Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans", "type"=>"journal", "authors"=>[{"first_name"=>"William", "last_name"=>"Hinkle", "scopus_author_id"=>"57188798660"}, {"first_name"=>"Michael", "last_name"=>"Cordell", "scopus_author_id"=>"55630037200"}, {"first_name"=>"Rudy", "last_name"=>"Leibel", "scopus_author_id"=>"7006213536"}, {"first_name"=>"Michael", "last_name"=>"Rosenbaum", "scopus_author_id"=>"7101819299"}, {"first_name"=>"Joy", "last_name"=>"Hirsch", "scopus_author_id"=>"35299240000"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84875288613", "doi"=>"10.1371/journal.pone.0059114", "pui"=>"368580196", "pmid"=>"23555620", "scopus"=>"2-s2.0-84875288613", "issn"=>"19326203", "isbn"=>"1932-6203"}, "id"=>"8779ffc3-dbe1-3826-a664-1e17e862ef3e", "abstract"=>"Treating obesity has proven to be an intractable challenge, in part, due to the difficulty of maintaining reduced weight. In our previous studies of in-patient obese subjects, we have shown that leptin repletion following a 10% or greater weight loss reduces many of the metabolic (decreased energy expenditure, sympathetic nervous system tone, and bioactive thyroid hormones) and behavioral (delayed satiation) changes that favor regain of lost weight. FMRI studies of these same subjects have shown leptin-sensitive increases in activation of the right hypothalamus and reduced activation of the cingulate, medial frontal and parahippocampal gryi, following weight loss, in response to food stimuli. In the present study, we expanded our cohort of in-patient subjects and employed psychophysiological interaction (PPI) analysis to examine changes in the functional connectivity of the right hypothalamus. During reduced-weight maintenance with placebo injections, the functional connectivity of the hypothalamus increased with visual areas and the dorsal anterior cingulate (dorsal ACC) in response to food cues, consistent with higher sensitivity to food. During reduced-weight maintenance with leptin injections, however, the functional connectivity of the right hypothalamus increased with the mid-insula and the central and parietal operculae, suggesting increased coupling with the interoceptive system, and decreased with the orbital frontal cortex, frontal pole and the dorsal ACC, suggesting a down-regulated sensitivity to food. These findings reveal neural mechanisms that may underlie observed changes in sensitivity to food cues in the obese population during reduced-weight maintenance and leptin repletion.", "link"=>"http://www.mendeley.com/research/effects-reduced-weight-maintenance-leptin-repletion-functional-connectivity-hypothalamus-obese-human", "reader_count"=>66, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>5, "Researcher"=>11, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>3, "Student > Master"=>14, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>5, "Researcher"=>11, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>3, "Student > Master"=>14, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Engineering"=>1, "Medicine and Dentistry"=>16, "Agricultural and Biological Sciences"=>19, "Neuroscience"=>7, "Psychology"=>14, "Chemistry"=>1, "Social Sciences"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Neuroscience"=>{"Neuroscience"=>7}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>14}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>19}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>6}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>2, "Brazil"=>1, "United Kingdom"=>1, "Germany"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84875288613"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84875288613?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875288613&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84875288613&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84875288613", "dc:identifier"=>"SCOPUS_ID:84875288613", "eid"=>"2-s2.0-84875288613", "dc:title"=>"Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans", "dc:creator"=>"Hinkle W.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-03-21", "prism:coverDisplayDate"=>"21 March 2013", "prism:doi"=>"10.1371/journal.pone.0059114", "citedby-count"=>"33", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Columbia University Medical Center", "affiliation-city"=>"New York", "affiliation-country"=>"United States"}, {"@_fa"=>"true", "affilname"=>"Columbia University Medical Center", "affiliation-city"=>"New York", "affiliation-country"=>"United States"}], "pubmed-id"=>"23555620", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e59114", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0059114", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"3", "html_views"=>"244"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"46", "xml_views"=>"1", "html_views"=>"137"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"3", "html_views"=>"76"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"3", "html_views"=>"132"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"97"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"91"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"50"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"3", "html_views"=>"59"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"50"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"57"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"99"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"139"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"114", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"228", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"197", "xml_views"=>"1", "html_views"=>"85"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"200", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"190", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"228", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"236", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"134", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"163", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"156", "xml_views"=>"6", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"235", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"281", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"362", "xml_views"=>"3", "html_views"=>"12"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"358", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"105", "xml_views"=>"0", "html_views"=>"6"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/994728"], "description"=>"<p>Brain