Better Prognosis of Patients with Glioma Expressing FGF2-Dependent PDGFRA Irrespective of Morphological Diagnosis
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{"title"=>"Better Prognosis of Patients with Glioma Expressing FGF2-Dependent PDGFRA Irrespective of Morphological Diagnosis", "type"=>"journal", "authors"=>[{"first_name"=>"Dongfeng", "last_name"=>"Chen", "scopus_author_id"=>"57199412367"}, {"first_name"=>"Annette", "last_name"=>"Persson", "scopus_author_id"=>"56209703100"}, {"first_name"=>"Yingyu", "last_name"=>"Sun", "scopus_author_id"=>"14062561100"}, {"first_name"=>"Leif G.", "last_name"=>"Salford", "scopus_author_id"=>"7006727966"}, {"first_name"=>"David Gisselsson", "last_name"=>"Nord", "scopus_author_id"=>"55955564800"}, {"first_name"=>"Elisabet", "last_name"=>"Englund", "scopus_author_id"=>"7004229929"}, {"first_name"=>"Tao", "last_name"=>"Jiang", "scopus_author_id"=>"56421086000"}, {"first_name"=>"Xiaolong", "last_name"=>"Fan", "scopus_author_id"=>"7403393699"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23630597", "sgr"=>"84876431830", "doi"=>"10.1371/journal.pone.0061556", "scopus"=>"2-s2.0-84876431830", "pui"=>"368766936", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"064a38cb-0387-369d-9d54-9bf214b7f589", "abstract"=>"Signaling of platelet derived growth factor receptor alpha (PDGFRA) is critically involved in the development of gliomas. However, the clinical relevance of PDGFRA expression in glioma subtypes and the mechanisms of PDGFRA expression in gliomas have been controversial. Under the supervision of morphological diagnosis, analysis of the GSE16011 and the Repository of Molecular Brain Neoplasia Data (Rembrandt) set revealed enriched PDGFRA expression in low-grade gliomas. However, gliomas with the top 25% of PDGFRA expression levels contained nearly all morphological subtypes, which was associated with frequent IDH1 mutation, 1p LOH, 19q LOH, less EGFR amplification, younger age at disease onset and better survival compared to those gliomas with lower levels of PDGFRA expression. SNP analysis in Rembrandt data set and FISH analysis in eleven low passage glioma cell lines showed infrequent amplification of PDGFRA. Using in vitro culture of these low passage glioma cells, we tested the hypothesis of gliogenic factor dependent expression of PDGFRA in glioma cells. Fibroblast growth factor 2 (FGF2) was able to maintain PDGFRA expression in glioma cells. FGF2 also induced PDGFRA expression in glioma cells with low or non-detectable PDGFRA expression. FGF2-dependent maintenance of PDGFRA expression was concordant with the maintenance of a subset of gliogenic genes and higher rates of cell proliferation. Further, concordant expression patterns of FGF2 and PDGFRA were detected in glioma samples by immunohistochemical staining. Our findings suggest a role of FGF2 in regulating PDGFRA expression in the subset of gliomas with younger age at disease onset and longer patient survival regardless of their morphological diagnosis.", "link"=>"http://www.mendeley.com/research/better-prognosis-patients-glioma-expressing-fgf2dependent-pdgfra-irrespective-morphological-diagnosi", "reader_count"=>9, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>5, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1031208"], "description"=>"<p><b>A</b>) Low-passage glioma cell lines were cultured in a growth factor cocktail consisting of SHH, PDGFA and FGF2 (+FGF2), or only SHH and PDGFA (−FGF2). The relative cell numbers after one passage of culture for 7 to 10 days are shown under the 2 conditions. <b>B</b>) L2 cells were cultured for 7 days with (+) or without (−) FGF2 support alone. The percentages of S-phase cells were evaluated by BrdU assays.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "proliferation"], "article_id"=>687712, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FGF2_dependent_cell_proliferation_in_vitro_/687712", "title"=>"FGF2-dependent cell proliferation <i>in vitro</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-22 02:08:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031206"], "description"=>"<p>The SNP data in the Rembrandt data set were analyzed for the gain or loss of <i>PDGFRA</i> (<b>A</b>) and <i>EGFR</i> (<b>B</b>) using dChip and GISTIC2.0 with glioma samples grouped according to the relative levels of PDGFRA or EGFR expression. In each plot, the X-axis indicates the relative levels of PDGFRA or EGFR expression, and the Y-axis indicates the extent of <i>PDGFRA</i> or <i>EGFR</i> gain or loss (2, 1, 0, −1 and −2 for above 3.7 copies of genes, 2.3–3.7 copies of gene, no detectable alteration, heterozygous loss, and homozygous loss, respectively).