Gene Expression Changes Associated with the Airway Wall Response to Injury
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Gene Expression Changes Associated with the Airway Wall Response to Injury", "type"=>"journal", "authors"=>[{"first_name"=>"Badrul", "last_name"=>"Yahaya", "scopus_author_id"=>"53872327800"}, {"first_name"=>"Gerry", "last_name"=>"McLachlan", "scopus_author_id"=>"7006560740"}, {"first_name"=>"Caroline", "last_name"=>"McCorquodale", "scopus_author_id"=>"6603595247"}, {"first_name"=>"David", "last_name"=>"Collie", "scopus_author_id"=>"7006607211"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368705058", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0058930", "scopus"=>"2-s2.0-84876062602", "pmid"=>"23593124", "sgr"=>"84876062602"}, "id"=>"e3b269ba-eb6f-3f62-ab7d-dac50931f21f", "abstract"=>"BACKGROUND: Understanding the way in which the airway heals in response to injury is fundamental to dissecting the mechanisms underlying airway disease pathology. As only limited data is available in relation to the in vivo characterisation of the molecular features of repair in the airway we sought to characterise the dynamic changes in gene expression that are associated with the early response to physical injury in the airway wall.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: We profiled gene expression changes in the airway wall using a large animal model of physical injury comprising bronchial brush biopsy in anaesthetised sheep. The experimental design featured sequential studies in the same animals over the course of a week and yielded data relating to the response at 6 hours, and 1, 3 and 7 days after injury. Notable features of the transcriptional response included the early and sustained preponderance of down-regulated genes associated with angiogenesis and immune cell activation, selection and differentiation. Later features of the response included the up-regulation of cell cycle genes at d1 and d3, and the latter pronounced up-regulation of extracellular matrix-related genes at d3 and d7.\\n\\nCONCLUSIONS/SIGNIFICANCE: It is possible to follow the airway wall response to physical injury in the same animal over the course of time. Transcriptional changes featured coordinate expression of functionally related genes in a reproducible manner both within and between animals. This characterisation will provide a foundation against which to assess the perturbations that accompany airway disease pathologies of comparative relevance.", "link"=>"http://www.mendeley.com/research/gene-expression-changes-associated-airway-wall-response-injury-1", "reader_count"=>5, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Australia"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84876062602"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84876062602?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876062602&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84876062602&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84876062602", "dc:identifier"=>"SCOPUS_ID:84876062602", "eid"=>"2-s2.0-84876062602", "dc:title"=>"Gene Expression Changes Associated with the Airway Wall Response to Injury", "dc:creator"=>"Yahaya B.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-04-09", "prism:coverDisplayDate"=>"9 April 2013", "prism:doi"=>"10.1371/journal.pone.0058930", "citedby-count"=>"2", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Universiti Sains Malaysia, Advanced Medical and Dental Institute", "affiliation-city"=>"Kepala Batas", "affiliation-country"=>"Malaysia"}], "pubmed-id"=>"23593124", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e58930", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0058930", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"27", "xml_views"=>"5", "html_views"=>"194"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"43"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"4", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"24"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"3", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"4", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"9"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1019449"], "description"=>"<p>In this instance the functional annotation is applied to the genes of cluster 004, and the results indicate that the gene lists are enriched for terms relating to the biological processes of ribosome and ribonucleoprotein biogenesis. See the legend for <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058930#pone-0058930-t002\" target=\"_blank\">table 2</a> for a description of the column headings.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Respiratory system", "Respiratory physiology", "Computational biology", "microarrays", "genetics", "gene expression", "Gene networks", "Model organisms", "Animal models", "Animal types", "Large animals", "Veterinary anatomy and physiology", "david", "annotation", "clustering", "applied", "genes", "sharing", "biolayout"], "article_id"=>678561, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Badrul Yahaya", "Gerry McLachlan", "Caroline McCorquodale", "David Collie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058930.t004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_results_of_DAVID_functional_annotation_clustering_applied_to_the_genes_sharing_a_coordinate_pattern_of_expression_as_identified_using_BioLayout_Express_3D_/678561", "title"=>"The results of DAVID functional annotation clustering applied to the genes sharing a coordinate pattern of expression as identified using BioLayout Express 3D.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-09 02:22:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1019450"], "description"=>"<p>In this instance the functional annotation is applied to the genes of cluster 003, and the results indicate that the gene lists are enriched for terms relating to cell division and its associated processes. See the legend for <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058930#pone-0058930-t002\" target=\"_blank\">table 2</a> for a description of the column headings.