areas showing significant increases in functional connectivity with the hypothalamic seed (indicated in green, upper right) are shown on standard space axial brain slices with the color indicating the Z score per the color gradient on the bottom. FP (Frontal Pole), SFG (Superior Frontal Gyrus), MGN (Medial Geniculate Nucleus), HC (Hippocampus),MFG (Middle Frontal Gyrus), ITG (Inferior Temporal Gyrus), supLOC (superior division of the Lateral Occipital Cortex), dorsal ACC (dorsal Anterior Cinqulate Cortex), IPL (Inferior Parietal Lobule).</p>", "links"=>[], "tags"=>["connectivity", "reduced-weight", "placebo", "injections"], "article_id"=>657773, "categories"=>["Chemistry", "Neuroscience"], "users"=>["William Hinkle", "Michael Cordell", "Rudy Leibel", "Michael Rosenbaum", "Joy Hirsch"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0059114.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_functional_connectivity_in_the_reduced_weight_maintenance_with_placebo_injections_comparison_/657773", "title"=>"Increased functional connectivity in the reduced-weight maintenance with placebo injections comparison.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 08:36:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/994730"], "description"=>"<p>Brain areas showing significant increases in functional connectivity with the hypothalamic seed (indicated in green) are shown on standard space axial brain slices with the color indicating the Z score per the color gradient on the bottom. SupLOC (superior division of Lateral Occipital Cortex), inf LOC (inferior division of the Lateral Occipital Cortex).</p>", "links"=>[], "tags"=>["connectivity", "reduced-weight", "leptin", "repletion"], "article_id"=>657775, "categories"=>["Chemistry", "Neuroscience"], "users"=>["William Hinkle", "Michael Cordell", "Rudy Leibel", "Michael Rosenbaum", "Joy Hirsch"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0059114.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_functional_connectivity_in_the_reduced_weight_maintenance_with_leptin_repletion_comparison_/657775", "title"=>"Increased functional connectivity in the reduced-weight maintenance with leptin repletion comparison.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 08:36:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/994732"], "description"=>"<p>Brain areas showing significant decreases in functional connectivity with the hypothalamic seed (indicated in yellow) are shown on standard space axial brain slices with the color indicating the Z score per the color gradient on the bottom. FP (Frontal Pole), SFG (Superior Frontal Gyrus), dorsal ACC (dorsal Anterior Cingulate Cortex), sup LOC (superior division of the Lateral Occipital Cortex), IPL (Inferior Parietal Lobule), OFC (Orbital Frontal Cortex), MFG (Medial Frontal Gyrus).</p>", "links"=>[], "tags"=>["connectivity", "reduced-weight", "leptin", "repletion"], "article_id"=>657777, "categories"=>["Chemistry", "Neuroscience"], "users"=>["William Hinkle", "Michael Cordell", "Rudy Leibel", "Michael Rosenbaum", "Joy Hirsch"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0059114.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Decreased_functional_connectivity_in_the_reduced_weight_maintenance_with_leptin_repletion_comparison_/657777", "title"=>"Decreased functional connectivity in the reduced-weight maintenance with leptin repletion comparison.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 08:37:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/994736", "https://ndownloader.figshare.com/files/994737", "https://ndownloader.figshare.com/files/994739", "https://ndownloader.figshare.com/files/994741", "https://ndownloader.figshare.com/files/994743", "https://ndownloader.figshare.com/files/994744"], "description"=>"<div><p>Treating obesity has proven to be an intractable challenge, in part, due to the difficulty of maintaining reduced weight. In our previous studies of in-patient obese subjects, we have shown that leptin repletion following a 10% or greater weight loss reduces many of the metabolic (decreased energy expenditure, sympathetic nervous system tone, and bioactive thyroid hormones) and behavioral (delayed satiation) changes that favor regain of lost weight. FMRI studies of these same subjects have shown leptin-sensitive increases in activation of the right hypothalamus and reduced activation of the cingulate, medial frontal and parahippocampal gryi, following weight loss, in response to food stimuli. In the present study, we expanded our cohort of in-patient subjects and employed psychophysiological interaction (PPI) analysis to examine changes in the functional connectivity of the right hypothalamus. During reduced-weight maintenance with placebo injections, the functional connectivity of the hypothalamus increased with visual areas and the dorsal anterior cingulate (dorsal ACC) in response to food cues, consistent with higher sensitivity to food. During reduced-weight maintenance with leptin injections, however, the functional connectivity of the right hypothalamus increased with the mid-insula and the central and parietal operculae, suggesting increased coupling with the interoceptive system, and decreased with the orbital frontal cortex, frontal pole and the dorsal ACC, suggesting a down-regulated sensitivity to food. These findings reveal neural mechanisms that may underlie observed changes in sensitivity to food cues in the obese population during reduced-weight maintenance and leptin repletion.