The Association between IgG4 Antibodies to Dietary Factors, Islet Autoimmunity and Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young
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{"title"=>"The Association between IgG4 Antibodies to Dietary Factors, Islet Autoimmunity and Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young", "type"=>"journal", "authors"=>[{"first_name"=>"Molly M.", "last_name"=>"Lamb", "scopus_author_id"=>"16480331500"}, {"first_name"=>"Melissa D.", "last_name"=>"Simpson", "scopus_author_id"=>"35604319300"}, {"first_name"=>"Jennifer", "last_name"=>"Seifert", "scopus_author_id"=>"7201868595"}, {"first_name"=>"Fraser W.", "last_name"=>"Scott", "scopus_author_id"=>"7202323910"}, {"first_name"=>"Marian", "last_name"=>"Rewers", "scopus_author_id"=>"7007102961"}, {"first_name"=>"Jill M.", "last_name"=>"Norris", "scopus_author_id"=>"55574196846"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84874579805", "sgr"=>"84874579805", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0057936", "pmid"=>"23469110", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"368451143"}, "id"=>"b7221e2a-91d9-331b-9c7c-d0bdd2cef84a", "abstract"=>"BACKGROUND: Infant dietary exposures have been linked to type 1 diabetes (T1D) development. IgG4 antibody responses to food antigens are associated with food intolerances but have not been explored prospectively in the period preceding T1D.\\n\\nMETHODS: Using a case-cohort design, IgG4 antibodies to ß-lactoglobulin, gluten, and ovalbumin were measured in plasma collected annually from 260 DAISY participants. Of those, 77 developed islet autoimmunity (IA), defined as positive for either insulin, GAD65 or IA-2 autoantibodies on two consecutive visits, and 22 developed T1D.\\n\\nRESULTS: In mixed model analysis adjusting for HLA-DR status, T1D family history, age and ethnicity, higher ß-lactoglobulin IgG4 concentrations were associated with shorter breastfeeding duration (beta = -0.03, 95% Confidence Interval: -0.05, -0.006) and earlier first cow's milk exposure (beta = -0.04, 95% Confidence Interval: -0.08, 0.00). Higher gluten IgG4 was associated with older age at gluten introduction (beta = 0.06, 95% Confidence Interval: 0.00, 0.13). In proportional hazards analysis adjusting for HLA-DR status, T1D family history and ethnicity, IgG4 against individual or multiple dietary antigens throughout childhood were not associated with IA. In addition, mean antigen-specific IgG4 concentrations in infancy (age <2 years) were not associated with risk of IA nor progression to T1D. Higher ovalbumin IgG4 at first IA positive visit was marginally associated with progression to T1D (Hazard Ratio: 1.39, 95% Confidence Interval: 1.00, 1.92).\\n\\nCONCLUSION: We found no association between the IgG4 response to β-lactoglobulin, gluten, and the development of either IA or T1D. The association between higher ovalbumin and progression to T1D in children with IA should be explored in other populations.", "link"=>"http://www.mendeley.com/research/association-between-igg4-antibodies-dietary-factors-islet-autoimmunity-type-1-diabetes-diabetes-auto", "reader_count"=>22, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>4, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>4, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>3, "Neuroscience"=>1, "Sports and Recreations"=>1, "Psychology"=>1, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1, "France"=>1, "Portugal"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>1}

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Relative Metric

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