</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "enriched", "pdgfra", "amplification", "glioma"], "article_id"=>687710, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Infrequent_association_between_enriched_PDGFRA_expression_and_PDGFRA_amplification_in_glioma_genomes_/687710", "title"=>"Infrequent association between enriched PDGFRA expression and <i>PDGFRA</i> amplification in glioma genomes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-22 02:08:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031218"], "description"=>"<p><b>++:</b> Markedly positive staining. <b>+:</b> Low-moderately positive staining. <b>−:</b> No positive staining.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "staining", "pdgfra", "fgf2", "glioma", "samples", "predominant"], "article_id"=>687721, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.t003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemical_staining_results_for_PDGFRA_and_FGF2_in_glioma_samples_Predominant_staining_intensity_in_each_sample_/687721", "title"=>"Immunohistochemical staining results for PDGFRA and FGF2 in glioma samples - Predominant staining intensity in each sample.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-22 02:08:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031217"], "description"=>"<p>Consecutive sections for each glioma samples were used for the staining of FGF2 and PDGFRA. Staining results of representative glioma samples are shown. In all samples, a correlation between the extent of FGF2 and PDGFRA staining was observed. The scale bars denote 20 µm.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "patterns", "fgf2", "pdgfra", "immunohistochemical", "staining", "glioma"], "article_id"=>687720, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.g008", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Concordant_patterns_of_FGF2_and_PDGFRA_immunohistochemical_staining_in_glioma_samples_/687720", "title"=>"Concordant patterns of FGF2 and PDGFRA immunohistochemical staining in glioma samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-22 02:08:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031211"], "description"=>"<p>Two glioma cell lines (L1 and L2) were cultured under +FGF2 or −FGF2 conditions. PDGFRA expression was undetectable in −FGF2 samples as assessed by flow cytometry; mRNA from three replicate samples under each of the two conditions were extracted and prepared for analysis with GeneChip human gene ST array. Data shown are the differential expression of subset of gliogenic genes under +FGF2 or −FGF2 conditions.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "maintained", "subset", "gliogenic", "genes", "glioma"], "article_id"=>687715, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.g006", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FGF2_maintained_the_expression_of_a_subset_of_gliogenic_genes_in_glioma_cells_/687715", "title"=>"FGF2 maintained the expression of a subset of gliogenic genes in glioma cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-22 02:08:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031210"], "description"=>"<p><b>A</b>) Fresh cells from 3 different glioma samples without detectable PDGFRA expression cultured with the support of FGF2 for 2 to 3 weeks were analyzed for PDGFRA expression and compared with the fresh cells from the same patients simultaneously. <b>B</b>) and <b>C</b>) L2 cells from xenograft gliomas <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061556#pone.0061556-Glanz1\" target=\"_blank\">[35]</a> were cultured for 9 days under +FGF2 or −FGF2 conditions and assessed for PDGFRA expression by flow cytometry and RT-PCR analysis, respectively. Non-cultured cells served as control (0 days).</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "pdgfra", "glioma"], "article_id"=>687714, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Induction_of_PDGFRA_expression_in_glioma_cells_/687714", "title"=>"Induction of PDGFRA expression in glioma cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-22 02:08:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031225", "https://ndownloader.figshare.com/files/1031226"], "description"=>"<div><p>Signaling of platelet derived growth factor receptor alpha (PDGFRA) is critically involved in the development of gliomas. However, the clinical relevance of PDGFRA expression in glioma subtypes and the mechanisms of PDGFRA expression in gliomas have been controversial. Under the supervision of morphological diagnosis, analysis of the GSE16011 and the Repository of Molecular Brain Neoplasia Data (Rembrandt) set revealed enriched PDGFRA expression in low-grade gliomas. However, gliomas with the top 25% of PDGFRA expression levels contained nearly all