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Respiratory system", "Respiratory physiology", "Computational biology", "microarrays", "genetics", "gene expression", "Gene networks", "Model organisms", "Animal models", "Animal types", "Large animals", "Veterinary anatomy and physiology", "david", "annotation", "clustering", "applied", "genes", "sharing", "biolayout"], "article_id"=>678562, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Badrul Yahaya", "Gerry McLachlan", "Caroline McCorquodale", "David Collie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058930.t003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_results_of_DAVID_functional_annotation_clustering_applied_to_the_genes_sharing_a_coordinate_pattern_of_expression_as_identified_using_BioLayout_Express_3D_/678562", "title"=>"The results of DAVID functional annotation clustering applied to the genes sharing a coordinate pattern of expression as identified using BioLayout Express 3D.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-09 02:22:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1019451"], "description"=>"<p>In this instance the functional annotation is applied to the genes of cluster 002, and the results indicate that the gene lists are enriched for terms relating to the biological processes of extracellular matrix organisation, collagen fibril organisation, collagen metabolism, and skeletal system development. See the legend for <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058930#pone-0058930-t002\" target=\"_blank\">table 2</a> for a description of the column headings.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Respiratory system", "Respiratory physiology", "Computational biology", "microarrays", "genetics", "gene expression", "Gene networks", "Model organisms", "Animal models", "Animal types", "Large animals", "Veterinary anatomy and physiology", "david", "annotation", "clustering", "applied", "genes", "sharing", "biolayout"], "article_id"=>678563, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Badrul Yahaya", "Gerry McLachlan", "Caroline McCorquodale", "David Collie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058930.t002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_results_of_DAVID_functional_annotation_clustering_applied_to_the_genes_sharing_a_coordinate_pattern_of_expression_as_identified_using_BioLayout_Express_3D_/678563", "title"=>"The results of DAVID functional annotation clustering applied to the genes sharing a coordinate pattern of expression as identified using BioLayout Express 3D.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-09 02:22:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1019452"], "description"=>"<p>The discovered gene groups were ranked according to the EASE enrichment score, which is the minus log transformation of the geometric mean of P-values from the enriched annotation terms associated with the different gene group members. Only groups with EASE scores larger than or equal to 4.0 were considered (geometric mean of Benjamini corrected P-values ≤0.05). For each group the relevant GO-terms for Biological Process are given, together with a list of the genes sharing that term, the number of genes in the query list mapped to any gene set in this ontology (List Total), the number of genes annotated to this gene set on the background list (Pop Hits), the mean Fold enrichment of the genes in the group, the Benjamini-corrected P value (the Fisher Exact Probability Value (representing the “degree of enrichment” of the annotation term within the group) further corrected for false discovery rate using the Benjamini correction) and the false discovery rate (FDR). In this table the two clusters within BioLayout cluster 001 were significantly enriched for terms relating to the formation of blood vessels, and immune cell selection, differentiation and activation.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Respiratory system", "Respiratory physiology", "Computational biology", "microarrays", "genetics", "gene expression", "Gene networks", "Model organisms", "Animal models", "Animal types", "Large animals", "Veterinary anatomy and physiology", "david", "annotation", "clustering", "genes", "demonstrating", "co-ordinate", "sharing"], "article_id"=>678564, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Badrul Yahaya", "Gerry McLachlan", "Caroline McCorquodale", "David Collie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058930.t001", "stats"=>{"downloads"=>5, "page_views"=>46, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_DAVID_Functional_Annotation_Clustering_tool_was_used_to_group_genes_demonstrating_co_ordinate_expression_on_the_basis_of_sharing_similar_biological_meaning_/678564", "title"=>"The DAVID Functional Annotation Clustering tool was used to group genes demonstrating co-ordinate expression on the basis of sharing similar biological meaning.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-09 02:22:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1019453", "https://ndownloader.figshare.com/files/1019463", "https://ndownloader.figshare.com/files/1019467", "https://ndownloader.figshare.com/files/1019469", "https://ndownloader.figshare.com/files/1019472", "https://ndownloader.figshare.com/files/1019475"], "description"=>"<div><p>Background</p><p>Understanding the way in which the airway heals in response to injury is fundamental to dissecting the mechanisms underlying airway disease pathology. As only limited data is available in relation to the in vivo characterisation of the molecular features of repair in the airway we sought to characterise the dynamic changes in gene expression that are associated with the early response to physical injury in the airway wall.</p><p>Methodology/Principal Findings</p><p>We profiled gene expression changes in the airway wall using a large animal model of physical injury comprising bronchial brush biopsy in anaesthetised sheep. The experimental design featured sequential studies in the same animals over the course of a week and yielded data relating to the response at 6 hours, and 1, 3 and 7 days after injury. Notable features of the transcriptional response included the early and sustained preponderance of down-regulated genes associated with angiogenesis and immune cell activation, selection and differentiation. Later features of the response included the up-regulation of cell cycle genes at d1 and d3, and the latter pronounced up-regulation of extracellular matrix-related genes at d3 and d7.