Biological Mechanisms Underlying Structural Changes Induced by Colorectal Field Carcinogenesis Measured with Low-Coherence Enhanced Backscattering (LEBS) Spectroscopy
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{"title"=>"Biological Mechanisms Underlying Structural Changes Induced by Colorectal Field Carcinogenesis Measured with Low-Coherence Enhanced Backscattering (LEBS) Spectroscopy", "type"=>"journal", "authors"=>[{"first_name"=>"Nikhil N.", "last_name"=>"Mutyal", "scopus_author_id"=>"36104339600"}, {"first_name"=>"Andrew", "last_name"=>"Radosevich", "scopus_author_id"=>"24773602100"}, {"first_name"=>"Ashish K.", "last_name"=>"Tiwari", "scopus_author_id"=>"55568510618"}, {"first_name"=>"Yolanda", "last_name"=>"Stypula", "scopus_author_id"=>"57200157797"}, {"first_name"=>"Ramesh", "last_name"=>"Wali", "scopus_author_id"=>"7006427978"}, {"first_name"=>"Dhananjay", "last_name"=>"Kunte", "scopus_author_id"=>"8602999200"}, {"first_name"=>"Hemant K.", "last_name"=>"Roy", "scopus_author_id"=>"7004925551"}, {"first_name"=>"Vadim", "last_name"=>"Backman", "scopus_author_id"=>"7004150806"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84874207115", "doi"=>"10.1371/journal.pone.0057206", "pui"=>"368387152", "scopus"=>"2-s2.0-84874207115", "issn"=>"19326203", "pmid"=>"23431406"}, "id"=>"f2d47185-9177-3954-8531-89977624a8e9", "abstract"=>"We previously reported the utility of Low-Coherence Enhanced Backscattering (LEBS) Spectroscopy in detecting optical changes in uninvolved rectal mucosa, changes that are indicative of the presence of advanced colorectal adenomas elsewhere in the colon (field carcinogenesis). We hypothesized that the alterations in optical signatures are due to structural changes in colonocytes. To elucidate those colonocyte changes, we used LEBS and an early time point in an animal model of colorectal field carcinogenesis--rats treated with azoxymethane (AOM). Changes in LEBS markers in intact mucosa from AOM-treated rats could be at least partially attributed to changes in colonocytes. To investigate the molecular mechanisms underlying the colonocyte abnormalities in premalignant colon, we took a candidate approach. We compared expression profiles of genes implicated directly or indirectly in cytoskeletal dysregulation in colorectal tissues from saline-treated versus AOM-treated rats. Our data suggest that a number of genes known to affect colon tumorigenesis are up-regulated in colonocytes, and genes previously reported to be tumor suppressors in metastatic cancer are down-regulated in colonocytes, despite the colonocytes being histologically normal. To further understand the role of the cytoskeleton in generating changes in optical markers of cells, we used pharmacological disruption (using colchicine) of the cytoskeleton. We found that differences in optical markers (between AOM- and control-treated rats) were negated by the disruption, suggesting cytoskeletal involvement in the optical changes. These studies provide significant insights into the micro-architectural alterations in early colon carcinogenesis, and may enable optimization of both bio-photonic and molecular risk stratification techniques to personalize colorectal cancer screening.", "link"=>"http://www.mendeley.com/research/biological-mechanisms-underlying-structural-changes-induced-colorectal-field-carcinogenesis-measured", "reader_count"=>17, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>6, "Student > Master"=>4, "Professor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>6, "Student > Master"=>4, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>5, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>5}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/701688"], "description"=>"<p>LEBS images show the different parameters (E, W & S) calculated from this peak and the scheme for calculation of LEBS marker using logistic regression of LEBS parameters by linear combination.