Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring
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{"title"=>"Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring", "type"=>"journal", "authors"=>[{"first_name"=>"Liesbeth", "last_name"=>"Knaepen", "scopus_author_id"=>"55189300900"}, {"first_name"=>"Ine", "last_name"=>"Rayen", "scopus_author_id"=>"48662765700"}, {"first_name"=>"Thierry D.", "last_name"=>"Charlier", "scopus_author_id"=>"8161866600"}, {"first_name"=>"Marianne", "last_name"=>"Fillet", "scopus_author_id"=>"7003785094"}, {"first_name"=>"Virginie", "last_name"=>"Houbart", "scopus_author_id"=>"6505713376"}, {"first_name"=>"Maarten", "last_name"=>"van Kleef", "scopus_author_id"=>"7006970405"}, {"first_name"=>"Harry W.", "last_name"=>"Steinbusch", "scopus_author_id"=>"7006557045"}, {"first_name"=>"Jacob", "last_name"=>"Patijn", "scopus_author_id"=>"55883601800"}, {"first_name"=>"Dick", "last_name"=>"Tibboel", "scopus_author_id"=>"7101632209"}, {"first_name"=>"Elbert A.", "last_name"=>"Joosten", "scopus_author_id"=>"9942147100"}, {"first_name"=>"Jodi L.", "last_name"=>"Pawluski", "scopus_author_id"=>"8119595300"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84874343527", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0057608", "pui"=>"368409422", "sgr"=>"84874343527", "issn"=>"19326203", "pmid"=>"23437400"}, "id"=>"c0167dc3-be1b-35a2-a3d9-dae4fed1b435", "abstract"=>"Early life events can significantly alter the development of the nociceptive circuit. In fact, clinical work has shown that maternal adversity, in the form of depression, and concomitant selective serotonin reuptake inhibitor (SSRI) treatment influence nociception in infants. The combined effects of maternal adversity and SSRI exposure on offspring nociception may be due to their effects on the developing hypothalamic-pituitary-adrenal (HPA) system. Therefore, the present study investigated long-term effects of maternal adversity and/or SSRI medication use on nociception of adult Sprague-Dawley rat offspring, taking into account involvement of the HPA system. Dams were subject to stress during gestation and were treated with fluoxetine (2×/5 mg/kg/day) prior to parturition and throughout lactation. Four groups of adult male offspring were used: 1. Control+Vehicle, 2. Control+Fluoxetine, 3. Prenatal Stress+Vehicle, 4. Prenatal Stress+Fluoxetine. Results show that post-operative pain, measured as hypersensitivity to mechanical stimuli after hind paw incision, was decreased in adult offspring subject to prenatal stress alone and increased in offspring developmentally exposed to fluoxetine alone. Moreover, post-operative pain was normalized in prenatally stressed offspring exposed to fluoxetine. This was paralleled by a decrease in corticosteroid binding globulin (CBG) levels in prenatally stressed offspring and a normalization of serum CBG levels in prenatally stressed offspring developmentally exposed to fluoxetine. Thus, developmental fluoxetine exposure normalizes the long-term effects of maternal adversity on post-operative pain in offspring and these effects may be due, in part, to the involvement of the HPA system.", "link"=>"http://www.mendeley.com/research/developmental-fluoxetine-exposure-normalizes-longterm-effects-maternal-stress-postoperative-pain-spr", "reader_count"=>41, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>4, "Student > Bachelor"=>4, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>4, "Student > Bachelor"=>4, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>14, "Neuroscience"=>7, "Psychology"=>6}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Neuroscience"=>{"Neuroscience"=>7}, "Psychology"=>{"Psychology"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>1}, "group_count"=>5}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/965311"], "description"=>"<p>Pregnant dams were stressed three times per day for 45 minutes from gestational day (G) 14 until G20. The stressor consisted of restraint in a plastic cylinder and exposure to bright light. Fluoxetine was administered orally to the dams from G21 until the day of weaning at three weeks of age (3 w). After weaning, 2 male offspring from control/vehicle, control/fluoxetine, stress/vehicle and stress/fluoxetine dams were subjected to behavioral testing (<i>N</i> = 8/12 per group). Their basal paw withdrawal thresholds (PWT) to mechanical stimuli and paw withdrawal latencies (PWL) to heat stimuli were tested at 4 weeks, i.e. a juvenile age during development, and at 8 weeks, when animals were at a young adult age. Also, a locomotor activity (LA) test was performed at the age of 8 weeks. One day after the last behavioral basal test at 8 weeks, all offspring received an incision of the left hind paw, after which PWT were measured daily until 9 days post incision (DPI9). To measure serum levels of corticosterone and corticosterone binding globulin (CBG), tail vein blood was withdrawn at the age of 5 and 8 weeks and at DPI1 and DPI7 (+).