Measuring Airway Surface Liquid Depth in Ex Vivo Mouse Airways by X-Ray Imaging for the Assessment of Cystic Fibrosis Airway Therapies
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{"title"=>"Measuring Airway Surface Liquid Depth in Ex Vivo Mouse Airways by X-Ray Imaging for the Assessment of Cystic Fibrosis Airway Therapies", "type"=>"journal", "authors"=>[{"first_name"=>"Kaye S.", "last_name"=>"Morgan", "scopus_author_id"=>"24402684400"}, {"first_name"=>"Martin", "last_name"=>"Donnelley", "scopus_author_id"=>"8535250700"}, {"first_name"=>"David M.", "last_name"=>"Paganin", "scopus_author_id"=>"36792475200"}, {"first_name"=>"Andreas", "last_name"=>"Fouras", "scopus_author_id"=>"16244599600"}, {"first_name"=>"Naoto", "last_name"=>"Yagi", "scopus_author_id"=>"7102277714"}, {"first_name"=>"Yoshio", "last_name"=>"Suzuki", "scopus_author_id"=>"36079792300"}, {"first_name"=>"Akihisa", "last_name"=>"Takeuchi", "scopus_author_id"=>"7201866875"}, {"first_name"=>"Kentaro", "last_name"=>"Uesugi", "scopus_author_id"=>"35447620000"}, {"first_name"=>"Richard C.", "last_name"=>"Boucher", "scopus_author_id"=>"7202772816"}, {"first_name"=>"David W.", "last_name"=>"Parsons", "scopus_author_id"=>"7202328307"}, {"first_name"=>"Karen K W", "last_name"=>"Siu", "scopus_author_id"=>"7102312063"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"84873806462", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0055822", "pui"=>"368227272", "pmid"=>"23383288", "scopus"=>"2-s2.0-84873806462"}, "id"=>"61072b88-467a-354e-b53e-e8fe38e7fb0f", "abstract"=>"In the airways of those with cystic fibrosis (CF), the leading pathophysiological hypothesis is that an ion channel defect results in a relative decrease in airway surface liquid (ASL) volume, producing thick and sticky mucus that facilitates the establishment and progression of early fatal lung disease. This hypothesis predicts that any successful CF airway treatment for this fundamental channel defect should increase the ASL volume, but up until now there has been no method of measuring this volume that would be compatible with in vivo monitoring. In order to accurately monitor the volume of the ASL, we have developed a new x-ray phase contrast imaging method that utilizes a highly attenuating reference grid. In this study we used this imaging method to examine the effect of a current clinical CF treatment, aerosolized hypertonic saline, on ASL depth in ex vivo normal mouse tracheas, as the first step towards non-invasive in vivo ASL imaging. The ex vivo tracheas were treated with hypertonic saline, isotonic saline or no treatment using a nebuliser integrated within a small animal ventilator circuit. Those tracheas exposed to hypertonic saline showed a transient increase in the ASL depth, which continued for nine minutes post-treatment, before returning to baseline by twelve minutes. These findings are consistent with existing measurements on epithelial cell cultures, and therefore suggest promise for the future development of in vivo testing of treatments. Our grid-based imaging technique measures the ASL depth with micron resolution, and can directly observe the effect of treatments expected to increase ASL depth, prior to any changes in overall lung health. The ability to non-invasively observe micron changes in the airway surface, particularly if achieved in an in vivo setting, may have potential in pre-clinical research designed to bring new treatments for CF and other airway diseases to clinical trials.", "link"=>"http://www.mendeley.com/research/measuring-airway-surface-liquid-depth-ex-vivo-mouse-airways-xray-imaging-assessment-cystic-fibrosis", "reader_count"=>21, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>2, "Student > Bachelor"=>2, "Professor"=>1, "Student > Doctoral Student"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>2, "Student > Bachelor"=>2, "Professor"=>1, "Student > Doctoral Student"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>5, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Physics and Astronomy"=>5, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>5}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/499682"], "description"=>"<p>A statistically significant difference (* p&lt;0.05) in thickness was present for the hypertonic saline group at 3 minutes compared to control.