Thioredoxin-Interacting Protein Gene Expression via MondoA Is Rapidly and Transiently Suppressed during Inflammatory Responses
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{"title"=>"Thioredoxin-Interacting Protein Gene Expression via MondoA Is Rapidly and Transiently Suppressed during Inflammatory Responses", "type"=>"journal", "authors"=>[{"first_name"=>"Yasuyoshi", "last_name"=>"Kanari", "scopus_author_id"=>"6603265451"}, {"first_name"=>"Yuki", "last_name"=>"Sato", "scopus_author_id"=>"55624472881"}, {"first_name"=>"Satoru", "last_name"=>"Aoyama", "scopus_author_id"=>"55618188100"}, {"first_name"=>"Tatsushi", "last_name"=>"Muta", "scopus_author_id"=>"7004780297"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pmid"=>"23520550", "scopus"=>"2-s2.0-84874764451", "doi"=>"10.1371/journal.pone.0059026", "pui"=>"368490017", "sgr"=>"84874764451"}, "id"=>"c348b1f3-99b5-3776-8e86-97aa2d335ffc", "abstract"=>"Whereas accumulating evidence indicates that a number of inflammatory genes are induced by activation of nuclear factor-κB and other transcription factors, less is known about genes that are suppressed by proinflammatory stimuli. Here we show that expression of thioredoxin-interacting protein (Txnip) is dramatically suppressed both in mRNA and protein levels upon stimulation with lipopolysaccharide in mouse and human macrophages. In addition to lipopolysaccharide, a Toll-like receptor 4 ligand, stimulation with other Toll-like receptor ligands such as CpG DNA also suppressed Txnip expression. Not only the Toll-like receptor ligands, but also other proinflammatory stimulators, such as interleukin-1β and tumor necrosis factor-α elicited the similar response in fibroblasts. Suppression of Txnip by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei and dissociation of the MondoA:Mlx complex that bound to the carbohydrate-response elements in the Txnip promoter in unstimulated cells. Lipopolysaccharide-mediated decrease of nuclear MondoA was inhibited in the presence of 2-deoxyglucose. Furthermore, blockage of glyceraldehyde-3-phosphate dehydrogenase by iodoacetate alleviated the suppression of Txnip mRNA by lipopolysaccharide, suggesting the involvement of glucose-metabolites in the regulation. Since Txnip is implicated in the regulation of glucose metabolism, this observation links between inflammatory responses and metabolic regulation.", "link"=>"http://www.mendeley.com/research/thioredoxininteracting-protein-gene-expression-via-mondoa-rapidly-transiently-suppressed-during-infl", "reader_count"=>20, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Other"=>4, "Student > Master"=>3, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Other"=>4, "Student > Master"=>3, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>8, "Design"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "Denmark"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/983382"], "description"=>"<p>(A and B) RAW264.7 cells were treated with Vehicle (dimethyl sulfoxide in (A) or diethyl ether in (B)), 10 µM compound C (Comp. C), or 50 nM okadaic acid for 1 h, followed by stimulation with 100 ng/ml LPS for 90 min. (C) RAW264.7 cells were treated with 0.5 mM iodoacetate or sodium acetate for 1 h, followed by treatment with 100 ng/ml LPS, 5 mM sodium azide, or 5 µM rotenone for 90 min. <i>Txnip</i> mRNA copy numbers normalized to that of β-actin are shown. Data shown are mean ± S.E. of triplicate samples of a representative of at least three independent experiments.</p>", "links"=>[], "tags"=>["inhibitors", "suppression"], "article_id"=>649289, "categories"=>["Molecular Biology", "Biochemistry", "Cell Biology", "Immunology"], "users"=>["Yasuyoshi Kanari", "Yuki Sato", "Satoru Aoyama", "Tatsushi Muta"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059026.g005", "stats"=>{"downloads"=>0, "page_views"=>79, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_various_inhibitors_on_Txnip_suppression_in_response_to_LPS_/649289", "title"=>"Effects of various inhibitors on <i>Txnip</i> suppression in response to LPS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-09 13:37:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/983381"], "description"=>"<p>(A) Chromatin immunoprecipitation assay was performed to examine occupation of Mlx, MondoA, and NF-YA in <i>Txnip</i> promoter region with RAW264.7 cells stimulated with or without 100 ng/ml LPS for 45 min. Enriched DNAs was eluted and <i>Txnip</i> promoter region was quantified by quantitative PCR. Data shown are mean ± S.E. of duplicate samples. (B) RAW264.7 cells stimulated with or without 100 ng/ml LPS for 45 min. Cells were fixed, permeabilized, and stained with anti-MondoA antibody and Alexa488-conjugated polyclonal anti-rabbit IgG antibody. Fluorescence microscopic images were obtained and analyzed by three-dimentional deconvolution. (C) Nuclear and cytoplasmic fractions of RAW264.7 cells stimulated with or without 100 ng/ml LPS for 45 min were analyzed by western blotting with anti-<i>MondoA</i>, histone deacetylase 1 (<i>Hdac1</i>) or ribosomal S6 ribosomal protein (<i>Rps6</i>). Data shown are a representative of at least three independent experiments.</p>", "links"=>[], "tags"=>["promoter", "lps"], "article_id"=>649288, "categories"=>["Molecular Biology", "Biochemistry", "Cell Biology", "Immunology"], "users"=>["Yasuyoshi Kanari", "Yuki Sato", "Satoru Aoyama", "Tatsushi Muta"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059026.g004", "stats"=>{"downloads"=>0, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dissociation_of_MondoA_Mlx_from_the_Txnip_promoter_on_LPS_stimulation_/649288", "title"=>"Dissociation of MondoA:Mlx from the <i>Txnip</i> promoter on LPS stimulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-09 13:37:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/983379"], "description"=>"<p>(A and B) Luciferase reporter plasmids containing indicated <i>Txnip</i> promoter fragments with or without point mutations (mt) at ChoREs, CCAAT boxes, or a FOXO binding site were transfected to RAW264.7 cells together with phRL-TK-luc. Transfected cells were stimulated with or without 100 ng/ml LPS for 4 h, then lysed for luciferase activity measurement. Relative luciferase activities normalized by internal control are shown as mean ± S.E. of triplicate samples. Data shown are a representative of at least three independent experiments.