Developmental Enamel Defects in Children Prenatally Exposed to Anti-Epileptic Drugs
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{"title"=>"Developmental Enamel Defects in Children Prenatally Exposed to Anti-Epileptic Drugs", "type"=>"journal", "authors"=>[{"first_name"=>"Pernille E.", "last_name"=>"Jacobsen", "scopus_author_id"=>"55617928400"}, {"first_name"=>"Tine B.", "last_name"=>"Henriksen", "scopus_author_id"=>"35399074200"}, {"first_name"=>"Dorte", "last_name"=>"Haubek", "scopus_author_id"=>"6603118275"}, {"first_name"=>"John R.", "last_name"=>"Østergaard", "scopus_author_id"=>"7004506853"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368490074", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0058213", "scopus"=>"2-s2.0-84874783629", "pmid"=>"23520494", "sgr"=>"84874783629"}, "id"=>"b7f3878e-9713-3d89-ab98-f3e0cd02237b", "abstract"=>"OBJECTIVE: Some anti-epileptic drugs (AED) have well-known teratogenic effects. The aim of the present study was to elucidate the effect of prenatal exposure to AED and the risk of enamel defects in the primary and permanent dentition.\\n\\nMETHODS: A total of 38 exposed and 129 non-exposed children, 6-10 years of age, were recruited from the Aarhus Birth Cohort and the Department of Neurology, Viborg Regional Hospital, Denmark. Medication during pregnancy was confirmed by the Danish Prescription Database. All children had their teeth examined and outcomes in terms of enamel opacities and enamel hypoplasia were recorded.\\n\\nRESULTS: Children prenatally exposed to AED have an increased prevalence of enamel hypoplasia (11% vs. 4%, odds ratio (OR) = 3.6 [95% confidence interval (CI): 0.9 to 15.4]), diffuse opacities (18% vs. 7%, OR = 3.0; [95% CI: 1.0 to 8.7, p<0.05]), and numerous (>3) white opacities (18% vs. 10%, OR = 2.2; [95% CI: 0.8 to 6.1]) in the primary dentition. In the permanent dentition, an increased risk of numerous (>3) white opacities (34% vs. 12%, OR = 3.3; [95% CI: 1.3 to 8.4]) was found.\\n\\nCONCLUSIONS: The present study shows that children prenatally exposed to AED have an increased risk of developing numerous teeth with white opacities in their primary and permanent dentition. In addition, they also have an increased risk of developing diffuse opacities and enamel hypoplasia in their primary teeth.", "link"=>"http://www.mendeley.com/research/developmental-enamel-defects-children-prenatally-exposed-antiepileptic-drugs-4", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/983046"], "description"=>"<p>A) white/yellow demarcated opacities B) yellow/brown opacities C) enamel hypoplasia D) diffuse opacities.</p>", "links"=>[], "tags"=>["enamel", "defects"], "article_id"=>649018, "categories"=>["Cell Biology", "Neuroscience", "Medicine", "Biotechnology", "Pharmacology", "Developmental Biology"], "users"=>["Pernille E. Jacobsen", "Tine B. Henriksen", "Dorte Haubek", "John R. Østergaard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058213.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Different_Enamel_Defects_on_the_Upper_Permanent_Incisors_/649018", "title"=>"Different Enamel Defects on the Upper Permanent Incisors.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-09 12:58:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1012119"], "description"=>"a<p>Number of women receiving a prescription and relate to a period 1 year before birth to 1 year after.</p>b<p>Others refer to prescriptions on drugs for topical use, such as Spirocort® or Brentan® and other medication for systemic use, such as propranolol or Klexane®.</p>c<p>Gestational mean age is given as weeks+days.</p>d<p>Data on smoking habits is obtained from the Aarhus Birth Cohort only.</p>", "links"=>[], "tags"=>["women-offspring", "dyads", "included"], "article_id"=>672531, "categories"=>["Cell Biology", "Neuroscience", "Medicine", "Biotechnology", "Pharmacology", "Developmental Biology"], "users"=>["Pernille E. Jacobsen", "Tine B. Henriksen", "Dorte Haubek", "John R. Østergaard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058213.t001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_women_offspring_dyads_by_whether_they_were_included_or_dropouts_/672531", "title"=>"Characteristics of women-offspring dyads by whether they were included or dropouts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-08 00:42:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1012173"], "description"=>"a<p>The permanent teeth only involve the incisors and 1<sup>st</sup> molar.</p>", "links"=>[], "tags"=>["children", "teeth", "affected", "enamel", "defects", "exposed", "antiepileptic", "drugs", "fetal", "findings"], "article_id"=>672579, "categories"=>["Cell Biology", "Neuroscience", "Medicine", "Biotechnology", "Pharmacology", "Developmental Biology"], "users"=>["Pernille E. Jacobsen", "Tine B. Henriksen", "Dorte Haubek", "John R. Østergaard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058213.t002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_children_with_the_number_of_teeth_affected_by_the_different_enamel_defects_by_whether_they_were_exposed_to_antiepileptic_drugs_during_fetal_life_and_whether_the_findings_were_in_primary_or_permanent_teeth_/672579", "title"=>"Number of children with the number of teeth affected by the different enamel defects by whether they were exposed to antiepileptic drugs during fetal life and whether the findings were in primary or permanent teeth.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-08 00:42:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1012148"], "description"=>"a<p>The permanent teeth only involve the incisors and 1<sup>st</sup> molars.</p>b<p>Include children who only have been exposed to lamotrigine for the whole period.</p>c<p>Include children, who have been exposed to poly pharmacy, other anti-epileptic drugs than lamotrigine or a mix of anti-epileptic drugs, including lamotrigine.</p>̂<p>Not significant despite confidence interval larger than 1.</p>*<p>p<0.05;</p>**<p>p<0.01;</p>***<p>p<0.001.</p>", "links"=>[], "tags"=>["ratios", "intervals", "teeth", "affected", "enamel", "defects", "children", "exposed", "fetal", "findings"], "article_id"=>672549, "categories"=>["Cell Biology", "Neuroscience", "Medicine", "Biotechnology", "Pharmacology", "Developmental Biology"], "users"=>["Pernille E. Jacobsen", "Tine B. Henriksen", "Dorte Haubek", "John R. Østergaard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058213.t003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_odds_ratios_and_confidence_intervals_of_the_number_of_teeth_affected_by_the_different_enamel_defects_and_by_whether_the_children_were_exposed_or_not_during_fetal_life_and_whether_the_findings_were_in_primary_or_permanent_teeth_/672549", "title"=>"The odds ratios and confidence intervals of the number of teeth affected by the different enamel defects and by whether the children were exposed or not, during fetal life and whether the findings were in primary or permanent teeth.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-08 00:42:29"}

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  • {"unique-ip"=>"197", "full-text"=>"220", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[256, 449, 572, 676, 775, 866, 955, 1041, 1127, 1213, 1290, 1370, 1437]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/People and places", "average_usage"=>[270, 456, 573, 676, 773, 867, 955, 1037, 1120, 1205, 1286, 1363, 1436]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[265, 456, 578, 682, 782, 881, 965, 1053, 1133, 1223, 1310, 1391, 1457]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[254, 431, 547, 651, 748, 842, 932, 1017, 1098, 1178, 1259, 1336, 1404]}, {"subject_area"=>"/Physical sciences/Materials science", "average_usage"=>[250, 417, 535, 649, 758, 857, 952, 1036, 1113, 1206, 1287, 1353, 1429]}]}
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