Modulatory Effects of the Piccolo Genotype on Emotional Memory in Health and Depression
Publication Date
April 19, 2013
Journal
PLOS ONE
Authors
Saskia Woudstra, Marie José Van Tol, Zoltán Bochdanovits, Nic J. Van Der Wee, et al
Volume
8
Issue
4
Pages
e61494
DOI
https://dx.plos.org/10.1371/journal.pone.0061494
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0061494
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23620758
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631241
Europe PMC
http://europepmc.org/abstract/MED/23620758
Web of Science
000317909500038
Scopus
84876439260
Mendeley
http://www.mendeley.com/research/modulatory-effects-piccolo-genotype-emotional-memory-health-depression
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Modulatory Effects of the Piccolo Genotype on Emotional Memory in Health and Depression", "type"=>"journal", "authors"=>[{"first_name"=>"Saskia", "last_name"=>"Woudstra", "scopus_author_id"=>"55178953900"}, {"first_name"=>"Marie José", "last_name"=>"van Tol", "scopus_author_id"=>"15048810700"}, {"first_name"=>"Zoltán", "last_name"=>"Bochdanovits", "scopus_author_id"=>"6505863919"}, {"first_name"=>"Nic J.", "last_name"=>"van der Wee", "scopus_author_id"=>"6603371837"}, {"first_name"=>"Frans G.", "last_name"=>"Zitman", "scopus_author_id"=>"7004412740"}, {"first_name"=>"Mark A.", "last_name"=>"van Buchem", "scopus_author_id"=>"7005065927"}, {"first_name"=>"Esther M.", "last_name"=>"Opmeer", "scopus_author_id"=>"36188680900"}, {"first_name"=>"André", "last_name"=>"Aleman", "scopus_author_id"=>"7006820955"}, {"first_name"=>"Brenda W.", "last_name"=>"Penninx", "scopus_author_id"=>"55800249300"}, {"first_name"=>"Dick J.", "last_name"=>"Veltman", "scopus_author_id"=>"7003711554"}, {"first_name"=>"Witte J.", "last_name"=>"Hoogendijk", "scopus_author_id"=>"7003816799"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84876439260", "sgr"=>"84876439260", "pui"=>"368765631", "isbn"=>"1932-6203", "pmid"=>"23620758", "doi"=>"10.1371/journal.pone.0061494"}, "id"=>"fa0c3502-bd9c-368e-b8f5-8398f1ed5d5e", "abstract"=>"Major depressive disorder (MDD) has been associated with biased memory formation for mood-congruent information, which may be related to altered monoamine levels. The piccolo (PCLO) gene, involved in monoaminergic neurotransmission, has previously been linked to depression in a genome-wide association study. Here, we investigated the role of the PCLO risk allele on functional magnetic resonance imaging (MRI) correlates of emotional memory in a sample of 89 MDD patients (64 PCLO risk allele carriers) and 29 healthy controls (18 PCLO risk allele carriers). During negative word encoding, risk allele carriers showed significant lower activity relative to non-risk allele carriers in the insula, and trend-wise in the anterior cingulate cortex and inferior frontal gyrus. Moreover, depressed risk allele carriers showed significant lower activity relative to non-risk allele carriers in the striatum, an effect which was absent in healthy controls. Finally, amygdalar response during processing new positive words vs. known words was blunted in healthy PCLO+ carriers and in MDD patients irrespective of genotype, which may indicate that signalling of salient novel information does not occur to the same extent in PCLO+ carriers and MDD patients. The PCLO risk allele may increase vulnerability for MDD by modulating local brain function with regard to responsiveness to salient stimuli (i.e. insula) and processing novel negative information. Also, depression-specific effects of PCLO on dorsal striatal activation during negative word encoding and the absence of amygdalar salience signalling for novel positive information further suggest a role of PCLO in symptom maintenance in MDD.", "link"=>"http://www.mendeley.com/research/modulatory-effects-piccolo-genotype-emotional-memory-health-depression", "reader_count"=>41, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>8, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>6, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>8, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>6, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>9, "Neuroscience"=>6, "Chemical Engineering"=>1, "Psychology"=>11, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Neuroscience"=>{"Neuroscience"=>6}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>11}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Unspecified"=>{"Unspecified"=>4}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Denmark"=>1, "Germany"=>1}, "group_count"=>2}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84876439260"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84876439260?