Specific Distribution of the Autophagic Protein GABARAPL1/GEC1 in the Developing and Adult Mouse Brain and Identification of Neuronal Populations Expressing GABARAPL1/GEC1
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{"title"=>"Specific Distribution of the Autophagic Protein GABARAPL1/GEC1 in the Developing and Adult Mouse Brain and Identification of Neuronal Populations Expressing GABARAPL1/GEC1", "type"=>"journal", "authors"=>[{"first_name"=>"Jaclyn Nicole", "last_name"=>"Le Grand", "scopus_author_id"=>"24461847200"}, {"first_name"=>"Karine", "last_name"=>"Bon", "scopus_author_id"=>"57199553580"}, {"first_name"=>"Annick", "last_name"=>"Fraichard", "scopus_author_id"=>"6602253965"}, {"first_name"=>"Jianhua", "last_name"=>"Zhang", "scopus_author_id"=>"54379444300"}, {"first_name"=>"Michèle", "last_name"=>"Jouvenot", "scopus_author_id"=>"7003302647"}, {"first_name"=>"Pierre Yves", "last_name"=>"Risold", "scopus_author_id"=>"6603795140"}, {"first_name"=>"Michaël", "last_name"=>"Boyer-Guittaut", "scopus_author_id"=>"24066228900"}, {"first_name"=>"Régis", "last_name"=>"Delage-Mourroux", "scopus_author_id"=>"55945638100"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"368921107", "sgr"=>"84877735282", "pmid"=>"23690988", "scopus"=>"2-s2.0-84877735282", "doi"=>"10.1371/journal.pone.0063133"}, "id"=>"1bc5ee18-c59b-3406-8160-85eb3398946e", "abstract"=>"Macroautophagy is a highly conserved cellular degradation process, regulated by autophagy-related (atg) factors, in which a double membrane autophagosome engulfs cytoplasmic components to target them for degradation. In yeast, the Atg8 protein is indispensable for autophagosome formation. In mammals, this is complicated by the presence of six Atg8 homologues grouped into the GABARAP and MAP1LC3 subfamilies. Although these proteins share a high similarity, their transcript expression, regulation and protein interactions differ, suggesting they may display individual properties and specific functions. GABARAPL1/GEC1 is a member of the GABARAP subfamily and its mRNA is the most highly expressed Atg8 homologue in the central nervous system. Consequently, we performed an in depth study of GABARAPL1 distribution in the developing and adult murine brain. Our results show that GABARAPL1 brain expression is visible as early as embryonic day 11 and progressively increases to a maximum level in the adult. Immunohistochemical staining was detected in both fibers and immature neurons in embryos but was restrained to neurons in adult tissue. By E17, intense punctate-like structures were visible and these accumulated in cortical primary neurons treated with the autophagosome/lysosome fusion inhibitor Bafilomycin A1 (Baf A1), suggesting that they represent autophagosomes. Finally, GABARAPL1 expression was particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta, a region affected in Parkinson's disease. Our study of cerebral GABARAPL1 protein expression provides insight into its role in the development and homeostasis of the mouse brain.", "link"=>"http://www.mendeley.com/research/specific-distribution-autophagic-protein-gabarapl1gec1-developing-adult-mouse-brain-identification-n", "reader_count"=>13, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>2, "Neuroscience"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>1, "Portugal"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1559964"], "description"=>"<p>Immunohistochemical and <i>in-situ</i> hybridization analysis of WT and GABARAP−/− cortical mouse brain tissue with an anti-GABARAPL1 antibody (<b>a</b>, <b>c–e</b>) and an anti-sense <i>gabarapl1</i> Dig-labelled probe (<b>b</b>). Anti-GABARAPL1 antibody displays a diffused cytoplasmic staining with brighter punctate structures (<b>a</b>: neurons of the DMX). <i>gabarapl1</i> mRNA and GABARAPL1 protein expression patterns were similar throughout the brain (<b>b</b>, <b>c</b>: Purkinje cells of the cerebellum). Anti-GABARAPL1 staining patterns remained the same between wild type and GABARAP knock out mice brains (<b>d</b>, <b>e</b>: cerebellar cortex). Scale bar represents 5 µm (<b>a</b>), 80 µm (<b>b</b>), 40 µm and 20 µm (<b>d</b>, <b>e</b>).