Membrane Phospholipid Fatty Acid Composition Regulates Cardiac SERCA Activity in a Hibernator, the Syrian Hamster (Mesocricetus auratus)
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{"title"=>"Membrane Phospholipid Fatty Acid Composition Regulates Cardiac SERCA Activity in a Hibernator, the Syrian Hamster (Mesocricetus auratus)", "type"=>"journal", "authors"=>[{"first_name"=>"Sylvain", "last_name"=>"Giroud", "scopus_author_id"=>"24471569000"}, {"first_name"=>"Carla", "last_name"=>"Frare", "scopus_author_id"=>"55672743100"}, {"first_name"=>"Arjen", "last_name"=>"Strijkstra", "scopus_author_id"=>"6603831786"}, {"first_name"=>"Ate", "last_name"=>"Boerema", "scopus_author_id"=>"8552484900"}, {"first_name"=>"Walter", "last_name"=>"Arnold", "scopus_author_id"=>"56235101900"}, {"first_name"=>"Thomas", "last_name"=>"Ruf", "scopus_author_id"=>"7006491406"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0063111", "sgr"=>"84877019588", "issn"=>"19326203", "pui"=>"368847418", "isbn"=>"1932-6203", "pmid"=>"23650545", "scopus"=>"2-s2.0-84877019588"}, "id"=>"b46147a8-3bf3-3358-8d80-24c996df0492", "abstract"=>"Polyunsaturated fatty acids (PUFA) have strong effects on hibernation and daily torpor. Increased dietary uptake of PUFA of the n-6 class, particularly of Linoleic acid (LA, C18:2 n-6) lengthens torpor bout duration and enables animals to reach lower body temperatures (T(b)) and metabolic rates. As previously hypothesized, this well-known influence of PUFA may be mediated via effects of the membrane fatty acid composition on sarcoplasmic reticulum (SR) Ca(2+-)ATPase 2a (SERCA) in the heart of hibernators. We tested the hypotheses that high proportions of n-6 PUFA in general, or specifically high proportions of LA (C18:2 n-6) in SR phospholipids (PL) should be associated with increased cardiac SERCA activity, and should allow animals to reach lower minimum T(b) in torpor. We measured activity of SERCA from hearts of hibernating and non-hibernating Syrian hamsters (Mesocricetus auratus) in vitro at 35 °C. Further, we determined the PL fatty acid composition of the SR membrane of these hearts. We found that SERCA activity strongly increased as the proportion of LA in SR PL increased but was negatively affected by the content of Docosahexaenoic acid (DHA; C22:6 n-3). SR PL from hibernating hamsters were characterized by high proportions of LA and low proportions of DHA. As a result, SERCA activity was significantly higher during entrance into torpor and in torpor compared to inter-bout arousal. Also, animals with increased SERCA activity reached lower T(b) during torpor. Interestingly, a subgroup of hamsters which never entered torpor but remained euthermic throughout winter displayed a phenotype similar to animals in summer. This was characterized by lower proportions of LA and increased proportions of DHA in SR membranes, which is apparently incompatible with torpor. We conclude that the PUFA composition of SR membranes affects cardiac function via modulating SERCA activity, and hence determines the minimum T(b) tolerated by hibernators.", "link"=>"http://www.mendeley.com/research/membrane-phospholipid-fatty-acid-composition-regulates-cardiac-serca-activity-hibernator-syrian-hams", "reader_count"=>24, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>15, "Medicine and Dentistry"=>3, "Psychology"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"France"=>1, "India"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1050418"], "description"=>"<p>Body temperatures of summer hamsters (“summer”, n = 7), non-hibernating winter hamsters (“winter”, n = 7), and hibernating hamsters during inter-bout arousal (“IBA”, n = 13), entrance into a hibernating bout (“cooling”, n = 9), and deep torpor (“torpid”, n = 18). Groups differing significantly (p<0.001, Tukey’s post-hoc comparisons) are denoted by different superscripts.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "proteins", "Transmembrane transport proteins", "Cryobiology", "ecology", "Ecophysiology", "Model organisms", "Animal models", "Zoology", "Animal physiology", "cardiovascular", "arrhythmias", "Heart failure", "temperatures", "physiological"], "article_id"=>695348, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Sylvain Giroud", "Carla Frare", "Arjen Strijkstra", "Ate Boerema", "Walter Arnold", "Thomas Ruf"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063111.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_temperatures_according_to_the_animal_physiological_states_/695348", "title"=>"Body temperatures according to the animal physiological states.