Fine-Mapping Angiotensin-Converting Enzyme Gene: Separate QTLs Identified for Hypertension and for ACE Activity
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Fine-Mapping Angiotensin-Converting Enzyme Gene: Separate QTLs Identified for Hypertension and for ACE Activity", "type"=>"journal", "authors"=>[{"first_name"=>"Chia Min", "last_name"=>"Chung", "scopus_author_id"=>"22950004900"}, {"first_name"=>"Ruey Yun", "last_name"=>"Wang", "scopus_author_id"=>"15737758600"}, {"first_name"=>"Cathy S.J.", "last_name"=>"Fann", "scopus_author_id"=>"7003548346"}, {"first_name"=>"Jaw Wen", "last_name"=>"Chen", "scopus_author_id"=>"35267970100"}, {"first_name"=>"Yuh Shiun", "last_name"=>"Jong", "scopus_author_id"=>"25940909100"}, {"first_name"=>"Yuh Shan", "last_name"=>"Jou", "scopus_author_id"=>"7005612299"}, {"first_name"=>"Hsin Chou", "last_name"=>"Yang", "scopus_author_id"=>"49762407800"}, {"first_name"=>"Chih Sen", "last_name"=>"Kang", "scopus_author_id"=>"22950901400"}, {"first_name"=>"Chien Chung", "last_name"=>"Chen", "scopus_author_id"=>"7501961993"}, {"first_name"=>"Huan Cheng", "last_name"=>"Chang", "scopus_author_id"=>"57145405100"}, {"first_name"=>"Wen Harn", "last_name"=>"Pan", "scopus_author_id"=>"7402219783"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23469169", "doi"=>"10.1371/journal.pone.0056119", "pui"=>"368465195", "issn"=>"19326203", "sgr"=>"84874627047", "scopus"=>"2-s2.0-84874627047"}, "id"=>"952b4fa1-b227-3113-997b-bc981a359058", "abstract"=>"Angiotensin-converting enzyme (ACE) has been implicated in multiple biological system, particularly cardiovascular diseases. However, findings associating ACE insertion/deletion polymorphism with hypertension or other related traits are inconsistent. Therefore, in a two-stage approach, we aimed to fine-map ACE in order to narrow-down the function-specific locations. We genotyped 31 single nucleotide polymorphisms (SNPs) of ACE from 1168 individuals from 305 young-onset (age ≤40) hypertension pedigrees, and found four linkage disequilibrium (LD) blocks. A tag-SNP, rs1800764 on LD block 2, upstream of and near the ACE promoter, was significantly associated with young-onset hypertension (p = 0.04). Tag-SNPs on all LD blocks were significantly associated with ACE activity (p-value: 10(-16) to <10(-33)). The two regions most associated with ACE activity were found between exon13 and intron18 and between intron 20 and 3'UTR, as revealed by measured haplotype analysis. These two major QTLs of ACE activity and the moderate effect variant upstream of ACE promoter for young-onset hypertension were replicated by another independent association study with 842 subjects.", "link"=>"http://www.mendeley.com/research/finemapping-angiotensinconverting-enzyme-gene-separate-qtls-identified-hypertension-ace-activity", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Other"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Other"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>5, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84874627047"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84874627047?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84874627047&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84874627047&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84874627047", "dc:identifier"=>"SCOPUS_ID:84874627047", "eid"=>"2-s2.0-84874627047", "dc:title"=>"Fine-Mapping Angiotensin-Converting Enzyme Gene: Separate QTLs Identified for Hypertension and for ACE Activity", "dc:creator"=>"Chung C.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-03-04", "prism:coverDisplayDate"=>"4 March 2013", "prism:doi"=>"10.1371/journal.pone.0056119", "citedby-count"=>"15", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Academia Sinica, Institute of Biomedical Sciences", "affiliation-city"=>"Taipei", "affiliation-country"=>"Taiwan"}, {"@_fa"=>"true", "affilname"=>"National Health Research Institutes Taiwan", "affiliation-city"=>"Zhunan", "affiliation-country"=>"Taiwan"}], "pubmed-id"=>"23469169", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e56119", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0056119", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"37", "xml_views"=>"4", "html_views"=>"219"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"3", "html_views"=>"77"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"64"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"44"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"5", "html_views"=>"35"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"45"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"8", "html_views"=>"11"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"5", "html_views"=>"8"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"5", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"4", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"7", "html_views"=>"16"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"8", "html_views"=>"4"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"8"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"4", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"0"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1011435"], "description"=>"<p>Young-onset hypertension is defined by SBP >140 mm Hg, DBP >90 mm Hg, or taking hypertensive medications and onset age ≤40 years.