</p> </div>", "links"=>[], "tags"=>["reduced", "leptin", "repletion", "connectivity", "hypothalamus", "obese", "humans"], "article_id"=>657778, "categories"=>["Chemistry", "Neuroscience"], "users"=>["William Hinkle", "Michael Cordell", "Rudy Leibel", "Michael Rosenbaum", "Joy Hirsch"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0059114.s001", "https://dx.doi.org/10.1371/journal.pone.0059114.s002", "https://dx.doi.org/10.1371/journal.pone.0059114.s003", "https://dx.doi.org/10.1371/journal.pone.0059114.s004", "https://dx.doi.org/10.1371/journal.pone.0059114.s005", "https://dx.doi.org/10.1371/journal.pone.0059114.s006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effects_of_Reduced_Weight_Maintenance_and_Leptin_Repletion_on_Functional_Connectivity_of_the_Hypothalamus_in_Obese_Humans__/657778", "title"=>"Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-03-22 08:37:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1007973"], "description"=>"<p><b>Seed: Right Hypothalamus:</b> Peak voxel location of changes in functional connectivity as a result of condition comparisons as represented by local maxima within clusters. Standard coordinates localized using the Montreal Neurological Institute MNI-152 brain template.</p>1<p>Located as local maxima in clusters expressed in the Montreal Neurological Institute 152 brain template.</p>", "links"=>[], "tags"=>["diabetes and endocrinology", "neuroscience"], "article_id"=>668599, "categories"=>["Chemistry", "Neuroscience"], "users"=>["William Hinkle", "Michael Cordell", "Rudy Leibel", "Michael Rosenbaum", "Joy Hirsch"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0059114.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_Functional_Connectivity_1_/668599", "title"=>"Changes in Functional Connectivity<sup>1</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-21 02:23:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1007990"], "description"=>"*<p>p<0.001 vs. Wt<sub>initial</sub>;</p>†<p>p<0.001 vs. Wt<sub>−10%placebo.</sub></p>", "links"=>[], "tags"=>["diabetes and endocrinology", "neuroscience"], "article_id"=>668616, "categories"=>["Chemistry", "Neuroscience"], "users"=>["William Hinkle", "Michael Cordell", "Rudy Leibel", "Michael Rosenbaum", "Joy Hirsch"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0059114.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_Characteristics_n_8202_8202_10_8_females_/668616", "title"=>"Subject Characteristics (n = 10, 8 females).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-21 02:23:36"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"66", "full-text"=>"77", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"21", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"44", "full-text"=>"47", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"25", "full-text"=>"40", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"16", "abstract"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"33", "full-text"=>"49", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"46", "full-text"=>"58", "pdf"=>"21", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"43", "full-text"=>"49", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"28", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"24", "full-text"=>"28", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"30", "full-text"=>"41", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"35", "full-text"=>"38", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"90", "full-text"=>"345", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"27", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"24", "full-text"=>"30", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"25", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"46", "full-text"=>"55", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"33", "full-text"=>"74", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"25", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"27", "full-text"=>"20", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"28", "full-text"=>"36", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"20", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"25", "full-text"=>"30", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"35", "full-text"=>"46", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"27", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"64", "full-text"=>"79", "pdf"=>"39", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"21", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[248, 440, 562, 666, 765, 856, 944, 1028, 1112, 1198, 1282, 1362, 1430]}, {"subject_area"=>"/Biology and life sciences/Neuroscience", "average_usage"=>[261, 444, 554, 655, 748, 834, 923, 1004, 1089, 1170, 1244, 1315, 1380]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[248, 441, 564, 668, 769, 859, 948, 1034, 1117, 1202, 1290, 1368, 1437]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[253, 430]}, {"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[244, 425, 535, 636, 728, 814, 900, 982, 1063, 1139, 1221, 1296, 1361]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[258, 449, 572, 679, 775, 866, 956, 1041, 1124, 1211, 1291, 1371, 1437]}]}
Loading … Spinner
There are currently no alerts