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "mrna", "staining", "wt"], "article_id"=>1079289, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_protein_and_gabarapl1_mRNA_staining_in_WT_and_GABARAP_mice_/1079289", "title"=>"GABARAPL1 protein and <i>gabarapl1</i> mRNA staining in WT and GABARAP−/− mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1559974"], "description"=>"<p>Immunostaining using anti-GFAP (green), anti-GABARAPL1 (green) or anti-NeuN (red) of embryonic cortical primary neurons grown in NBM or Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% FBS. GABARAPL1 staining is abundant under conditions that support neuronal cell differentiation (NBM grown, GFAP-negative cells) and scarce under conditions that support glial cell differentiation (DMEM grown, GFAP-positive cells). All GABARAPL1 positive cells are also labeled with NeuN. Scale bar represents 40 µm (<b>a</b>, <b>e–f</b>) and 80 µm (<b>b–d</b>).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "embryonic", "cortical", "cultures", "grown", "nbm", "dmem"], "article_id"=>1079299, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_in_embryonic_cortical_primary_cultures_grown_in_NBM_or_DMEM_medium_/1079299", "title"=>"GABARAPL1 expression in embryonic cortical primary cultures grown in NBM or DMEM medium.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1559987"], "description"=>"<p>Immunostaining using anti-GABARAPL1 (green) and anti-p62 (red) of embryonic cortical primary neurons incubated with or without Baf A1, a described inhibitor of the autophagic flux. The control cells show a diffuse and punctiform staining of GABARAPL1 and p62 in the cell body as well as in the cell processes. The incubation of the cells with Baf A1 induces an important increase in the number of GABARAPL1 and p62-positively stained vesicles suggesting that the GABARAPL1 staining observed in neurons is due to its association with autophagic vesicles. Scale bar represents 20 µm.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "embryonic", "cortical", "cultures", "baf", "a1"], "article_id"=>1079312, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_in_embryonic_cortical_primary_cultures_after_Baf_A1_treatment_/1079312", "title"=>"GABARAPL1 expression in embryonic cortical primary cultures after Baf A1 treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560011"], "description"=>"<p>Immunohistochemical analysis of WT mouse brain tissues with an anti-GABARAPL1 antibody (<b>a–f</b>). Representative images of intense labelling in the dorsal motor nucleus of the vagus nerve- DMX (<b>a</b>) and nucleus of the diagonal band- NDB (<b>b</b>), moderate labelling in the paraventricular nucleus of the hypothalamus PVH (<b>c</b>) and the cerebellar cortex (<b>d</b>) and weakly labelled neurons in the caudate putamen (<b>e</b>) and the globus pallidus (<b>f</b>). Scale bar represents 20 µm.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "localization", "gabarapl1", "cerebral"], "article_id"=>1079328, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cellular_localization_of_GABARAPL1_in_various_cerebral_regions_/1079328", "title"=>"Cellular localization of GABARAPL1 in various cerebral regions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560022"], "description"=>"<p>Immunohistochemical analysis of WT mouse brain tissue with an anti-GABARAPL1 antibody. Images represent typical GABARAPL1 protein expression patterns in neurons found in the cortex-CTX (<b>b</b>), caudate putament-CP (<b>c</b>) and nucleus of the diagonal band-NDB (<b>d</b>). Scale bar represents 20 µm. Abbreviations: ACB (nucleus acumbens), CLA (claustrum), CP (caudate putamen), CTX (cortex), EPd (dorsal endopiriform nucleus), IG (induseumgriseum), LPO (lateral preoptic area), LSr (lateral septal nucleus- rostral part), LSc (lateral septal nucleus- caudal part), MS (medialis strialis), NDB (nucleus of the diagonal band), OT (olfactory tract), PIR (piriform area), SI (substantia innominata).