A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease", "type"=>"journal", "authors"=>[{"first_name"=>"Carl J.", "last_name"=>"Yeoman", "scopus_author_id"=>"35762512300"}, {"first_name"=>"Susan M.", "last_name"=>"Thomas", "scopus_author_id"=>"56413692400"}, {"first_name"=>"Margret E Berg", "last_name"=>"Miller", "scopus_author_id"=>"36717994700"}, {"first_name"=>"Alexander V.", "last_name"=>"Ulanov", "scopus_author_id"=>"56262555200"}, {"first_name"=>"Manolito", "last_name"=>"Torralba", "scopus_author_id"=>"35747428100"}, {"first_name"=>"Sarah", "last_name"=>"Lucas", "scopus_author_id"=>"55343002000"}, {"first_name"=>"Marcus", "last_name"=>"Gillis", "scopus_author_id"=>"36094108000"}, {"first_name"=>"Melissa", "last_name"=>"Cregger", "scopus_author_id"=>"14007447200"}, {"first_name"=>"Andres", "last_name"=>"Gomez", "scopus_author_id"=>"55195413900"}, {"first_name"=>"Mengfei", "last_name"=>"Ho", "scopus_author_id"=>"7403080933"}, {"first_name"=>"Steven R.", "last_name"=>"Leigh", "scopus_author_id"=>"7004384016"}, {"first_name"=>"Rebecca", "last_name"=>"Stumpf", "scopus_author_id"=>"7006494055"}, {"first_name"=>"Douglas J.", "last_name"=>"Creedon", "scopus_author_id"=>"6603579690"}, {"first_name"=>"Michael A.", "last_name"=>"Smith", "scopus_author_id"=>"55574240051"}, {"first_name"=>"Jon S.", "last_name"=>"Weisbaum", "scopus_author_id"=>"6504355524"}, {"first_name"=>"Karen E.", "last_name"=>"Nelson", "scopus_author_id"=>"7403227781"}, {"first_name"=>"Brenda A.", "last_name"=>"Wilson", "scopus_author_id"=>"35509126100"}, {"first_name"=>"Bryan A.", "last_name"=>"White", "scopus_author_id"=>"7401649990"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pui"=>"368304269", "sgr"=>"84873539965", "doi"=>"10.1371/journal.pone.0056111", "scopus"=>"2-s2.0-84873539965", "pmid"=>"23405259"}, "id"=>"dd54ba06-45c6-3804-80e5-3b37e6f265b9", "abstract"=>"BACKGROUND: Bacterial vaginosis (BV) is the most common vaginal disorder of reproductive-age women. Yet the cause of BV has not been established. To uncover key determinants of BV, we employed a multi-omic, systems-biology approach, including both deep 16S rRNA gene-based sequencing and metabolomics of lavage samples from 36 women. These women varied demographically, behaviorally, and in terms of health status and symptoms.\\n\\nPRINCIPAL FINDINGS: 16S rRNA gene-based community composition profiles reflected Nugent scores, but not Amsel criteria. In contrast, metabolomic profiles were markedly more concordant with Amsel criteria. Metabolomic profiles revealed two distinct symptomatic BV types (SBVI and SBVII) with similar characteristics that indicated disruption of epithelial integrity, but each type was correlated to the presence of different microbial taxa and metabolites, as well as to different host behaviors. The characteristic odor associated with BV was linked to increases in putrescine and cadaverine, which were both linked to Dialister spp. Additional correlations were seen with the presence of discharge, 2-methyl-2-hydroxybutanoic acid, and Mobiluncus spp., and with pain, diethylene glycol and Gardnerella spp.\\n\\nCONCLUSIONS: The results not only provide useful diagnostic biomarkers, but also may ultimately provide much needed insight into the determinants of BV.", "link"=>"http://www.mendeley.com/research/multiomic-systemsbased-approach-reveals-metabolic-markers-bacterial-vaginosis-insight-disease", "reader_count"=>99, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Researcher"=>21, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>25, "Student > Postgraduate"=>7, "Student > Master"=>14, "Other"=>5, "Student > Bachelor"=>10, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Researcher"=>21, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>25, "Student > Postgraduate"=>7, "Student > Master"=>14, "Other"=>5, "Student > Bachelor"=>10, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>8, "Engineering"=>2, "Environmental Science"=>4, "Biochemistry, Genetics and Molecular Biology"=>6, "Mathematics"=>1, "Agricultural and Biological Sciences"=>51, "Medicine and Dentistry"=>14, "Arts and Humanities"=>1, "Physics and Astronomy"=>1, "Chemistry"=>2, "Computer Science"=>4, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Chemistry"=>{"Chemistry"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>51}, "Computer Science"=>{"Computer Science"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>8}, "Environmental Science"=>{"Environmental Science"=>4}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"United States"=>6, "Denmark"=>1, "United Kingdom"=>2, "Slovenia"=>1, "Spain"=>1}, "group_count"=>2}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84873539965"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84873539965?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873539965&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84873539965&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84873539965", "dc:identifier"=>"SCOPUS_ID:84873539965", "eid"=>"2-s2.0-84873539965", "dc:title"=>"A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease", "dc:creator"=>"Yeoman C.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-02-06", "prism:coverDisplayDate"=>"6 February 2013", "prism:doi"=>"10.1371/journal.pone.0056111", "citedby-count"=>"48", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Montana State University", "affiliation-city"=>"Bozeman", "affiliation-country"=>"United States"}, {"@_fa"=>"true", "affilname"=>"University of Illinois at Urbana-Champaign", "affiliation-city"=>"Urbana", "affiliation-country"=>"United States"}], "pubmed-id"=>"23405259", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e56111", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0056111", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

Counter

