Iron Oxide Nanoparticle-Micelles (ION-Micelles) for Sensitive (Molecular) Magnetic Particle Imaging and Magnetic Resonance Imaging
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{"title"=>"Iron Oxide Nanoparticle-Micelles (ION-Micelles) for Sensitive (Molecular) Magnetic Particle Imaging and Magnetic Resonance Imaging", "type"=>"journal", "authors"=>[{"first_name"=>"Lucas W E", "last_name"=>"Starmans", "scopus_author_id"=>"47761604500"}, {"first_name"=>"Dirk", "last_name"=>"Burdinski", "scopus_author_id"=>"8662795300"}, {"first_name"=>"Nicole P M", "last_name"=>"Haex", "scopus_author_id"=>"55605443000"}, {"first_name"=>"Rik P M", "last_name"=>"Moonen", "scopus_author_id"=>"37117398900"}, {"first_name"=>"Gustav J.", "last_name"=>"Strijkers", "scopus_author_id"=>"6701384173"}, {"first_name"=>"Klaas", "last_name"=>"Nicolay", "scopus_author_id"=>"7007180335"}, {"first_name"=>"Holger", "last_name"=>"Grüll", "scopus_author_id"=>"55915692500"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84874235413", "doi"=>"10.1371/journal.pone.0057335", "pui"=>"368400397", "pmid"=>"23437371", "scopus"=>"2-s2.0-84874235413", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"dacbb827-64f0-37ef-9532-7b43c0828f09", "abstract"=>"BACKGROUND: Iron oxide nanoparticles (IONs) are a promising nanoplatform for contrast-enhanced MRI. Recently, magnetic particle imaging (MPI) was introduced as a new imaging modality, which is able to directly visualize magnetic particles and could serve as a more sensitive and quantitative alternative to MRI. However, MPI requires magnetic particles with specific magnetic properties for optimal use. Current commercially available iron oxide formulations perform suboptimal in MPI, which is triggering research into optimized synthesis strategies. Most synthesis procedures aim at size control of iron oxide nanoparticles rather than control over the magnetic properties. In this study, we report on the synthesis, characterization and application of a novel ION platform for sensitive MPI and MRI.\\n\\nMETHODS AND RESULTS: IONs were synthesized using a thermal-decomposition method and subsequently phase-transferred by encapsulation into lipidic micelles (ION-Micelles). Next, the material and magnetic properties of the ION-Micelles were analyzed. Most notably, vibrating sample magnetometry measurements showed that the effective magnetic core size of the IONs is 16 nm. In addition, magnetic particle spectrometry (MPS) measurements were performed. MPS is essentially zero-dimensional MPI and therefore allows to probe the potential of iron oxide formulations for MPI. ION-Micelles induced up to 200 times higher signal in MPS measurements than commercially available iron oxide formulations (Endorem, Resovist and Sinerem) and thus likely allow for significantly more sensitive MPI. In addition, the potential of the ION-Micelle platform for molecular MPI and MRI was showcased by MPS and MRI measurements of fibrin-binding peptide functionalized ION-Micelles (FibPep-ION-Micelles) bound to blood clots.\\n\\nCONCLUSIONS: The presented data underlines the potential of the ION-Micelle nanoplatform for sensitive (molecular) MPI and warrants further investigation of the FibPep-ION-Micelle platform for in vivo, non-invasive imaging of fibrin in preclinical disease models of thrombus-related pathologies and atherosclerosis.", "link"=>"http://www.mendeley.com/research/iron-oxide-nanoparticlemicelles-ionmicelles-sensitive-molecular-magnetic-particle-imaging-magnetic-r-4", "reader_count"=>47, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>9, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>23, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>9, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>23, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>12, "Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>1, "Materials Science"=>2, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>7, "Physics and Astronomy"=>4, "Chemistry"=>7}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>12}, "Materials Science"=>{"Materials Science"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Chemistry"=>{"Chemistry"=>7}, "Physics and Astronomy"=>{"Physics and Astronomy"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>5}}, "reader_count_by_country"=>{"Germany"=>1, "India"=>1}, "group_count"=>5}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/957550"], "description"=>"<p>Schematic overview of the (A–B) iron oxide nanoparticles and (C–D) ION-Micelle synthesis.