Effect of Acute Stressor and Serotonin Transporter Genotype on Amygdala First Wave Transcriptome in Mice
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{"title"=>"Effect of Acute Stressor and Serotonin Transporter Genotype on Amygdala First Wave Transcriptome in Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Christa", "last_name"=>"Hohoff", "scopus_author_id"=>"6701844438"}, {"first_name"=>"Ali", "last_name"=>"Gorji", "scopus_author_id"=>"7003473874"}, {"first_name"=>"Sylvia", "last_name"=>"Kaiser", "scopus_author_id"=>"7103104947"}, {"first_name"=>"Edith", "last_name"=>"Willscher", "scopus_author_id"=>"27468044900"}, {"first_name"=>"Eberhard", "last_name"=>"Korsching", "scopus_author_id"=>"6602406666"}, {"first_name"=>"Oliver", "last_name"=>"Ambrée", "scopus_author_id"=>"8764118800"}, {"first_name"=>"Volker", "last_name"=>"Arolt", "scopus_author_id"=>"56247579900"}, {"first_name"=>"Klaus Peter", "last_name"=>"Lesch", "scopus_author_id"=>"19735689200"}, {"first_name"=>"Norbert", "last_name"=>"Sachser", "scopus_author_id"=>"35547933900"}, {"first_name"=>"Jürgen", "last_name"=>"Deckert", "scopus_author_id"=>"55918597000"}, {"first_name"=>"Lars", "last_name"=>"Lewejohann", "scopus_author_id"=>"23035366700"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368506720", "sgr"=>"84874904480", "issn"=>"19326203", "pmid"=>"23536833", "scopus"=>"2-s2.0-84874904480", "doi"=>"10.1371/journal.pone.0058880", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"da124011-9c6e-325c-b646-0b2f8b81259a", "abstract"=>"The most prominent brain region evaluating the significance of external stimuli immediately after their onset is the amygdala. Stimuli evaluated as being stressful actuate a number of physiological processes as an immediate stress response. Variation in the serotonin transporter gene has been associated with increased anxiety- and depression-like behavior, altered stress reactivity and adaptation, and pathophysiology of stress-related disorders. In this study the instant reactions to an acute stressor were measured in a serotonin transporter knockout mouse model. Mice lacking the serotonin transporter were verified to be more anxious than their wild-type conspecifics. Genome-wide gene expression changes in the amygdala were measured after the mice were subjected to control condition or to an acute stressor of one minute exposure to water. The dissection of amygdalae and stabilization of RNA was conducted within nine minutes after the onset of the stressor. This extremely short protocol allowed for analysis of first wave primary response genes, typically induced within five to ten minutes of stimulation, and was performed using Affymetrix GeneChip Mouse Gene 1.0 ST Arrays. RNA profiling revealed a largely new set of differentially expressed primary response genes between the conditions acute stress and control that differed distinctly between wild-type and knockout mice. Consequently, functional categorization and pathway analysis indicated genes related to neuroplasticity and adaptation in wild-types whereas knockouts were characterized by impaired plasticity and genes more related to chronic stress and pathophysiology. Our study therefore disclosed different coping styles dependent on serotonin transporter genotype even directly after the onset of stress and accentuates the role of the serotonergic system in processing stressors and threat in the amygdala. Moreover, several of the first wave primary response genes that we found might provide promising targets for future therapeutic interventions of stress-related disorders also in humans.", "link"=>"http://www.mendeley.com/research/effect-acute-stressor-serotonin-transporter-genotype-amygdala-first-wave-transcriptome-mice", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>5, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>5, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Environmental Science"=>1, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>5, "Neuroscience"=>4, "Psychology"=>3, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>4}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"India"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/983692"], "description"=>"<p>a) Activity-related measures exemplified as the path length covered during the test. Bars represent the median values and the dots represent the data of each individual animal. b) Anxiety-related behavior measured as the proportion of time spent in open arms. Serotonintransporter knockout mice (5-HTT <i>KO</i>, n = 17) were less active and spent a lower proportion of time on open arms indicating increased anxiety compared to wild-type (5-HTT <i>WT</i>, n = 14) mice. Statistics: Wilcoxon exact rank sum test: ** = P<0.01, *** = P<0.001.