Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow: In Vitro Comparison of Their Tropism towards Gliomas
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{"title"=>"Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow: In Vitro Comparison of Their Tropism towards Gliomas", "type"=>"journal", "authors"=>[{"first_name"=>"Courtney", "last_name"=>"Pendleton", "scopus_author_id"=>"23470868800"}, {"first_name"=>"Qian", "last_name"=>"Li", "scopus_author_id"=>"56525555400"}, {"first_name"=>"David A.", "last_name"=>"Chesler", "scopus_author_id"=>"36745502300"}, {"first_name"=>"Kristy", "last_name"=>"Yuan", "scopus_author_id"=>"55619437300"}, {"first_name"=>"Hugo", "last_name"=>"Guerrero-Cazares", "scopus_author_id"=>"15848345600"}, {"first_name"=>"Alfredo", "last_name"=>"Quinones-Hinojosa", "scopus_author_id"=>"7004875939"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368517983", "sgr"=>"84874850959", "issn"=>"19326203", "pmid"=>"23554877", "scopus"=>"2-s2.0-84874850959", "doi"=>"10.1371/journal.pone.0058198", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"a9ae2e24-2d00-3e3b-a2db-411472dc8d60", "abstract"=>"INTRODUCTION: Glioblastoma is the most common primary malignant brain tumor, and is refractory to surgical resection, radiation, and chemotherapy. Human mesenchymal stem cells (hMSC) may be harvested from bone marrow (BMSC) and adipose (AMSC) tissue. These cells are a promising avenue of investigation for the delivery of adjuvant therapies. Despite extensive research into putative mechanisms for the tumor tropism of MSCs, there remains no direct comparison of the efficacy and specificity of AMSC and BMSC tropism towards glioma. METHODS: Under an IRB-approved protocol, intraoperative human Adipose MSCs (hAMSCs) were established and characterized for cell surface markers of mesenchymal stem cell origin in conjunction with the potential for tri-lineage differentiation (adipogenic, chondrogenic, and osteogenic). Validated experimental hAMSCs were compared to commercially derived hBMSCs (Lonza) and hAMSCs (Invitrogen) for growth responsiveness and glioma tropism in response to glioma conditioned media obtained from primary glioma neurosphere cultures. RESULTS: Commercial and primary culture AMSCs and commercial BMSCs demonstrated no statistically significant difference in their migration towards glioma conditioned media in vitro. There was statistically significant difference in the proliferation rate of both commercial AMSCs and BMSCs as compared to primary culture AMSCs, suggesting primary cultures have a slower growth rate than commercially available cell lines. CONCLUSIONS: Adipose- and bone marrow-derived mesenchymal stem cells have similar in vitro glioma tropism. Given the well-documented ability to harvest larger numbers of AMSCs under local anesthesia, adipose tissue may provide a more efficient source of MSCs for research and clinical applications, while minimizing patient morbidity during cell harvesting.", "link"=>"http://www.mendeley.com/research/mesenchymal-stem-cells-derived-adipose-tissue-vs-bone-marrow-vitro-comparison-tropism-towards-glioma", "reader_count"=>112, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Researcher"=>10, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>30, "Student > Postgraduate"=>6, "Other"=>6, "Student > Master"=>19, "Student > Bachelor"=>18, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Researcher"=>10, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>30, "Student > Postgraduate"=>6, "Other"=>6, "Student > Master"=>19, "Student > Bachelor"=>18, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>10, "Agricultural and Biological Sciences"=>44, "Philosophy"=>1, "Business, Management and Accounting"=>1, "Chemical Engineering"=>1, "Chemistry"=>5, "Engineering"=>7, "Biochemistry, Genetics and Molecular Biology"=>12, "Materials Science"=>1, "Medicine and Dentistry"=>26, "Neuroscience"=>1, "Psychology"=>1, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>26}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>10}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Engineering"=>{"Engineering"=>7}, "Chemistry"=>{"Chemistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>44}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>12}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"Austria"=>1, "United States"=>2, "Japan"=>1, "Taiwan"=>1, "Brazil"=>3, "United Kingdom"=>1}, "group_count"=>3}

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  • {"files"=>["https://ndownloader.figshare.com/files/984798"], "description"=>"<p>Percentage of each antigen was analyzed using Kaluza software and labeled in the responsive graph.</p>", "links"=>[], "tags"=>["adipose-derived", "mesenchymal", "lines", "invitrogen", "supplied", "amsc", "confirmed", "facs", "documenting", "hematopoetic", "antigens", "adhesion", "markers"], "article_id"=>650350, "categories"=>["Cancer", "Cell Biology", "Developmental Biology"], "users"=>["Courtney Pendleton", "Qian Li", "David A. Chesler", "Kristy Yuan", "Hugo Guerrero-Cazares", "Alfredo Quinones-Hinojosa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058198.g001", "stats"=>{"downloads"=>3, "page_views"=>143, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Stemness_of_the_primary_adipose_derived_mesenchymal_stem_cell_lines_AMSC_and_the_Invitrogen_supplied_commercial_AMSC_line_confirmed_with_FACS_documenting_the_absence_of_hematopoetic_surface_antigens_CD31_CD45_and_the_presence_of_cell_adhesion_markers_CD7/650350", "title"=>"Stemness of the primary adipose-derived mesenchymal stem cell lines (AMSC), and the Invitrogen supplied commercial AMSC line, confirmed with FACS documenting the absence of hematopoetic surface antigens CD31/CD45 and the presence of cell adhesion markers CD73/CD90/CD105.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-13 08:59:20"}
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Relative Metric

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