Endometrial Receptivity: A Revisit to Functional Genomics Studies on Human Endometrium and Creation of HGEx-ERdb
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{"title"=>"Endometrial Receptivity: A Revisit to Functional Genomics Studies on Human Endometrium and Creation of HGEx-ERdb", "type"=>"journal", "authors"=>[{"first_name"=>"Sonali R.", "last_name"=>"Bhagwat", "scopus_author_id"=>"55906162500"}, {"first_name"=>"Darshan S.", "last_name"=>"Chandrashekar", "scopus_author_id"=>"36979008900"}, {"first_name"=>"Ruchi", "last_name"=>"Kakar", "scopus_author_id"=>"55631798200"}, {"first_name"=>"Sravanthi", "last_name"=>"Davuluri", "scopus_author_id"=>"36450281400"}, {"first_name"=>"Akhilesh K.", "last_name"=>"Bajpai", "scopus_author_id"=>"36450107100"}, {"first_name"=>"Sumeet", "last_name"=>"Nayak", "scopus_author_id"=>"55631800200"}, {"first_name"=>"Sumit", "last_name"=>"Bhutada", "scopus_author_id"=>"36469836500"}, {"first_name"=>"Kshitish", "last_name"=>"Acharya", "scopus_author_id"=>"55851234600"}, {"first_name"=>"Geetanjali", "last_name"=>"Sachdeva", "scopus_author_id"=>"6701376616"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368601733", "isbn"=>"1932-6203", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0058419", "scopus"=>"2-s2.0-84875409452", "pmid"=>"23555582", "sgr"=>"84875409452"}, "id"=>"f6f923b4-7594-3bde-9b99-fcb71f0a53a2", "abstract"=>"BACKGROUND: Endometrium acquires structural and functional competence for embryo implantation only during the receptive phase of menstrual cycle in fertile women. Sizeable data are available to indicate that this ability is acquired by modulation in the expression of several genes/gene products. However, there exists little consensus on the identity, number of expressed/not-detected genes and their pattern of expression (up or down regulation).\\n\\nMETHODS: Literature search was carried out to retrieve the data on endometrial expression of genes/proteins in various conditions. Data were compiled to generate a comprehensive database, Human Gene Expression Endometrial Receptivity database (HGEx-ERdb). The database was used to identify the Receptivity Associated Genes (RAGs) which display the similar pattern of expression across different investigations. Transcript levels of select RAGs encoding cell adhesion proteins were compared between two human endometrial epithelial cell lines; RL95-2 and HEC-1-A by quantitative real time polymerase chain reaction (q-RT-PCR). Further select RAGs were investigated for their expression in pre-receptive (n = 4) and receptive phase (n = 4) human endometrial tissues by immunohistochemical studies. JAr spheroid attachment assays were carried out to assess the functional significance of two RAGs.\\n\\nRESULTS: HGEx-ERdb (http://resource.ibab.ac.in/HGEx-ERdb/) helped identification of 179 RAGs, of which 151 genes were consistently expressed and upregulated and 28 consistently not-detected and downregulated in receptive phase as compared to pre-receptive phase. q-RT-PCR confirmed significantly higher (p<0.005) expression of Thrombospondin1 (THBS1), CD36 and Mucin 16 transcripts, in RL95-2 as compared to HEC-1-A. Further, the pretreatment with antibodies against CD36 and COMP led to a reduction in the percentage of JAr spheroids attached to RL95-2. Immunohistochemical studies demonstrated significantly higher (p<0.05) expression of endometrial THBS1, Cartilage Oligomeric Matrix Protein (COMP) and CD36 in the receptive phase as compared to pre-receptive phase human endometrial tissues.\\n\\nCONCLUSION: HGEx-ERdb is a catalogue of 19,285 genes, reported for their expression in human endometrium. Further 179 genes were identified as the RAGs. Expression analysis of some RAGs validated the utility of approach employed in creation of HGEx-ERdb. Studies aimed towards defining the specific functions of RAGs and their potential networks may yield relevant information about the major 'nodes' which regulate endometrial receptivity.", "link"=>"http://www.mendeley.com/research/endometrial-receptivity-revisit-functional-genomics-studies-human-endometrium-creation-hgexerdb", "reader_count"=>43, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>11, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Other"=>5, "Student > Master"=>3, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>11, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Other"=>5, "Student > Master"=>3, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>10, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>15, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>1, "Social Sciences"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Poland"=>1, "United Kingdom"=>1, "Estonia"=>1, "India"=>2}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/997738"], "description"=>"<p>Only significant (p<0.05) annotations are shown. UP-EX genes enriched various biological processes such as regulation of cell proliferation, response to wounding, immune response, cell adhesion and cellular, chemical homeostasis, regulation of cell death and blood vessel development. These included 160 biological processes. Only those biological processes with gene count of at least 10 are shown in panel B.</p>", "links"=>[], "tags"=>["ontology", "categorize", "receptivity", "genes", "molecular", "functions", "processes", "cellular"], "article_id"=>659934, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.g002", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_Ontology_GO_analysis_to_categorize_the_Receptivity_Associated_Genes_RAGs_according_to_A_molecular_functions_B_biological_processes_C_cellular_components_/659934", "title"=>"Gene Ontology (GO) analysis to categorize the Receptivity Associated Genes (RAGs) according to A) molecular functions B) biological processes C) cellular components.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-27 10:13:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/997753"], "description"=>"<p>Panel A shows cytoplasmic localization of CD36 and COMP in RL95-2 and HEC-1A. Respective negatives controls stained with rabbit IgGs are shown in the insets. Magnification: 63X. Panel B displays percentage spheroids attached to RL95-2 cells, pretreated with antibodies against CD36 or COMP or both. Percent spheroids attached to RL95-2 cells pretreated with same concentration of rabbit IgG are also shown (p<0.0002).</p>", "links"=>[], "tags"=>["localization", "cd36", "comp", "proteins", "vitro", "spheroid", "attachment"], "article_id"=>659948, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.g006", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunofluorescent_localization_of_CD36_and_COMP_proteins_and_their_functional_significance_as_assessed_by_in_vitro_spheroid_attachment_assays_/659948", "title"=>"Immunofluorescent localization of CD36 and COMP proteins and their functional significance as assessed by in vitro spheroid attachment assays.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-27 10:17:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/997731"], "description"=>"<p>Strategies used for creation of HGEx-ERdb, <i>in silico</i> characterization of RAGs and experimental validation.</p>", "links"=>[], "tags"=>["characterization", "rags"], "article_id"=>659930, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Strategies_used_for_creation_of_HGEx_ERdb_in_silico_characterization_of_RAGs_and_experimental_validation_/659930", "title"=>"Strategies used for creation of HGEx-ERdb, <i>in silico</i> characterization of RAGs and experimental validation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-27 10:12:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1008306"], "description"=>"<p>Up-Ex Receptivity Associated Genes (RAGs) and their Reliability Scores.</p>", "links"=>[], "tags"=>["receptivity", "genes"], "article_id"=>668922, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.t003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Up_Ex_Receptivity_Associated_Genes_RAGs_and_their_Reliability_Scores_/668922", "title"=>"Up-Ex Receptivity Associated Genes (RAGs) and their Reliability Scores.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-26 02:28:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/997747"], "description"=>"<p>Relative levels of the transcripts for MUC16, CD36 and THBS1 in RL95-2 as compared to HEC-1-A, are shown in panel A. Panel B demonstrates relative levels of the transcripts for SPP1 and DPP4 in HEC-1-A as compared to RL95-2. ** p <0.0005, *** p <0.0002, p value indicates the significance of the difference.