C5a Receptor Deficiency Alters Energy Utilization and Fat Storage
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{"title"=>"C5a Receptor Deficiency Alters Energy Utilization and Fat Storage", "type"=>"journal", "authors"=>[{"first_name"=>"Christian", "last_name"=>"Roy", "scopus_author_id"=>"56858022000"}, {"first_name"=>"Abhishek", "last_name"=>"Gupta", "scopus_author_id"=>"57108873300"}, {"first_name"=>"Alexandre", "last_name"=>"Fisette", "scopus_author_id"=>"23970259200"}, {"first_name"=>"Marc", "last_name"=>"Lapointe", "scopus_author_id"=>"35170223600"}, {"first_name"=>"Pegah", "last_name"=>"Poursharifi", "scopus_author_id"=>"35389437600"}, {"first_name"=>"Denis", "last_name"=>"Richard", "scopus_author_id"=>"55991119800"}, {"first_name"=>"Hui Ling", "last_name"=>"Lu", "scopus_author_id"=>"55516883200"}, {"first_name"=>"Bao", "last_name"=>"Lu", "scopus_author_id"=>"26643425700"}, {"first_name"=>"Norma", "last_name"=>"Gerard", "scopus_author_id"=>"7103204399"}, {"first_name"=>"Craig", "last_name"=>"Gerard", "scopus_author_id"=>"7102241882"}, {"first_name"=>"Katherine", "last_name"=>"Cianflone", "scopus_author_id"=>"35497578900"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368859887", "sgr"=>"84877117500", "issn"=>"19326203", "pmid"=>"23667486", "scopus"=>"2-s2.0-84877117500", "doi"=>"10.1371/journal.pone.0062531"}, "id"=>"220e950d-6f0b-3bd9-a6cc-4c0ef9460001", "abstract"=>"OBJECTIVE: To investigate the impact of whole body C5a receptor (C5aR) deficiency on energy metabolism and fat storage.\\n\\nDESIGN: Male wildtype (WT) and C5aR knockout (C5aRKO) mice were fed a low fat (CHOW) or a high fat high sucrose diet-induced obesity (DIO) diet for 14 weeks. Body weight and food intake were measured weekly. Indirect calorimetry, dietary fatload clearance, insulin and glucose tolerance tests were also evaluated. Liver, muscle and adipose tissue mRNA gene expression were measured by RT-PCR.\\n\\nRESULTS: At week one and 12, C5aRKO mice on DIO had increased oxygen consumption. After 12 weeks, although food intake was comparable, C5aRKO mice had lower body weight (-7% CHOW, -12% DIO) as well as smaller gonadal (-38% CHOW, -36% DIO) and inguinal (-29% CHOW, -30% DIO) fat pads than their WT counterparts. Conversely, in WT mice, C5aR was upregulated in DIO vs CHOW diets in gonadal adipose tissue, muscle and liver, while C5L2 mRNA expression was lower in C5aRKO on both diet. Furthermore, blood analysis showed lower plasma triglyceride and non-esterified fatty acid levels in both C5aRKO groups, with faster postprandial triglyceride clearance after a fatload. Additionally, C5aRKO mice showed lower CD36 expression in gonadal and muscle on both diets, while DGAT1 expression was higher in gonadal (CHOW) and liver (CHOW and DIO) and PPARγ was increased in muscle and liver.\\n\\nCONCLUSION: These observations point towards a role (either direct or indirect) for C5aR in energy expenditure and fat storage, suggesting a dual role for C5aR in metabolism as well as in immunity.", "link"=>"http://www.mendeley.com/research/c5a-receptor-deficiency-alters-energy-utilization-fat-storage", "reader_count"=>5, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1056257"], "description"=>"<div><p>Objective</p><p>To investigate the impact of whole body C5a receptor (C5aR) deficiency on energy metabolism and fat storage.</p><p>Design</p><p>Male wildtype (WT) and C5aR knockout (C5aRKO) mice were fed a low fat (CHOW) or a high fat high sucrose diet-induced obesity (DIO) diet for 14 weeks. Body weight and food intake were measured weekly. Indirect calorimetry, dietary fatload clearance, insulin and glucose tolerance tests were also evaluated. Liver, muscle and adipose tissue mRNA gene expression were measured by RT-PCR.</p><p>Results</p><p>At week one and 12, C5aRKO mice on DIO had increased oxygen consumption. After 12 weeks, although food intake was comparable, C5aRKO mice had lower body weight (−7% CHOW, −12% DIO) as well as smaller gonadal (−38% CHOW, −36% DIO) and inguinal (−29% CHOW, −30% DIO) fat pads than their WT counterparts. Conversely, in WT mice, C5aR was upregulated in DIO vs CHOW diets in gonadal adipose tissue, muscle and liver, while C5L2 mRNA expression was lower in C5aRKO on both diet. Furthermore, blood analysis showed lower plasma triglyceride and non-esterified fatty acid levels in both C5aRKO groups, with faster postprandial triglyceride clearance after a fatload. Additionally, C5aRKO mice showed lower CD36 expression in gonadal and muscle on both diets, while DGAT1 expression was higher in gonadal (CHOW) and liver (CHOW and DIO) and PPAR<b>γ</b> was increased in muscle and liver.