In Vivo Study of Spherical Gold Nanoparticles: Inflammatory Effects and Distribution in Mice
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"In Vivo Study of Spherical Gold Nanoparticles: Inflammatory Effects and Distribution in Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Hui", "last_name"=>"Chen", "scopus_author_id"=>"40761074800"}, {"first_name"=>"Alisha", "last_name"=>"Dorrigan", "scopus_author_id"=>"55613278900"}, {"first_name"=>"Sonia", "last_name"=>"Saad", "scopus_author_id"=>"9734266500"}, {"first_name"=>"Dominic J.", "last_name"=>"Hare", "scopus_author_id"=>"26028822000"}, {"first_name"=>"Michael B.", "last_name"=>"Cortie", "scopus_author_id"=>"7004426392"}, {"first_name"=>"Stella M.", "last_name"=>"Valenzuela", "scopus_author_id"=>"7006649358"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368451103", "sgr"=>"84874577394", "issn"=>"19326203", "pmid"=>"23469154", "scopus"=>"2-s2.0-84874577394", "doi"=>"10.1371/journal.pone.0058208", "isbn"=>"10.1371/journal.pone.0058208"}, "id"=>"920271ea-9499-3747-9310-feb74f127c88", "abstract"=>"OBJECTIVES: Gold nanoparticles (AuNPs) of 21 nm have been previously well characterized in vitro for their capacity to target macrophages via active uptake. However, the short-term impact of such AuNPs on physiological systems, in particular resident macrophages located in fat tissue in vivo, is largely unknown. This project investigated the distribution, organ toxicity and changes in inflammatory cytokines within the adipose tissue after mice were exposed to AuNPs.\\n\\nMETHODS: Male C57BL/6 mice were injected intraperitoneally (IP) with a single dose of AuNPs (7.85 μg AuNPs/g). Body weight and energy intake were recorded daily. Tissues were collected at 1 h, 24 h and 72 h post-injection to test for organ toxicity. AuNP distribution was examined using electron microscopy. Proinflammatory cytokine expression and macrophage number within the abdominal fat pad were determined using real-time PCR.\\n\\nRESULTS: At 72 hours post AuNP injection, daily energy intake and body weight were found to be similar between Control and AuNP treated mice. However, fat mass was significantly smaller in AuNP-treated mice. Following IP injection, AuNPs rapidly accumulated within the abdominal fat tissue and some were seen in the liver. A reduction in TNFα and IL-6 mRNA levels in the fat were observed from 1 h to 72 h post AuNP injection, with no observable changes in macrophage number. There was no detectable toxicity to vital organs (liver and kidney).\\n\\nCONCLUSION: Our 21 nm spherical AuNPs caused no measurable organ or cell toxicity in mice, but were correlated with significant fat loss and inhibition of inflammatory effects. With the growing incidence of obesity and obesity-related diseases, our findings offer a new avenue for the potential development of gold nanoparticles as a therapeutic agent in the treatment of such disorders.", "link"=>"http://www.mendeley.com/research/vivo-study-spherical-gold-nanoparticles-inflammatory-effects-distribution-mice", "reader_count"=>94, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>4, "Researcher"=>15, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>28, "Student > Postgraduate"=>5, "Student > Master"=>21, "Other"=>1, "Student > Bachelor"=>11, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>4, "Researcher"=>15, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>28, "Student > Postgraduate"=>5, "Student > Master"=>21, "Other"=>1, "Student > Bachelor"=>11, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Agricultural and Biological Sciences"=>32, "Chemistry"=>11, "Engineering"=>3, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>11, "Nursing and Health Professions"=>1, "Materials Science"=>4, "Medicine and Dentistry"=>12, "Neuroscience"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>7, "Physics and Astronomy"=>2, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>7}, "Engineering"=>{"Engineering"=>3}, "Chemistry"=>{"Chemistry"=>11}, "Neuroscience"=>{"Neuroscience"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>32}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>11}}, "reader_count_by_country"=>{"Turkey"=>1, "South Africa"=>1, "United Kingdom"=>2, "Portugal"=>2}, "group_count"=>2}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84874577394"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84874577394?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84874577394&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84874577394&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84874577394", "dc:identifier"=>"SCOPUS_ID:84874577394", "eid"=>"2-s2.0-84874577394", "dc:title"=>"In Vivo Study of Spherical Gold Nanoparticles: Inflammatory Effects and Distribution in Mice", "dc:creator"=>"Chen H.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-02-28", "prism:coverDisplayDate"=>"28 February 2013", "prism:doi"=>"10.1371/journal.pone.0058208", "citedby-count"=>"102", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Technology Sydney", "affiliation-city"=>"Sydney", "affiliation-country"=>"Australia"}], "pubmed-id"=>"23469154", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e58208", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0058208", "share_count"=>1, "like_count"=>0, "comment_count"=>2, "click_count"=>0, "total_count"=>3}

