Performance of Multiplex Cytokine Assays in Serum and Saliva among Community-Dwelling Postmenopausal Women
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{"title"=>"Performance of Multiplex Cytokine Assays in Serum and Saliva among Community-Dwelling Postmenopausal Women", "type"=>"journal", "authors"=>[{"first_name"=>"Richard W.", "last_name"=>"Browne", "scopus_author_id"=>"7201586899"}, {"first_name"=>"Alpdogan", "last_name"=>"Kantarci", "scopus_author_id"=>"6603698171"}, {"first_name"=>"Michael J.", "last_name"=>"LaMonte", "scopus_author_id"=>"7004665740"}, {"first_name"=>"Christopher A.", "last_name"=>"Andrews", "scopus_author_id"=>"35278102200"}, {"first_name"=>"Kathleen M.", "last_name"=>"Hovey", "scopus_author_id"=>"6602526732"}, {"first_name"=>"Karen L.", "last_name"=>"Falkner", "scopus_author_id"=>"7004182691"}, {"first_name"=>"Ali", "last_name"=>"Cekici", "scopus_author_id"=>"35291436900"}, {"first_name"=>"Danielle", "last_name"=>"Stephens", "scopus_author_id"=>"36464349100"}, {"first_name"=>"Robert J.", "last_name"=>"Genco", "scopus_author_id"=>"7103042999"}, {"first_name"=>"Frank A.", "last_name"=>"Scannapieco", "scopus_author_id"=>"7004617726"}, {"first_name"=>"Thomas E.", "last_name"=>"van Dyke", "scopus_author_id"=>"7102373370"}, {"first_name"=>"Jean", "last_name"=>"Wactawski-Wende", "scopus_author_id"=>"6602579908"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368686389", "sgr"=>"84875930353", "pmid"=>"23577067", "scopus"=>"2-s2.0-84875930353", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0059498", "issn"=>"19326203"}, "id"=>"ae9d2d74-2da9-3cbc-9949-89860d00bc8f", "abstract"=>"Multiplexing arrays increase the throughput and decrease sample requirements for studies employing multiple biomarkers. The goal of this project was to examine the performance of Multiplex arrays for measuring multiple protein biomarkers in saliva and serum. Specimens from the OsteoPerio ancillary study of the Women's Health Initiative Observational Study were used. Participants required the presence of at least 6 teeth and were excluded based on active cancer and certain bone issues but were not selected on any specific condition. Quality control (QC) samples were created from pooled serum and saliva. Twenty protein markers were measured on five multiplexing array panels. Sample pretreatment conditions were optimized for each panel. Recovery, lower limit of quantification (LLOQ) and imprecision were determined for each analyte. Statistical adjustment at the plate level was used to reduce imprecision estimates and increase the number of usable observations. Sample pre-treatment improved recovery estimates for many analytes. The LLOQ for each analyte agreed with manufacturer specifications except for MMP-1 and MMP-2 which were significantly higher than reported. Following batch adjustment, 17 of 20 biomarkers in serum and 9 of 20 biomarkers in saliva demonstrated acceptable precision, defined as <20% coefficient of variation (<25% at LLOQ). The percentage of cohort samples having levels within the reportable range for each analyte varied from 10% to 100%. The ratio of levels in saliva to serum varied from 1∶100 to 28∶1. Correlations between saliva and serum were of moderate positive magnitude and significant for CRP, MMP-2, insulin, adiponectin, GM-CSF and IL-5. Multiplex arrays exhibit high levels of analytical imprecision, particularly at the batch level. Careful sample pre-treatment can enhance recovery and reduce imprecision. Following statistical adjustments to reduce batch effects, we identified biomarkers that are of acceptable quality in serum and to a lesser degree in saliva using Multiplex arrays.", "link"=>"http://www.mendeley.com/research/performance-multiplex-cytokine-assays-serum-saliva-among-communitydwelling-postmenopausal-women", "reader_count"=>50, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>16, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Student > Master"=>9, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>16, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Student > Master"=>9, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>4, "Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>17, "Medicine and Dentistry"=>13, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>6, "Chemistry"=>2, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Chemistry"=>{"Chemistry"=>2}, "Psychology"=>{"Psychology"=>6}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>2, "Spain"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1017229"], "description"=>"<p>The x-axis is analyte concentration and the y-axis is the coefficient of variation of six replicate measurements of authentic serum spiked with analyte by standard additions methodology.</p>", "links"=>[], "tags"=>["estimation", "quantification", "matrix", "metalloproteinase"], "article_id"=>676736, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.g002", "stats"=>{"downloads"=>5, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Empirical_estimation_of_the_lower_limit_of_quantification_LLOQ_for_matrix_metalloproteinase_1_MMP_1_and_MMP_2_/676736", "title"=>"Empirical estimation of the lower limit of quantification (LLOQ) for matrix metalloproteinase 1 (MMP-1) and MMP-2.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-05 01:52:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017242"], "description"=>"<p>CV, % coefficient of variation; AI, ratio of analytical imprecision (CV of QC materials) over interindividual variation (CV of all participant values) with a target value of <0.25; QC data for IL-1β and IL-8 were insufficient in saliva, no data is reported; Bolded Adjusted Between Run CV indicate analytes that are in the acceptable range (<25%) for imprecision.