Comparison of Treatment Outcomes of New Smear-Positive Pulmonary Tuberculosis Patients by HIV and Antiretroviral Status in a TB/HIV Clinic, Malawi
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{"title"=>"Comparison of treatment outcomes of new smear-positive pulmonary tuberculosis patients by HIV and antiretroviral status in a TB/HIV clinic, Malawi", "type"=>"journal", "authors"=>[{"first_name"=>"Hannock", "last_name"=>"Tweya", "scopus_author_id"=>"22982486800"}, {"first_name"=>"Caryl", "last_name"=>"Feldacker", "scopus_author_id"=>"24381784000"}, {"first_name"=>"Sam", "last_name"=>"Phiri", "scopus_author_id"=>"23486751200"}, {"first_name"=>"Anne", "last_name"=>"Ben-Smith", "scopus_author_id"=>"56037112000"}, {"first_name"=>"Lukas", "last_name"=>"Fenner", "scopus_author_id"=>"23396832100"}, {"first_name"=>"Andreas", "last_name"=>"Jahn", "scopus_author_id"=>"24502651000"}, {"first_name"=>"Mike", "last_name"=>"Kalulu", "scopus_author_id"=>"53982838300"}, {"first_name"=>"Ralf", "last_name"=>"Weigel", "scopus_author_id"=>"57137689900"}, {"first_name"=>"Chancy", "last_name"=>"Kamba", "scopus_author_id"=>"55314797300"}, {"first_name"=>"Rabecca", "last_name"=>"Banda", "scopus_author_id"=>"55601401900"}, {"first_name"=>"Matthias", "last_name"=>"Egger", "scopus_author_id"=>"34768019000"}, {"first_name"=>"Olivia", "last_name"=>"Keiser", "scopus_author_id"=>"35227431700"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23457534", "doi"=>"10.1371/journal.pone.0056248", "sgr"=>"84874027323", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "scopus"=>"2-s2.0-84874027323", "issn"=>"19326203", "pui"=>"368367944"}, "id"=>"8b8761d7-c32c-343d-a068-aa634bea2ced", "abstract"=>"BACKGROUND: Smear-positive pulmonary TB is the most infectious form of TB. Previous studies on the effect of HIV and antiretroviral therapy on TB treatment outcomes among these highly infectious patients demonstrated conflicting results, reducing understanding of important issues.\\n\\nMETHODS: All adult smear-positive pulmonary TB patients diagnosed between 2008 and 2010 in Malawi's largest public, integrated TB/HIV clinic were included in the study to assess treatment outcomes by HIV and antiretroviral therapy status using logistic regression.\\n\\nRESULTS: Of 2,361 new smear-positive pulmonary TB patients, 86% had successful treatment outcome (were cured or completed treatment), 5% died, 6% were lost to follow-up, 1% failed treatment, and 2% transferred-out. Overall HIV prevalence was 56%. After adjusting for gender, age and TB registration year, treatment success was higher among HIV-negative than HIV-positive patients (adjusted odds ratio 1.49; 95% CI: 1.14-1.94). Of 1,275 HIV-infected pulmonary TB patients, 492 (38%) received antiretroviral therapy during the study. Pulmonary TB patients on antiretroviral therapy were more likely to have successful treatment outcomes than those not on ART (adjusted odds ratio : 1.83; 95% CI: 1.29-2.60).\\n\\nCONCLUSION: HIV co-infection was associated with poor TB treatment outcomes. Despite high HIV prevalence and the integrated TB/HIV setting, only a minority of patients started antiretroviral therapy. Intensified patient education and provider training on the benefits of antiretroviral therapy could increase antiretroviral therapy uptake and improve TB treatment success among these most infectious patients.", "link"=>"http://www.mendeley.com/research/comparison-treatment-outcomes-new-smearpositive-pulmonary-tuberculosis-patients-hiv-antiretroviral-s", "reader_count"=>105, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Librarian"=>4, "Student > Doctoral Student"=>7, "Researcher"=>18, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>5, "Student > Master"=>27, "Other"=>9, "Student > Bachelor"=>7, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Librarian"=>4, "Student > Doctoral Student"=>7, "Researcher"=>18, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>5, "Student > Master"=>27, "Other"=>9, "Student > Bachelor"=>7, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>10, "Materials Science"=>1, "Medicine and Dentistry"=>56, "Agricultural and Biological Sciences"=>8, "Business, Management and Accounting"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>11, "Computer Science"=>5, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>56}, "Social Sciences"=>{"Social Sciences"=>11}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Computer Science"=>{"Computer Science"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>10}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Malawi"=>1, "United States"=>3, "Tanzania"=>1, "Brazil"=>1, "South Africa"=>1, "Kenya"=>1, "Switzerland"=>2, "Peru"=>1, "Ethiopia"=>1, "India"=>1}, "group_count"=>8}

Scopus | Further Information

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PMC Usage Stats | Further Information

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Relative Metric

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