</p>", "links"=>[], "tags"=>["chores", "ccaat", "boxes"], "article_id"=>649286, "categories"=>["Molecular Biology", "Biochemistry", "Cell Biology", "Immunology"], "users"=>["Yasuyoshi Kanari", "Yuki Sato", "Satoru Aoyama", "Tatsushi Muta"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059026.g003", "stats"=>{"downloads"=>0, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Essential_roles_for_ChoREs_and_CCAAT_boxes_in_the_Txnip_promoter_/649286", "title"=>"Essential roles for ChoREs and CCAAT boxes in the <i>Txnip</i> promoter.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-09 13:37:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/983375"], "description"=>"<p>RAW264.7 cells (A and B), BMDM (C and D), or differentiated THP-1 cells (E) were stimulated with 100 ng/ml LPS. Cells were lysed at the indicated time after stimulation. <i>Txnip</i> mRNA copy numbers normalized to that of <i>β-actin</i> are shown (A and C). Data shown are mean ± S.E. of at least 4 independent experiments. Txnip and β-actin proteins were detected by western blotting (B, D, and E). Data shown are a representative of at least three independent experiments.</p>", "links"=>[], "tags"=>["immunology", "molecular biology", "cell biology", "Biochemistry"], "article_id"=>649282, "categories"=>["Molecular Biology", "Biochemistry", "Cell Biology", "Immunology"], "users"=>["Yasuyoshi Kanari", "Yuki Sato", "Satoru Aoyama", "Tatsushi Muta"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059026.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Suppression_of_Txnip_expression_by_LPS_/649282", "title"=>"Suppression of <i>Txnip</i> expression by LPS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-09 13:37:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/983383", "https://ndownloader.figshare.com/files/983384"], "description"=>"<div><p>Whereas accumulating evidence indicates that a number of inflammatory genes are induced by activation of nuclear factor-κB and other transcription factors, less is known about genes that are suppressed by proinflammatory stimuli. Here we show that expression of thioredoxin-interacting protein (<i>Txnip</i>) is dramatically suppressed both in mRNA and protein levels upon stimulation with lipopolysaccharide in mouse and human macrophages. In addition to lipopolysaccharide, a Toll-like receptor 4 ligand, stimulation with other Toll-like receptor ligands such as CpG DNA also suppressed <i>Txnip</i> expression. Not only the Toll-like receptor ligands, but also other proinflammatory stimulators, such as interleukin-1β and tumor necrosis factor-α elicited the similar response in fibroblasts. Suppression of <i>Txnip</i> by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei and dissociation of the MondoA:Mlx complex that bound to the carbohydrate-response elements in the <i>Txnip</i> promoter in unstimulated cells. Lipopolysaccharide-mediated decrease of nuclear MondoA was inhibited in the presence of 2-deoxyglucose. Furthermore, blockage of glyceraldehyde-3-phosphate dehydrogenase by iodoacetate alleviated the suppression of <i>Txnip</i> mRNA by lipopolysaccharide, suggesting the involvement of glucose-metabolites in the regulation. Since <i>Txnip</i> is implicated in the regulation of glucose metabolism, this observation links between inflammatory responses and metabolic regulation.</p> </div>", "links"=>[], "tags"=>["thioredoxin-interacting", "mondoa", "transiently", "suppressed", "inflammatory", "responses"], "article_id"=>649290, "categories"=>["Molecular Biology", "Biochemistry", "Cell Biology", "Immunology"], "users"=>["Yasuyoshi Kanari", "Yuki Sato", "Satoru Aoyama", "Tatsushi Muta"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0059026.s001", "https://dx.doi.org/10.1371/journal.pone.0059026.s002"], "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Thioredoxin_Interacting_Protein_Gene_Expression_via_MondoA_Is_Rapidly_and_Transiently_Suppressed_during_Inflammatory_Responses__/649290", "title"=>"Thioredoxin-Interacting Protein Gene Expression via MondoA Is Rapidly and Transiently Suppressed during Inflammatory Responses", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-03-09 13:37:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/983378"], "description"=>"<p>BMDM (A), NIH3T3 (B), or RAW264.7 (C) cells were stimulated with 2 µM CpG DNA 100 ng/ml LPS, 10 ng/ml IL-1β, 10 ng/ml TNF-α, or 10 ng/ml IL-10. Cells were lysed at the indicated time after stimulation. Txnip, β-actin, phosphorylated STAT3 (pSTAT3), or STAT3 proteins were detected by western blotting. Data shown are a representative of at least three independent experiments.</p>", "links"=>[], "tags"=>["proinflammatory"], "article_id"=>649285, "categories"=>["Molecular Biology", "Biochemistry", "Cell Biology", "Immunology"], "users"=>["Yasuyoshi Kanari", "Yuki Sato", "Satoru Aoyama", "Tatsushi Muta"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059026.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Suppression_of_Txnip_expression_by_proinflammatory_stimulation_/649285", "title"=>"Suppression of <i>Txnip</i> expression by proinflammatory stimulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-09 13:37:23"}

PMC Usage Stats | Further Information

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Relative Metric

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