</p>", "links"=>[], "tags"=>["overview", "oxide", "nanoparticles", "ion-micelle"], "article_id"=>627681, "categories"=>["Biotechnology", "Cell Biology"], "users"=>["Lucas W. E. Starmans", "Dirk Burdinski", "Nicole P. M. Haex", "Rik P. M. Moonen", "Gustav J. Strijkers", "Klaas Nicolay", "Holger Grüll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057335.g002", "stats"=>{"downloads"=>1, "page_views"=>56, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_overview_of_the_A_8211_B_iron_oxide_nanoparticles_and_C_8211_D_ION_Micelle_synthesis_/627681", "title"=>"Schematic overview of the (A–B) iron oxide nanoparticles and (C–D) ION-Micelle synthesis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:08:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/957590", "https://ndownloader.figshare.com/files/957592", "https://ndownloader.figshare.com/files/957595"], "description"=>"<div><p>Background</p><p>Iron oxide nanoparticles (IONs) are a promising nanoplatform for contrast-enhanced MRI. Recently, magnetic particle imaging (MPI) was introduced as a new imaging modality, which is able to directly visualize magnetic particles and could serve as a more sensitive and quantitative alternative to MRI. However, MPI requires magnetic particles with specific magnetic properties for optimal use. Current commercially available iron oxide formulations perform suboptimal in MPI, which is triggering research into optimized synthesis strategies. Most synthesis procedures aim at size control of iron oxide nanoparticles rather than control over the magnetic properties. In this study, we report on the synthesis, characterization and application of a novel ION platform for sensitive MPI and MRI.</p> <p>Methods and Results</p><p>IONs were synthesized using a thermal-decomposition method and subsequently phase-transferred by encapsulation into lipidic micelles (ION-Micelles). Next, the material and magnetic properties of the ION-Micelles were analyzed. Most notably, vibrating sample magnetometry measurements showed that the effective magnetic core size of the IONs is 16 nm. In addition, magnetic particle spectrometry (MPS) measurements were performed. MPS is essentially zero-dimensional MPI and therefore allows to probe the potential of iron oxide formulations for MPI. ION-Micelles induced up to 200 times higher signal in MPS measurements than commercially available iron oxide formulations (Endorem, Resovist and Sinerem) and thus likely allow for significantly more sensitive MPI. In addition, the potential of the ION-Micelle platform for molecular MPI and MRI was showcased by MPS and MRI measurements of fibrin-binding peptide functionalized ION-Micelles (FibPep-ION-Micelles) bound to blood clots.</p> <p>Conclusions</p><p>The presented data underlines the potential of the ION-Micelle nanoplatform for sensitive (molecular) MPI and warrants further investigation of the FibPep-ION-Micelle platform for <i>in vivo</i>, non-invasive imaging of fibrin in preclinical disease models of thrombus-related pathologies and atherosclerosis.</p> </div>", "links"=>[], "tags"=>["oxide", "nanoparticle-micelles", "imaging", "resonance", "imaging"], "article_id"=>627716, "categories"=>["Biotechnology", "Cell Biology"], "users"=>["Lucas W. E. Starmans", "Dirk Burdinski", "Nicole P. M. Haex", "Rik P. M. Moonen", "Gustav J. Strijkers", "Klaas Nicolay", "Holger Grüll"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057335.s001", "https://dx.doi.org/10.1371/journal.pone.0057335.s002", "https://dx.doi.org/10.1371/journal.pone.0057335.s003"], "stats"=>{"downloads"=>1, "page_views"=>40, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Iron_Oxide_Nanoparticle_Micelles_ION_Micelles_for_Sensitive_Molecular_Magnetic_Particle_Imaging_and_Magnetic_Resonance_Imaging__/627716", "title"=>"Iron