Pterostilbene Exerts Antitumor Activity via the Notch1 Signaling Pathway in Human Lung Adenocarcinoma Cells
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{"title"=>"Pterostilbene Exerts Antitumor Activity via the Notch1 Signaling Pathway in Human Lung Adenocarcinoma Cells", "type"=>"journal", "authors"=>[{"first_name"=>"Yang", "last_name"=>"Yang", "scopus_author_id"=>"56402168300"}, {"first_name"=>"Xiaolong", "last_name"=>"Yan", "scopus_author_id"=>"23996046600"}, {"first_name"=>"Weixun", "last_name"=>"Duan", "scopus_author_id"=>"15135845700"}, {"first_name"=>"Juanjuan", "last_name"=>"Yan", "scopus_author_id"=>"55262384800"}, {"first_name"=>"Wei", "last_name"=>"Yi", "scopus_author_id"=>"35766062300"}, {"first_name"=>"Zhenxin", "last_name"=>"Liang", "scopus_author_id"=>"55535907400"}, {"first_name"=>"Ning", "last_name"=>"Wang", "scopus_author_id"=>"56779659700"}, {"first_name"=>"Yue", "last_name"=>"Li", "scopus_author_id"=>"55929425000"}, {"first_name"=>"Wensheng", "last_name"=>"Chen", "scopus_author_id"=>"57195523924"}, {"first_name"=>"Shiqiang", "last_name"=>"Yu", "scopus_author_id"=>"22837324100"}, {"first_name"=>"Zhenxiao", "last_name"=>"Jin", "scopus_author_id"=>"27170820700"}, {"first_name"=>"Dinghua", "last_name"=>"Yi", "scopus_author_id"=>"8618748600"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368848003", "sgr"=>"84877077775", "pmid"=>"23671619", "scopus"=>"2-s2.0-84877077775", "doi"=>"10.1371/journal.pone.0062652", "issn"=>"19326203"}, "id"=>"014bf9b5-7a89-36c2-ac38-56bb98769ecc", "abstract"=>"Although pterostilbene (PTE) has been shown to have potent antitumor activities against various cancer types, the molecular mechanisms of these activities remain unclear. In this study, we investigated the antitumor activity of PTE against human lung adenocarcinoma in vitro and in vivo and explored the role of the Notch1 signaling pathway in this process. PTE treatment resulted in a dose- and time-dependent decrease in the viability of A549 cells. Additionally, PTE exhibited strong antitumor activity, as evidenced not only by a reduced mitochondrial membrane potential (MMP) and a decreased intracellular glutathione content but also by increases in the apoptotic index and the level of reactive oxygen species (ROS). Furthermore, PTE treatment induced the activation of the Notch1 Intracellular Domain (NICD) protein and activated Hes1. DAPT (a gamma secretase inhibitor) and Notch1 siRNA prevented the induction of NICD and Hes1 activation by PTE treatment and sensitized the cells to PTE treatment. The down-regulation of Notch signaling also prevented the activation of pro-survival pathways (most notably the PI3K/Akt pathway) after PTE treatment. In summary, lung adenocarcinoma cells may enhance Notch1 activation as a protective mechanism in response to PTE treatment. Combining a gamma secretase inhibitor with PTE treatment may represent a novel approach for treating lung adenocarcinoma by inhibiting the survival pathways of cancer cells.", "link"=>"http://www.mendeley.com/research/pterostilbene-exerts-antitumor-activity-via-notch1-signaling-pathway-human-lung-adenocarcinoma-cells-2", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1052548"], "description"=>"<p>(A) Cells were treated with PTE at different concentrations (1.5, 3 and 6 µM) for different durations (12, 24 and 36 h). Cell viability was assessed using the MTT assay and was expressed as an OD value. (B) The cell morphology was observed under an inverted/phase contrast microscope (treated for 24 h), and images were taken (×200). Significant cell shrinkage and a decreased cellular attachment rate were observed in the PTE-treated group. (C) Apoptosis of the cells was detected by the TUNEL assay (×200), and the level of cell apoptosis was expressed as the apoptotic index. TUNEL staining was performed to stain the nuclei of apoptotic cells (green), and DAPI was used to stain the nuclei of all cells (blue). The apoptotic index was expressed as the number of green cells/the total number of cells counted×100%. The results are expressed as the mean ± SEM, n = 6. **P<0.01 compared with the control group, <sup>##</sup>P<0.01 compared with the PTE 1.5 µM group, <sup>$$</sup>P<0.01 compared with the PTE 3 µM group. PTE, pterostilbene; OD, optical density.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "morphology", "apoptotic", "adenocarcinoma"], "article_id"=>696939, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_on_the_viability_morphology_and_apoptotic_index_of_lung_adenocarcinoma_cells_/696939", "title"=>"The effects of PTE on the viability, morphology and apoptotic index of lung adenocarcinoma cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:55:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052549"], "description"=>"<p>The MMP was estimated by flow cytometry after staining the cells with the fluorescent dye JC-1. Representative flow cytometry results are shown. The subpopulations and their fractions are indicated: normal MMP cells (upper right) and low MMP cells (low right). The MMP level was expressed as the proportion of cells with a low MMP. The results are expressed as the mean ± SEM, n = 6. **P<0.01 compared with the control group, <sup>##</sup>P<0.01 compared with the PTE 1.5 µM group, <sup>$$</sup>P<0.01 compared with the PTE 3 µM group. PTE, pterostilbene; MMP, mitochondrial membrane potential.