</p>", "links"=>[], "tags"=>["imprecision", "multiplexed", "analytes", "serum", "saliva", "pooled"], "article_id"=>676749, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.t004", "stats"=>{"downloads"=>4, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estimates_of_imprecision_of_multiplexed_analytes_in_serum_and_saliva_using_pooled_quality_control_materials_/676749", "title"=>"Estimates of imprecision of multiplexed analytes in serum and saliva using pooled quality control materials.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-05 01:52:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017241"], "description"=>"<p>Total N Tested; number of participant samples sent for testing, Total N pass QC; number of participant samples after removal of failed QC batches,</p><p>% above/below; percent of samples to pass QC but fall above or below the quantifiable range of the assay based on <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059498#pone-0059498-t003\" target=\"_blank\">table 3</a>.</p>", "links"=>[], "tags"=>["serum", "samples", "tested", "parathyroid", "matrix", "metalloproteinase", "obesity", "c-reactive"], "article_id"=>676748, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.t005", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Descriptive_statistics_of_all_study_participant_serum_samples_tested_for_Bone_Panel_osteoprotegrin_OPG_leptin_parathyroid_hormone_PTH_and_insulin_Matrix_Metalloproteinase_Panel_MMP_2_MMP_8_MMP_9_and_Obesity_Panel_adiponectin_and_C_reactive_protein_CRP_/676748", "title"=>"Descriptive statistics of all study participant serum samples tested for Bone Panel (osteoprotegrin (OPG), leptin, parathyroid hormone (PTH) and insulin), Matrix Metalloproteinase Panel (MMP-2, MMP-8, MMP-9) and Obesity Panel (adiponectin and C-reactive protein (CRP)).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-05 01:52:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017238"], "description"=>"<p>MMP Panel: MMP-2, MMP-8 and MMP-9; Bone Panel: OPG, Leptin, PTH and Insulin; 10-Plex: IL-1β, IL-10,</p><p>IL-6, GM-CSF, IL-5, IFN-γ, TNF-α, IL-2, IL-4 and IL-8; Obesity Panel: Adiponectin and CRP; 2-Plex Panel: TNF-α and MCP-1.</p>", "links"=>[], "tags"=>["diluents", "multiplexed", "assay"], "article_id"=>676745, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dilution_factors_and_diluents_for_each_multiplexed_assay_panel_/676745", "title"=>"Dilution factors and diluents for each multiplexed assay panel.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-05 01:52:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017236"], "description"=>"<p>ND, not determined as baseline sample level was>highest calibrator.</p>*<p>all replicate samples achieved CV <20% and therefore the manufacturer’s stated LLOQ is accepted.</p>", "links"=>[], "tags"=>["assay", "calibration", "stated", "quantification", "empirically", "derived", "lloq", "percent", "serum"], "article_id"=>676743, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.t003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multiplex_assay_performance_characteristics_including_the_kit_manufacturer_8217_s_calibration_range_and_stated_lower_limit_of_quantification_LLOQ_empirically_derived_LLOQ_and_percent_recovery_in_serum_and_saliva_/676743", "title"=>"Multiplex assay performance characteristics including the kit manufacturer’s calibration range, and stated lower limit of quantification (LLOQ), empirically derived LLOQ and percent recovery in serum and saliva.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-05 01:52:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017237"], "description"=>"<p>EDTA, ethylenediaminetetraacetic acid disodium salt.</p>", "links"=>[], "tags"=>["percent", "recoveries", "10plex", "analytes", "undiluted", "serum", "two-fold", "dilution"], "article_id"=>676744, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.t002", "stats"=>{"downloads"=>4, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_percent_recoveries_of_10plex_analytes_in_undiluted_neat_serum_and_following_two_fold_dilution_in_sample_diluent_/676744", "title"=>"Comparison of percent recoveries of 10plex analytes in undiluted (neat) serum and following two-fold dilution in sample diluent.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-05 01:52:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017244"], "description"=>"<p>Total N Tested; number of participant samples sent for testing, Total N pass QC; number of participant samples after removal of failed QC batches.</p><p>% above/below; percent of samples to pass QC but fall above or below the quantifiable range of the assay based on <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059498#pone-0059498-t003\" target=\"_blank\">table 3</a>.</p><p>1– TNF-α assayed as part of the 10-Plex.</p><p>2– TNF-α assayed with MCP-1.</p>*<p>- the QC material was insufficient for evaluation of these analytes, all data within analytic range is reported and has not been adjusted by batch.</p>", "links"=>[], "tags"=>["saliva", "samples", "tested"], "article_id"=>676751, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.t008", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Descriptive_statistics_of_all_study_participant_saliva_samples_tested_for_8220_10_plex_8221_Panel_TNF_945_IL_1_946_IL_6_IFN_947_IL_4_IL_10_IL_2_IL_5_IL_8_GM_CSF_and_8220_4_plex_8221_Panel_TNF_945_and_MCP_1_/676751", "title"=>"Descriptive statistics of all study participant saliva samples tested for “10-plex” Panel (TNF-α, IL-1β, IL-6, IFN-γ, IL-4, IL-10, IL-2, IL-5, IL-8, GM-CSF) and “4-plex” Panel (TNF-α and MCP-1).