GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation", "type"=>"journal", "authors"=>[{"first_name"=>"Russell S.", "last_name"=>"Taichman", "scopus_author_id"=>"6701662790"}, {"first_name"=>"Lalit R.", "last_name"=>"Patel", "scopus_author_id"=>"35737826300"}, {"first_name"=>"Rachel", "last_name"=>"Bedenis", "scopus_author_id"=>"57194415141"}, {"first_name"=>"Jingcheng", "last_name"=>"Wang", "scopus_author_id"=>"55742671700"}, {"first_name"=>"Savannah", "last_name"=>"Weidner", "scopus_author_id"=>"36674038900"}, {"first_name"=>"Taibriana", "last_name"=>"Schumann", "scopus_author_id"=>"55428745100"}, {"first_name"=>"Kenji", "last_name"=>"Yumoto", "scopus_author_id"=>"55659988100"}, {"first_name"=>"Janice E.", "last_name"=>"Berry", "scopus_author_id"=>"7402634264"}, {"first_name"=>"Yusuke", "last_name"=>"Shiozawa", "scopus_author_id"=>"16744664800"}, {"first_name"=>"Kenneth J.", "last_name"=>"Pienta", "scopus_author_id"=>"35391524600"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368794590", "sgr"=>"84876545834", "pmid"=>"23637920", "scopus"=>"2-s2.0-84876545834", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0061873", "issn"=>"19326203"}, "id"=>"c3ec31ab-ba7d-31d3-bcd5-28872363622c", "abstract"=>"Disseminated tumor cells (DTCs) are believed to lie dormant in the marrow before they can be activated to form metastases. How DTCs become dormant in the marrow and how dormant DTCs escape dormancy remains unclear. Recent work has shown that prostate cancer (PCa) cell lines express the growth-arrest specific 6 (GAS6) receptors Axl, Tyro3, and Mer, and become growth arrested in response to GAS6. We therefore hypothesized that GAS6 signaling regulates the proliferative activity of DTCs in the marrow. To explore this possibility, in vivo studies were performed where it was observed that when Tyro3 expression levels exceed Axl expression, the PCa cells exhibit rapid growth. When when Axl levels predominate, PCa cells remain largely quiescent. These findings suggest that a balance between the expression of Axl and Tyro3 is associated with a molecular switch between a dormant and a proliferative phenotype in PCa metastases.", "link"=>"http://www.mendeley.com/research/gas6-receptor-status-associated-dormancy-bone-metastatic-tumor-formation", "reader_count"=>36, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>5, "Researcher"=>8, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>5, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>5, "Researcher"=>8, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>5, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>9, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>16, "Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"Mexico"=>1, "Italy"=>1}, "group_count"=>3}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84876545834"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84876545834?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876545834&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84876545834&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84876545834", "dc:identifier"=>"SCOPUS_ID:84876545834", "eid"=>"2-s2.0-84876545834", "dc:title"=>"GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation", "dc:creator"=>"Taichman R.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-04-24", "prism:coverDisplayDate"=>"24 April 2013", "prism:doi"=>"10.1371/journal.pone.0061873", "citedby-count"=>"61", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Michigan School of Dentistry", "affiliation-city"=>"Ann Arbor", "affiliation-country"=>"United States"}], "pubmed-id"=>"23637920", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e61873", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0061873", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"60", "xml_views"=>"3", "html_views"=>"138"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"4", "html_views"=>"81"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"4", "html_views"=>"91"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"69"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"45"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"69"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"110"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"3", "html_views"=>"100"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"25"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1035059"], "description"=>"<p>(A) FACS analysis for GAS6 receptors. The human PC3, VCaP, LNCaP, and DU145 PCa cell lines, human bone marrow endothelial cells (HBME), MG-63 human osteosarcoma cell line and primary human fetal osetoblasts (hFOB) were stained with antibodies targeting Axl, Tyro3 or Mer and the % expression were compared to IgG controls for each antibody for n = 3 samples. The data is expressed as avg. ± s.d. *<i>p</i><0.05 compared to expression of Axl for each cell type. (B). Western blot analysis for Tyro3. Since Tyro3 expression was not detected in (A) by FACS, validation by Western Blot of PCa cell lysates (30 µg) was performed. Lysates (1 µg) recovered from HEK293 cells which over expressed of human Tyro 3 (or vector control) were used as positive and negative controls for Tyro3 expression. Normalization of PCa cell extracts was evaluated by staining with antibody to ß-Actin (not shown).