  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"89", "xml_views"=>"6", "html_views"=>"385"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"46", "xml_views"=>"1", "html_views"=>"214"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"25", "xml_views"=>"6", "html_views"=>"202"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"163"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"99"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"145"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"117"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"126"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"3", "html_views"=>"195"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"161"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"84"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"127"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"141"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"156"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"151"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"283"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"137"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"149"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"171"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"302"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"101"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"92"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"72"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"68"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"62"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"67"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"104"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"66"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"38"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"74"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"7", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/494729"], "description"=>"<p>Rarefaction curves showing the richness of microbiomes for all samples colored by Nugent score (A; green = 0–3, orange = 4–6, red = 7–10) or Amsel classification (B; red = positive, green = negative) are presented along with Shannon diversity indexes (C), with samples grouped by Nugent score or Amsel criteria and colored as in rarefaction curves.</p>", "links"=>[], "tags"=>["Infectious diseases", "Computational biology", "women's health", "Biochemistry"], "article_id"=>165229, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Richness_and_Diversity_of_Each_Sample_/165229", "title"=>"Richness and Diversity of Each Sample.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:27:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/495874"], "description"=>"D<p>Metabolite linked to douching in network.</p>", "links"=>[], "tags"=>["Infectious diseases", "Computational biology", "women's health", "Biochemistry"], "article_id"=>166366, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.t003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Metabotype_defining_Metabolites_/166366", "title"=>"Metabotype defining Metabolites.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:46:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/495701"], "description"=>"<p>Measured as <sup>1</sup>Days since <sup>2</sup>Times weekly <sup>3</sup>Times monthly <sup>4</sup>In past 6 months.</p>", "links"=>[], "tags"=>["lengths"], "article_id"=>166203, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.t005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Network_path_lengths_to_BV_/166203", "title"=>"Network path lengths to BV.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:43:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/495548"], "description"=>"<p>Shown is a diagram depicting classical components of a cell membrane that is depleted in either of the metabolome profiles of the two symptomatic BV types.</p>", "links"=>[], "tags"=>["membrane"], "article_id"=>166057, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.g008", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cell_Membrane_Degradation_/166057", "title"=>"Cell Membrane Degradation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:40:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/495423"], "description"=>"<p>Pearson's (between parametric data) and Spearman's (between non-parametric and either parametric or non-parametric data) correlations >0.6 (green) or <−0.4 (red) are shown as edges connecting patient metadata relating to demographics, hygiene and sexual behaviors and sexual practices, OTUs, microbial genera, metabolites and patient symptoms. Figures presented represent sub-networks of the complete network (Fig S2). Node identities are listed or described in the key. The identities of numbered metabolites are listed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056111#pone.0056111.s007\" target=\"_blank\">Table S2</a>.</p>", "links"=>[], "tags"=>["sub-network", "linear", "relationships"], "article_id"=>165927, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.g007", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SBVII_Sub_Network_View_of_Linear_Relationships_among_Variables_/165927", "title"=>"SBVII Sub-Network View of Linear Relationships among Variables.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:38:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/495299"], "description"=>"<p>Pearson’s (between parametric data) and Spearman's (between non-parametric and either parametric or non-parametric data) correlations >0.6 (green) or <−0.4 (red) are shown as edges connecting patient metadata relating to demographics, hygiene and sexual behaviors and sexual practices, OTUs, microbial genera, metabolites and patient symptoms. Figures presented represent sub-networks of the complete network (Fig S2). Node identities are listed or described in the key for <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056111#pone-0056111-g007\" target=\"_blank\">figure 7</a>. The identities of numbered metabolites are listed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056111#pone.0056111.s007\" target=\"_blank\">Table S2</a>.