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-01 01:29:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1050419"], "description"=>"<p>Levels of SERCA activity in summer hamsters (“summer”, n = 7), non-hibernating winter hamsters (“winter”, n = 7), and hibernating hamsters during inter-bout arousal (“IBA”, n = 13), entrance into a hibernation bout (“cooling”, n = 9), and deep torpor (“torpid”, n = 18). Groups differing significantly (p<0.01, Tukey’s post-hoc comparisons) are denoted by different superscripts.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "proteins", "Transmembrane transport proteins", "Cryobiology", "ecology", "Ecophysiology", "Model organisms", "Animal models", "Zoology", "Animal physiology", "cardiovascular", "arrhythmias", "Heart failure", "cardiac", "sarcoplasmic", "reticulum", "calcium", "atpase", "2a"], "article_id"=>695349, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Sylvain Giroud", "Carla Frare", "Arjen Strijkstra", "Ate Boerema", "Walter Arnold", "Thomas Ruf"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063111.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Levels_of_cardiac_Sarcoplasmic_Reticulum_Calcium_ATPase_2a_SERCA_activity_/695349", "title"=>"Levels of cardiac Sarcoplasmic Reticulum Calcium ATPase 2a (SERCA) activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-01 01:29:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1050420"], "description"=>"<p>Exponential ranged major axis regression: intercept = 8.99, slope = −10.78, p<0.01).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "proteins", "Transmembrane transport proteins", "Cryobiology", "ecology", "Ecophysiology", "Model organisms", "Animal models", "Zoology", "Animal physiology", "cardiovascular", "arrhythmias", "Heart failure", "cardiac", "sarcoplasmic", "reticulum", "calcium", "atpase", "2a", "torpid"], "article_id"=>695350, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Sylvain Giroud", "Carla Frare", "Arjen Strijkstra", "Ate Boerema", "Walter Arnold", "Thomas Ruf"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063111.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_temperature_as_a_function_of_cardiac_Sarcoplasmic_Reticulum_Calcium_ATPase_2a_SERCA_activity_in_torpid_hamsters_/695350", "title"=>"Body temperature as a function of cardiac Sarcoplasmic Reticulum Calcium ATPase 2a (SERCA) activity in torpid hamsters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-01 01:29:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1050421"], "description"=>"<p>SERCA activity as a function of the proportions (% of total fatty acids) of (a) Linoleic acid (LA 18:2 n-6), (b) Docosahexanoic acid (DHA 22:6 n-3), and (c) the ratio of LA/DHA in the sarcoplasmic reticulum membrane. Black dots indicate data from torpid animals, black triangles from cooling animals, grey dots from animals during inter-bout arousals, and open dots from summer and non-hibernating winter animals (Difference of slopes between groups: (a) F = 1.78, p = 0.15; (b) F = 0.89, p = 0.48; (c) F = 2.07, p = 0.10; regression statistics for all 54 animals from linear ranged major axis analysis: (a) intercept = −1.70, slope = 0.05, adjusted R<sup>2</sup> = 0.27, p<0.01; (b) intercept = 0.50, slope = −0.12, adjusted R<sup>2</sup> = 0.04, p = 0.04; (c) intercept = −1.29, slope = 0.03, adjusted R<sup>2</sup> = 0.18, p = 0.02).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "proteins", "Transmembrane transport proteins", "Cryobiology", "ecology", "Ecophysiology", "Model organisms", "Animal models", "Zoology", "Animal physiology", "cardiovascular", "arrhythmias", "Heart failure", "sarcoplasmic", "reticulum", "calcium", "atpase", "2a", "fatty"], "article_id"=>695351, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Sylvain Giroud", "Carla Frare", "Arjen Strijkstra", "Ate Boerema", "Walter Arnold", "Thomas Ruf"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063111.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cardiac_Sarcoplasmic_Reticulum_Calcium_ATPase_2a_SERCA_activity_and_fatty_acid_composition_/695351", "title"=>"Cardiac Sarcoplasmic Reticulum Calcium ATPase 2a (SERCA) activity and fatty acid composition.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-01 01:29:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1050422"], "description"=>"<p>Linear ranged major axis analysis: intercept = 10.29, slope = −1.61, p<0.01, R<sup>2</sup> = 0.40.