Counter

  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"79", "xml_views"=>"1", "html_views"=>"304"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"52", "xml_views"=>"3", "html_views"=>"213"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"47", "xml_views"=>"1", "html_views"=>"259"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"150"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"52", "xml_views"=>"0", "html_views"=>"163"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"55", "xml_views"=>"0", "html_views"=>"194"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"175"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"41", "xml_views"=>"3", "html_views"=>"170"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"39", "xml_views"=>"2", "html_views"=>"190"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"181"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"42", "xml_views"=>"4", "html_views"=>"176"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"36", "xml_views"=>"2", "html_views"=>"180"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"165"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"150"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"127"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"35", "xml_views"=>"2", "html_views"=>"133"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"154"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"36", "xml_views"=>"2", "html_views"=>"175"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"50", "xml_views"=>"2", "html_views"=>"168"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"138"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"149"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"129"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"110"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"45", "xml_views"=>"0", "html_views"=>"164"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"125"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"102"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"115"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"107"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"95"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"114"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"136"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"57", "xml_views"=>"0", "html_views"=>"201"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"150"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"141"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"136"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"36", "xml_views"=>"1", "html_views"=>"179"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"176"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"52", "xml_views"=>"0", "html_views"=>"163"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"45", "xml_views"=>"0", "html_views"=>"158"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"148"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"3", "html_views"=>"117"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"33", "xml_views"=>"2", "html_views"=>"96"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"116"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"99"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"149"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"92"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"80"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"41", "xml_views"=>"2", "html_views"=>"66"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"9", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"44"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"15"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/974739"], "description"=>"<p>AuNPs in (A) the liver connective tissue and (B) a 5 µm capillary within the liver adipose tissue (Mag 5.00K x), and in (C) a Kupffer cell within the sinusoid of the liver (Mag 4.19K x).</p>", "links"=>[], "tags"=>["ip"], "article_id"=>642678, "categories"=>["Biotechnology", "Biochemistry", "Immunology"], "users"=>["Hui Chen", "Alisha Dorrigan", "Sonia Saad", "Dominic J. Hare", "Michael B. Cortie", "Stella M. Valenzuela"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058208.g003", "stats"=>{"downloads"=>1, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AuNP_distribution_within_mouse_liver_following_IP_injection_/642678", "title"=>"AuNP distribution within mouse liver following IP injection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-01 14:48:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/974736"], "description"=>"<p>Scanning electron microscopy (SEM) images of AuNPs in adipose tissue (A, B, C) and liver sections (D, E, F) at 1 h (A, D), 24 h (B, E), and 72 h (C, F) post AuNP injection (Mag 2.01K x).