Developmental Regulation of Nucleolus Size during Drosophila Eye Differentiation
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{"title"=>"Developmental Regulation of Nucleolus Size during Drosophila Eye Differentiation", "type"=>"journal", "authors"=>[{"first_name"=>"Nicholas E.", "last_name"=>"Baker", "scopus_author_id"=>"7201670161"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368465610", "scopus"=>"2-s2.0-84874631406", "isbn"=>"1932-6203", "pmid"=>"23472166", "sgr"=>"84874631406", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0058266"}, "id"=>"bd3b95e1-25e6-3a51-b4cd-b7fbe9b6f8f1", "abstract"=>"When cell cycle withdrawal accompanies terminal differentiation, biosynthesis and cellular growth are likely to change also. In this study, nucleolus size was monitored during cell fate specification in the Drosophila eye imaginal disc using fibrillarin antibody labeling. Nucleolus size is an indicator of ribosome biogenesis and can correlate with cellular growth rate. Nucleolar size was reduced significantly during cell fate specification and differentiation, predominantly as eye disc cells entered a cell cycle arrest that preceded cell fate specification. This reduction in nucleolus size required Dpp and Hh signaling. A transient enlargement of the nucleolus accompanied cell division in the Second Mitotic Wave. Nucleoli continued to diminish in postmitotic cells following fate specification. These results suggest that cellular growth is regulated early in the transition from proliferating progenitor cells to terminal cell fate specification, contemporary with regulation of the cell cycle, and requiring the same extracellular signals.", "link"=>"http://www.mendeley.com/research/developmental-regulation-nucleolus-size-during-drosophila-eye-differentiation", "reader_count"=>21, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>2, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Master"=>3, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>2, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Master"=>3, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>1, "Neuroscience"=>2, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "reader_count_by_country"=>{"France"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1553636"], "description"=>"<p>All panels show Cyclin B protein in green as a marker for cells between S-phase and mitotic metaphase, and pH3 in magenta as a marker for mitotic cells. The yellow arrow indicates the Second Mitotic Wave in all figures. A) wild type. Most Second Mitotic Wave mitosis occurs in a band close to the morphogenetic furrow. B) GMR-GAL4, UAS-CycD, UAS-Cdk4. The Second Mitotic Wave is followed by a fairly synchronous additional cell cycle approximately 8 columns more posteriorly. The peak of mitosis in this “Third Mitotic Wave” is indicated by the orange arrow. The Second and Third Mitotic Waves are clearly separated by a zone where most cells are in G1 phase and lack Cyclin B. C) GMR-GAL4, UAS-CycE. The Second Mitotic Wave is followed by generalized and apparently unsynchronized proliferation of interommatidial cells.</p>", "links"=>[], "tags"=>["induced", "cyclin"], "article_id"=>1073547, "categories"=>["Neuroscience", "Genetics", "Developmental Biology"], "users"=>["Nicholas E. Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058266.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Proliferation_induced_by_Cyclin_overexpression_/1073547", "title"=>"Proliferation induced by Cyclin overexpression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 10:07:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1553601"], "description"=>"<p>A. High resolution micrograph of the eye imaginal disc, divided into nine zones from anterior to posterior, according to mitotic behavior (see text for details). Nucleoli labeled in magenta (anti-fibrillarin); mitotic figures labelled in green (anti-phosphoH3). B. Nucleolar labeling from panel A, z-projected from apical to basal within the disc epithelium and digitally processed for automated measurement (see methods). C. Nucleolus cross-section in pixels. Mean±1 standard deviation shown for each zone. D. Nucleolus cross-section in pixels. Mean±1 standard deviation shown. Within each zone, nucleoli from separated 3–5 μ deep apical or basal layers of the disc epithelium were analyzed separately (basal nucleoli: black circles; apical nucleoli, grey circles). These data were pooled in panel C.</p>", "links"=>[], "tags"=>["nucleolus"], "article_id"=>1073512, "categories"=>["Neuroscience", "Genetics", "Developmental Biology"], "users"=>["Nicholas E. Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058266.g002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Timecourse_of_changes_in_nucleolus_size_/1073512", "title"=>"Timecourse of changes in nucleolus size.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 10:07:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1553740"], "description"=>"<p>A. Eye imaginal disc labelled for nucleoli (magenta). Clones mutant for <i>smo</i> and <i>Mad</i> lack beta-galactosidase expression (green). Blue arrow shows the onset of fate specification in the morphogenetic furrow. Nucleoli remain the same size within <i>smo Mad</i> clones. Outside the clone nucleoli become progressively smaller. Nucleoli mutant for <i>smo</i> and <i>Mad</i> also appear more intensely labelled. Fibrillarin channel and enlargements shown to the right. The distinction is evident posterior to the furrow in the enlarged panels. B. Clones mutant for <i>Mad</i> lack beta-galactosidase expression (green). Nucleoli mutant for <i>Mad</i> shrink at the same time as in wild type cells. Fibrillarin channel and enlargements shown to the right. C. Clones mutant for <i>smo</i> lack beta-galactosidase expression (green). Nucleoli mutant for <i>smo</i> shrink at the same time as in wild type cells. Fibrillarin channel and enlargements shown to the right. In panels A–C, fibrillarin labeling is shown as a maximum projection of multiple layers, because nucleoli occupy varying positions in the z-axis. Beta-galactosidase labeling is shown for only a single, central, z-plane, so that parts of the negatively-marked clones were not obscured. To accurately determine the genotype of each nucleolus, beta-galactosidase and fibrillarin labeling must be examined for each confocal plane (not shown).</p>", "links"=>[], "tags"=>["dpp", "hh", "nucleolar"], "article_id"=>1073649, "categories"=>["Neuroscience", "Genetics", "Developmental Biology"], "users"=>["Nicholas E. Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058266.g007", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Requirement_for_Dpp_and_Hh_signaling_in_nucleolar_size_/1073649", "title"=>"Requirement for Dpp and Hh signaling in nucleolar size.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 10:07:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1553604"], "description"=>"<p>Nucleolus size over time. Data shown are mean and standard deviations of the average nucleolus size from each Zone, normalized to Zone 1 from the same eye disc. Statistical significance between samples: *, p<0.05; **, p<0.01; ***, p<0.001. A. Blue - cells with apical nuclei in GMR-Gal4/+; Green - cells with basal nuclei in GMR-Gal4/+. Nucleoli from unspecified cells with basal nuclei were significantly larger in Zones 6, 8 & 9. B. Orange - cells with apical nuclei in <i>GMR-p21</i>; Magenta - cells with basal nuclei in <i>GMR-p21.</i> Nucleoli from unspecified cells with basal nuclei were significantly larger in Zones 7 & 8. Note that nucleolar sizes did not differ in Zone 6. C. Comparison of apical nucleoli from GMR-Gal4/+ (blue) and GMR-p21 (orange). No significant differences were noted. D. Comparison of basal nucleoli from GMR-Gal4/+ (green) and GMR-p21 (magenta). Basal nucleoli from GMR-p21 were significantly smaller in Zone 6.</p>", "links"=>[], "tags"=>["nucleolus"], "article_id"=>1073515, "categories"=>["Neuroscience", "Genetics", "Developmental Biology"], "users"=>["Nicholas E. Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058266.g003", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_p21_Cip1_WAF1_expression_on_nucleolus_size_/1073515", "title"=>"Effect of p21<sup>Cip1/WAF1</sup> expression on nucleolus size.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 10:07:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1553649"], "description"=>"<p>Nucleolous size over time. Data shown are mean and standard deviations of the average nucleolus size from each Zone, normalized to Zone 1 from the same eye disc. Statistical significance between samples: *, p<0.05; **, p<0.01; ***, p<0.001. A. Blue - cells with apical nuclei in GMR-Gal4/+; Green - cells with basal nuclei in GMR-Gal4/+. Nucleoli from unspecified cells with basal nuclei were significantly larger in Zones 6–9. B. Black - cells with apical nuclei in GMR-Gal4 UAS-CycD UAS-Cdk4/+; Mauve - cells with basal nuclei in GMR-Gal4 UAS-CycD UAS-Cdk4/+. Nucleoli from unspecified cells with basal nuclei were significantly larger in Zones 6–9. The significant difference in Zone 2 is hard to interpret since GMR-Gal4 is not active there. C. Comparison of apical nucleoli from GMR-Gal4/+ (blue) and GMR-Gal4 UAS-CycD UAS-Cdk4/+ (black). No significant differences were noted until Zone 9. D. Comparison of basal nucleoli from GMR-Gal4/+ (green) and GMR-Gal4 UAS-CycD UAS-Cdk4/+ (mauve). No significant differences were noted.