</p><p>Conclusions/Significance</p><p>It is possible to follow the airway wall response to physical injury in the same animal over the course of time. Transcriptional changes featured coordinate expression of functionally related genes in a reproducible manner both within and between animals. This characterisation will provide a foundation against which to assess the perturbations that accompany airway disease pathologies of comparative relevance.</p></div>", "links"=>[], "tags"=>["Anatomy and physiology", "Respiratory system", "Respiratory physiology", "Computational biology", "microarrays", "genetics", "gene expression", "Gene networks", "Model organisms", "Animal models", "Animal types", "Large animals", "Veterinary anatomy and physiology", "airway"], "article_id"=>678565, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Badrul Yahaya", "Gerry McLachlan", "Caroline McCorquodale", "David Collie"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0058930.s001", "https://dx.doi.org/10.1371/journal.pone.0058930.s002", "https://dx.doi.org/10.1371/journal.pone.0058930.s003", "https://dx.doi.org/10.1371/journal.pone.0058930.s004", "https://dx.doi.org/10.1371/journal.pone.0058930.s005", "https://dx.doi.org/10.1371/journal.pone.0058930.s006"], "stats"=>{"downloads"=>50, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_Expression_Changes_Associated_with_the_Airway_Wall_Response_to_Injury_/678565", "title"=>"Gene Expression Changes Associated with the Airway Wall Response to Injury", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-04-09 02:22:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1019445"], "description"=>"<p>Separate clusters of co-ordinately expressed genes identified on the basis of application of the Markov clustering algorithm are differentially coloured. Functional annotation of the genes present in the four largest clusters shown (Clusters 001–004) indicated that there was a significant enrichment for biological process terms within each cluster. The mean fold-change of gene expression during the time-course of the injury response is also shown for each cluster.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Respiratory system", "Respiratory physiology", "Computational biology", "microarrays", "genetics", "gene expression", "Gene networks", "Model organisms", "Animal models", "Animal types", "Large animals", "Veterinary anatomy and physiology", "graph", "visualise", "co-ordinately", "genes", "1145", "differentially", "regulated", "twofold"], "article_id"=>678557, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Badrul Yahaya", "Gerry McLachlan", "Caroline McCorquodale", "David Collie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058930.g001", "stats"=>{"downloads"=>2, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Node_and_edge_graph_used_to_visualise_co_ordinately_expressed_genes_from_the_1145_unique_genes_that_were_significantly_differentially_regulated_with_greater_than_twofold_change_in_expression_at_least_once_during_the_course_of_the_injury_response_/678557", "title"=>"Node and edge graph used to visualise co-ordinately expressed genes from the 1145 unique genes that were significantly differentially regulated (with greater than twofold change in expression) at least once during the course of the injury response.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-09 02:22:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1019447"], "description"=>"<p>The figure summarizes the network of predicted associations for this group of proteins. The network nodes are proteins. The edges which represent the predicted functional associations are drawn in coloured lines. These lines represent the existence of the types of evidence used in predicting the associations. A green line indicates the presence of neighbourhood evidence, a blue line – co-ocurrence evidence, a purple line – experimental evidence, a light blue line – database evidence and a black line – co-expression evidence.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Respiratory system", "Respiratory physiology", "Computational biology", "microarrays", "genetics", "gene expression", "Gene networks", "Model organisms", "Animal models", "Animal types", "Large animals", "Veterinary anatomy and physiology", "default", "proteins", "coded", "genes", "up-regulated", "two-fold", "airway", "enriched", "relating", "processes", "inflammatory", "defence"], "article_id"=>678559, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Badrul Yahaya", "Gerry McLachlan", "Caroline McCorquodale", "David Collie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058930.g002", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_STRING_9_0_analysis_Homo_sapiens_at_http_string_db_org_parameters_default_setting_of_proteins_coded_by_genes_significantly_up_regulated_more_than_two_fold_at_6_h_after_physical_injury_to_the_airway_wall_that_were_enriched_for_terms_relating_to_the_biolog/678559", "title"=>"STRING-9.0 analysis (<i>Homo sapiens</i> at: (http://string-db.org/); parameters: default setting) of proteins coded by genes significantly up-regulated more than two-fold at 6 h after physical injury to the airway wall that were enriched for terms relating to the biological processes of response to wounding, and inflammatory and defence responses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-09 02:22:39"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"24", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"3", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"1", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"0", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"29", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Agriculture", "average_usage"=>[241, 422, 551, 659, 765, 866, 954, 1043, 1142, 1235, 1311, 1397, 1462]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[248, 440, 562, 666, 765, 856, 944, 1028, 1112, 1198, 1282, 1362, 1430]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[281, 484, 611, 728, 835, 934, 1030, 1123, 1214, 1299, 1383, 1464]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}]}
Loading … Spinner
There are currently no alerts