, "Chemistry"=>7}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>2}, "Chemistry"=>{"Chemistry"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Austria"=>1, "Brazil"=>1, "Denmark"=>1, "Germany"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/493801"], "description"=>"<p>LPS treatment was performed post cell labeling with nanoemulsion <b>B</b>, free drug dissolved in DMSO and DMSO. Cells not exposed to LPS were designated as untreated. * # $ represents statistical significance comparisons (p<0.0001) between treatments. Each data point represents the average of four independent measurements, where the error bars are the standard error of the mean (SEM).</p>", "links"=>[], "tags"=>["macrophages", "assessed", "lps"], "article_id"=>164320, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Sravan Kumar Patel", "Yang Zhang", "John A. Pollock", "Jelena M. Janjic"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055802.g008", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Production_of_PGE_2_in_macrophages_assessed_after_LPS_treatment_/164320", "title"=>"Production of PGE<sub>2</sub> in macrophages assessed after LPS treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-07 01:12:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/493418"], "description"=>"<p>(A) <sup>19</sup>F NMR of cells labeled with nanoemulsion <b>B</b>. 0.02% v/v aqueous TFA set at −76.00 ppm was used as reference for <sup>19</sup>F NMR. (B) NIRF image (at 800 nm) of cells labeled with nanoemulsion <b>B</b> in NMR tube.</p>", "links"=>[], "tags"=>["nmr", "nirf", "imaging", "nanoemulsion", "labeled"], "article_id"=>163938, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Sravan Kumar Patel", "Yang Zhang", "John A. Pollock", "Jelena M. Janjic"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055802.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_19_F_NMR_and_NIRF_imaging_of_nanoemulsion_B_labeled_macrophages_/163938", "title"=>"<sup>19</sup>F NMR and NIRF imaging of nanoemulsion B labeled macrophages.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-07 01:05:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/493514"], "description"=>"<p>Data points represent cells labeled with different concentrations of nanoemulsion <b>B</b> (0–1.4 mg/mL PFPE).</p>", "links"=>[], "tags"=>["nmr-nirf", "labeled", "macrophage"], "article_id"=>164036, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Sravan Kumar Patel", "Yang Zhang", "John A. Pollock", "Jelena M. Janjic"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055802.g005", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_19_F_NMR_NIRF_correlation_of_labeled_macrophage_cells_/164036", "title"=>"<sup>19</sup>F NMR-NIRF correlation of labeled macrophage cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-07 01:07:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/493238"], "description"=>"<p>(A) Representative size distribution by intensity of nanoemulsions <b>A</b> (black) and <b>B</b> (red). (B) Stability of nanoemulsion <b>A</b>. (C) Stability of nanoemulsion <b>B</b>. Error bars represent half width of polydispersity index (PDIw/2).</p>", "links"=>[], "tags"=>["nanoemulsions", "droplet", "diameter"], "article_id"=>163758, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Sravan Kumar Patel", "Yang Zhang", "John A. Pollock", "Jelena M. Janjic"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055802.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Shelf_life_of_nanoemulsions_with_average_droplet_diameter_nm_at_4_176_C_and_25_176_C_/163758", "title"=>"Shelf life of nanoemulsions with average droplet diameter (nm) at 4°C and 25°C.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-07 01:02:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/493592"], "description"=>"<p>(A) Cells labeled with anti-CD45 (FITC) green and incorporated nanoemulsion <b>C</b> containing celecoxib and Cellvue® Burgundy dye represented as red. (B) Cells not exposed to the nanoemulsion <b>C</b> exhibit CD45 labeling with FITC (green) but no red signal. Transmitted light DIC image acquired simultaneously shows field of view (Bar = 30 µm). The microscope image acquisition parameters were identical between the experimental and control, and the images were all acquired within 15 min of one another.</p>", "links"=>[], "tags"=>["images"], "article_id"=>164116, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Sravan Kumar Patel", "Yang Zhang", "John A. Pollock", "Jelena M. Janjic"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055802.g006", "stats"=>{"downloads"=>1, "page_views"=>85, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fluorescence_images_of_macrophages_/164116", "title"=>"Fluorescence images of macrophages.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-07 01:08:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/493854"], "description"=>"a<p>Nanoemulsion <b>C</b> is used for confocal microscopy of labeled macrophages.</p>", "links"=>[], "tags"=>["immunology", "oncology", "radiology and medical imaging"], "article_id"=>164375, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Sravan Kumar Patel", "Yang Zhang", "John A. Pollock", "Jelena M. Janjic"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055802.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Composition_of_nanoemulsions_/164375", "title"=>"Composition of nanoemulsions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-07 01:12:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/493184"], "description"=>"<p>Droplet carrying celecoxib, perfluoropoly (ethylene glycol) ether (PFPE) and near-infrared fluorescence (NIRF) dye. Cremophor EL® (CrEL) and Pluronic® P105 (P105) are the nonionic surfactants. Miglyol 810N is the hydrophobic oil phase.</p>", "links"=>[], "tags"=>["nanoemulsion"], "article_id"=>163708, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Sravan Kumar Patel", "Yang Zhang", "John A. Pollock", "Jelena M. Janjic"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055802.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Proposed_nanoemulsion_droplet_/163708", "title"=>"Proposed nanoemulsion droplet.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-07 01:01:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/493343"], "description"=>"<p>(A) Nanoemulsion <b>A</b> (B) Nanoemulsion <b>B</b>. Each data point represent mean of at least three replicates and the error bars are standard deviation of the mean. Values are reported as percent control (0 mg/mL PFPE).</p>", "links"=>[], "tags"=>["viability"], "article_id"=>163869, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Sravan Kumar Patel", "Yang Zhang", "John A. Pollock", "Jelena M. Janjic"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055802.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Macrophage_cell_viability_post_labeling_/163869", "title"=>"Macrophage cell viability post labeling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-07 01:04:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/493704"], "description"=>"<p>(A) Cells labeled with CD45-FITC (green) and incorporated nanoemulsion <b>C</b> containing celecoxib and Cellvue® Burgundy dye exhibit broad expression of CD45 as well as localized points of fluorescent signal indicating internalization of CD45 protein. (B) The same cell and focal plane as viewed in panel A reveals the internalized Cellvue® Burgundy labeled nanoemulsions as discrete particles. (C) The transmitted light DIC view of the cell reveals the black refractive droplets, coincident with the red and green fluorescent signals (Bar = 5 µm). (D) A different cell labeled with CD45-FITC (green), (E) internalized Cellvue® Burgundy (red) and (F) transmitted light DIC view reveals discrete droplets (Bar = 5 µm). (G) The cell shown in panel D was imaged in serial section and rendered by maximum-projection to represent all of the Cellvue® Burgundy labeled particles viewed from above and (H) in 90° cross-section, to reveal that the droplets are distributed throughout the cell cytoplasm.</p>", "links"=>[], "tags"=>["fluorescence", "images", "macrophages", "exposed", "nanoemulsion"], "article_id"=>164222, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Sravan Kumar Patel", "Yang Zhang", "John A. Pollock", "Jelena M. Janjic"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055802.g007", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Magnified_fluorescence_images_of_individual_macrophages_exposed_to_nanoemulsion_C_/164222", "title"=>"Magnified fluorescence images of individual macrophages exposed to nanoemulsion C.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-07 01:10:22"}

PMC Usage Stats | Further Information

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Relative Metric

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