Decreased Mitochondrial DNA Content in Association with Exposure to Polycyclic Aromatic Hydrocarbons in House Dust during Wintertime: From a Population Enquiry to Cell Culture
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{"title"=>"Decreased Mitochondrial DNA Content in Association with Exposure to Polycyclic Aromatic Hydrocarbons in House Dust during Wintertime: From a Population Enquiry to Cell Culture", "type"=>"journal", "authors"=>[{"first_name"=>"Nicky", "last_name"=>"Pieters", "scopus_author_id"=>"55224662700"}, {"first_name"=>"Gudrun", "last_name"=>"Koppen", "scopus_author_id"=>"6602938815"}, {"first_name"=>"Karen", "last_name"=>"Smeets", "scopus_author_id"=>"15844080400"}, {"first_name"=>"Dorota", "last_name"=>"Napierska", "scopus_author_id"=>"8571992200"}, {"first_name"=>"Michelle", "last_name"=>"Plusquin", "scopus_author_id"=>"8703214600"}, {"first_name"=>"Sofie", "last_name"=>"De Prins", "scopus_author_id"=>"55599237200"}, {"first_name"=>"Hendrik", "last_name"=>"Van De Weghe", "scopus_author_id"=>"56031326700"}, {"first_name"=>"Vera", "last_name"=>"Nelen", "scopus_author_id"=>"6603545877"}, {"first_name"=>"Bianca", "last_name"=>"Cox", "scopus_author_id"=>"24177917700"}, {"first_name"=>"Ann", "last_name"=>"Cuypers", "scopus_author_id"=>"55883509300"}, {"first_name"=>"Peter", "last_name"=>"Hoet", "scopus_author_id"=>"7005776723"}, {"first_name"=>"Greet", "last_name"=>"Schoeters", "scopus_author_id"=>"34573619800"}, {"first_name"=>"Tim S.", "last_name"=>"Nawrot", "scopus_author_id"=>"6701621197"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84877020751", "pmid"=>"23658810", "sgr"=>"84877020751", "doi"=>"10.1371/journal.pone.0063208", "isbn"=>"1932-6203", "issn"=>"19326203", "pui"=>"368847975"}, "id"=>"62f4082c-b2be-37e3-adf9-4a8ad228854b", "abstract"=>"Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants that are formed in combustion processes. At the cellular level, exposure to PAHs causes oxidative stress and/or some of it congeners bind to DNA, which may interact with mitochondrial function. However, the influence of these pollutants on mitochondrial DNA (mtDNA) content remains largely unknown. We determined whether indoor exposure to PAHs is associated with mitochondrial damage as represented by blood mtDNA content. Blood mtDNA content (ratio mitochondrial/nuclear DNA copy number) was determined by real-time qPCR in 46 persons, both in winter and summer. Indoor PAH exposure was estimated by measuring PAHs in sedimented house dust, including 6 volatile PAHs and 8 non-volatile PAHs. Biomarkers of oxidative stress at the level of DNA and lipid peroxidation were measured. In addition to the epidemiologic enquiry, we exposed human TK6 cells during 24 h at various concentrations (range: 0 to 500 {\\textmu}M) of benzo(a)pyrene and determined mtDNA content. Mean blood mtDNA content averaged ({\\textpm} SD) 0.95 {\\textpm} 0.185. The median PAH content amounted 554.1 ng/g dust (25(th)-75(th) percentile: 390.7-767.3) and 1385 ng/g dust (25(th)-75(th) percentile: 1000-1980) in winter for volatile and non-volatile PAHs respectively. Independent for gender, age, BMI and the consumption of grilled meat or fish, blood mtDNA content decreased by 9.85% (95% CI: -15.16 to -4.2; p = 0.002) for each doubling of non-volatile PAH content in the house dust in winter. The corresponding estimate for volatile PAHs was -7.3% (95% CI: -13.71 to -0.42; p = 0.04). Measurements of oxidative stress were not correlated with PAH exposure. During summer months no association was found between mtDNA content and PAH concentration. The ability of benzo(a)pyrene (range 0 {\\textmu}M to 500 {\\textmu}M) to lower mtDNA content was confirmed in vitro in human TK6 cells. Based on these findings, mtDNA content can be a target of PAH toxicity in humans.", "link"=>"http://www.mendeley.com/research/decreased-mitochondrial-dna-content-association-exposure-polycyclic-aromatic-hydrocarbons-house-dust", "reader_count"=>39, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>13, "Other"=>2, "Student > Master"=>5, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>13, "Other"=>2, "Student > Master"=>5, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>11, "Biochemistry, Genetics and Molecular Biology"=>5, "Mathematics"=>1, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>10, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Chemistry"=>{"Chemistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>11}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>4}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1052980"], "description"=>"a<p>Percentage was calculated for each doubling in isoprostane and 8-hydroxydeoxyguanosine (based on a model with isoprostane, 8-hydroxydeoxyguanosine and log PAH).