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876439260&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84876439260&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84876439260", "dc:identifier"=>"SCOPUS_ID:84876439260", "eid"=>"2-s2.0-84876439260", "dc:title"=>"Modulatory Effects of the Piccolo Genotype on Emotional Memory in Health and Depression", "dc:creator"=>"Woudstra S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-04-19", "prism:coverDisplayDate"=>"19 April 2013", "prism:doi"=>"10.1371/journal.pone.0061494", "citedby-count"=>"15", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Vrije Universiteit Amsterdam", "affiliation-city"=>"Amsterdam", "affiliation-country"=>"Netherlands"}, {"@_fa"=>"true", "affilname"=>"Amsterdam UMC - Vrije Universiteit Amsterdam", "affiliation-city"=>"Amsterdam", "affiliation-country"=>"Netherlands"}], "pubmed-id"=>"23620758", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e61494", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0061494", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"4", "html_views"=>"164"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"22", "xml_views"=>"3", "html_views"=>"88"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"62"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"43"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"9"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"2"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"2"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"1"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1030021"], "description"=>"<div><p>Major depressive disorder (MDD) has been associated with biased memory formation for mood-congruent information, which may be related to altered monoamine levels. The piccolo (<i>PCLO</i>) gene, involved in monoaminergic neurotransmission, has previously been linked to depression in a genome-wide association study. Here, we investigated the role of the <i>PCLO</i> risk allele on functional magnetic resonance imaging (MRI) correlates of emotional memory in a sample of 89 MDD patients (64 <i>PCLO</i> risk allele carriers) and 29 healthy controls (18 <i>PCLO</i> risk allele carriers). During negative word encoding, risk allele carriers showed significant lower activity relative to non-risk allele carriers in the insula, and trend-wise in the anterior cingulate cortex and inferior frontal gyrus. Moreover, depressed risk allele carriers showed significant lower activity relative to non-risk allele carriers in the striatum, an effect which was absent in healthy controls. Finally, amygdalar response during processing new positive words vs. known words was blunted in healthy PCLO+ carriers and in MDD patients irrespective of genotype, which may indicate that signalling of salient novel information does not occur to the same extent in PCLO+ carriers and MDD patients. The <i>PCLO</i> risk allele may increase vulnerability for MDD by modulating local brain function with regard to responsiveness to salient stimuli (i.e. insula) and processing novel negative information. Also, depression-specific effects of PCLO on dorsal striatal activation during negative word encoding and the absence of amygdalar salience signalling for novel positive information further suggest a role of PCLO in symptom maintenance in MDD.</p></div>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "neuroscience", "neuroimaging", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "piccolo", "genotype"], "article_id"=>686797, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Saskia Woudstra", "Marie-José van Tol", "Zoltán Bochdanovits", "Nic J. van der Wee", "Frans G. Zitman", "Mark A. van Buchem", "Esther M. Opmeer", "André Aleman", "Brenda W. Penninx", "Dick J. Veltman", "Witte J. Hoogendijk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061494", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Modulatory_Effects_of_the_Piccolo_Genotype_on_Emotional_Memory_in_Health_and_Depression_/686797", "title"=>"Modulatory Effects of the Piccolo Genotype on Emotional Memory in Health and Depression", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-19 01:53:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1030020"], "description"=>"<p>Sample characteristics and task performance of the total sample. SD: standard deviation; n:number of participants; PCLO+: <i>PCLO</i> risk allele carriers; PCLO−: <i>PCLO</i> non-risk allele carries; A: Amsterdam; L: Leiden; G:Groningen; MDD: major depressive disorder; HC: healthy controls; IDS: Inventory of Depressive Symptomatology; MADRS: Montgomery-Åsberg Depression Rating Scale; SSRI: Selective Serotonin Reuptake Inhibitors; p: proportion correct answers; neg: negative (words); pos: positive (words); neu: neutral (words); sec: seconds; rt: response time.</p><p>Mean proportion correct and response times for encoding (subsequent hits) and recognition (hits, false alarms, correct rejection) indices. Correct RECognition (CREC): correct recognition of a previously encoded word; False Alarm (FA): incorrect indication of a newly presented word as a previously encoded word; Correct REJection (CREJ): correct recognition of a newly presented word as a new word; Subsequent Correct Recognition (SCR): consists of a word, presented during the encoding phase, that is correctly recognized during the subsequent recognition phase.</p>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "neuroscience", "neuroimaging", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions"], "article_id"=>686796, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Saskia Woudstra", "Marie-José van Tol", "Zoltán Bochdanovits", "Nic J. van der Wee", "Frans G. Zitman", "Mark A. van Buchem", "Esther M. Opmeer", "André Aleman", "Brenda W. Penninx", "Dick J. Veltman", "Witte J. Hoogendijk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061494.