Salivary MicroRNAs as Promising Biomarkers for Detection of Esophageal Cancer
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{"title"=>"Salivary MicroRNAs as Promising Biomarkers for Detection of Esophageal Cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Zijun", "last_name"=>"Xie", "scopus_author_id"=>"55637081500"}, {"first_name"=>"Gang", "last_name"=>"Chen", "scopus_author_id"=>"57114100100"}, {"first_name"=>"Xuchao", "last_name"=>"Zhang", "scopus_author_id"=>"55999072500"}, {"first_name"=>"Dongfeng", "last_name"=>"Li", "scopus_author_id"=>"57197284305"}, {"first_name"=>"Jian", "last_name"=>"Huang", "scopus_author_id"=>"57187208300"}, {"first_name"=>"Cuiqin", "last_name"=>"Yang", "scopus_author_id"=>"55636926900"}, {"first_name"=>"Pingyong", "last_name"=>"Zhang", "scopus_author_id"=>"55636652300"}, {"first_name"=>"Yuxuan", "last_name"=>"Qin", "scopus_author_id"=>"57198579984"}, {"first_name"=>"Yifan", "last_name"=>"Duan", "scopus_author_id"=>"57198829614"}, {"first_name"=>"Bo", "last_name"=>"Gong", "scopus_author_id"=>"55637630000"}, {"first_name"=>"Zijun", "last_name"=>"Li", "scopus_author_id"=>"55637448700"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84875654001", "pui"=>"368634622", "doi"=>"10.1371/journal.pone.0057502", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84875654001", "pmid"=>"23560033"}, "id"=>"3f7a6bc2-91a7-3387-aac8-347870d1ee30", "abstract"=>"BACKGROUND AND PURPOSE: Tissue microRNAs (miRNAs) can detect cancers and predict prognosis. Several recent studies reported that tissue, plasma, and saliva miRNAs share similar expression profiles. In this study, we investigated the discriminatory power of salivary miRNAs (including whole saliva and saliva supernatant) for detection of esophageal cancer.\\n\\nMATERIALS AND METHODS: By Agilent microarray, six deregulated miRNAs from whole saliva samples from seven patients with esophageal cancer and three healthy controls were selected. The six selected miRNAs were subjected to validation of their expression levels by RT-qPCR using both whole saliva and saliva supernatant samples from an independent set of 39 patients with esophageal cancer and 19 healthy controls.\\n\\nRESULTS: Six miRNAs (miR-10b*, miR-144, miR-21, miR-451, miR-486-5p, and miR-634) were identified as targets by Agilent microarray. After validation by RT-qPCR, miR-10b*, miR-144, and miR-451 in whole saliva and miR-10b*, miR-144, miR-21, and miR-451 in saliva supernatant were significantly upregulated in patients, with sensitivities of 89.7, 92.3, 84.6, 79.5, 43.6, 89.7, and 51.3% and specificities of 57.9, 47.4, 57.9%, 57.9, 89.5, 47.4, and 84.2%, respectively.\\n\\nCONCLUSIONS: We found distinctive miRNAs for esophageal cancer in both whole saliva and saliva supernatant. These miRNAs possess discriminatory power for detection of esophageal cancer. Because saliva collection is noninvasive and convenient, salivary miRNAs show great promise as biomarkers for detection of esophageal cancer in areas at high risk.", "link"=>"http://www.mendeley.com/research/salivary-micrornas-promising-biomarkers-detection-esophageal-cancer", "reader_count"=>54, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>1, "Student > Master"=>12, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>2, "Librarian"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>1, "Student > Master"=>12, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>2, "Librarian"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Agricultural and Biological Sciences"=>21, "Medicine and Dentistry"=>19, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemical Engineering"=>1, "Psychology"=>1, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Psychology"=>{"Psychology"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>21}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "United Kingdom"=>1, "Malaysia"=>1, "Spain"=>1, "India"=>1}, "group_count"=>6}