</p>", "links"=>[], "tags"=>["Molecular cell biology", "hematology", "hematopoiesis", "oncology", "Basic cancer research", "metastasis", "Tumor physiology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "receptor", "pca"], "article_id"=>690823, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Russell S. Taichman", "Lalit R. Patel", "Rachel Bedenis", "Jingcheng Wang", "Savannah Weidner", "Taibriana Schumann", "Kenji Yumoto", "Janice E. Berry", "Yusuke Shiozawa", "Kenneth J. Pienta"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0061873.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GAS6_receptor_expression_by_PCa_cell_lines_/690823", "title"=>"GAS6 receptor expression by PCa cell lines.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-24 00:13:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1035061"], "description"=>"<p>Human PC3 cells were plated at 2,500 cells/well into 96-well flat bottom tissue culture with increasing concentrations of (A) murine or (B) human GAS6 (0, 0.5, 1.0, 2.0, and 4.0 µg/ml). Proliferation over time was quantified by impedance measurements in the ACEA RT-CES real-time cellular proliferation assay system. n = 6 wells. The data is expressed as avg. ± s.d. over time. *<i>p</i><0.05 compared to 0 µg/ml GAS6.</p>", "links"=>[], "tags"=>["Molecular cell biology", "hematology", "hematopoiesis", "oncology", "Basic cancer research", "metastasis", "Tumor physiology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "gas6", "inhibits", "pc3", "cells"], "article_id"=>690825, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Russell S. Taichman", "Lalit R. Patel", "Rachel Bedenis", "Jingcheng Wang", "Savannah Weidner", "Taibriana Schumann", "Kenji Yumoto", "Janice E. Berry", "Yusuke Shiozawa", "Kenneth J. Pienta"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0061873.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Murine_and_human_GAS6_inhibits_growth_of_human_PC3_cells_in_vitro_/690825", "title"=>"Murine and human GAS6 inhibits growth of human PC3 cells in vitro.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-24 00:13:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1035066"], "description"=>"<p>(<b>A</b>) Experimental model. Human PCa cell lines (PC3<sup>Luc</sup>, DU145<sup>Luc</sup>) were implanted <i>s.c.</i> into male SCID mice as a model of a primary (1°) tumor development, and removed after 1 month. At monthly intervals thereafter human PCa cells were identified by anti-HLA staining; proliferative status (Ki67 staining) and Axl or Tyro3 levels were evaluated by FACS. (<b>B</b>) When <i>s.c.</i> tumors were identified and removed, and the animals were reimaged 1 day later and at 2 months by BLI to determine if regrowth had occurred at the primary tumor bed. ROI = Region of interest (<b>C</b>) Percent expression of HLA by lineage depleted (Lin<sup>-</sup>) marrow cells or by primary tumor cells at 1 month. (<b>D</b>) Percent expression of Ki67 by lineage depleted (Lin<sup>-</sup>) marrow cells or by primary tumor cells at 1 month. Percent expression of Axl or Tyro3 by primary tumor cells established with (<b>E</b>) DU145 or (<b>F</b>) PC3 cells or by DTCs recovered from marrow over time. (<b>G</b>) At 5 months bone metastatic lesions were detected in animals initially implanted with <i>s.c.</i> DU145. Percent expression of HLA by DTCs isolated from the non-metastatic limb or in the metastatic lesion. (<b>H</b>) Expression of Ki67 by HLA expressing DTCs, or by PCa cells recovered from bone metastatic lesions. (<b>I</b>) Percent expression of Axl and Tyro3 by HLA expressing DTCs isolated from the non-metastatic limb or by cells recovered from the metastatic lesion. *<i>p</i><0.05 compared to expression of each receptor in the primary tumors.</p>", "links"=>[], "tags"=>["Molecular cell biology", "hematology", "hematopoiesis", "oncology", "Basic cancer research", "metastasis", "Tumor physiology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "tyro3", "pca"], "article_id"=>690830, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Russell S. Taichman", "Lalit R. Patel", "Rachel Bedenis", "Jingcheng Wang", "Savannah Weidner", "Taibriana Schumann", "Kenji Yumoto", "Janice E. Berry", "Yusuke Shiozawa", "Kenneth J. Pienta"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0061873.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Axl_and_Tyro3_expression_during_experimental_PCa_progression_/690830", "title"=>"Axl and Tyro3 expression during experimental PCa progression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-24 00:13:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/1035069"], "description"=>"<p>Immunohistochemistry for Axl and Tyro3 expression during PC3 progression to metastasis from a <i>s.c.