</p><p>Conclusion</p><p>These observations point towards a role (either direct or indirect) for C5aR in energy expenditure and fat storage, suggesting a dual role for C5aR in metabolism as well as in immunity.</p></div>", "links"=>[], "tags"=>["Anatomy and physiology", "Physiological processes", "Energy metabolism", "Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Model organisms", "Animal models", "mouse", "Metabolic disorders", "nutrition", "receptor", "deficiency", "alters"], "article_id"=>699785, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Christian Roy", "Abhishek Gupta", "Alexandre Fisette", "Marc Lapointe", "Pegah Poursharifi", "Denis Richard", "HuiLing Lu", "Bao Lu", "Norma Gerard", "Craig Gerard", "Katherine Cianflone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0062531", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_C5a_Receptor_Deficiency_Alters_Energy_Utilization_and_Fat_Storage_/699785", "title"=>"C5a Receptor Deficiency Alters Energy Utilization and Fat Storage", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-07 02:43:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1056253"], "description"=>"<p>Gene expression for immune factors <i>CD11c</i> (A) and <i>F4/80</i> (B) and for lipid-related factors fatty acid transporter (<i>CD36</i>), fatty acid synthase (<i>FAS</i>), lipoprotein lipase (<i>LPL</i>), diacylglycerolacyltransferase-1 (<i>DGAT1</i>), diacylglycerolacyltransferase-2 (<i>DGAT2</i>) and peroxisome-proliferator activated receptor gamma (<i>PPARG</i>) (G) were evaluated in WT CHOW diet (open bars), C5aRKO CHOW (solid bars), WT DIO diet (checkered bars) and C5aRKO DIO (striped bars) in gonadal adipose tissue, where n = 6–12 per group. MCP-1 (C) and KC (D) secretion were measured in <i>ex vivo</i> adipose tissue in WT (white bars) and C5aRKO (diagonally striped bars) mice following overnight (24h) treatment with C5a (50 ng/mL), LPS, or both vs control (CTL) where n = 8–10 per group. <i>Ex vivo</i> C3 secretion (E) and ASP production (F) were measured in media from adipose tissue of WT CHOW diet, C5aRKO CHOW, WT DIO and C5aRKO DIO incubated for 24 h. Results are expressed as means ± SEM; statistical differences were determined by ANOVA followed by Bonferroni post-test, where *P<0.05, **P<0.001 and ***P<0.0001 vs CTL (C, D) or vs WT on their respective diet (A,B,E-G) unless otherwise indicated.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Physiological processes", "Energy metabolism", "Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Model organisms", "Animal models", "mouse", "Metabolic disorders", "nutrition", "adipose", "metabolic", "c5arko"], "article_id"=>699783, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Christian Roy", "Abhishek Gupta", "Alexandre Fisette", "Marc Lapointe", "Pegah Poursharifi", "Denis Richard", "HuiLing Lu", "Bao Lu", "Norma Gerard", "Craig Gerard", "Katherine Cianflone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0062531.g006", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Evaluation_of_adipose_tissue_immune_and_metabolic_function_in_C5aRKO_mice_/699783", "title"=>"Evaluation of adipose tissue immune and metabolic function in C5aRKO mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-07 02:43:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/1056256"], "description"=>"<p>Body and tissue weights, food intake and plasma triglyceride (TG), non-esterified fatty acids (NEFA) and cholesterol were measured in wildtype (WT) and C5aRKO on chow and high fat high sucrose diet-induced obesity (DIO) diet for n = 10–14 per group. Results are expressed as means ± SEM, and statistical differences were evaluated by ANOVA followed by Bonferroni post-test, where *P<0.05 and ***P<0.0001 vs WT on their respective diet, or for DIO vs CHOW where “a” indicates P<0.05 for WT DIO vs WT CHOW and “b” indicates P<0.05 for C5aRKO DIO vs C5aRKO CHOW.