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  • {"files"=>["https://ndownloader.figshare.com/files/1002725", "https://ndownloader.figshare.com/files/1002730"], "description"=>"<div><p>Background and Purpose</p><p>Tissue microRNAs (miRNAs) can detect cancers and predict prognosis. Several recent studies reported that tissue, plasma, and saliva miRNAs share similar expression profiles. In this study, we investigated the discriminatory power of salivary miRNAs (including whole saliva and saliva supernatant) for detection of esophageal cancer.</p> <p>Materials and Methods</p><p>By Agilent microarray, six deregulated miRNAs from whole saliva samples from seven patients with esophageal cancer and three healthy controls were selected. The six selected miRNAs were subjected to validation of their expression levels by RT-qPCR using both whole saliva and saliva supernatant samples from an independent set of 39 patients with esophageal cancer and 19 healthy controls.</p> <p>Results</p><p>Six miRNAs (miR-10b*, miR-144, miR-21, miR-451, miR-486-5p, and miR-634) were identified as targets by Agilent microarray. After validation by RT-qPCR, miR-10b*, miR-144, and miR-451 in whole saliva and miR-10b*, miR-144, miR-21, and miR-451 in saliva supernatant were significantly upregulated in patients, with sensitivities of 89.7, 92.3, 84.6, 79.5, 43.6, 89.7, and 51.3% and specificities of 57.9, 47.4, 57.9%, 57.9, 89.5, 47.4, and 84.2%, respectively.</p> <p>Conclusions</p><p>We found distinctive miRNAs for esophageal cancer in both whole saliva and saliva supernatant. These miRNAs possess discriminatory power for detection of esophageal cancer. Because saliva collection is noninvasive and convenient, salivary miRNAs show great promise as biomarkers for detection of esophageal cancer in areas at high risk.</p> </div>", "links"=>[], "tags"=>["micrornas", "biomarkers", "detection", "esophageal"], "article_id"=>663815, "categories"=>["Molecular Biology", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Zijun Xie", "Gang Chen", "Xuchao Zhang", "Dongfeng Li", "Jian Huang", "Cuiqin Yang", "Pingyong Zhang", "Yuxuan Qin", "Yifan Duan", "Bo Gong", "Zijun Li"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057502.s001", "https://dx.doi.org/10.1371/journal.pone.0057502.s002"], "stats"=>{"downloads"=>13, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Salivary_MicroRNAs_as_Promising_Biomarkers_for_Detection_of_Esophageal_Cancer_/663815", "title"=>"Salivary MicroRNAs as Promising Biomarkers for Detection of Esophageal Cancer", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-04-02 07:09:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1008729"], "description"=>"<p>Note: 1. High temperature: >60°C. 2. According to the standard of mainland China, the definition of an alcoholic is as follows: male, ≥40 g/d; female, ≥20 g/d; consumption of alcohol (g)  =  volume of alcohol (mL) × concentration of alcohol (%) ×0.8.</p>", "links"=>[], "tags"=>["ec", "patients"], "article_id"=>669348, "categories"=>["Molecular Biology", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Zijun Xie", "Gang Chen", "Xuchao Zhang", "Dongfeng Li", "Jian Huang", "Cuiqin Yang", "Pingyong Zhang", "Yuxuan Qin", "Yifan Duan", "Bo Gong", "Zijun Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057502.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_EC_patients_and_healthy_controls_/669348", "title"=>"Characteristics of EC patients and healthy controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-01 02:35:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1002724"], "description"=>"<p>A) Whole saliva miR-10b*. B)whole saliva miR-144, and C) whole saliva miR-451. D)saliva supernatant miR-10b*. E)saliva supernatant miR-144. F)saliva supernatant miR-21. G) saliva supernatant miR-451.</p>", "links"=>[], "tags"=>["esophageal", "cancer"], "article_id"=>663814, "categories"=>["Molecular Biology", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Zijun Xie", "Gang Chen", "Xuchao Zhang", "Dongfeng Li", "Jian Huang", "Cuiqin Yang", "Pingyong Zhang", "Yuxuan Qin", "Yifan Duan", "Bo Gong", "Zijun Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057502.g003", "stats"=>{"downloads"=>6, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Receiver_operating_characteristic_curve_analysis_for_esophageal_cancer_diagnosis_/663814", "title"=>"Receiver operating characteristic curve analysis for esophageal cancer diagnosis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-02 07:08:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/1008706"], "description"=>"<p>Note:<sup>1</sup>W =  whole saliva, S =  saliva supernatant; <sup>2</sup>N/A  =  not available due to patients' refusal of further tests or treatments; meanwhile, some patients in stage IV could not undergo operations and resected tumors were not available, so the differentiation of the tumors in these patients could not be determined.