</p>", "links"=>[], "tags"=>["lebs"], "article_id"=>372081, "categories"=>["Physics", "Cancer", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Nikhil N. Mutyal", "Andrew Radosevich", "Ashish K. Tiwari", "Yolanda Stypula", "Ramesh Wali", "Dhananjay Kunte", "Hemant K. Roy", "Vadim Backman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057206.g001", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_image_of_LEBS_peak_from_intact_rat_tissue_/372081", "title"=>"Representative image of LEBS peak from intact rat tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 10:42:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/701731"], "description"=>"<p>The LEBS marker is altered in the intact AOM-treated rat tissue and in isolated colonocytes as compared to saline-treated rats, demonstrating differences in micro- and nano-architecture that can be captured with the LEBS technique. The magnitude of the alteration in the LEBS marker is higher for intact tissue compared to colonocytes. <b>c,d)</b> The effect size (2.c.) and delta (2.d.) between AOM-treated and saline-treated rats are higher for intact tissue than for isolated colonocytes. Because colonocytes are part of the intact tissue, this result suggests that colonocytes are partially responsible for differences in LEBS marker from intact tissue.</p>", "links"=>[], "tags"=>["changes", "colon"], "article_id"=>372130, "categories"=>["Physics", "Cancer", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Nikhil N. Mutyal", "Andrew Radosevich", "Ashish K. Tiwari", "Yolanda Stypula", "Ramesh Wali", "Dhananjay Kunte", "Hemant K. Roy", "Vadim Backman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057206.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Structural_Changes_from_intact_colon_tissue_are_partially_from_colon_cells_a_b_/372130", "title"=>"Structural Changes from intact colon tissue are partially from colon cells. a,b)", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 10:42:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/701961"], "description"=>"<p><b>a,b)</b> The graphs show the difference in LEBS markers for colonocytes from Saline-treated and AOM-treated rats, before and after cytoskeletal disruption. AOM treatment significantly altered (p<0.05) the LEBS marker compared to saline-treated controls. Disruption of the cytoskeletal assembly with colchicine nullified this difference (p = 0.71) <b>c,d)</b> The effect size and delta between LEBS markers from saline-treated and AOM-treated rat colonocytes are higher before cytoskeletal disruption. The difference in structure measured by the LEBS marker between saline-treated and AOM-treated rat colonocytes was negated by disruption of the cytoskeleton, suggesting that the cytoskeleton plays a role in determining or signaling intracellular changes in early carcinogenesis.</p>", "links"=>[], "tags"=>["changes", "colon", "cells", "aberrant"], "article_id"=>372354, "categories"=>["Physics", "Cancer", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Nikhil N. Mutyal", "Andrew Radosevich", "Ashish K. Tiwari", "Yolanda Stypula", "Ramesh Wali", "Dhananjay Kunte", "Hemant K. Roy", "Vadim Backman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057206.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Structural_Changes_from_colon_cells_are_primarily_from_aberrant_cytoskeleton_/372354", "title"=>"Structural Changes from colon cells are primarily from aberrant cytoskeleton.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 10:43:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/701868"], "description"=>"<p>The alterations in cytoskeletal gene regulation of precancerous (AOM-treated) rat cells compared to control (saline-treated) rat cells suggest possible involvement of the cytoskeleton in determining the structural differences measured by LEBS (Fig. 2).</p>", "links"=>[], "tags"=>["rats", "saline", "showing", "up-", "down-regulation", "genes", "cytoskeleton"], "article_id"=>372265, "categories"=>["Physics", "Cancer", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Nikhil N. Mutyal", "Andrew Radosevich", "Ashish K. Tiwari", "Yolanda Stypula", "Ramesh Wali", "Dhananjay Kunte", "Hemant K. Roy", "Vadim Backman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057206.g003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clustergram_for_9_rats_four_saline_and_five_AOM_showing_the_fold_up_or_down_regulation_of_genes_involved_in_cytoskeleton_regulation_/372265", "title"=>"Clustergram for 9 rats (four saline and five AOM) showing the fold up- or down-regulation of genes involved in cytoskeleton regulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 10:43:19"}

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Relative Metric

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