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "mmp", "adenocarcinoma", "cells", "treated", "24"], "article_id"=>696940, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_on_the_MMP_of_lung_adenocarcinoma_cells_treated_for_24_h_/696940", "title"=>"The effects of PTE on the MMP of lung adenocarcinoma cells treated for 24 h.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:55:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052551"], "description"=>"<p>(A) To determine the ROS concentration, the cells were loaded with DCFH-DA, and the fluorescence intensity was measured using a microplate fluorescence reader. The fluorescence intensity in the control group was defined as 100%. (B) The intracellular GSH content was measured using a GSH kit. The differences in the GSH level between groups were expressed as a percentage of the control. (C) The GSH and GSSG levels were evaluated by comparison with the standards and were normalized to the protein content. The results are expressed as the GSH/GSSG ratio. The results are expressed as the mean ± SEM, n = 6. **P<0.01 compared with the control group, <sup>##</sup>P<0.01 compared with the PTE 1.5 µM group, <sup>$$</sup>P<0.01 compared with the PTE 3 µM group. PTE, pterostilbene; ROS, reactive oxygen species; GSH, glutathione; GSSG, glutathione disulfide.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "ros", "gsh", "adenocarcinoma", "cells", "treated", "24"], "article_id"=>696942, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_on_ROS_generation_the_GSH_level_and_the_GSH_GSSG_ratio_in_lung_adenocarcinoma_cells_treated_for_24_h_/696942", "title"=>"The effects of PTE on ROS generation, the GSH level and the GSH/GSSG ratio in lung adenocarcinoma cells treated for 24 h.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:55:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052553"], "description"=>"<p>(A) Representative Western blot results are shown. The PTE treatment increased the expression levels of NICD, Hes1, Nicastrin, Presenilin-1, Bax and Cytochrome c. (B) Representative images of Notch1 immunofluorescence are shown (×400). (C) Representative images of Hes1 immunofluorescence are shown (×400). The results are expressed as the mean ± SEM, n = 6. **P<0.01 compared with the control group, <sup>##</sup>P<0.01 compared with the PTE 1.5 µM group, <sup>$$</sup>P<0.01 compared with the PTE 3 µM group. PTE, pterostilbene.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "proteins", "notch1", "pathway", "mitochondrial", "apoptotic", "adenocarcinoma", "cells", "treated", "24"], "article_id"=>696944, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_on_proteins_in_the_Notch1_signaling_pathway_and_the_mitochondrial_apoptotic_pathway_in_lung_adenocarcinoma_cells_treated_for_24_h_/696944", "title"=>"The effects of PTE on proteins in the Notch1 signaling pathway and the mitochondrial apoptotic pathway in lung adenocarcinoma cells treated for 24 h.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:55:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052555"], "description"=>"<p>(A) Cell viability was assessed using the MTT assay, and the viability was expressed as an OD value. (B) Apoptosis was detected by the TUNEL assay (×200) and was expressed as the apoptotic index. TUNEL staining was performed to stain the nuclei of the apoptotic cells (green), and DAPI was used to stain the nuclei of all cells (blue). The apoptotic index was expressed as the number of green cells/the total number of cells counted×100%. The results are expressed as the mean ± SEM, n = 6. **P<0.01 compared with the control group, <sup>##</sup>P<0.01 compared with the PTE 6 µM group, <sup>$$</sup>P<0.01 compared with the PTE 6 µM+DAPT 10 µM group. PTE, pterostilbene; OD, optical density.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "dapt", "viability", "apoptotic", "adenocarcinoma", "cells", "treated", "24"], "article_id"=>696946, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_combined_with_DAPT_on_the_viability_and_apoptotic_index_of_lung_adenocarcinoma_cells_treated_for_24_h_/696946", "title"=>"The effects of PTE combined with DAPT on the viability and apoptotic index of lung adenocarcinoma cells treated for 24 h.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:55:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052557"], "description"=>"<p>Representative Western blot results are shown. The results are expressed as the mean ± SEM, n = 6. **P<0.01 compared with the control group, <sup>##</sup>P<0.01 compared with the PTE 6 µM group, <sup>$$</sup>P<0.01 compared with the PTE 6 µM+DAPT 10 µM group. PTE, pterostilbene.