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_characteristics_and_task_performance_/686796", "title"=>"Sample characteristics and task performance.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-19 01:53:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1030017"], "description"=>"<p>Sample characteristics and task performance of the total sample, divided into genotype × diagnosis. SD: standard deviation; n:number of participants; PCLO+: <i>PCLO</i> risk allele carriers; PCLO−: <i>PCLO</i> non-risk allele carries; A: Amsterdam; L: Leiden; G:Groningen; MDD: major depressive disorder; HC: healthy controls; IDS: Inventory of Depressive Symptomatology; MADRS: Montgomery-Åsberg Depression Rating Scale; SSRI: Selective Serotonin Reuptake Inhibitors; p: proportion correct answers; neg: negative (words); pos: positive (words); neu: neutral (words); sec: seconds; rt: response time.</p><p>Mean proportion correct and response times for encoding (subsequent hits) and recognition (hits, false alarms, correct rejection) indices. Correct RECognition (CREC): correct recognition of a previously encoded word; False Alarm (FA): incorrect indication of a newly presented word as a previously encoded word; Correct REJection (CREJ): correct recognition of a newly presented word as a new word; Subsequent Correct Recognition (SCR): consists of a word, presented during the encoding phase, that is correctly recognized during the subsequent recognition phase.</p>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "neuroscience", "neuroimaging", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions"], "article_id"=>686793, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Saskia Woudstra", "Marie-José van Tol", "Zoltán Bochdanovits", "Nic J. van der Wee", "Frans G. Zitman", "Mark A. van Buchem", "Esther M. Opmeer", "André Aleman", "Brenda W. Penninx", "Dick J. Veltman", "Witte J. Hoogendijk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061494.t002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_characteristics_and_task_performance_group_215_diagnosis_/686793", "title"=>"Sample characteristics and task performance group × diagnosis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-19 01:53:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1030015"], "description"=>"<p>PCLO+ carriers within the MDD group show reduced striatal activity relative to the PCLO− carriers within the MDD group during negative word encoding. No effect of genotype is seen in the HC group. Panel A shows sagittal, coronal, and axial section at peak activation (results shown at <i>P</i><.005; black circle: dorsal putamen, Z = 4.65 (right). Panel B shows the cluster means for each peak voxel, with their standard errors for the different groups. PCLO: Piccolo genotype; PCLO+: PCLO risk allele carriers; PCLO−: PCLO non-risk allele carriers; MDD: Major Depressive Disorder; HC: Healthy controls; AU: arbitrary units.</p>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "neuroscience", "neuroimaging", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "encoding"], "article_id"=>686791, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Saskia Woudstra", "Marie-José van Tol", "Zoltán Bochdanovits", "Nic J. van der Wee", "Frans G. Zitman", "Mark A. van Buchem", "Esther M. Opmeer", "André Aleman", "Brenda W. Penninx", "Dick J. Veltman", "Witte J. Hoogendijk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061494.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genotype_215_diagnosis_interaction_during_negative_word_encoding_in_the_striatum_/686791", "title"=>"Genotype × diagnosis interaction during negative word encoding in the striatum.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-19 01:53:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1030016"], "description"=>"<p>Panel A shows valence specific effects during word encoding (results shown at <i>P</i><.005). Black circle: inferior frontal gyrus (right); MNI [x = 36 y = 27 z = −3], Z = 3.9. Panel B: Parameter estimates and 95% confidence intervals showing direction of effect for each valence during word encoding in peakvoxel (MNI [x = 36 y = 27 z = −3]). PCLO: Piccolo genotype; PCLO+: PCLO risk allele carriers; PCLO−: PCLO non-risk allele carriers; MDD: Major Depressive Disorder; HC: Healthy controls; AU: arbitrary units.</p>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "neuroscience", "neuroimaging", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions"], "article_id"=>686792, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Saskia Woudstra", "Marie-José van Tol", "Zoltán Bochdanovits", "Nic J. van der Wee", "Frans G. Zitman", "Mark A. van Buchem", "Esther M. Opmeer", "André Aleman", "Brenda W. Penninx", "Dick J. Veltman", "Witte J. Hoogendijk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061494.g004", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Valence_specific_effects_during_word_encoding_/686792", "title"=>"Valence specific effects during word encoding.