</p>", "links"=>[], "tags"=>["sub-network", "linear", "relationships"], "article_id"=>165800, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.g006", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SBVI_Sub_Network_View_of_Linear_Relationships_among_Variables_/165800", "title"=>"SBVI Sub-Network View of Linear Relationships among Variables.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:36:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/495660"], "description"=>"A<p>Non-BV by respective criteria <sup>B</sup> Metabolite was increased in Type II BV and Nugent-defined Non-BV <sup>1–59</sup> Represent rank order for each BV type * Metabolite not seen in BV types but seen in most or ** all non-BV types. Blank squares indicate either less than 2-fold enrichment or <i>p</i>-value>0.05 or both.</p>", "links"=>[], "tags"=>["metabolites"], "article_id"=>166159, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.t004", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Significantly_affected_Metabolites_Non_BV_vs_BV_/166159", "title"=>"Significantly-affected Metabolites (Non-BV vs BV).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:42:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/494842"], "description"=>"<p>Shown is a heatmap of the relative enrichment of the most abundant thirty microbial genera across the entire sample set and the relationships among samples. Highly abundant genera tend toward bright green, while less abundant genera tend toward blue, as shown in the key. Dendrograms show the relationship among samples. Red bars in the dendrogram show the relationship of samples with symptomatic BV. Nugent scores are presented beneath the dendrogram.</p>", "links"=>[], "tags"=>["taxonomic", "enrichment"], "article_id"=>165340, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.g002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heatmap_of_Taxonomic_Enrichment_by_Sample_/165340", "title"=>"Heatmap of Taxonomic Enrichment by Sample.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:29:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/494966"], "description"=>"<p>Shown are nMDS plots of the 16S rRNA reads clustered by genus for all taxa (A), or for just <i>Gardnerella</i> and <i>Lactobacillus</i> (B), or metabolite profiles (C). Samples from patients determined by Amsel criteria to have BV are shown in red, while samples determined by Amsel to be healthy are shown in green. Samples with a high (7–10; up-pointing triangles), moderate (4–6; diamonds) and low (0–3; down-pointing triangles) are indicated. The two metabotypes are delineated by hollow (type I) and solid (type II) symbols.</p>", "links"=>[], "tags"=>["multidimensional", "scaling"], "article_id"=>165468, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nonmetric_Multidimensional_Scaling_Analyses_/165468", "title"=>"Nonmetric Multidimensional Scaling Analyses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:31:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/495195"], "description"=>"<p>Shown is a Venn diagram of the numbers of unique and shared metabolites that delineate high Nugent scoring (≥7), Type I symptomatic BV or Type II symptomatic BV from other samples.</p>", "links"=>[], "tags"=>["diagram", "discriminative"], "article_id"=>165701, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.g005", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Venn_Diagram_of_Discriminative_Metabolites_/165701", "title"=>"Venn Diagram of Discriminative Metabolites.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:35:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/495753"], "description"=>"<p>BV Symptoms: (D)ischarge, (O)dor, (P)ain, (I)tching, p(H), (C)lue cells; Ethnicity: (A)frican American, A(S)ian American, (C)aucasian; Marital status: (M)arried, (S)ingle/Divorced; Tampon use/New partner (in past 6 months): (Y)es, (N)o; Oral and Anal sex frequency is denoted as times monthly, Vaginal sex and Bathing frequency is weekly; Condom use: (N)o, (L)ess than half of the time, (M)ore than half of the time, (A)lways.</p>nr<p>Not reported; <sup>1</sup>Biotype as per Ravel <i>et al.</i>, 2011; <sup>2</sup>Near equal numbers of <i>L. gasserii</i> were detected.</p>", "links"=>[], "tags"=>["Infectious diseases", "Computational biology", "women's health", "Biochemistry"], "article_id"=>166255, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_Descriptions_/166255", "title"=>"Sample Descriptions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:44:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/495813"], "description"=>"1<p>Only samples found to contain <i>L. iners</i> are shown</p>", "links"=>[], "tags"=>["pcr", "enumeration", "lactobacillus", "inners"], "article_id"=>166305, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.t002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantitative_PCR_Enumeration_of_Lactobacillus_inners_by_Sample_/166305", "title"=>"Quantitative PCR Enumeration of Lactobacillus inners by Sample.