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "dapt", "notch1", "pro-survival", "adenocarcinoma", "cells", "treated", "24"], "article_id"=>696948, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_combined_with_DAPT_on_the_Notch1_signaling_and_pro_survival_factors_in_lung_adenocarcinoma_cells_treated_for_24_h_/696948", "title"=>"The effects of PTE combined with DAPT on the Notch1 signaling and pro-survival factors in lung adenocarcinoma cells treated for 24 h.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:55:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052561"], "description"=>"<p>(A) Cell viability was assessed using the MTT assay and was expressed as an OD value. (B) Apoptosis was detected by the TUNEL assay (×200) and was expressed as the apoptotic index. TUNEL staining was performed to stain the nuclei of the apoptotic cells (green), and DAPI was used to stain the nuclei of all cells (blue). The apoptotic index was expressed as the number of green cells/the total number of cells counted×100%. (C) Representative Western blot results are shown. The results are expressed as the mean ± SEM, n = 6. **P<0.01 compared with the control siRNA group, <sup>##</sup>P<0.01 compared with the PTE 6 µM group, <sup>$$</sup>P<0.01 compared with the Notch siRNA PTE 6 µM group. PTE, pterostilbene; OD, optical density.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "notch1", "sirna", "apoptotic", "adenocarcinoma"], "article_id"=>696952, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_combined_with_Notch1_siRNA_on_the_viability_apoptotic_index_and_Notch1_signaling_of_lung_adenocarcinoma_cells_/696952", "title"=>"The effects of PTE combined with Notch1 siRNA on the viability, apoptotic index and Notch1 signaling of lung adenocarcinoma cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:55:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052563"], "description"=>"<p>(A) Cell viability was assessed using the MTT assay and was expressed as an OD value. (B) Representative Western blot results are shown. The results are expressed as the mean ± SEM, n = 6. **P<0.01 compared with the control siRNA group, <sup>##</sup>P<0.01 compared with the PTE 6 µM group, <sup>$$</sup>P<0.01 compared with the Akt siRNA+PTE 6 µM group. PTE, pterostilbene; OD, optical density.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "akt", "sirna", "viability", "adenocarcinoma"], "article_id"=>696954, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_combined_with_Akt_siRNA_on_the_viability_and_Akt_signaling_of_lung_adenocarcinoma_cells_/696954", "title"=>"The effects of PTE combined with Akt siRNA on the viability and Akt signaling of lung adenocarcinoma cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:55:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052566"], "description"=>"<p>(A) Photographs showing the morphology of the tumor xenografts in different groups. (B) The tumor growth curve was drawn using the tumor volume and the treatment duration. (C) Representative Western blot results are shown. The results are expressed as the mean ± SEM, n = 3. **P<0.01 compared with the control group, <sup>##</sup>P<0.01 compared with the PTE group, <sup>$$</sup>P<0.01 compared with the PTE+DAPT group. PTE, pterostilbene.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "dapt", "xenografts"], "article_id"=>696957, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g009"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_combined_with_DAPT_on_tumor_xenografts_in_vivo_/696957", "title"=>"The effects of PTE combined with DAPT on tumor xenografts in vivo.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:55:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052572"], "description"=>"<p>(A) Photographs showing the morphology of the tumor xenografts in different groups. (B) The tumor growth curve was drawn using the tumor volume and the treatment duration. (C) Representative Western blot results are shown. The results are expressed as the mean ± SEM, n = 3. **P<0.01 compared with the control group, <sup>##</sup>P<0.01 compared with the PTE group, <sup>$$</sup>P<0.01 compared with the PTE+LY group. PTE, pterostilbene; LY, LY294002.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Signaling in selected disciplines", "Developmental signaling", "Signaling pathways", "phytochemistry", "phytochemicals", "oncology", "Cancers and neoplasms", "Lung and intrathoracic tumors", "Adenocarcinoma of the lung", "pte", "ly", "xenografts"], "article_id"=>696963, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yang Yang", "Xiaolong Yan", "Weixun Duan", "Juanjuan Yan", "Wei Yi", "Zhenxin Liang", "Ning Wang", "Yue Li", "Wensheng Chen", "Shiqiang Yu", "Zhenxiao Jin", "Dinghua Yi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0062652.g010"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_PTE_combined_with_LY_on_tumor_xenografts_in_vivo_/696963", "title"=>"The effects of PTE combined with LY on tumor xenografts in vivo.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 01:56:03"}

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Relative Metric

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