</p><p>SqrtACE activity, square root of angiotensin-converting enzyme activity;</p><p>BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure.</p>*<p>p<0.05 for comparison between men and women, using the mixed model controlled for intra-family correlation.</p>", "links"=>[], "tags"=>["genetics and genomics", "public health and epidemiology", "Computational biology", "epidemiology", "Evolutionary biology"], "article_id"=>671842, "categories"=>["Immunology", "Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Chia-Min Chung", "Ruey-Yun Wang", "Cathy S. J. Fann", "Jaw-Wen Chen", "Yuh-Shiun Jong", "Yuh-Shan Jou", "Hsin-Chou Yang", "Chih-Sen Kang", "Chien-Chung Chen", "Huan-Cheng Chang", "Wen-Harn Pan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056119.t001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_participants_/671842", "title"=>"Characteristics of the participants.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-04 00:30:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1011412"], "description"=>"*<p>SNPs in stage-1 haplotype analysis.</p>†<p>Additional SNPs.</p>", "links"=>[], "tags"=>["snps", "rs4311", "rs4366", "variants", "ace"], "article_id"=>671811, "categories"=>["Immunology", "Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Chia-Min Chung", "Ruey-Yun Wang", "Cathy S. J. Fann", "Jaw-Wen Chen", "Yuh-Shiun Jong", "Yuh-Shan Jou", "Hsin-Chou Yang", "Chih-Sen Kang", "Chien-Chung Chen", "Huan-Cheng Chang", "Wen-Harn Pan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056119.t004", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Additional_SNPs_between_rs4311_and_rs4366_to_determine_which_variants_influence_ACE_activity_variation_/671811", "title"=>"Additional SNPs between rs4311 and rs4366 to determine which variants influence ACE activity variation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-04 00:30:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1011484"], "description"=>"*<p>The bin from rs4311 to rs4366 for further fine-mapping.</p>", "links"=>[], "tags"=>["ace", "haplotypes", "frequencies", "means", "serum"], "article_id"=>671891, "categories"=>["Immunology", "Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Chia-Min Chung", "Ruey-Yun Wang", "Cathy S. J. Fann", "Jaw-Wen Chen", "Yuh-Shiun Jong", "Yuh-Shan Jou", "Hsin-Chou Yang", "Chih-Sen Kang", "Chien-Chung Chen", "Huan-Cheng Chang", "Wen-Harn Pan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056119.t003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ranked_ACE_haplotypes_frequencies_and_means_of_serum_ACE_levels_/671891", "title"=>"Ranked ACE haplotypes frequencies and means of serum ACE levels.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-04 00:31:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/976412"], "description"=>"<p>We selected 41 SNPs (distributed over <i>ACE</i> and another 11 surrounding genes) based on Assay-on-Demand (Applied Biosystems) by using the Han Chinese SNP database with SNPbrowser software. The number of SNPs for each gene is shown in parentheses.</p>", "links"=>[], "tags"=>["first-stage", "fine-mapping", "ace", "qtl", "41", "snps", "flanking", "chromosome"], "article_id"=>643893, "categories"=>["Immunology", "Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Chia-Min Chung", "Ruey-Yun Wang", "Cathy S. J. Fann", "Jaw-Wen Chen", "Yuh-Shiun Jong", "Yuh-Shan Jou", "Hsin-Chou Yang", "Chih-Sen Kang", "Chien-Chung Chen", "Huan-Cheng Chang", "Wen-Harn Pan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056119.g001", "stats"=>{"downloads"=>1, "page_views"=>49, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_first_stage_fine_mapping_for_ACE_activity_QTL_with_41_SNPs_flanking_ACE_structural_gene_and_the_surrounding_region_on_chromosome_17q23_/643893", "title"=>"The first-stage fine-mapping for ACE activity QTL with 41 SNPs flanking ACE structural gene and the surrounding region on chromosome 17q23.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 08:45:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1011460"], "description"=>"*<p>The estimates and standard error (SE) of ACE activity, the odds ratio (OR) and the 95% confidence interval (CI) of young-onset hypertension were performed individually for each SNP by generalized estimating equations; adjusted for age, gender, and drugs; and controlled for intra-family correlation.</p>†<p>Young-onset hypertension was treated as a binary trait, and was regressed on genotypes constructed from measured genotyped tag-SNPs using a generalized linear model with a logit link function, adjusting age, gender, and anti-hypertensive medications.</p>", "links"=>[], "tags"=>["acquiring", "young-onset", "hypertension"], "article_id"=>671864, "categories"=>["Immunology", "Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Chia-Min Chung", "Ruey-Yun Wang", "Cathy S. J. Fann", "Jaw-Wen Chen", "Yuh-Shiun Jong", "Yuh-Shan Jou", "Hsin-Chou Yang", "Chih-Sen Kang", "Chien-Chung Chen", "Huan-Cheng Chang", "Wen-Harn Pan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056119.t002", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ACE_activity_and_risk_of_acquiring_young_onset_hypertension_among_people_with_different_genotypes_/671864", "title"=>"ACE activity and risk of acquiring young-onset hypertension among people with different genotypes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-04 00:31:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/976416"], "description"=>"<p>Haplotype, tag-SNP, and