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience"], "article_id"=>1079339, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_in_the_telencephalon_/1079339", "title"=>"GABARAPL1 expression in the telencephalon.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560054"], "description"=>"<p>Immunohistochemical analysis of WT mouse brain tissue with an anti-GABARAPL1 antibody and different neuronal population markers. Images represent double staining with anti-GABARAPL1 and either anti-choline acetyltransferase in the cerebellar cortex-CBX (<b>a–c</b>), anti-calbindin in the caudate putamen-CP (<b>d–f</b>), anti-parvalbumin in the globus pallidus-GP (<b>g–i</b>) or anti-dopamine transporter in the <i>substantia nigra</i>, <i>pars compacta</i>-SNpc (<b>j–l</b>). Scale bar represents 10 µm.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "neuronal"], "article_id"=>1079371, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_in_different_neuronal_populations_/1079371", "title"=>"GABARAPL1 expression in different neuronal populations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560064"], "description"=>"<p>Immunohistochemical analysis of WT mouse brain tissue with an anti-GABARAPL1 antibody. Images represent typical GABARAPL1 protein expression patterns in neurons found in the anterodorsal nucleus of the thalamus-AD (<b>b</b>) and paraventricular nucleus of the hypothalamus-PVH (<b>c</b>). Scale bar represents 20 µm. Abbreviations: AD (anterodorsal nucleus of the thalamus), AHN (anterior hypothalamic nucleus), AM (anteromedial nucleus of the thalamus), AV (anteroventral nucleus of the thalamus), BLA (basolateral nucleus of the amygdala), BMA (basomedial nucleus of the amygdala), CEA (central nucleus of the amygdala), CLA (claustrum), CM (central medial nucleus of the thalamus), COA (cortical nucleus of the amygdala), CP (caudate putamen), CTX (cortex), DG (dentate gyrus), EPd (endopiriform nucleus- dorsal part), EPv (endopiriform nucleus-ventral part), GP (globus pallidus), HPF (hippocampal formation), IA (intercalated nucleus of the amygdala), IAD (interanterodorsal nucleus of the thalamus), IAM (interanteromedial nucleus of the thalamus), IMD (intermediodorsal thalamic nucleus), LD (lateral dorsal nucleus of the thalamus), LH (lateral habenula), LHA (lateral hypothalamus area), MD (mediodorsal nucleus of the thalamus), MEA (medial nucleus of the amygdala), MH (medial habenula), NLOT (nucleus of the lateral olfactory tract), PIR (piriform area), PVH (paraventricular nucleus of the hypothalamus), PVT (paraventricular nucleus of the thalamus), RE (nucleus reuniens), RH (rhomboid nucleus), RT (reticular nucleus of the thalamus), SI (substantia innominata), SMT (submedial nucleus of the thalamus), VAL (ventral anterior-lateral complex of the thalamus), VM (ventral medial nucleus of the thalamus), ZI (zona incerta).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience"], "article_id"=>1079382, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_within_the_diencephalon_/1079382", "title"=>"GABARAPL1 expression within the diencephalon.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560092"], "description"=>"<p>Immunohistochemical analysis of WT mouse brain tissue with an anti-GABARAPL1 antibody. Displayed are representative images of the ventral tegmental area (VTA) (<b>b</b>), <i>the substantia nigra pars compacta</i> (SNpc) (<b>c</b>), and hippocampal formation (HPF) (<b>d</b>). Scale bar represents 20 µm. Abbreviations: CTX (Cortex), CA1/3 (ammon's horn, field CA1/CA3), ENT/ENTl (entorhinal area, lateral part), DG (dentate gyrus), HPF (hippocampal formation), IF (interfasicular nucleus raphé), INC (interstitial nucleus of Cajal), IPN (interpenduncular nucleus), MG (medial geniculate complex), MRN (mesenphalic reticular nucleus), ND (nucleus of Darkschewitsch), PAG (periaque ductal gray), PG (pontine gray), RL (rostral linear nucleus raphé), RN (red nucleus), SC (superior colluculus), SNc/r (<i>substantia nigra</i>, compact part/reticular part), SUBd/v (subiculum, dorsal part/ventral part), TR (post-piriform transition area), VTA (ventral tegmental area).