</p>", "links"=>[], "tags"=>["rags", "q-rtpcr", "rl95-2", "adhesive", "hec-1-a"], "article_id"=>659942, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.g004", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_select_RAGs_by_q_RTPCR_in_RL95_2_a_more_adhesive_cell_line_and_HEC_1_A_a_less_adhesive_cell_line_/659942", "title"=>"Validation of select RAGs by q-RTPCR in RL95-2 (a more adhesive cell line) and HEC-1-A (a less adhesive cell line).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-27 10:15:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/1008280"], "description"=>"<p>Up-Ex Receptivity Associated Genes (RAGs) and their Reliability Scores.</p>", "links"=>[], "tags"=>["receptivity", "genes"], "article_id"=>668899, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.t001", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Up_Ex_Receptivity_Associated_Genes_RAGs_and_their_Reliability_Scores_/668899", "title"=>"Up-Ex Receptivity Associated Genes (RAGs) and their Reliability Scores.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-26 02:28:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/997743"], "description"=>"<p>(p<0.05).</p>", "links"=>[], "tags"=>["transcription", "binding", "sites", "regions", "receptivity", "genes"], "article_id"=>659938, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.g003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_silico_analysis_by_GATHER_to_identify_the_transcription_factor_binding_sites_TFBS_in_the_regulatory_regions_of_receptivity_associated_genes_RAGs_/659938", "title"=>"<i>In silico</i> analysis by GATHER to identify the transcription factor binding sites (TFBS) in the regulatory regions of receptivity associated genes (RAGs).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-27 10:14:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/997757", "https://ndownloader.figshare.com/files/997758", "https://ndownloader.figshare.com/files/997760", "https://ndownloader.figshare.com/files/997763", "https://ndownloader.figshare.com/files/997765", "https://ndownloader.figshare.com/files/997767"], "description"=>"<div><p>Background</p><p>Endometrium acquires structural and functional competence for embryo implantation only during the receptive phase of menstrual cycle in fertile women. Sizeable data are available to indicate that this ability is acquired by modulation in the expression of several genes/gene products. However, there exists little consensus on the identity, number of expressed/not-detected genes and their pattern of expression (up or down regulation).</p> <p>Methods</p><p>Literature search was carried out to retrieve the data on endometrial expression of genes/proteins in various conditions. Data were compiled to generate a comprehensive database, Human Gene Expression Endometrial Receptivity database (HGEx-ERdb). The database was used to identify the Receptivity Associated Genes (RAGs) which display the similar pattern of expression across different investigations. Transcript levels of select RAGs encoding cell adhesion proteins were compared between two human endometrial epithelial cell lines; RL95-2 and HEC-1-A by quantitative real time polymerase chain reaction (q-RT-PCR). Further select RAGs were investigated for their expression in pre-receptive (n = 4) and receptive phase (n = 4) human endometrial tissues by immunohistochemical studies. JAr spheroid attachment assays were carried out to assess the functional significance of two RAGs.</p> <p>Results</p><p>HGEx-ERdb (<a href=\"http://resource.ibab.ac.in/HGEx-ERdb/\" target=\"_blank\">http://resource.ibab.ac.in/HGEx-ERdb/</a>) helped identification of 179 RAGs, of which 151 genes were consistently expressed and upregulated and 28 consistently not-detected and downregulated in receptive phase as compared to pre-receptive phase. q-RT-PCR confirmed significantly higher (p<0.005) expression of Thrombospondin1 (THBS1), CD36 and Mucin 16 transcripts, in RL95-2 as compared to HEC-1-A. Further, the pretreatment with antibodies against CD36 and COMP led to a reduction in the percentage of JAr spheroids attached to RL95-2. Immunohistochemical studies demonstrated significantly higher (p<0.05) expression of endometrial THBS1, Cartilage Oligomeric Matrix Protein (COMP) and CD36 in the receptive phase as compared to pre-receptive phase human endometrial tissues.