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "proteins", "Transmembrane transport proteins", "Cryobiology", "ecology", "Ecophysiology", "Model organisms", "Animal models", "Zoology", "Animal physiology", "cardiovascular", "arrhythmias", "Heart failure", "proportions", "fatty", "linoleic", "docosahexanoic", "sarcoplasmic", "reticulum", "membrane", "torpid"], "article_id"=>695352, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Sylvain Giroud", "Carla Frare", "Arjen Strijkstra", "Ate Boerema", "Walter Arnold", "Thomas Ruf"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063111.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_temperature_as_a_function_of_the_ratio_of_the_proportions_of_total_fatty_acids_of_Linoleic_acid_and_Docosahexanoic_acid_LA_18_2_n_6_DHA_22_6_n_3_in_the_sarcoplasmic_reticulum_membrane_of_torpid_hamsters_/695352", "title"=>"Body temperature as a function of the ratio of the proportions (% of total fatty acids) of Linoleic acid and Docosahexanoic acid (LA 18:2 n-6/DHA 22:6 n-3) in the sarcoplasmic reticulum membrane of torpid hamsters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-01 01:29:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/1050423"], "description"=>"<p>The unsaturation index was calculated as followed: UI = Σ [(% each fatty acid) (no. double bonds/fatty acid)]. Groups differing significantly with p<0.05 (Tukey’s post-hoc comparisons) are denoted by different superscripts.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "proteins", "Transmembrane transport proteins", "Cryobiology", "ecology", "Ecophysiology", "Model organisms", "Animal models", "Zoology", "Animal physiology", "cardiovascular", "arrhythmias", "Heart failure", "proportions", "fatty", "cardiac", "sarcoplasmic", "reticulum", "phospholipids", "unsaturation", "hamsters", "non-hibernating", "hibernating", "torpor", "bout", "inter-bout", "arousal"], "article_id"=>695353, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Sylvain Giroud", "Carla Frare", "Arjen Strijkstra", "Ate Boerema", "Walter Arnold", "Thomas Ruf"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063111.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fatty_acid_proportions_of_total_fatty_acids_of_cardiac_sarcoplasmic_reticulum_phospholipids_means_177_standard_deviation_ratio_of_certain_fatty_acid_proportions_and_unsaturation_index_8220_UI_8221_of_summer_hamsters_8220_Summer_8221_n_8202_8202_7_non_hib/695353", "title"=>"Fatty acid proportions (% of total fatty acids) of cardiac sarcoplasmic reticulum phospholipids (means ± standard deviation), ratio of certain fatty acid proportions, and unsaturation index (“UI”) of summer hamsters (“Summer”, n = 7), non-hibernating winter hamsters (“Winter”, n = 7), and hibernating hamsters during entrance into a torpor bout (“Cooling”, n = 9), during deep torpor (“Torpid”, n = 18) and during inter-bout arousal (“IBA”, n = 13).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-01 01:29:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1050424"], "description"=>"<p>The model detects potential causal effects between LA or DHA and SERCA activity (SERCA2a ∼ LA 18:2n-6, SERCA2a ∼ DHA 22:6n-3), and between SERCA activity and Tb (Tb ∼ SERCA2a) of the hamsters. The “Estimates” correspond to the coefficients of the different regressions calculated by the model, and inform on the relative strength of the respective dyadic relations.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "proteins", "Transmembrane transport proteins", "Cryobiology", "ecology", "Ecophysiology", "Model organisms", "Animal models", "Zoology", "Animal physiology", "cardiovascular", "arrhythmias", "Heart failure", "linoleic", "docosahexanoic", "log-transformed", "cardiac", "sarcoplasmic", "reticulum", "calcium", "atpase", "hamsters", "torpid", "inter-bout", "animals"], "article_id"=>695354, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Sylvain Giroud", "Carla Frare", "Arjen Strijkstra", "Ate Boerema", "Walter Arnold", "Thomas Ruf"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063111.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Path_analyses_between_Linoleic_acid_LA_or_Docosahexanoic_acid_DHA_log_transformed_cardiac_Sarcoplasmic_Reticulum_Calcium_ATPase_SERCA2a_activity_and_body_temperature_Tb_in_all_hamsters_summer_winter_cooling_torpid_and_inter_bout_arousal_and_for_torpid_an/695354", "title"=>"Path analyses between Linoleic acid (LA) or Docosahexanoic acid (DHA), log-transformed cardiac Sarcoplasmic Reticulum Calcium ATPase (SERCA2a) activity and body temperature (Tb) in all hamsters (summer, winter, cooling, torpid and inter-bout arousal) and for torpid animals only.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-01 01:29:14"}

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Relative Metric

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