</p>", "links"=>[], "tags"=>["overview"], "article_id"=>635124, "categories"=>["Chemistry", "Neuroscience", "Genetics", "Mental Health"], "users"=>["Liesbeth Knaepen", "Ine Rayen", "Thierry D. Charlier", "Marianne Fillet", "Virginie Houbart", "Maarten van Kleef", "Harry W. Steinbusch", "Jacob Patijn", "Dick Tibboel", "Elbert A. Joosten", "Jodi L. Pawluski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057608.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_overview_of_the_study_/635124", "title"=>"Schematic overview of the study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 10:35:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/965313"], "description"=>"<p>There was no effect of maternal stress or fluoxetine on the PWL to heat stimuli at the left (<b>A</b>) or right hind paw (<b>B</b>) of male offspring at the age of 4 and 8 weeks. Also, there was no effect of time, since there was no difference in PWL between the age of 4 and 8 weeks. CV: control vehicle, CF: control fluoxetine, SV: stress vehicle, SF: stress fluoxetine (<i>N</i> = 8/12 per group).</p>", "links"=>[], "tags"=>["basal", "nociceptive", "paw", "latency", "thresholds"], "article_id"=>635126, "categories"=>["Chemistry", "Neuroscience", "Genetics", "Mental Health"], "users"=>["Liesbeth Knaepen", "Ine Rayen", "Thierry D. Charlier", "Marianne Fillet", "Virginie Houbart", "Maarten van Kleef", "Harry W. Steinbusch", "Jacob Patijn", "Dick Tibboel", "Elbert A. Joosten", "Jodi L. Pawluski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057608.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_177_SEM_basal_nociceptive_paw_withdrawal_latency_PWL_thresholds_s_to_heat_stimuli_/635126", "title"=>"Mean(±SEM) basal nociceptive paw withdrawal latency (PWL) thresholds (s) to heat stimuli.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 10:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/965314"], "description"=>"<p>There was an overall interaction effect of time*condition*treatment observed for PWT to mechanical stimuli after incision. Also main effects of condition and treatment were observed. Significant differences were shown by post hoc correction and denoted by a, b, c, d and e symbols (A). Contralateral PWT were not affected by paw incision (B), since there were no differences observed between the groups. Area under the curve (AUC) analysis (C) of the ipsilateral PWT graphs in A, showed a main effect of condition (#) and a main effect of treatment (##). Contralateral AUC (D) showed a trend for a main effect of condition with control offspring having a tendency for lower PWT than stress offspring (<sup>$</sup>). DPI: days post incision, CV: control vehicle, CF: control fluoxetine, SV: stress vehicle, SF: stress fluoxetine (<i>N</i> = 8/12 per group).</p>", "links"=>[], "tags"=>["pwts", "offspring", "exposed", "stimuli", "incision", "hind"], "article_id"=>635127, "categories"=>["Chemistry", "Neuroscience", "Genetics", "Mental Health"], "users"=>["Liesbeth Knaepen", "Ine Rayen", "Thierry D. Charlier", "Marianne Fillet", "Virginie Houbart", "Maarten van Kleef", "Harry W. Steinbusch", "Jacob Patijn", "Dick Tibboel", "Elbert A. Joosten", "Jodi L. Pawluski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057608.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_177_SEM_PWTs_in_male_offspring_exposed_to_mechanical_stimuli_g_after_incision_of_the_left_hind_paw_/635127", "title"=>"Mean (±SEM) PWTs in male offspring exposed to mechanical stimuli (g) after incision of the left hind paw.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 10:35:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/965321"], "description"=>"<p>A time*condition interaction effect was observed in control offspring, but not stress offspring, having a higher corticosterone level at the 8 week time-point (<b>A</b>, *). There was a main effect of time on serum corticosterone levels and post hoc corrections showed that the levels at 8 weeks were significantly higher than levels at all other time-points (<b>A</b>, #). No effect of condition or treatment was observed on AUC of serum corticosterone levels (<b>B</b>). A condition*treatment interaction effect, with lower serum CBG levels in SV offspring, compared to SF and CV offspring (<b>C</b>, *). A main effect of time was observed and post hoc correction showed that this was attributable to the decrease in serum CBG at DPI1 (<b>C</b>, #). A significant interaction effect of condition*treatment was shown in AUC of CBG serum levels, with lower AUC values for SV offspring, compared to SF offspring (<b>D</b>, *). DPI: days post incision, CV: control vehicle, CF: control fluoxetine, SV: stress vehicle, SF: stress fluoxetine (<i>N</i> = 8/12 per group).</p>", "links"=>[], "tags"=>["auc", "serum", "corticosterone", "cbg"], "article_id"=>635133, "categories"=>["Chemistry", "Neuroscience", "Genetics", "Mental Health"], "users"=>["Liesbeth Knaepen", "Ine Rayen", "Thierry D. Charlier", "Marianne Fillet", "Virginie Houbart", "Maarten van Kleef", "Harry W. Steinbusch", "Jacob Patijn", "Dick Tibboel", "Elbert A. Joosten", "Jodi L. Pawluski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057608.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_177_SEM_and_AUC_of_serum_levels_of_corticosterone_and_CBG_of_male_offspring_/635133", "title"=>"Mean (±SEM) and AUC of serum levels of corticosterone and CBG of male offspring.