</p>", "links"=>[], "tags"=>["thickness"], "article_id"=>170193, "categories"=>["Cell Biology", "Genetics", "Medicine", "Physics"], "users"=>["Kaye S. Morgan", "Martin Donnelley", "David M. Paganin", "Andreas Fouras", "Naoto Yagi", "Yoshio Suzuki", "Akihisa Takeuchi", "Kentaro Uesugi", "Richard C. Boucher", "David W. Parsons", "Karen K. W. Siu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055822.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Change_in_tissue_thickness_relative_to_initial_thickness_as_a_function_of_time_/170193", "title"=>"Change in tissue thickness (relative to initial thickness), as a function of time.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:21:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/499452"], "description"=>"<p>Single-grid based image of the airway surface under hypertonic saline treatment, showing the sample thickness gradient in the <i>x</i> direction (the thickness gradient in the <i>y</i> direction is not shown as most features run vertically and do not provide <i>y-</i>contrast) <i>a)</i> before hypertonic saline treatment, <i>b)</i> 3 minutes after treatment, <i>c)</i> 6 minutes after treatment and <i>d)</i> the projected thickness calculated from image <i>c)</i>.</p>", "links"=>[], "tags"=>["genetics and genomics", "physics", "respiratory medicine", "radiology and medical imaging"], "article_id"=>169954, "categories"=>["Cell Biology", "Genetics", "Medicine", "Physics"], "users"=>["Kaye S. Morgan", "Martin Donnelley", "David M. Paganin", "Andreas Fouras", "Naoto Yagi", "Yoshio Suzuki", "Akihisa Takeuchi", "Kentaro Uesugi", "Richard C. Boucher", "David W. Parsons", "Karen K. W. Siu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055822.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Figure_3/169954", "title"=>"Figure 3", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:20:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/499571"], "description"=>"<p>A statistically significant increase in the ASL depth occurred with hypertonic saline treatment at 3 minutes (** p&lt;0.01), 6 minutes (**** p&lt;0.0001) and 9 minutes (*** p&lt;0.001) compared to control.</p>", "links"=>[], "tags"=>["hypertonic", "saline", "isotonic", "rx"], "article_id"=>170076, "categories"=>["Cell Biology", "Genetics", "Medicine", "Physics"], "users"=>["Kaye S. Morgan", "Martin Donnelley", "David M. Paganin", "Andreas Fouras", "Naoto Yagi", "Yoshio Suzuki", "Akihisa Takeuchi", "Kentaro Uesugi", "Richard C. Boucher", "David W. Parsons", "Karen K. W. Siu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055822.g004", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/ASL_depth_as_a_function_of_time_in_response_to_hypertonic_saline_7_isotonic_saline_0_7_or_no_treatment_No_Rx_Control_/170076", "title"=>"ASL depth as a function of time, in response to hypertonic saline (7%), isotonic saline (0.7%) or no treatment (No Rx – Control).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:20:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/499212"], "description"=>"<p>The sample is arranged so that the imaged ASL region is the ventral tracheal surface.</p>", "links"=>[], "tags"=>["trachea", "mounted", "vertically", "air-filled", "capillaries", "submerged", "phosphate", "buffered", "saline"], "article_id"=>169693, "categories"=>["Cell Biology", "Genetics", "Medicine", "Physics"], "users"=>["Kaye S. Morgan", "Martin Donnelley", "David M. Paganin", "Andreas Fouras", "Naoto Yagi", "Yoshio Suzuki", "Akihisa Takeuchi", "Kentaro Uesugi", "Richard C. Boucher", "David W. Parsons", "Karen K. W. Siu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0055822.g001", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_i_Ex_vivo_i_trachea_mounted_vertically_between_air_filled_capillaries_and_submerged_in_a_warm_phosphate_buffered_saline_bath_for_imaging_/169693", "title"=>"<i>Ex vivo</i> trachea mounted vertically between air-filled capillaries and submerged in a warm phosphate buffered saline bath for imaging.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:18:36"}
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Relative Metric

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