</p><p>Adjusted for gender, age, BMI and the consumption of grilled meat or fish. 8-hydroxydeoxyguanosine was additionally adjusted for urinary creatinine levels.</p><p>Adjusted for gender, age, BMI and the consumption of grilled meat or fish.</p>", "links"=>[], "tags"=>["Biochemistry", "Bioenergetics", "Energy-producing organelles", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Stress signaling cascade", "Cellular stress responses", "Population biology", "epidemiology", "Environmental epidemiology", "Environmental sciences", "Environmental engineering", "pollution", "Clinical research design", "hematology", "White cells", "plasma", "isoprostane", "urinary", "8-hydroxydeoxyguanosine", "pah", "mitochondrial", "dna"], "article_id"=>697306, "categories"=>["Medicine", "Engineering", "Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Nicky Pieters", "Gudrun Koppen", "Karen Smeets", "Dorota Napierska", "Michelle Plusquin", "Sofie De Prins", "Hendrik Van De Weghe", "Vera Nelen", "Bianca Cox", "Ann Cuypers", "Peter Hoet", "Greet Schoeters", "Tim S. Nawrot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0063208.t005", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estimated_change_95_CI_in_plasma_isoprostane_and_Urinary_8_hydroxydeoxyguanosine_in_association_with_PAH_exposure_and_mitochondrial_DNA_mtDNA_content_/697306", "title"=>"Estimated change (95% CI) in plasma isoprostane and Urinary 8-hydroxydeoxyguanosine in association with PAH exposure and mitochondrial DNA (mtDNA) content.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-03 02:01:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052975"], "description"=>"<p>Data are presented as number (%) or arithmetic mean ±SD.</p>*<p>Frequency of consumption of grilled food: data for one person, winter missing.</p>", "links"=>[], "tags"=>["Biochemistry", "Bioenergetics", "Energy-producing organelles", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Stress signaling cascade", "Cellular stress responses", "Population biology", "epidemiology", "Environmental epidemiology", "Environmental sciences", "Environmental engineering", "pollution", "Clinical research design", "hematology", "White cells", "stratified"], "article_id"=>697301, "categories"=>["Medicine", "Engineering", "Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Nicky Pieters", "Gudrun Koppen", "Karen Smeets", "Dorota Napierska", "Michelle Plusquin", "Sofie De Prins", "Hendrik Van De Weghe", "Vera Nelen", "Bianca Cox", "Ann Cuypers", "Peter Hoet", "Greet Schoeters", "Tim S. Nawrot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0063208.t002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_study_population_stratified_for_winter_and_summer_/697301", "title"=>"Characteristics of the study population stratified for winter and summer.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-03 02:01:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052974"], "description"=>"<p>Median amount (25th–75th percentile) of volatile and non-volatile PAHs and benzo<i>(a)</i>pyrene found in house dust (ng/g dust).</p>", "links"=>[], "tags"=>["Biochemistry", "Bioenergetics", "Energy-producing organelles", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Stress signaling cascade", "Cellular stress responses", "Population biology", "epidemiology", "Environmental epidemiology", "Environmental sciences", "Environmental engineering", "pollution", "Clinical research design", "hematology", "White cells", "volatile", "non-volatile", "pahs"], "article_id"=>697300, "categories"=>["Medicine", "Engineering", "Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Nicky Pieters", "Gudrun Koppen", "Karen Smeets", "Dorota Napierska", "Michelle Plusquin", "Sofie De Prins", "Hendrik Van De Weghe", "Vera Nelen", "Bianca Cox", "Ann Cuypers", "Peter Hoet", "Greet Schoeters", "Tim S. Nawrot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0063208.t003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_amount_25th_75th_percentile_of_volatile_and_non_volatile_PAHs_and_benzo_a_pyrene_found_in_house_dust_ng_g_dust_/697300", "title"=>"Median amount (25th–75th percentile) of volatile and non-volatile PAHs and benzo<i>(a)</i>pyrene found in house dust (ng/g dust).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-03 02:01:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052969"], "description"=>"<p>PHE, phenanthrene; FLU, fluoranthene; PYR, pyrene; BaA, benzo<i>(a)</i>anthracene; CHR, chrysene; BbF, benzo<i>(b)</i>fluoranthene; BkF, benzo(<i>k)</i>fluoranthene; BAP, benzo<i>(a)</i>pyrene; PIY, indenol<i>(1,2,3-cd)</i>pyrene; BPE, benzo<i>(g,h,i)</i>perylene; NAP, naphthalene; ACN, acenaphtylene; ACE, acenapthnene; FLE, fluorene; ANT, anthracene; dBA, dibenzo<i>(a,h)</i>anthracene.