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience"], "article_id"=>1079409, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_within_the_mesencephalon_/1079409", "title"=>"GABARAPL1 expression within the mesencephalon.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560105"], "description"=>"<p>Immunohistochemical analysis of WT mouse brain tissue with an anti-GABARAPL1 antibody. Displayed are representative images of the Purkinje cells of the cerebellum (<b>b</b>), dorsal motornucleus of the vagus nerve-DMX (<b>c</b>) and hypoglossal nucleus-XII (<b>d</b>). Scale bar represents 20 µm. Abbreviations: AMB (nucleus ambiguous), AN (ansiform lobule), AP (area postrema), CBX (cerebellar cortex), COPY (copula pyramidis), CU (cuneate nucleus), DEC (declive), DMX (dorsal motornucleus of the vagus nerve), ECU (external cuneate nucleus), IO (inferior olivary complex), IRN (intermediate reticular nucleus), LRN (lateral reticular nucleus), MDRN (medullary reticular nucleus), NTS (nucleus of the solitary tract), PARN (parvicellular reticular nucleus), PAS (parasolitary nucleus), PRM (paramedian lobule), PYR (pyramus), SPV (spinal nucleus of the trigeminal), RO (nucleus raphé obscurus), RPA (nucleus raphé pallidus), UVU (uvuia), XII (hypoglossal nucleus).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience"], "article_id"=>1079422, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g009"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_within_the_rhombencephalon_/1079422", "title"=>"GABARAPL1 expression within the rhombencephalon.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560116"], "description"=>"<p>Western blotting analysis of WT mouse head tissue protein extracts using anti-GABARAPL1 and anti-Actin antibodies (<b>a</b>). Quantification of GABARAPL1 protein expression levels in the developing embryonic mouse brain (<b>b</b>). GABARAPL1 signals were normalized according to Actin amounts for each sample then displayed as a percentage of control adult brain expression. Data = mean ± SEM. **<i>p</i><0.05 versus E11, *<i>p</i><0.1 versus E11.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "embryonic"], "article_id"=>1079433, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g010"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_during_embryonic_development_E11_to_E17_/1079433", "title"=>"GABARAPL1 expression during embryonic development (E11 to E17).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560135"], "description"=>"<p>Videomicrographs of GABARAPL1-immunolabeled horizontal sections passing through the diencephalon (<b>a</b>, <b>b</b>) or rhombencephalon (<b>c</b>, <b>d</b>) of an E11 embryo. The GABARAPL1 immunohistochemical signal is intense in the mantle layer but is not observed in the germinal neuroepithelial layer. In the mantle layer, both immature neurons and fiber tracts are labeled. This is obvious in the mesencephalon, in which the large decussation of the pyramidal commissure is intensely labeled (<b>c</b>). At higher magnifications (<b>b</b>, <b>d</b>) the signal is detected within the cytoplasm of immature neurons (whole mantle layer in <b>b</b>, arrow in <b>d</b>), in which it is diffusely distributed, or large fibers (arrowheads in <b>d</b>). Scale bar represents 200 µm (<b>a</b>, <b>c</b>), 50 µm (<b>b</b>, <b>d</b>). Abbreviations: AQ (aqueduct), IC (inferior colliculus), mtl (mantle layer), nh (neuroepithelial layer), pyd (pyramidal tract), 3v (third ventricle), 4v (fourth ventricle).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "diencephalon", "rhombencephalon", "e11"], "article_id"=>1079451, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g011"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_in_the_diencephalon_and_rhombencephalon_of_an_E11_embryo_/1079451", "title"=>"GABARAPL1 expression in the diencephalon and rhombencephalon of an E11 embryo.