Oxide Nanoparticle-Micelles (ION-Micelles) for Sensitive (Molecular) Magnetic Particle Imaging and Magnetic Resonance Imaging", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-02-20 02:08:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/957559"], "description"=>"<p>(A) Typical TEM micrograph of the IONs; inset shows occasional presence of a subset of particles with a smaller diameter (arrows). (B) Size distribution profile of the IONs obtained from TEM analysis of 400 nanoparticles. (C) Selected area electron diffraction (SAED) pattern acquired from IONs.</p>", "links"=>[], "tags"=>["electron", "microscopy"], "article_id"=>627690, "categories"=>["Biotechnology", "Cell Biology"], "users"=>["Lucas W. E. Starmans", "Dirk Burdinski", "Nicole P. M. Haex", "Rik P. M. Moonen", "Gustav J. Strijkers", "Klaas Nicolay", "Holger Grüll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057335.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transmission_electron_microscopy_analysis_of_the_IONs_/627690", "title"=>"Transmission electron microscopy analysis of the IONs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:08:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1004903"], "description"=>"<p>Calculated atomic lattice spacing d (Å) corresponding to diffraction pattern in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057335#pone-0057335-g003\" target=\"_blank\">Fig. 3C</a> compared to standard atomic spacing for bulk magnetite (Fe<sub>3</sub>O<sub>4</sub>) along with their respective hkl indices from the PDF database.</p>", "links"=>[], "tags"=>["atomic", "lattice", "spacing", "corresponding", "diffraction", "compared", "magnetite", "respective", "hkl", "indices", "pdf"], "article_id"=>665517, "categories"=>["Biotechnology", "Cell Biology"], "users"=>["Lucas W. E. Starmans", "Dirk Burdinski", "Nicole P. M. Haex", "Rik P. M. Moonen", "Gustav J. Strijkers", "Klaas Nicolay", "Holger Grüll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057335.t002", "stats"=>{"downloads"=>7, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Calculated_atomic_lattice_spacing_d_corresponding_to_diffraction_pattern_in_Fig_3C_compared_to_standard_atomic_spacing_for_bulk_magnetite_Fe_3_O_4_along_with_their_respective_hkl_indices_from_the_PDF_database_/665517", "title"=>"Calculated atomic lattice spacing d (Å) corresponding to diffraction pattern in Fig. 3C compared to standard atomic spacing for bulk magnetite (Fe<sub>3</sub>O<sub>4</sub>) along with their respective hkl indices from the PDF database.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 01:31:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/957569"], "description"=>"<p>(A,B) Typical Cryo-TEM micrographs of the ION-Micelles showing that the ION-Micelles are mostly dispersed as single particles or as small aggregates of particles in HBS. (C) Occasionally, larger ION-Micelle aggregates were observed. (D) Typical intensity-weighted and (E) number-weighted size-distribution profiles of the ION-Micelles obtained by dynamic light scattering measurements.</p>", "links"=>[], "tags"=>["dls", "ion-micelles", "hepes", "buffered", "saline"], "article_id"=>627700, "categories"=>["Biotechnology", "Cell Biology"], "users"=>["Lucas W. E. Starmans", "Dirk Burdinski", "Nicole P. M. Haex", "Rik P. M. Moonen", "Gustav J. Strijkers", "Klaas Nicolay", "Holger Grüll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057335.g004", "stats"=>{"downloads"=>1, "page_views"=>44, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cryo_TEM_and_DLS_analysis_of_the_ION_Micelles_in_HEPES_buffered_saline_HBS_/627700", "title"=>"Cryo-TEM and DLS analysis of the ION-Micelles in HEPES buffered saline (HBS).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:08:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/957571"], "description"=>"<p>(A) Magnetization curve of the ION-Micelles at room temperature. Inset: zoomed-in view around zero field. (B) Number-weighted particle size distribution of the ION-Micelles calculated from the magnetization curve. d<sub>max</sub> is the diameter corresponding to the maximum of the peak. (C) MPS experimental data of the ION-Micelles, Endorem, Resovist and Sinerem plotted as magnetic moment (normalized for iron content) versus frequency.