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 10:37:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1010520"], "description"=>"<p>There were no differences in distances between the groups. CV: control vehicle, CF: control fluoxetine, SV: stress vehicle, SF: stress fluoxetine (<i>N</i> = 8–12/group).</p>", "links"=>[], "tags"=>["distances", "animals", "travelled"], "article_id"=>670926, "categories"=>["Chemistry", "Neuroscience", "Genetics", "Mental Health"], "users"=>["Liesbeth Knaepen", "Ine Rayen", "Thierry D. Charlier", "Marianne Fillet", "Virginie Houbart", "Maarten van Kleef", "Harry W. Steinbusch", "Jacob Patijn", "Dick Tibboel", "Elbert A. Joosten", "Jodi L. Pawluski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057608.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_177_SEM_distances_that_the_animals_travelled_in_the_open_arena_at_the_age_of_eight_weeks_/670926", "title"=>"Mean (±SEM) distances that the animals travelled in the open arena at the age of eight weeks.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 00:15:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1010551"], "description"=>"<p>No differences were observed in PWT for the left and right hind paw between the groups. CV: control vehicle, CF: control fluoxetine, SV: stress vehicle, SF: stress fluoxetine (<i>N</i> = 8–12/group).</p>", "links"=>[], "tags"=>["pwts", "von", "frey", "stimuli", "reflecting", "hind", "paws"], "article_id"=>670952, "categories"=>["Chemistry", "Neuroscience", "Genetics", "Mental Health"], "users"=>["Liesbeth Knaepen", "Ine Rayen", "Thierry D. Charlier", "Marianne Fillet", "Virginie Houbart", "Maarten van Kleef", "Harry W. Steinbusch", "Jacob Patijn", "Dick Tibboel", "Elbert A. Joosten", "Jodi L. Pawluski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057608.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_177_SEM_PWTs_to_von_Frey_stimuli_g_reflecting_sensitivity_of_the_hind_paws_to_mechanical_stimuli_at_the_age_of_4_weeks_/670952", "title"=>"Mean (±SEM) PWTs to von Frey stimuli (g), reflecting sensitivity of the hind paws to mechanical stimuli at the age of 4 weeks.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 00:15:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1010576"], "description"=>"<p>CV: control vehicle, CF: control fluoxetine, SV: stress vehicle, SF: stress fluoxetine, (<i>N</i> = 4–6/group).</p>", "links"=>[], "tags"=>["weights", "litters", "pups", "postnatal"], "article_id"=>670981, "categories"=>["Chemistry", "Neuroscience", "Genetics", "Mental Health"], "users"=>["Liesbeth Knaepen", "Ine Rayen", "Thierry D. Charlier", "Marianne Fillet", "Virginie Houbart", "Maarten van Kleef", "Harry W. Steinbusch", "Jacob Patijn", "Dick Tibboel", "Elbert A. Joosten", "Jodi L. Pawluski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057608.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_177_SEM_weights_g_of_litters_and_number_of_male_and_female_pups_on_postnatal_day_PD_1_/670981", "title"=>"Mean (±SEM) weights (g) of litters and number of male and female pups on postnatal day (PD 1).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 00:16:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1010603"], "description"=>"<p>A statistically significant main effect of time was observed (F(3, 108) = 592.36, <i>P</i> = 0.001). DPI: days post incision, 8 w: 8 weeks, CV: control vehicle, CF: control fluoxetine, SV: stress vehicle, SF: stress fluoxetine (<i>N</i> = 8–12/group).</p>", "links"=>[], "tags"=>["weights"], "article_id"=>671008, "categories"=>["Chemistry", "Neuroscience", "Genetics", "Mental Health"], "users"=>["Liesbeth Knaepen", "Ine Rayen", "Thierry D. Charlier", "Marianne Fillet", "Virginie Houbart", "Maarten van Kleef", "Harry W. Steinbusch", "Jacob Patijn", "Dick Tibboel", "Elbert A. Joosten", "Jodi L. Pawluski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057608.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_177_SEM_weights_g_of_male_offspring_/671008", "title"=>"Mean (±SEM) weights (g) of male offspring.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 00:16:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1010628"], "description"=>"<p>(<i>N</i> = 7–11).</p>", "links"=>[], "tags"=>["serum", "fluoxetine", "norfluoxetine", "postnatal"], "article_id"=>671034, "categories"=>["Chemistry", "Neuroscience", "Genetics", "Mental Health"], "users"=>["Liesbeth Knaepen", "Ine Rayen", "Thierry D. Charlier", "Marianne Fillet", "Virginie Houbart", "Maarten van Kleef", "Harry W. Steinbusch", "Jacob Patijn", "Dick Tibboel", "Elbert A. Joosten", "Jodi L. Pawluski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0057608.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_177_SEM_serum_levels_of_fluoxetine_ng_mL_and_norfluoxetine_ng_mL_during_the_postnatal_period_P_8202_8202_postnatal_day_/671034", "title"=>"Mean (±SEM) serum levels of fluoxetine (ng/mL) and norfluoxetine (ng/mL) during the postnatal period. (P = postnatal day).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 00:17:14"}

PMC Usage Stats | Further Information

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Relative Metric

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