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Physiological processes", "Energy metabolism", "Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Model organisms", "Animal models", "mouse", "Metabolic disorders", "nutrition", "intake", "plasma", "wildtype", "c5ar", "knockout"], "article_id"=>699784, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Christian Roy", "Abhishek Gupta", "Alexandre Fisette", "Marc Lapointe", "Pegah Poursharifi", "Denis Richard", "HuiLing Lu", "Bao Lu", "Norma Gerard", "Craig Gerard", "Katherine Cianflone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0062531.t001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_and_tissue_weights_food_intake_and_plasma_parameters_in_wildtype_and_C5aR_knockout_mice_/699784", "title"=>"Body and tissue weights, food intake and plasma parameters in wildtype and C5aR knockout mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-07 02:43:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1056251"], "description"=>"<p>Plasma levels of C3 (A) and C5a (B) in WT and C5aRKO on chow and DIO diet for n = 8–12 per group. Gene expression in quadriceps muscle tissue (C) and liver (D) for fatty acid transporter (<i>CD36</i>), fatty acid synthase (<i>FAS</i>), lipoprotein lipase (<i>LPL</i>), diacylglycerolacyltransferase-1 (<i>DGAT1</i>), diacylglycerolacyltransferase-2 (<i>DGAT2</i>) and peroxisome-proliferator activated receptor gamma (<i>PPARG</i>) were measured in WT CHOW diet (open bars), C5aRKO CHOW (solid bars), WT diet-induced obesity (DIO) diet (checkered bars) and C5aRKO DIO (striped bars) for n = 6–12 per group. Results are expressed as means ± SEM; statistical differences were determined by t-test, where *P<0.05 and**P<0.001 and ***P<0.0001 for C5aRKO vs WT on the same diet, unless otherwise indicated.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Physiological processes", "Energy metabolism", "Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Model organisms", "Animal models", "mouse", "Metabolic disorders", "nutrition", "c5a", "plasma", "mrna", "genes", "implicated", "substrate"], "article_id"=>699782, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Christian Roy", "Abhishek Gupta", "Alexandre Fisette", "Marc Lapointe", "Pegah Poursharifi", "Denis Richard", "HuiLing Lu", "Bao Lu", "Norma Gerard", "Craig Gerard", "Katherine Cianflone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0062531.g005", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_C3_and_C5a_plasma_level_and_mRNA_expression_in_muscle_and_liver_of_genes_implicated_in_substrate_utilization_/699782", "title"=>"C3 and C5a plasma level and mRNA expression in muscle and liver of genes implicated in substrate utilization.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-07 02:43:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1056245"], "description"=>"<p>(<b>A</b>): Growth curve during diet treatment with CHOW or high fat high sucrose diet-induced obesity (DIO) diet in wildtype (WT) and C5aRKO mice (<b>B</b>): Final body weight for WT and C5aRKO mice on CHOW or DIO diet. (C and D): Tissue weights of gonadal (C) and inguinal (D) fat pads of WT and C5aRKO mice at the end of the protocol. Results are presented as means ± SEM of n = 12–14 mice per group, data are analysed by 2 way ANOVA (A), or ANOVA followed by t-test (B–D) where *P<0.05, **P<0.01 and ***P<0.001 and comparisons refer to C5aRKO vs WT on their respective diets, unless otherwise indicated.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Physiological processes", "Energy metabolism", "Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Model organisms", "Animal models", "mouse", "Metabolic disorders", "nutrition", "c5ar", "deficient"], "article_id"=>699779, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Christian Roy", "Abhishek Gupta", "Alexandre Fisette", "Marc Lapointe", "Pegah Poursharifi", "Denis Richard", "HuiLing Lu", "Bao Lu", "Norma Gerard", "Craig Gerard", "Katherine Cianflone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0062531.g002", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Altered_body_weight_and_fat_pad_weight_in_C5aR_deficient_mice_/699779", "title"=>"Altered body weight and fat pad weight in C5aR deficient mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-07 02:42:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1056243"], "description"=>"<p>(A and B): Oxygen consumption after diet treatment for one week (A) and 12 weeks (B), evaluated over a 48 hour period for wildtype (WT, open circles) and C5aRKO mice (solid circles) on a high fat high sucrose diet-induced obesity (DIO) diet. (C): Respiration quotient (RQ) for the same 48 hour period for WT and C5aRKO mice on CHOW or DIO diet. (D): Total walking distance over the 48-hour period for WT and C5aRKO mice on CHOW or DIO diet. Results are presented as means ± SEM of n = 8 mice per group. For calorimetry results, “dark cycle” indicates the active period. Data were analysed by 2-way RM-ANOVA (A and B) and by ANOVA followed by t-test (C and D), where *P<0.05 for C5aRKO vs WT on their respective diets, unless otherwise indicated.