</p>", "links"=>[], "tags"=>["ion-micelles"], "article_id"=>627702, "categories"=>["Biotechnology", "Cell Biology"], "users"=>["Lucas W. E. Starmans", "Dirk Burdinski", "Nicole P. M. Haex", "Rik P. M. Moonen", "Gustav J. Strijkers", "Klaas Nicolay", "Holger Grüll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057335.g005", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_of_ION_Micelles_magnetic_properties_/627702", "title"=>"Analysis of ION-Micelles magnetic properties.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:08:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/1004877"], "description"=>"<p>r<sub>1</sub>: longitudinal relaxivity;</p><p>r<sub>2</sub>: transversal relaxivity;</p>*<p>Z-average</p>", "links"=>[], "tags"=>["relaxometric", "performed", "37"], "article_id"=>665497, "categories"=>["Biotechnology", "Cell Biology"], "users"=>["Lucas W. E. Starmans", "Dirk Burdinski", "Nicole P. M. Haex", "Rik P. M. Moonen", "Gustav J. Strijkers", "Klaas Nicolay", "Holger Grüll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057335.t001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Physical_characteristics_and_relaxivities_Relaxometric_measurements_were_performed_at_1_41_T_and_37_176_C_/665497", "title"=>"Physical characteristics and relaxivities. Relaxometric measurements were performed at 1.41 T and 37 °C.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 01:31:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/957544"], "description"=>"<p>Schematic overview and TEM-micrograph of an ION displaying a magnetic core and a non-magnetic layer.</p>", "links"=>[], "tags"=>["overview", "tem-micrograph", "ion", "displaying", "non-magnetic"], "article_id"=>627675, "categories"=>["Biotechnology", "Cell Biology"], "users"=>["Lucas W. E. Starmans", "Dirk Burdinski", "Nicole P. M. Haex", "Rik P. M. Moonen", "Gustav J. Strijkers", "Klaas Nicolay", "Holger Grüll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057335.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_overview_and_TEM_micrograph_of_an_ION_displaying_a_magnetic_core_and_a_non_magnetic_layer_/627675", "title"=>"Schematic overview and TEM-micrograph of an ION displaying a magnetic core and a non-magnetic layer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:07:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/957585"], "description"=>"<p>(A) Schematic overview of fibrin-binding peptides (FibPep) conjugation to the ION-Micelles. (B) Photograph and (C) sagittal MR image of blood clots incubated with either FibPep-ION-Micelles (left) or NCFibPep-ION-Micelles (right). (D) MR signal to noise ratio of the (NC)FibPep-ION-Micelles incubated clots. (E) Third harmonic (76 kHz) MPS signal amplitude and estimated iron content of blood clots incubated with (NC)FibPep-ION-Micelles. Estimated iron content was calculated using the third harmonic MPS signal and a previously defined conversion factor for this particular batch IONs of 6.87 mAm<sup>2</sup>/g Fe. (F) Iron content of blood clots incubated with (NC)FibPep-ION-Micelles. Data represents mean ± standard deviation (n = 4).</p>", "links"=>[], "tags"=>["clot", "binding", "fibpep-ion-micelles"], "article_id"=>627711, "categories"=>["Biotechnology", "Cell Biology"], "users"=>["Lucas W. E. Starmans", "Dirk Burdinski", "Nicole P. M. Haex", "Rik P. M. Moonen", "Gustav J. Strijkers", "Klaas Nicolay", "Holger Grüll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057335.g006", "stats"=>{"downloads"=>3, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_vitro_blood_clot_binding_test_using_FibPep_ION_Micelles_and_negative_control_NCFibPep_ION_Micelles_/627711", "title"=>"<i>In vitro</i> blood clot binding test using FibPep-ION-Micelles and negative control NCFibPep-ION-Micelles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:08:31"}

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Relative Metric

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