Prevalence of Symptomatic Heart Failure with Reduced and with Normal Ejection Fraction in an Elderly General Population–The CARLA Study
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{"title"=>"Prevalence of Symptomatic Heart Failure with Reduced and with Normal Ejection Fraction in an Elderly General Population-The CARLA Study", "type"=>"journal", "authors"=>[{"first_name"=>"Daniel", "last_name"=>"Tiller", "scopus_author_id"=>"38362356100"}, {"first_name"=>"Martin", "last_name"=>"Russ", "scopus_author_id"=>"14066362300"}, {"first_name"=>"Karin Halina", "last_name"=>"Greiser", "scopus_author_id"=>"6506546226"}, {"first_name"=>"Sebastian", "last_name"=>"Nuding", "scopus_author_id"=>"6602895567"}, {"first_name"=>"Henning", "last_name"=>"Ebelt", "scopus_author_id"=>"8282083000"}, {"first_name"=>"Alexander", "last_name"=>"Kluttig", "scopus_author_id"=>"9433677000"}, {"first_name"=>"Jan A.", "last_name"=>"Kors", "scopus_author_id"=>"7005293297"}, {"first_name"=>"Joachim", "last_name"=>"Thiery", "scopus_author_id"=>"55737881700"}, {"first_name"=>"Mathias", "last_name"=>"Bruegel", "scopus_author_id"=>"15520498400"}, {"first_name"=>"Johannes", "last_name"=>"Haerting", "scopus_author_id"=>"56216227400"}, {"first_name"=>"Karl", "last_name"=>"Werdan", "scopus_author_id"=>"7103009985"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23555000", "doi"=>"10.1371/journal.pone.0059225", "sgr"=>"84875021861", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "scopus"=>"2-s2.0-84875021861", "issn"=>"19326203", "pui"=>"368535292"}, "id"=>"8ced4aaa-2ae1-3625-8be4-cd1d535f8fbf", "abstract"=>"BACKGROUND/OBJECTIVES Chronic heart failure (CHF) is one of the most important public health concerns in the industrialized world having increasing incidence and prevalence. Although there are several studies describing the prevalence of heart failure with reduced ejection fraction (HFREF) and heart failure with normal ejection fraction (HFNEF) in selected populations, there are few data regarding the prevalence and the determinants of symptomatic heart failure in the general population. METHODS Cross-sectional data of a population-based German sample (1,779 subjects aged 45-83 years) were analyzed to determine the prevalence and determinants of chronic SHF and HFNEF defined according to the European Society of Cardiology using symptoms, echocardiography and serum NT-proBNP. Prevalence was age-standardized to the German population as of December 31st, 2005. RESULTS The overall age-standardized prevalence of symptomatic CHF was 7.7% (95%CI 6.0-9.8) for men and 9.0% (95%CI 7.0-11.5) for women. The prevalence of CHF strongly increased with age from 3.0% among 45-54- year-old subjects to 22.0% among 75-83- year-old subjects. Symptomatic HFREF could be shown in 48% (n = 78), symptomatic HFNEF in 52% (n = 85) of subjects with CHF. The age-standardized prevalence of HFREF was 3.8 % (95%CI 2.4-5.8) for women and 4.6 % (95%CI 3.6-6.3) for men. The age-standardized prevalence of HFNEF for women and men was 5.1 % (95%CI 3.8-7.0) and 3.0 % (95%CI 2.1-4.5), respectively. Persons with CHF were more likely to have hypertension (PR = 3.4; 95%CI 1.6-7.3) or to have had a previous myocardial infarction (PR = 2.5, 95%CI 1.8-3.5). CONCLUSION The prevalence of symptomatic CHF appears high in this population compared with other studies. While more women were affected by HFNEF than men, more male subjects suffered from HFREF. The high prevalence of symptomatic CHF seems likely to be mainly due to the high prevalence of cardiovascular risk factors in this population.", "link"=>"http://www.mendeley.com/research/prevalence-symptomatic-heart-failure-reduced-normal-ejection-fraction-elderly-general-populationthe", "reader_count"=>41, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>4, "Researcher"=>7, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>5, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>5, "Lecturer"=>2, "Professor"=>2, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>4, "Researcher"=>7, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>5, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>5, "Lecturer"=>2, "Professor"=>2, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>34, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>34}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Poland"=>1, "United Kingdom"=>1, "Germany"=>1}, "group_count"=>2}