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560191"], "description"=>"<p>Videomicrographs of GABARAPL1-immunolabeled horizontal sections passing through the telencephalon and tectum (<b>a</b>, <b>b</b>), pallium (<b>c</b>) or rhombencephalon (<b>d</b>) of an E14 embryo. GABARAPL1 labeling in the mantle layer is intense in all regions, with both cell bodies and fiber tracts (posterior commissure in a or Hook bundle in <b>d</b>) displaying the immunohistochemical signal. In the pallium, ventricular and subventricular zones as well as the subplates are not intensely labeled, while the intermediate zone and cortical plates display an intense labeling. Note the absence of staining in the choroid plexus. Scale bar represents 200 µm (<b>a</b>, <b>c</b>) and 50 µm (<b>b</b>, <b>d</b>). Abbreviations: AQ (aqueduct), ch (choroid plexus), cp (cortical plate), hb (Hook bundle), hbr (habenular recess), IC (inferior colliculus), iz (intermediate zone), lv (lateral ventricle), pc (posterior commissure), sbp (subplate), svz (subventricular zone), vz (ventricular zone), 4v (fourth ventricle).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "pallium", "rhombencephalon", "e14"], "article_id"=>1079496, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g012"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_in_the_telencephalon_tectum_pallium_and_rhombencephalon_of_an_E14_embryo_/1079496", "title"=>"GABARAPL1 expression in the telencephalon, tectum, pallium and rhombencephalon of an E14 embryo.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560203"], "description"=>"<p>Videomicrographs of GABARAPL1-immunolabeled horizontal sections passing through the telencephalon (<b>a</b>, <b>b</b>), eye (<b>c</b>) or rhombencephalon (<b>d–f</b>) of an E17 embryo. GABARAPL1 labeling is present in both perikarya and fiber tracts (note the dense labeling of the optic tract as it leaves the eye. In the pallium, the intermediate zone is particularly well labeled. However, in the rhombencephalon, the labeling is less homogeneous than in earlier stages, and some cell bodies display a labeling which is more intense than in surrounding tissue, indicating that the adult pattern is beginning to differentiate. This is clear in the motoneurons of the mesencephalic nucleus of the trigeminal nerve (e, arrows in <b>f</b>). A punctate-like staining also became visible at this stage (arrows in <b>d</b>). Scale bar represents 300 µm (<b>a</b>), 100 µm (<b>b</b>, <b>c</b>, <b>e</b>), 20 µm (<b>f</b>) ) and 10 µm (<b>d</b>). Abbreviations: iz (intermediate zone), opt (optic tract).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "telencephalon", "rhombencephalon", "e17"], "article_id"=>1079508, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.g013"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GABARAPL1_expression_in_the_telencephalon_and_rhombencephalon_of_an_E17_embryo_/1079508", "title"=>"GABARAPL1 expression in the telencephalon and rhombencephalon of an E17 embryo.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-15 11:26:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1560204"], "description"=>"<p>GABARAPL1 protein expression in different regions of the mouse CNS is displayed with a relative quantification of the intensity of staining observed. 0: absence of labeling, +: weak intensity, ++ moderate intensity, +++: strong intensity.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "Biochemistry", "metabolism", "Protein metabolism", "Tissue distribution", "proteins", "Computational biology", "Molecular genetics", "gene expression", "genetics", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "neuroscience", "Developmental neuroscience", "gabarapl1"], "article_id"=>1079509, "categories"=>["Biological Sciences"], "users"=>["Jaclyn Nicole Le Grand", "Karine Bon", "Annick Fraichard", "Jianhua Zhang", "Michèle Jouvenot", "Pierre-Yves Risold", "Michaël Boyer-Guittaut", "Régis Delage-Mourroux"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0063133.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_GABARAPL1_in_the_Mouse_Brain_/1079509", "title"=>"Distribution of GABARAPL1 in the Mouse Brain.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-15 11:26:37"}

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Relative Metric

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