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-06 01:45:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/483183", "https://ndownloader.figshare.com/files/483185", "https://ndownloader.figshare.com/files/483187", "https://ndownloader.figshare.com/files/483189", "https://ndownloader.figshare.com/files/483192", "https://ndownloader.figshare.com/files/483193", "https://ndownloader.figshare.com/files/483195", "https://ndownloader.figshare.com/files/483196"], "description"=>"<div><h3>Background</h3><p>Bacterial vaginosis (BV) is the most common vaginal disorder of reproductive-age women. Yet the cause of BV has not been established. To uncover key determinants of BV, we employed a multi-omic, systems-biology approach, including both deep 16S rRNA gene-based sequencing and metabolomics of lavage samples from 36 women. These women varied demographically, behaviorally, and in terms of health status and symptoms.</p> <h3>Principal Findings</h3><p>16S rRNA gene-based community composition profiles reflected Nugent scores, but not Amsel criteria. In contrast, metabolomic profiles were markedly more concordant with Amsel criteria. Metabolomic profiles revealed two distinct symptomatic BV types (SBVI and SBVII) with similar characteristics that indicated disruption of epithelial integrity, but each type was correlated to the presence of different microbial taxa and metabolites, as well as to different host behaviors. The characteristic odor associated with BV was linked to increases in putrescine and cadaverine, which were both linked to <em>Dialister</em> spp. Additional correlations were seen with the presence of discharge, 2-methyl-2-hydroxybutanoic acid, and <em>Mobiluncus</em> spp., and with pain, diethylene glycol and <em>Gardnerella</em> spp.</p> <h3>Conclusions</h3><p>The results not only provide useful diagnostic biomarkers, but also may ultimately provide much needed insight into the determinants of BV.</p> </div>", "links"=>[], "tags"=>["multi-omic", "systems-based", "reveals", "metabolic", "markers", "bacterial", "vaginosis", "disease"], "article_id"=>156018, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0056111.s001", "https://dx.doi.org/10.1371/journal.pone.0056111.s002", "https://dx.doi.org/10.1371/journal.pone.0056111.s003", "https://dx.doi.org/10.1371/journal.pone.0056111.s004", "https://dx.doi.org/10.1371/journal.pone.0056111.s005", "https://dx.doi.org/10.1371/journal.pone.0056111.s006", "https://dx.doi.org/10.1371/journal.pone.0056111.s007", "https://dx.doi.org/10.1371/journal.pone.0056111.s008"], "stats"=>{"downloads"=>27, "page_views"=>54, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Multi_Omic_Systems_Based_Approach_Reveals_Metabolic_Markers_of_Bacterial_Vaginosis_and_Insight_into_the_Disease__/156018", "title"=>"A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-02-06 01:40:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/495082"], "description"=>"<p>Shown is a heatmap of the relative enrichment of each metabolite across the entire sample set and the relationships among samples and among metabolites. Highly abundant metabolites tend toward red, while less abundant metabolites tend toward blue. Dendrograms show the relationship among samples (top) and among metabolites (left). The two BV metabotypes observed (I and II) are labeled at their branching point. Red bars in the top dendrogram show the relationship of samples with symptomatic BV. Nugent scores are shown for each sample. Metabolite mentioned in-text are labeled, others are numbered as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056111#pone.0056111.s007\" target=\"_blank\">Table S2</a>.</p>", "links"=>[], "tags"=>["metabolite", "enrichment"], "article_id"=>165577, "categories"=>["Biological Sciences", "Biochemistry", "Mathematics", "Infectious Diseases"], "users"=>["Carl J. Yeoman", "Susan M. Thomas", "Margret E. Berg Miller", "Alexander V. Ulanov", "Manolito Torralba", "Sarah Lucas", "Marcus Gillis", "Melissa Cregger", "Andres Gomez", "Mengfei Ho", "Steven R. Leigh", "Rebecca Stumpf", "Douglas J. Creedon", "Michael A. Smith", "Jon S. Weisbaum", "Karen E. Nelson", "Brenda A. Wilson", "Bryan A. White"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056111.g004", "stats"=>{"downloads"=>5, "page_views"=>55, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heatmap_of_Metabolite_Enrichment_by_Sample_/165577", "title"=>"Heatmap of Metabolite Enrichment by Sample.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-06 01:32:57"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"57", "full-text"=>"51", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"36", "full-text"=>"38", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"35", "full-text"=>"37", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"23", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"30", "full-text"=>"30", "pdf"=>"13", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"3", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"37", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"14", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"10", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"6", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"4", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"9", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"5", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"4", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"13", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"60", "full-text"=>"55", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"8", "cited-by"=>"1", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[293, 503, 638, 755, 861, 960, 1056, 1146, 1239, 1323, 1403, 1491, 1568]}, {"subject_area"=>"/Computer and information sciences", "average_usage"=>[297, 488, 616, 724, 828, 939, 1038, 1127, 1223, 1311, 1393, 1479, 1556]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Infectious diseases", "average_usage"=>[297, 523, 655, 765, 866, 971, 1070, 1159, 1256, 1337, 1424, 1496, 1568]}, {"subject_area"=>"/Medicine and health sciences/Urology", "average_usage"=>[264, 490, 621, 739, 833, 927, 1020, 1102, 1204, 1282, 1349, 1432, 1504]}]}
Loading … Spinner
There are currently no alerts