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-19 01:53:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/1030014"], "description"=>"<p>PCLO+ carriers show trend-wise hypoactivation of the inferior frontal gyrus and anterior cingulate cortex relative to PCLO− carriers during negative word encoding. Panel A shows sagittal, coronal, and axial section at peak activation (black circle: IFG, red circle: dorsal part of pgACC; results shown at <i>P</i><.005; IFG, Z = 3.79 (left), Z = 3.42 (right); pgACC, Z = 3.12 (left), Z = 3.49 (right)). Panel B shows the cluster means for each peak voxel, with their standard errors for the different groups. PCLO: Piccolo genotype; PCLO+: PCLO risk allele carriers; PCLO−: PCLO non-risk allele carriers; MDD: Major Depressive Disorder; HC: Healthy controls; AU: arbitrary units.</p>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "neuroscience", "neuroimaging", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "genotype", "encoding", "inferior", "frontal", "gyrus", "anterior", "cingulate"], "article_id"=>686790, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Saskia Woudstra", "Marie-José van Tol", "Zoltán Bochdanovits", "Nic J. van der Wee", "Frans G. Zitman", "Mark A. van Buchem", "Esther M. Opmeer", "André Aleman", "Brenda W. Penninx", "Dick J. Veltman", "Witte J. Hoogendijk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061494.g002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PCLO_genotype_effect_during_negative_word_encoding_in_the_inferior_frontal_gyrus_and_anterior_cingulate_cortex_/686790", "title"=>"PCLO genotype effect during negative word encoding in the inferior frontal gyrus and anterior cingulate cortex.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-19 01:53:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1030018"], "description"=>"<p>Main effects of encoding of emotional words vs. neutral words. Main effects are reported at <i>P</i><sub>FDR</sub><.05, whole brain corrected with a minimum cluster size of 10. MNI: Montreal Neurological Institute; BA: Brodmann area; k: clustersize; L: left; R: right; a: clustersize at <i>p</i><.05 FDR whole brain corrected.</p>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "neuroscience", "neuroimaging", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "encoding", "words"], "article_id"=>686794, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Saskia Woudstra", "Marie-José van Tol", "Zoltán Bochdanovits", "Nic J. van der Wee", "Frans G. Zitman", "Mark A. van Buchem", "Esther M. Opmeer", "André Aleman", "Brenda W. Penninx", "Dick J. Veltman", "Witte J. Hoogendijk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061494.t003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Main_effects_of_encoding_of_emotional_words_vs_neutral_words_/686794", "title"=>"Main effects of encoding of emotional words vs. neutral words.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-19 01:53:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1030012"], "description"=>"<p>PCLO+ carriers show significant hypoactivation of the insula, relative to PCLO− carriers during negative word encoding. Panel A shows sagittal, coronal, and axial section at peak activation (green circle: insula; results shown at <i>P</i><.005; Z = 3.92 (left), Z = 4.26 (right)). Panel B shows the cluster means for each peak voxel, with their standard errors for the different groups. PCLO: Piccolo genotype; PCLO+: PCLO risk allele carriers; PCLO−: PCLO non-risk allele carriers; MDD: Major Depressive Disorder; HC: Healthy controls; AU: arbitrary units.</p>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "neuroscience", "neuroimaging", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "genotype", "encoding"], "article_id"=>686788, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Saskia Woudstra", "Marie-José van Tol", "Zoltán Bochdanovits", "Nic J. van der Wee", "Frans G. Zitman", "Mark A. van Buchem", "Esther M. Opmeer", "André Aleman", "Brenda W. Penninx", "Dick J. Veltman", "Witte J. Hoogendijk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061494.g001", "stats"=>{"downloads"=>2, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PCLO_genotype_effect_during_negative_word_encoding_in_the_insula_/686788", "title"=>"PCLO genotype effect during negative word encoding in the insula.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-19 01:53:08"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"47", "full-text"=>"47", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"7", "abstract"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"7", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"19", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"32", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"32", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"10", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"1", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[248, 440, 562, 666, 765, 856, 944, 1028, 1112, 1198, 1282, 1362, 1430]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Neuroscience", "average_usage"=>[261, 444, 554, 655, 748, 834, 923, 1004, 1089, 1170, 1244, 1315, 1380]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[248, 441, 564, 668, 769, 859, 948, 1034, 1117, 1202, 1290, 1368, 1437]}, {"subject_area"=>"/Social sciences/Linguistics", "average_usage"=>[290, 461, 572, 671, 770, 847, 934, 1000, 1096, 1189, 1263, 1319, 1382]}]}
Loading … Spinner
There are currently no alerts