</p> <p>Conclusion</p><p>HGEx-ERdb is a catalogue of 19,285 genes, reported for their expression in human endometrium. Further 179 genes were identified as the RAGs. Expression analysis of some RAGs validated the utility of approach employed in creation of HGEx-ERdb. Studies aimed towards defining the specific functions of RAGs and their potential networks may yield relevant information about the major ‘nodes’ which regulate endometrial receptivity.</p> </div>", "links"=>[], "tags"=>["revisit", "genomics", "studies", "endometrium"], "article_id"=>659952, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0058419.s001", "https://dx.doi.org/10.1371/journal.pone.0058419.s002", "https://dx.doi.org/10.1371/journal.pone.0058419.s003", "https://dx.doi.org/10.1371/journal.pone.0058419.s004", "https://dx.doi.org/10.1371/journal.pone.0058419.s005", "https://dx.doi.org/10.1371/journal.pone.0058419.s006"], "stats"=>{"downloads"=>7, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Endometrial_Receptivity_A_Revisit_to_Functional_Genomics_Studies_on_Human_Endometrium_and_Creation_of_HGEx_ERdb_/659952", "title"=>"Endometrial Receptivity: A Revisit to Functional Genomics Studies on Human Endometrium and Creation of HGEx-ERdb", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-03-27 10:17:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1008259"], "description"=>"<p>Down-Nd Receptivity Associated Genes (RAGs) and their Reliability Scores.</p>", "links"=>[], "tags"=>["receptivity", "genes"], "article_id"=>668875, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.t004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Down_Nd_Receptivity_Associated_Genes_RAGs_and_their_Reliability_Scores_/668875", "title"=>"Down-Nd Receptivity Associated Genes (RAGs) and their Reliability Scores.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-26 02:27:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1008329"], "description"=>"<p>Up-Ex Receptivity Associated Genes (RAGs) and their Reliability Scores.</p>", "links"=>[], "tags"=>["receptivity", "genes"], "article_id"=>668947, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Up_Ex_Receptivity_Associated_Genes_RAGs_and_their_Reliability_Scores_/668947", "title"=>"Up-Ex Receptivity Associated Genes (RAGs) and their Reliability Scores.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-26 02:29:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/997750"], "description"=>"<p>A) Immunohistochemical localization of CD36, THBS1 and COMP in receptive phase (a,b,c) and pre-receptive phase (d,e,f) endometrial tissues. Panels g and i represent the sections stained with rabbit IgG and h shows the section stained with mouse IgG. B) Semiquantitative analysis to compare the intensities of immunoreactive CD36, THBS1 and COMP in epithelial and stromal compartments of receptive and pre-receptive phase human endometrial samples. *p<0.05, ** p <0.005, *** p<0.002 C) Immunohistochemical localization of CD36,THBS1 and COMP in the luminal epithelium of human endometrial tissues collected in receptive phase (a,b,c) and pre-receptive phase (d,e,f) of menstrual cycle. Panels g and i represent the sections stained with rabbit IgG and panel h is stained with mouse IgG. Magnification at 40X.</p>", "links"=>[], "tags"=>["proteins", "encoded", "rags", "receptive", "pre-receptive", "endometrial"], "article_id"=>659945, "categories"=>["Physiology", "Biological Sciences", "Cell Biology", "Genetics", "Immunology"], "users"=>["Sonali R. Bhagwat", "Darshan S. Chandrashekar", "Ruchi Kakar", "Sravanthi Davuluri", "Akhilesh K. Bajpai", "Sumeet Nayak", "Sumit Bhutada", "Kshitish Acharya", "Geetanjali Sachdeva"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058419.g005", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunolocalization_of_the_proteins_encoded_by_select_RAGs_in_receptive_and_pre_receptive_phase_human_endometrial_tissues_/659945", "title"=>"Immunolocalization of the proteins encoded by select RAGs in receptive and pre-receptive phase human endometrial tissues.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-27 10:16:40"}

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Relative Metric

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