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  • {"files"=>["https://ndownloader.figshare.com/files/988595"], "description"=>"<p>Age-standardized prevalence of self-reported symptoms of CHF, NT-proBNP >220 pg/ml, systolic dysfunction and diastolic impairment as measured by echocardiography (regardless of any CHF diagnosis) (different denominators are due to by differences in the number of subjects with missing data for HFREF and HFNEF).</p>", "links"=>[], "tags"=>["prevalence", "self-reported", "symptoms", "nt-probnp", "systolic", "dysfunction", "diastolic", "impairment", "echocardiography", "chf", "denominators", "differences", "subjects", "hfref"], "article_id"=>653042, "categories"=>["Biotechnology"], "users"=>["Daniel Tiller", "Martin Russ", "Karin Halina Greiser", "Sebastian Nuding", "Henning Ebelt", "Alexander Kluttig", "Jan A. Kors", "Joachim Thiery", "Mathias Bruegel", "Johannes Haerting", "Karl Werdan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059225.g004", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Age_standardized_prevalence_of_self_reported_symptoms_of_CHF_NT_proBNP_gt_220_pg_ml_systolic_dysfunction_and_diastolic_impairment_as_measured_by_echocardiography_regardless_of_any_CHF_diagnosis_different_denominators_are_due_to_by_differences_in_the_numb/653042", "title"=>"Age-standardized prevalence of self-reported symptoms of CHF, NT-proBNP >220 pg/ml, systolic dysfunction and diastolic impairment as measured by echocardiography (regardless of any CHF diagnosis) (different denominators are due to by differences in the number of subjects with missing data for HFREF and HFNEF).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-16 07:29:03"}
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  • {"files"=>["https://ndownloader.figshare.com/files/1012636"], "description"=>"<p>Prevalence of Heart Failure in the CARLA Study compared with other population-based studies.</p>", "links"=>[], "tags"=>["carla", "compared", "population-based"], "article_id"=>673044, "categories"=>["Biotechnology"], "users"=>["Daniel Tiller", "Martin Russ", "Karin Halina Greiser", "Sebastian Nuding", "Henning Ebelt", "Alexander Kluttig", "Jan A. Kors", "Joachim Thiery", "Mathias Bruegel", "Johannes Haerting", "Karl Werdan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059225.t003", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prevalence_of_Heart_Failure_in_the_CARLA_Study_compared_with_other_population_based_studies_/673044", "title"=>"Prevalence of Heart Failure in the CARLA Study compared with other population-based studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-15 00:50:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1012612"], "description"=>"1<p>Proportions age-standardized to the age-distribution of the German standard population as of 31.12.2005, means weighted with age-specific weights of standard population (except for mean age)</p>2<p>SBP = systolic blood pressure, DBP = diastolic blood pressure, smoking = smoking tobacco products defined as cigarettes/cigars/pipes,</p>3<p>given as median and inter-quartile-range</p>4<p>glomerular filtration rate according to the simplified MDRD (Modification of Diet in Renal Disease) equation</p>5<p>CVD: including prevalent myocardial infarction, coronary artery bypass graft, percutaneous transluminal coronary angioplasty, stroke, carotid surgery</p>6<p>Hypertension defined as SBP >  = 140and/or DBP> = 90 mmHg, and/or use of antihypertensive medication by ATC code</p>7<p>Diabetes defined as self-reported physician-diagnosed diabetes mellitus and/or use of anti-diabetic medication by ATC code</p>", "links"=>[], "tags"=>["carla"], "article_id"=>673021, "categories"=>["Biotechnology"], "users"=>["Daniel Tiller", "Martin Russ", "Karin Halina Greiser", "Sebastian Nuding", "Henning Ebelt", "Alexander Kluttig", "Jan A. Kors", "Joachim Thiery", "Mathias Bruegel", "Johannes Haerting", "Karl Werdan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059225.t001", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_the_CARLA_Study_population_2002_8211_2006_/673021", "title"=>"Baseline characteristics of the CARLA Study population (2002–2006).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-15 00:50:21"}

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Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[253, 430]}, {"subject_area"=>"/Medicine and health sciences/Vascular medicine", "average_usage"=>[222, 394, 496, 593, 683, 762, 835, 910, 980, 1047, 1116, 1184, 1244]}]}
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