morphological subtypes, which was associated with frequent <i>IDH1</i> mutation, 1p LOH, 19q LOH, less EGFR amplification, younger age at disease onset and better survival compared to those gliomas with lower levels of PDGFRA expression. SNP analysis in Rembrandt data set and FISH analysis in eleven low passage glioma cell lines showed infrequent amplification of <i>PDGFRA</i>. Using <i>in vitro</i> culture of these low passage glioma cells, we tested the hypothesis of gliogenic factor dependent expression of PDGFRA in glioma cells. Fibroblast growth factor 2 (FGF2) was able to maintain PDGFRA expression in glioma cells. FGF2 also induced PDGFRA expression in glioma cells with low or non-detectable PDGFRA expression. FGF2-dependent maintenance of PDGFRA expression was concordant with the maintenance of a subset of gliogenic genes and higher rates of cell proliferation. Further, concordant expression patterns of FGF2 and PDGFRA were detected in glioma samples by immunohistochemical staining. Our findings suggest a role of FGF2 in regulating PDGFRA expression in the subset of gliomas with younger age at disease onset and longer patient survival regardless of their morphological diagnosis.</p></div>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "prognosis", "patients", "glioma", "expressing", "fgf2-dependent", "pdgfra", "irrespective", "morphological"], "article_id"=>687727, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0061556.s001", "https://dx.doi.org/10.1371/journal.pone.0061556.s002"], "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Better_Prognosis_of_Patients_with_Glioma_Expressing_FGF2_Dependent_PDGFRA_Irrespective_of_Morphological_Diagnosis_/687727", "title"=>"Better Prognosis of Patients with Glioma Expressing FGF2-Dependent PDGFRA Irrespective of Morphological Diagnosis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-04-22 02:08:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031220"], "description"=>"<p>PDGFRA expression among the glioma samples in GSE16011 and the Rembrandt data sets was analyzed independent of morphological diagnosis. The samples with the upmost 25% of PDGFRA expression (PDGFRA-high) were compared with the samples with the lowest 25% of PDGFRA expression (PDGFRA-low) and the samples with the 50% intermediate levels of PDGFRA expression (PDGFRA intermediate) regarding frequencies of IDH1 mutation, age at diagnosis and survival period. The data on IDH1 mutation, LOH at 1p and 19q, and EGFR amplification for GSE16011 data set were derived from the results of Gravendeel et al <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061556#pone.0061556-Gravendeel1\" target=\"_blank\">[27]</a>. The data on LOH in regions of 1p36 (1p36.23 or 1p36.32 or 1p36.31) and 19q13 (19q13.32 or 19q13.41) as analyzed by Mariani <i>et al.</i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061556#pone.0061556-Mariani1\" target=\"_blank\">[47]</a>, and EGFR amplification for the Rembrandt data set were derived from GISTIC2.0 analysis of the 50K <i>HindIII</i> SNP array data <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061556#pone.0061556-Madhavan1\" target=\"_blank\">[28]</a>. The differences for <i>IDH1</i> mutation rate, LOH at 1p and 19q and EGFR amplification were analyzed using chi-square test. The median age at diagnosis and survival period between the PDGFRA subgroups were analyzed using Fisher's exact test, One-way Anova and log-rank tests, respectively.</p>*<p>: Comparison with the PDGFRA-high group.</p>**<p>: The number of patients with known survival data.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "gliomas", "varying", "pdgfra"], "article_id"=>687723, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.t001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathological_and_clinical_parameters_of_gliomas_with_varying_extent_of_PDGFRA_expression_/687723", "title"=>"Pathological and clinical parameters of gliomas with varying extent of PDGFRA expression.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-22 02:08:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031204"], "description"=>"<p>In both GSE16011 (<b>A, B</b>) and Rembrandt (<b>C, D</b>) data sets, PDGFRA expression (Mean ± 2 SEM, SEM: standard error of the mean) was highly variable among the samples of each morphological subtype (<b>A</b> and <b>C.</b> NT: non-tumor; AII, astrocytoma grade II; AIII: astrocytoma grade III; GBM, glioblastoma; OD: oligodendroglioma; OA: oligoastrocytoma). Low-grade gliomas showed significantly higher levels of PDGFRA expression compared to high-grade gliomas (<b>B</b> and <b>D</b>). Kaplan-Meier plots showed that in both GSE16011 (<b>E</b>) and Rembrandt (<b>F</b>) data sets, the survival of patients with the upper 25% PDGFRA expression (PDGFRA-high) in glioma samples irrespective of their morphological diagnosis was significantly longer compared with those glioma patients with PDGFRA expression at the lowest 25% (PDGFRA-low) and the intermediate 50% (log-rank test).