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Physiological processes", "Energy metabolism", "Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Model organisms", "Animal models", "mouse", "Metabolic disorders", "nutrition", "locomotor"], "article_id"=>699778, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Christian Roy", "Abhishek Gupta", "Alexandre Fisette", "Marc Lapointe", "Pegah Poursharifi", "Denis Richard", "HuiLing Lu", "Bao Lu", "Norma Gerard", "Craig Gerard", "Katherine Cianflone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0062531.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Oxygen_consumption_and_locomotor_activity_/699778", "title"=>"Oxygen consumption and locomotor activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-07 02:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1056248"], "description"=>"<p>(A): Plasma glucose levels following an intraperitoneal injection of glucose in WT (open symbols) and C5aRKO (solid symbols) mice after 13 weeks of low fat CHOW or diet-induced obesity (DIO) diet for n = 6–7 mice per group. (B): Plasma glucose levels following an intra-peritoneal injection of insulin in WT (open symbols) and C5aRKO (solid symbols) mice after 13 weeks of CHOW or DIO diet for n = 6–7 mice per group. Triglyceride (TG; C and D) postprandial lipid clearance following an oral fat load for WT (open symbols), C5aRKO (solid symbols) mice on CHOW (C) and diet-induced obesity (DIO) (D) diets for n = 5 mice per group. Results are presented as means ± SEM; data are analysed by 2-way RM-ANOVA followed by Bonferroni post-test for individual time point differences, where *P<0.05, and **P<0.001 for KO vs. WT and by t-test for the incremental area-under-the curve (IAUC), where *P<0.05 vs WT on the same diet.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Physiological processes", "Energy metabolism", "Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Model organisms", "Animal models", "mouse", "Metabolic disorders", "nutrition", "glucose", "insulin", "postprandial", "lipid", "clearance", "c5arko"], "article_id"=>699781, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Christian Roy", "Abhishek Gupta", "Alexandre Fisette", "Marc Lapointe", "Pegah Poursharifi", "Denis Richard", "HuiLing Lu", "Bao Lu", "Norma Gerard", "Craig Gerard", "Katherine Cianflone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0062531.g004", "stats"=>{"downloads"=>0, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Metabolic_response_to_glucose_and_insulin_tolerance_tests_and_postprandial_lipid_clearance_in_C5aRKO_mice_/699781", "title"=>"Metabolic response to glucose and insulin tolerance tests and postprandial lipid clearance in C5aRKO mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-07 02:43:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1056246"], "description"=>"<p>C5aR mRNA expression for WT CHOW (open bars) and WT diet-induced obesity (DIO) (checkered bars) for (A) gonadal adipose tissue, (B) quadriceps muscle, and (C) liver were measured. C5L2 mRNA expression for WT CHOW (open bars), WT DIO (checkered bars), KO CHOW (black bars) and KO DIO (striped bars) for (D) gonadal adipose tissue, (E) quadriceps muscle, and (F) liver were evaluated. Results are expressed as means ± SEM; n = 9–12 per group. Statistical differences were determined by t-test, for C5aRKO vs WT on their respective diets where *P<0.05, **P<0.001 and ***P<0.0001.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Physiological processes", "Energy metabolism", "Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Model organisms", "Animal models", "mouse", "Metabolic disorders", "nutrition", "c5l2"], "article_id"=>699780, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Christian Roy", "Abhishek Gupta", "Alexandre Fisette", "Marc Lapointe", "Pegah Poursharifi", "Denis Richard", "HuiLing Lu", "Bao Lu", "Norma Gerard", "Craig Gerard", "Katherine Cianflone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0062531.g003", "stats"=>{"downloads"=>5, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_C5aR_and_C5L2_expression_in_adipose_muscle_and_liver_of_mice_/699780", "title"=>"C5aR and C5L2 expression in adipose, muscle and liver of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-07 02:43:00"}

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Relative Metric

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