</p>", "links"=>[], "tags"=>["aunps", "tissues", "ip"], "article_id"=>642675, "categories"=>["Biotechnology", "Biochemistry", "Immunology"], "users"=>["Hui Chen", "Alisha Dorrigan", "Sonia Saad", "Dominic J. Hare", "Michael B. Cortie", "Stella M. Valenzuela"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058208.g002", "stats"=>{"downloads"=>0, "page_views"=>32, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Localisation_of_AuNPs_within_specific_mouse_tissues_following_IP_injection_/642675", "title"=>"Localisation of AuNPs within specific mouse tissues following IP injection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-01 14:48:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/974732"], "description"=>"<p>Scanning electron microscopy (SEM) images of abdominal adipose tissue in (A) control mouse and (B) AuNP-injected mouse at 24 h (Mag 2.01K x). (C, D) Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) images of abdominal adipose tissue at 24 h. (C) displaying the carbon present throughout the tissue sample, of medium to low signal intensity, (D) displays the gold present throughout the tissue sample, concentrated around the periphery of a portion of tissue within the section, of medium to high intensity. The strength of the signal transmitted for a selected element is represented by a corresponding colour, blue signifying the lowest signal strength and red the highest.</p>", "links"=>[], "tags"=>["adipose", "aunps", "intraperitoneal", "injection"], "article_id"=>642673, "categories"=>["Biotechnology", "Biochemistry", "Immunology"], "users"=>["Hui Chen", "Alisha Dorrigan", "Sonia Saad", "Dominic J. Hare", "Michael B. Cortie", "Stella M. Valenzuela"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058208.g001", "stats"=>{"downloads"=>1, "page_views"=>37, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Abdominal_adipose_tissue_distribution_of_AuNPs_following_intraperitoneal_injection_into_mice_/642673", "title"=>"Abdominal adipose tissue distribution of AuNPs following intraperitoneal injection into mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-01 14:47:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/974740"], "description"=>"<p>mRNA levels of (A) CD68, (B) TNFα and (C) IL-6 in abdominal fat at different time points post AuNPs injection. Results are expressed as mean ± SE, n = 4–8 in each group. *P<0.05, compared with Control group. CON, control; Au, AuNPs. The differences among groups were analysed using one-way ANOVA, followed by <i>post hoc</i> Fisher's Least Significance Difference tests.</p>", "links"=>[], "tags"=>["mrna", "cytokine", "abdominal", "points", "ip", "injection"], "article_id"=>642679, "categories"=>["Biotechnology", "Biochemistry", "Immunology"], "users"=>["Hui Chen", "Alisha Dorrigan", "Sonia Saad", "Dominic J. Hare", "Michael B. Cortie", "Stella M. Valenzuela"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058208.g004", "stats"=>{"downloads"=>1, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_mRNA_cytokine_expression_levels_in_mouse_abdominal_fat_tissue_at_different_time_points_post_IP_injection_of_AuNPs_/642679", "title"=>"Changes in mRNA cytokine expression levels in mouse abdominal fat tissue at different time points post IP injection of AuNPs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-01 14:48:34"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"42", "full-text"=>"40", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"59", "full-text"=>"70", "pdf"=>"25", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"34", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"40", "full-text"=>"38", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"36", "full-text"=>"38", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"24", "full-text"=>"30", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"30", "full-text"=>"31", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"21", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"24", "full-text"=>"23", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"10", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"23", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"6", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"33", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"25", "full-text"=>"26", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"14", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"15", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"10", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"29", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"26", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"22", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"15", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[248, 440, 562, 666, 765, 856, 944, 1028, 1112, 1198, 1282, 1362, 1430]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 466, 591, 701, 799, 887, 982, 1067, 1155, 1237, 1317, 1395, 1458]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[256, 449, 572, 676, 775, 866, 955, 1041, 1127, 1213, 1290, 1370, 1437]}, {"subject_area"=>"/Engineering and technology", "average_usage"=>[254, 440, 558, 675, 785, 883, 972, 1061, 1154, 1248, 1336, 1414, 1489]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[248, 441, 564, 668, 769, 859, 948, 1034, 1117, 1202, 1290, 1368, 1437]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[267, 466, 592, 709, 806, 901, 989, 1075, 1162, 1254, 1342, 1424, 1486]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[254, 431, 547, 651, 748, 842, 932, 1017, 1098, 1178, 1259, 1336, 1404]}]}
Loading … Spinner
There are currently no alerts