LD block information derived by Haploview and genotyped tag-SNPs for verification study are shown in the top figure. The rs number for each SNP is provided. The numbers at the top of the upper panel in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056119#pone-0056119-g002\" target=\"_blank\">Figure 2(A)</a> and at the bottom of the lower panel in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056119#pone-0056119-g002\" target=\"_blank\">Figure 2(B)</a> are the serial numbers of the 31 genotyped SNPs. The open and filled triangles in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056119#pone-0056119-g002\" target=\"_blank\">Figure 2(A)</a> display tag-SNPs. The filled triangles are those selected for verification study. <sup>a</sup>A value displays frequency of the haplotype in the LD block on the left side. <sup>b</sup>A value of multiallelic D' representing the level of recombination between the two blocks. <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056119#pone-0056119-g002\" target=\"_blank\">Figure 2(B)</a>. Differences of mean ACE activity between genotypes (solid and dashed lines) were determined individually for each SNP by generalized estimating equations (GEE), and adjusted for age, gender, and antihypertensive medications. The distribution and relative locations of the 31 SNPs are shown in the lower panel of <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056119#pone-0056119-g002\" target=\"_blank\">Figure 2</a>.</p>", "links"=>[], "tags"=>["second-stage", "fine-mapping", "ace", "qtl"], "article_id"=>643897, "categories"=>["Immunology", "Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Chia-Min Chung", "Ruey-Yun Wang", "Cathy S. J. Fann", "Jaw-Wen Chen", "Yuh-Shiun Jong", "Yuh-Shan Jou", "Hsin-Chou Yang", "Chih-Sen Kang", "Chien-Chung Chen", "Huan-Cheng Chang", "Wen-Harn Pan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056119.g002", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_second_stage_fine_mapping_for_ACE_activity_QTL_on_the_ACE_structural_gene_/643897", "title"=>"The second-stage fine-mapping for ACE activity QTL on the ACE structural gene.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 08:46:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/976419"], "description"=>"<p>Box plots display mean expression ± one quartile. Gray medium dash line stands for mean level. Results are grouped by haplotype. ACE mRNA levels are relative to β-actin. * P<0.05 vs. Haplotype 2.</p>", "links"=>[], "tags"=>["mrna", "angiotensin", "enzyme", "lymphoblast"], "article_id"=>643900, "categories"=>["Immunology", "Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Chia-Min Chung", "Ruey-Yun Wang", "Cathy S. J. Fann", "Jaw-Wen Chen", "Yuh-Shiun Jong", "Yuh-Shan Jou", "Hsin-Chou Yang", "Chih-Sen Kang", "Chien-Chung Chen", "Huan-Cheng Chang", "Wen-Harn Pan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056119.g003", "stats"=>{"downloads"=>0, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_mRNA_expression_levels_of_angiotensin_I_8211_converting_enzyme_in_lymphoblast_cells_/643900", "title"=>"Total mRNA expression levels of angiotensin I–converting enzyme in lymphoblast cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 08:46:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/976421"], "description"=>"<p>Potential SNPs or regions of the ACE gene influencing inter-individual variation of the circulating ACE activity in present and previous studies.</p>", "links"=>[], "tags"=>["snps", "regions", "ace", "inter-individual", "circulating"], "article_id"=>643902, "categories"=>["Immunology", "Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Chia-Min Chung", "Ruey-Yun Wang", "Cathy S. J. Fann", "Jaw-Wen Chen", "Yuh-Shiun Jong", "Yuh-Shan Jou", "Hsin-Chou Yang", "Chih-Sen Kang", "Chien-Chung Chen", "Huan-Cheng Chang", "Wen-Harn Pan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0056119.g004", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Potential_SNPs_or_regions_of_the_ACE_gene_influencing_inter_individual_variation_of_the_circulating_ACE_activity_in_present_and_previous_studies_/643902", "title"=>"Potential SNPs or regions of the ACE gene influencing inter-individual variation of the circulating ACE activity in present and previous studies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 08:46:55"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"31", "full-text"=>"26", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"41", "full-text"=>"41", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"4", "abstract"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"7", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"31", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"10", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[295, 511, 651, 775, 882, 992, 1100, 1201, 1304, 1400, 1486, 1570, 1650]}, {"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[302, 488, 607, 717, 832, 931, 1024, 1117, 1212, 1302, 1389, 1469, 1535]}, {"subject_area"=>"/Biology and life sciences/Population biology", "average_usage"=>[269, 448, 558, 658, 744, 830, 914, 995, 1068, 1139, 1214, 1284, 1349]}, {"subject_area"=>"/Medicine and health sciences/Vascular medicine", "average_usage"=>[222, 394, 496, 593, 683, 762, 835, 910, 980, 1047, 1116, 1184, 1244]}]}
Loading … Spinner
There are currently no alerts