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-05 01:52:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017243"], "description"=>"<p>All values are batch adjusted.</p><p>Median of Ratios – median of ratios computed for each participant.</p>*<p>Saliva values for these analytes are not adjusted due to insufficient QC data.</p><p>Pearson Correlation of natural log adjusted values, LCL, UCL lower and upper 95% confidence interval.</p>", "links"=>[], "tags"=>["pearson"], "article_id"=>676750, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.t009", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Saliva_Serum_Ratio_and_Pearson_Correlation_for_all_samples_/676750", "title"=>"Saliva:Serum Ratio and Pearson Correlation for all samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-05 01:52:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017240"], "description"=>"<p>Total N Tested; number of participant samples sent for testing, Total N pass QC; number of participant samples after removal of failed QC batches,</p><p>% above/below; percent of samples to pass QC but fall above or below the quantifiable range of the assay based on <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059498#pone-0059498-t003\" target=\"_blank\">table 3</a>.</p><p>1– TNF-α assayed as part of the 10-Plex.</p><p>2– TNF-α assayed with MCP-1.</p>", "links"=>[], "tags"=>["serum", "samples", "tested"], "article_id"=>676747, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.t006", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Descriptive_statistics_of_all_study_participant_serum_samples_tested_for_8220_10_plex_8221_Panel_TNF_945_IL_1_946_IL_6_IFN_947_IL_4_IL_10_IL_2_IL_5_IL_8_GM_CSF_and_8220_4_plex_8221_Panel_TNF_945_and_MCP_1_/676747", "title"=>"Descriptive statistics of all study participant serum samples tested for “10-plex” Panel (TNF-α, IL-1β, IL-6, IFN-γ, IL-4, IL-10, IL-2, IL-5, IL-8, GM-CSF) and “4-plex” Panel (TNF-α and MCP-1).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-05 01:52:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017239"], "description"=>"<p>Total N Tested; number of participant samples sent for testing, Total N pass QC; number of participant samples after removal of failed QC batches</p><p>% above/below; percent of samples to pass QC but fall above or below the quantifiable range of the assay based on <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059498#pone-0059498-t003\" target=\"_blank\">table 3</a>.</p>", "links"=>[], "tags"=>["saliva", "samples", "tested", "parathyroid", "matrix", "metalloproteinase", "obesity", "c-reactive"], "article_id"=>676746, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.t007", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Descriptive_statistics_of_all_study_participant_saliva_samples_tested_for_Bone_Panel_osteoprotegrin_OPG_leptin_parathyroid_hormone_PTH_and_insulin_Matrix_Metalloproteinase_Panel_MMP_2_MMP_8_MMP_9_and_Obesity_Panel_adiponectin_and_C_reactive_protein_CRP_/676746", "title"=>"Descriptive statistics of all study participant saliva samples tested for Bone Panel (osteoprotegrin (OPG), leptin, parathyroid hormone (PTH) and insulin), Matrix Metalloproteinase Panel (MMP-2, MMP-8, MMP-9) and Obesity Panel (adiponectin and C-reactive protein (CRP)).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-05 01:52:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1017225"], "description"=>"<p>Initial 1∶2 dilution causes a 3 fold increase in observed concentration followed by 50% decreases with each successive serial dilution.</p>", "links"=>[], "tags"=>["serum", "spiked", "highest", "calibrator", "diluted"], "article_id"=>676735, "categories"=>["Physiology", "Cell Biology", "Biotechnology", "Immunology"], "users"=>["Richard W. Browne", "Alpdogan Kantarci", "Michael J. LaMonte", "Christopher A. Andrews", "Kathleen M. Hovey", "Karen L. Falkner", "Ali Cekici", "Danielle Stephens", "Robert J. Genco", "Frank A. Scannapieco", "Thomas E. Van Dyke", "Jean Wactawski-Wende"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0059498.g001", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Observed_concentration_of_IL_1_946_in_serum_sample_spiked_1_8758_20_with_highest_calibrator_and_then_diluted_and_analyzed_in_replicate_/676735", "title"=>"Observed concentration of IL-1β in serum sample spiked 1∶20 with highest calibrator and then diluted and analyzed in replicate.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-05 01:52:15"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"36", "full-text"=>"35", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"36", "full-text"=>"40", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"24", "full-text"=>"28", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"36", "full-text"=>"40", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"6", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"31", "full-text"=>"34", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"33", "full-text"=>"38", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"29", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"38", "full-text"=>"41", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"33", "full-text"=>"35", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"39", "full-text"=>"38", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
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Relative Metric

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