Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse Model
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{"title"=>"Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse Model", "type"=>"journal", "authors"=>[{"first_name"=>"Emily J.", "last_name"=>"Dhurandhar", "scopus_author_id"=>"37114328800"}, {"first_name"=>"David B.", "last_name"=>"Allison", "scopus_author_id"=>"7202902345"}, {"first_name"=>"Thomas", "last_name"=>"van Groen", "scopus_author_id"=>"55074007100"}, {"first_name"=>"Inga", "last_name"=>"Kadish", "scopus_author_id"=>"6603478429"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84875656786", "doi"=>"10.1371/journal.pone.0060437", "pui"=>"368635031", "pmid"=>"23565247", "scopus"=>"2-s2.0-84875656786", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"85df11f9-1453-3028-9e36-2748f5ab2093", "abstract"=>"It has been shown that caloric restriction (CR) delays aging and possibly delays the development of Alzheimer's disease (AD). We conjecture that the mechanism may involve interoceptive cues, rather than reduced energy intake per se. We determined that hunger alone, induced by a ghrelin agonist, reduces AD pathology and improves cognition in the APP-SwDI mouse model of AD. Long-term treatment with a ghrelin agonist was sufficient to improve the performance in the water maze. The treatment also reduced levels of amyloid beta (Aβ) and inflammation (microglial activation) at 6 months of age compared to the control group, similar to the effect of CR. Thus, a hunger-inducing drug attenuates AD pathology, in the absence of CR, and the neuroendocrine aspects of hunger also prevent age-related cognitive decline.", "link"=>"http://www.mendeley.com/research/hunger-absence-caloric-restriction-improves-cognition-attenuates-alzheimers-disease-pathology-mouse-3", "reader_count"=>69, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>14, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>2, "Other"=>5, "Student > Master"=>11, "Student > Bachelor"=>10, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>14, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>2, "Other"=>5, "Student > Master"=>11, "Student > Bachelor"=>10, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>24, "Economics, Econometrics and Finance"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>3, "Materials Science"=>1, "Medicine and Dentistry"=>14, "Neuroscience"=>7, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>9, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>9}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Design"=>{"Design"=>1}, "Neuroscience"=>{"Neuroscience"=>7}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>24}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "reader_count_by_country"=>{"Canada"=>1, "Netherlands"=>1, "United States"=>3, "Japan"=>2, "Denmark"=>1, "United Kingdom"=>1, "Portugal"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>3}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1003372"], "description"=>"<p>Bottom row, ELISA measurements of IL-6 and IL-10, respectively, levels in the hippocampal formation.</p>", "links"=>[], "tags"=>["graphs", "inflammation", "iba1", "gfap", "staining", "stratum", "oriens"], "article_id"=>664259, "categories"=>["Neuroscience", "Pharmacology"], "users"=>["Emily J. Dhurandhar", "David B. Allison", "Thomas van Groen", "Inga Kadish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060437.g006", "stats"=>{"downloads"=>3, "page_views"=>32, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Four_bar_graphs_showing_the_data_from_the_inflammation_measurements_top_row_density_measurements_of_Iba1_and_GFAP_staining_in_stratum_oriens_of_the_hippocampus_respectively_p_8202_8202_0_0042_for_Iba_1_/664259", "title"=>"Four bar graphs showing the data from the inflammation measurements, top row, density measurements of Iba1 and GFAP staining in stratum oriens of the hippocampus, respectively (p = 0.0042 for Iba-1).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-03 04:03:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1003364"], "description"=>"<p>Note that the control and LY animals gain equal weight during the treatment period, but the CR animals are significantly lighter; further, the CR mice had a significantly (p<0.001) lower fat mass compared to the other two groups. Right: Bar graph showing the percent of fat of the total body weight as determined by QMR. Note the reduced fat content of the CR mice.</p>", "links"=>[], "tags"=>["neuroscience", "pharmacology", "neurological disorders"], "article_id"=>664251, "categories"=>["Neuroscience", "Pharmacology"], "users"=>["Emily J. Dhurandhar", "David B. Allison", "Thomas van Groen", "Inga Kadish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060437.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Left_Change_in_body_weight_over_the_treatment_period_/664251", "title"=>"Left: Change in body weight over the treatment period.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-03 04:02:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1003366"], "description"=>"<p>No significant differences between the groups were present.</p>", "links"=>[], "tags"=>["graphs", "spent", "parts", "elevated", "groups"], "article_id"=>664253, "categories"=>["Neuroscience", "Pharmacology"], "users"=>["Emily J. Dhurandhar", "David B. Allison", "Thomas van Groen", "Inga Kadish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060437.g002", "stats"=>{"downloads"=>1, "page_views"=>123, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Two_bar_graphs_showing_the_time_spent_in_different_parts_of_the_open_field_and_elevated_plus_maze_respectively_of_the_three_groups_of_mice_/664253", "title"=>"Two bar graphs showing the time spent in different parts of the open field and elevated plus maze, respectively, of the three groups of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-03 04:02:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/1003367"], "description"=>"<p>Left: The daily mean performance in the water maze. Right: the probe trial performance of the three groups of mice. Note that the improvement in trial time was significantly more in LY compared to the control (p = 0.023) and nearly significantly more in CR compared to the control (p = 0.08). Both LY and CR groups had a significant preference for the correct quadrant in the probe trial (p<0.05).</p>", "links"=>[], "tags"=>["graphs", "curves", "groups"], "article_id"=>664254, "categories"=>["Neuroscience", "Pharmacology"], "users"=>["Emily J. Dhurandhar", "David B. Allison", "Thomas van Groen", "Inga Kadish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060437.g003", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Two_graphs_showing_the_learning_curves_of_the_three_groups_of_mice_/664254", "title"=>"Two graphs showing the learning curves of the three groups of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-03 04:02:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1003368"], "description"=>"<p>A non-significant decrease in Aβ staining in stratum oriens and a significant reduction in Aβ staining in the dentate gyrus in both LY and CR mice compared to the control is shown. Lower panel, Aβ levels measured by ELISA. Insoluble Aβ-40 levels are significantly reduced in CR and LY groups compared to the control (*student's t-test p = 0.03 for both comparisons). Insoluble Aβ-42 levels are reduced in CR and LY compared to the control (**Tukey-Kramer HSD p = 0.02 for both comparisons). so - stratum oriens; sp - stratum pyramidale.</p>", "links"=>[], "tags"=>["coronal", "sections", "dorsal", "hippocampus", "stained"], "article_id"=>664255, "categories"=>["Neuroscience", "Pharmacology"], "users"=>["Emily J. Dhurandhar", "David B. Allison", "Thomas van Groen", "Inga Kadish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0060437.g004", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Two_series_of_coronal_sections_of_the_dorsal_hippocampus_stained_for_A_946_/664255", "title"=>"Two series of coronal sections of the dorsal hippocampus stained for Aβ.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-03 04:03:01"}

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