</p>", "links"=>[], "tags"=>["cyclin", "nucleolus"], "article_id"=>1073559, "categories"=>["Neuroscience", "Genetics", "Developmental Biology"], "users"=>["Nicholas E. Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058266.g005", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_Cyclin_D_Cdk4_expression_on_nucleolus_size_/1073559", "title"=>"Effect of Cyclin D/Cdk4 expression on nucleolus size.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 10:07:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1553584"], "description"=>"<p>A. Epithelial layer of the eye-antennal imaginal disc. Nucleoli labeled in magenta (anti-fibrillarin); mitotic figures labelled in green (anti-phosphoH3). Postmitotic fate specification begins within the morphogenetic furrow (yellow arrow), flanked by a First Mitotic Wave where unpatterned proliferation ends (orange arrow), and the Second Mitotic Wave where a subset of retinal progenitor cells divide (blue arrow). Blue bar indicates the approximate extent of Hedgehog (Hh) expression posterior to the furrow. Hedgehog induces Dpp within the furrow (lavender bar). Dpp and Hh together regulate differentiation and the cell cycle arrest that precedes the furrow (see text). B. Peripodial layer of the eye-antennal imaginal disc. Proliferation is largely unpatterned. C. Higher magnification of antennal region (box ‘c’ in panel A). Nucleoli were smaller in the cells of more distal regions (towards the top). D. Higher magnification of anterior eye region (box ‘d’ in panel A). Nucleoli resemble those from the antennal disc. E. Higher magnification of posterior eye region (box ‘e’ in panel A). Nucleoli are much smaller than in the antennal disc or anterior eye disc. Labeling intensity is also reduced (peak labeling is approx 0.6x the gray value of panel F). F. Higher magnification of the peripodial epithelium. Nucleoli are similar in size to the anterior eye disc and the antennal disc, but larger and more intense than nucleoli from the posterior eye region (compare panel E).</p>", "links"=>[], "tags"=>["imaginal"], "article_id"=>1073496, "categories"=>["Neuroscience", "Genetics", "Developmental Biology"], "users"=>["Nicholas E. Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058266.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nucleoli_in_the_eye_8211_antennal_imaginal_disc_/1073496", "title"=>"Nucleoli in the eye–antennal imaginal disc.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 10:07:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1553659"], "description"=>"<p>Nucleolous size over time. Data shown are mean and standard deviations of the average nucleolus size from each Zone, normalized to Zone 1 from the same eye disc. Statistical significance between samples: *, p<0.05; **, p<0.01; ***, p<0.001. A. Blue - cells with apical nuclei in GMR-Gal4/+; Green - cells with basal nuclei in GMR-Gal4/+ (same data as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058266#pone-0058266-g005\" target=\"_blank\">Figure 5A</a>). Nucleoli from unspecified cells with basal nuclei were significantly larger in Zones 6–9. B. Brown - cells with apical nuclei in GMR-Gal4 UAS-CycE/+; Gray - cells with basal nuclei in GMR-Gal4 UAS-CycD UAS-CycE/+. No significant differences were seen between nucleoli from unspecified cells with basal nuclei and nucleoli from differentiating cells with apical nuclei. C. Comparison of apical nucleoli from GMR-Gal4/+ (blue) and GMR-Gal4 UAS-CycE/+ (brown). No significant differences were noted. D. Comparison of basal nucleoli from GMR-Gal4/+ (green) and GMR-Gal4 UAS-CycE/+ (gray). From Zone 6 onwards nucleoli were smaller in GMR-Gal4 UAS-CycE/+ and this was statistically significant in Zone 8.</p>", "links"=>[], "tags"=>["cyclin", "nucleolus"], "article_id"=>1073569, "categories"=>["Neuroscience", "Genetics", "Developmental Biology"], "users"=>["Nicholas E. Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058266.g006", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_Cyclin_E_expression_on_nucleolus_size_/1073569", "title"=>"Effect of Cyclin E expression on nucleolus size.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-05 10:07:53"}

PMC Usage Stats | Further Information

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Relative Metric

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