</p>", "links"=>[], "tags"=>["mirna", "ec"], "article_id"=>669327, "categories"=>["Molecular Biology", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Zijun Xie", "Gang Chen", "Xuchao Zhang", "Dongfeng Li", "Jian Huang", "Cuiqin Yang", "Pingyong Zhang", "Yuxuan Qin", "Yifan Duan", "Bo Gong", "Zijun Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057502.t003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationships_between_miRNA_expression_levels_means_177_SD_and_clinical_characteristics_of_EC_patients_/669327", "title"=>"Relationships between miRNA expression levels (means ± SD) and clinical characteristics of EC patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-01 02:35:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1008686"], "description"=>"<p>Note: EC, esophageal cancer; NC, normal control.</p>", "links"=>[], "tags"=>["mirnas"], "article_id"=>669304, "categories"=>["Molecular Biology", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Zijun Xie", "Gang Chen", "Xuchao Zhang", "Dongfeng Li", "Jian Huang", "Cuiqin Yang", "Pingyong Zhang", "Yuxuan Qin", "Yifan Duan", "Bo Gong", "Zijun Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057502.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_miRNAs_detected_in_each_sample_/669304", "title"=>"Number of miRNAs detected in each sample.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-01 02:35:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1002721"], "description"=>"<p><b>A</b>) whole saliva miR-10b*. <b>B</b>) whole saliva miR-144. <b>C</b>) whole saliva miR-451. <b>D</b>) saliva supernatant miR-10b*. <b>E</b>) saliva supernatant miR-144. <b>F</b>) saliva supernatant miR-21. <b>G</b>) saliva supernatant miR-451. miRNA expression levels were calculated by the 2<sup>−ΔΔCt</sup> method. These miRNAs were significantly upregulated in the EC (n = 39) compared with the healthy (n = 19) group.</p>", "links"=>[], "tags"=>["charts", "aberrantly"], "article_id"=>663813, "categories"=>["Molecular Biology", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Zijun Xie", "Gang Chen", "Xuchao Zhang", "Dongfeng Li", "Jian Huang", "Cuiqin Yang", "Pingyong Zhang", "Yuxuan Qin", "Yifan Duan", "Bo Gong", "Zijun Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057502.g002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bar_charts_of_expression_levels_of_aberrantly_expressed_miRNAs_/663813", "title"=>"Bar charts of expression levels of aberrantly expressed miRNAs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-02 07:08:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1002718"], "description"=>"<p>A) With the exception of sample 4, the values of the six EC group samples were higher than those of the three healthy group samples. B) With the exception of sample 2, the values of the six EC group samples were higher than those of the three healthy group samples. C) With the exception of sample 10, the values of the seven EC group samples were higher than those of the two healthy group samples. D) With the exception of sample 10, the values of the seven EC group samples were higher than those of the two healthy group samples. E) All EC group values were lower than the three of the healthy group. F) Several studies have reported that miRNAs are aberrantly expressed in cancer tissue and plasma of EC patients; however, the gTotalGeneSignal value of miR-21 did not differ between the EC and healthy groups. However, it was also selected as a target miRNA.</p>", "links"=>[], "tags"=>["charts", "gtotalgenesignal"], "article_id"=>663812, "categories"=>["Molecular Biology", "Biotechnology", "Chemistry", "Cell Biology"], "users"=>["Zijun Xie", "Gang Chen", "Xuchao Zhang", "Dongfeng Li", "Jian Huang", "Cuiqin Yang", "Pingyong Zhang", "Yuxuan Qin", "Yifan Duan", "Bo Gong", "Zijun Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0057502.g001", "stats"=>{"downloads"=>1, "page_views"=>65, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_bar_charts_of_gTotalGeneSignal_value_of_the_six_target_miRNAs_/663812", "title"=>"The bar charts of gTotalGeneSignal value of the six target miRNAs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-02 07:07:55"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"28", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
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  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
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Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[256, 449, 572, 676, 775, 866, 955, 1041, 1127, 1213, 1290, 1370, 1437]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[244, 425, 535, 636, 728, 814, 900, 982, 1063, 1139, 1221, 1296, 1361]}, {"subject_area"=>"/Medicine and health sciences/Oncology", "average_usage"=>[249, 468, 599, 718, 820, 920, 1008, 1093, 1181, 1281, 1357, 1444, 1517]}]}
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