</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "pdgfra", "glioma", "subtypes"], "article_id"=>687708, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.g001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_expression_of_PDGFRA_in_glioma_subtypes_and_its_association_with_patient_survival_time_/687708", "title"=>"Differential expression of PDGFRA in glioma subtypes and its association with patient survival time.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-22 02:08:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031219"], "description"=>"<p>Freshly isolated glioma cells were stained with anti-CD45 and anti-PDGFRA mAbs and analyzed by flow cytometry. The remaining cells were cultured under +FGF2 condition, karyotyped and also assessed for <i>PDGFRA</i> copy numbers with FISH analysis. The FGF2 dependent PDGFRA expression was observed in cells derived from patients L3, L5, L6, L8, L11, L12, L13, and also L14. Cells from L1, L4 and L10, which initially did not express PDGFRA, expressed PDGFRA following FGF2 supported culture protocol.</p>*<p>: 41–42,X, -Y, der (1) t (1; 17)(p36; q21), add (4)(q31), del (6)(q21), +7, −10, −11, −13, −14,? dup (14)(q12q22),−15,−17,+2mar,inc[cp9]/80–84,idemx2[cp16].</p>**<p>: 46,XY, ins (1; 4)(p36; q31q25), t (1; 12)(q21; p11) <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061556#pone.0061556-Assanah1\" target=\"_blank\">[18]</a>/46,XY, add (1)(p36), del (10)(q24), del (15)(q24), −17, +mar <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061556#pone.0061556-Holland1\" target=\"_blank\">[7]</a>. UD: undetectable.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "pdgfra", "amplification", "glioma", "cells"], "article_id"=>687722, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_No_association_between_PDGFRA_expression_and_PDGFRA_amplification_in_glioma_cells_as_detected_by_FISH_assay_/687722", "title"=>"No association between PDGFRA expression and <i>PDGFRA</i> amplification in glioma cells as detected by FISH assay.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-22 02:08:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031213"], "description"=>"<p>The relative expression levels of FGF2 (Mean ± 2SEM) were analyzed in the GSE16011 (<b>A</b> and <b>B</b>) and the Rembrandt (<b>C</b> and <b>D</b>) data sets according to the morphological diagnosis of gliomas (<b>A</b> and <b>C</b>). Low-grade gliomas showed significantly higher levels of FGF2 expression compared to high-grade gliomas (<b>B</b> and <b>D</b>, <i>t</i> test).</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "fgf2", "low-grade"], "article_id"=>687717, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.g007", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enriched_FGF2_expression_in_low_grade_gliomas_/687717", "title"=>"Enriched FGF2 expression in low-grade gliomas.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-22 02:08:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1031207"], "description"=>"<p><b>A</b>) Percentages of PDGFRA-positive cells in the indicated glioma cell lines (L1–L9) following a culture for 7 to 10 days with (+) or without (−) FGF2 support. <b>B</b>) Maintenance of PDGFRA expression in glioma cells (L1 and L2) cultured with the support of FGF2 alone for 7 days. In contrast to PDGFRA, the expression of CD44 was not affected by FGF2. <b>C</b>) RT-PCR detection of PDGFRA expression in the parallel cultures as in <b>B</b>).</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Molecular cell biology", "gene expression", "neuroscience", "Molecular neuroscience", "Signaling pathways", "Neurobiology of disease and regeneration", "Anatomy and physiology", "Neurological system", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "oncology", "Cancers and neoplasms", "Neurological tumors", "pdgfra"], "article_id"=>687711, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Dongfeng Chen", "Annette Persson", "Yingyu Sun", "Leif G. Salford", "David Gisselsson Nord", "Elisabet Englund", "Tao Jiang", "Xiaolong Fan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0061556.g003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FGF2_dependent_maintenance_of_PDGFRA_expression_/687711", "title"=>"FGF2-dependent maintenance of PDGFRA expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-22 02:08:31"}

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Relative Metric

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