</p>", "links"=>[], "tags"=>["plus-maze"], "article_id"=>649539, "categories"=>["Biochemistry", "Biological Sciences", "Neuroscience", "Physiology", "Mental Health"], "users"=>["Christa Hohoff", "Ali Gorji", "Sylvia Kaiser", "Edith Willscher", "Eberhard Korsching", "Oliver Ambrée", "Volker Arolt", "Klaus-Peter Lesch", "Norbert Sachser", "Jürgen Deckert", "Lars Lewejohann"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058880.g001", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Elevated_plus_maze_test_/649539", "title"=>"Elevated plus-maze test.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-12 08:06:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/983693"], "description"=>"<p>Trunk blood samples were taken 130 sec after the mice were either being placed for 1 min in 21°C water (acute stress) or left untouched in the home-cage for 1 min (control). Bars represent the mean concentration, whiskers express SEM. An ANOVA revealed no significant effect of genotype (F<sub>1,26</sub> = 2.36, P = 0.14) but a trend for increased stress hormone concentrations in mice subjected to acute stress (F<sub>1,26</sub> = 3.21, P = 0.085).</p>", "links"=>[], "tags"=>["Mental health", "physiology", "Computational biology", "neuroscience", "Biochemistry"], "article_id"=>649540, "categories"=>["Biochemistry", "Biological Sciences", "Neuroscience", "Physiology", "Mental Health"], "users"=>["Christa Hohoff", "Ali Gorji", "Sylvia Kaiser", "Edith Willscher", "Eberhard Korsching", "Oliver Ambrée", "Volker Arolt", "Klaus-Peter Lesch", "Norbert Sachser", "Jürgen Deckert", "Lars Lewejohann"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058880.g002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Corticosterone_stress_hormone_concentration_/649540", "title"=>"Corticosterone stress hormone concentration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-12 08:06:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/983694", "https://ndownloader.figshare.com/files/983695"], "description"=>"<div><p>The most prominent brain region evaluating the significance of external stimuli immediately after their onset is the amygdala. Stimuli evaluated as being stressful actuate a number of physiological processes as an immediate stress response. Variation in the serotonin transporter gene has been associated with increased anxiety- and depression-like behavior, altered stress reactivity and adaptation, and pathophysiology of stress-related disorders. In this study the instant reactions to an acute stressor were measured in a serotonin transporter knockout mouse model. Mice lacking the serotonin transporter were verified to be more anxious than their wild-type conspecifics. Genome-wide gene expression changes in the amygdala were measured after the mice were subjected to control condition or to an acute stressor of one minute exposure to water. The dissection of amygdalae and stabilization of RNA was conducted within nine minutes after the onset of the stressor. This extremely short protocol allowed for analysis of first wave primary response genes, typically induced within five to ten minutes of stimulation, and was performed using Affymetrix GeneChip Mouse Gene 1.0 ST Arrays. RNA profiling revealed a largely new set of differentially expressed primary response genes between the conditions acute stress and control that differed distinctly between wild-type and knockout mice. Consequently, functional categorization and pathway analysis indicated genes related to neuroplasticity and adaptation in wild-types whereas knockouts were characterized by impaired plasticity and genes more related to chronic stress and pathophysiology. Our study therefore disclosed different coping styles dependent on serotonin transporter genotype even directly after the onset of stress and accentuates the role of the serotonergic system in processing stressors and threat in the amygdala. Moreover, several of the first wave primary response genes that we found might provide promising targets for future therapeutic interventions of stress-related disorders also in humans.</p> </div>", "links"=>[], "tags"=>["acute", "stressor", "serotonin", "transporter", "genotype", "amygdala", "transcriptome", "mice"], "article_id"=>649541, "categories"=>["Biochemistry", "Biological Sciences", "Neuroscience", "Physiology", "Mental Health"], "users"=>["Christa Hohoff", "Ali Gorji", "Sylvia Kaiser", "Edith Willscher", "Eberhard Korsching", "Oliver Ambrée", "Volker Arolt", "Klaus-Peter Lesch", "Norbert Sachser", "Jürgen Deckert", "Lars Lewejohann"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0058880.s001", "https://dx.doi.org/10.1371/journal.pone.0058880.s002"], "stats"=>{"downloads"=>16, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effect_of_Acute_Stressor_and_Serotonin_Transporter_Genotype_on_Amygdala_First_Wave_Transcriptome_in_Mice__/649541", "title"=>"Effect of Acute Stressor and Serotonin Transporter Genotype on Amygdala First Wave Transcriptome in Mice", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-03-12 08:06:18"}
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PMC Usage Stats | Further Information

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Relative Metric

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