</i> primary tumor. (<b>A</b>) Primary tumor, marrow DTCs and femur metastasis stained with DAPI nuclear stain (blue), human HLA antigens (green), and Tyro3 (red). Double stained cells for HLA and Tyro3 appear yellow or white when merged. Inserts represent each individual stain merged in the larger panel. (<b>B</b>) Sections stained with DAPI nuclear stain (blue), human HLA antigens (green), and Axl (red). Double stained cells for HLA and Axl appear yellow or white when merged. Bar = 100 microns.</p>", "links"=>[], "tags"=>["Molecular cell biology", "hematology", "hematopoiesis", "oncology", "Basic cancer research", "metastasis", "Tumor physiology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "axl", "tyro3", "pca", "progression", "pc3"], "article_id"=>690833, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Russell S. Taichman", "Lalit R. Patel", "Rachel Bedenis", "Jingcheng Wang", "Savannah Weidner", "Taibriana Schumann", "Kenji Yumoto", "Janice E. Berry", "Yusuke Shiozawa", "Kenneth J. Pienta"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0061873.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_Axl_and_Tyro3_during_experimental_PCa_progression_by_PC3_cells_/690833", "title"=>"Expression of Axl and Tyro3 during experimental PCa progression by PC3 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-24 00:13:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1035071"], "description"=>"<p>(<b>A</b>) Experimental model. Human PCa cell lines (PC3<sup>Luc</sup> and DU145<sup>Luc</sup>) were injected <i>i.c.</i> into SCID mice and PCa cells were recovered at (<b>B</b>) at 72h. * <i>p</i><0.05 compared to the expression of Tyro3 to Axl. As bone metastatic lesions were identified by BLI, paired limbs were flushed and human PCa cells were identified by anti-HLA staining. Axl or Tyro3 levels were evaluated by FACS for (<b>C</b>) Du145 and (<b>D</b>) PC3 cells. *<i>p</i><0.05 compared to the expression of each receptor by paired DTC sample.</p>", "links"=>[], "tags"=>["Molecular cell biology", "hematology", "hematopoiesis", "oncology", "Basic cancer research", "metastasis", "Tumor physiology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "axl", "tyro3", "intracardiac", "injection", "disseminated"], "article_id"=>690835, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Russell S. Taichman", "Lalit R. Patel", "Rachel Bedenis", "Jingcheng Wang", "Savannah Weidner", "Taibriana Schumann", "Kenji Yumoto", "Janice E. Berry", "Yusuke Shiozawa", "Kenneth J. Pienta"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0061873.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_Axl_and_Tyro3_following_intracardiac_injection_and_establishment_of_disseminated_disease_/690835", "title"=>"Expression of Axl and Tyro3 following intracardiac injection and establishment of disseminated disease.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-24 00:13:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1035073"], "description"=>"<p>Conceptual model demonstrating for Axl and Tyro3 expression during prostate cancer progression to metastasis. When Axl expression by PCa cells predominates, GAS6 inhibits growth. When Tyro3 expression predominates or when Tyro3 and Axl expression is equivalent, proliferation appears to be the predominant response of PCa to GAS6.</p>", "links"=>[], "tags"=>["Molecular cell biology", "hematology", "hematopoiesis", "oncology", "Basic cancer research", "metastasis", "Tumor physiology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "axl", "tyro3", "pca", "progression"], "article_id"=>690837, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Russell S. Taichman", "Lalit R. Patel", "Rachel Bedenis", "Jingcheng Wang", "Savannah Weidner", "Taibriana Schumann", "Kenji Yumoto", "Janice E. Berry", "Yusuke Shiozawa", "Kenneth J. Pienta"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0061873.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Conceptual_model_of_Axl_and_Tyro3_expression_during_PCa_progression_to_metastasis_/690837", "title"=>"Conceptual model of Axl and Tyro3 expression during PCa progression to metastasis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-04-24 00:13:57"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"62", "full-text"=>"64", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"39", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"29", "full-text"=>"35", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"25", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"23", "full-text"=>"18", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"9", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"9", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"16", "pdf"=>"10", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"25", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"31", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"23", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"21", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[248, 440, 562, 666, 765, 856, 944, 1028, 1112, 1198, 1282, 1362, 1430]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[248, 441, 564, 668, 769, 859, 948, 1034, 1117, 1202, 1290, 1368, 1437]}]}
Loading … Spinner
There are currently no alerts