</p>", "links"=>[], "tags"=>["Biochemistry", "Bioenergetics", "Energy-producing organelles", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Stress signaling cascade", "Cellular stress responses", "Population biology", "epidemiology", "Environmental epidemiology", "Environmental sciences", "Environmental engineering", "pollution", "Clinical research design", "hematology", "White cells", "pah-component"], "article_id"=>697297, "categories"=>["Medicine", "Engineering", "Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Nicky Pieters", "Gudrun Koppen", "Karen Smeets", "Dorota Napierska", "Michelle Plusquin", "Sofie De Prins", "Hendrik Van De Weghe", "Vera Nelen", "Bianca Cox", "Ann Cuypers", "Peter Hoet", "Greet Schoeters", "Tim S. Nawrot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0063208.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_amount_of_each_PAH_component_in_winter_and_in_summer_ng_g_dust_/697297", "title"=>"Median amount of each PAH-component in winter and in summer (ng/g dust).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 02:01:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052977"], "description"=>"*<p>Primer efficiency was determined in two different experiments.</p><p>Mitochondrial encoded NADH dehydrogenase 1 (ND-1; Beta actin (β-actin); Acidic ribosomal phosphoprotein P0 (36B4).</p>", "links"=>[], "tags"=>["Biochemistry", "Bioenergetics", "Energy-producing organelles", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Stress signaling cascade", "Cellular stress responses", "Population biology", "epidemiology", "Environmental epidemiology", "Environmental sciences", "Environmental engineering", "pollution", "Clinical research design", "hematology", "White cells", "genes"], "article_id"=>697303, "categories"=>["Medicine", "Engineering", "Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Nicky Pieters", "Gudrun Koppen", "Karen Smeets", "Dorota Napierska", "Michelle Plusquin", "Sofie De Prins", "Hendrik Van De Weghe", "Vera Nelen", "Bianca Cox", "Ann Cuypers", "Peter Hoet", "Greet Schoeters", "Tim S. Nawrot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0063208.t007", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_selected_genes_for_qPCR_/697303", "title"=>"Characteristics of selected genes for qPCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-03 02:01:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052979"], "description"=>"<p>TK6 cells viability and number of dead and living cells per exposure condition to benzo<i>(a)</i>pyrene (BAP).</p>", "links"=>[], "tags"=>["Biochemistry", "Bioenergetics", "Energy-producing organelles", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Stress signaling cascade", "Cellular stress responses", "Population biology", "epidemiology", "Environmental epidemiology", "Environmental sciences", "Environmental engineering", "pollution", "Clinical research design", "hematology", "White cells", "cells", "viability"], "article_id"=>697304, "categories"=>["Medicine", "Engineering", "Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Nicky Pieters", "Gudrun Koppen", "Karen Smeets", "Dorota Napierska", "Michelle Plusquin", "Sofie De Prins", "Hendrik Van De Weghe", "Vera Nelen", "Bianca Cox", "Ann Cuypers", "Peter Hoet", "Greet Schoeters", "Tim S. Nawrot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0063208.t006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TK6_cells_viability_and_number_of_dead_and_living_cells_per_exposure_condition_to_benzo_a_pyrene_BAP_/697304", "title"=>"TK6 cells viability and number of dead and living cells per exposure condition to benzo<i>(a)</i>pyrene (BAP).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-03 02:01:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052976"], "description"=>"<p>Data are presented as median (IQR = 25–75 percentile)or number (%).</p><p>Heating source data per household.</p>", "links"=>[], "tags"=>["Biochemistry", "Bioenergetics", "Energy-producing organelles", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Stress signaling cascade", "Cellular stress responses", "Population biology", "epidemiology", "Environmental epidemiology", "Environmental sciences", "Environmental engineering", "pollution", "Clinical research design", "hematology", "White cells"], "article_id"=>697302, "categories"=>["Medicine", "Engineering", "Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Nicky Pieters", "Gudrun Koppen", "Karen Smeets", "Dorota Napierska", "Michelle Plusquin", "Sofie De Prins", "Hendrik Van De Weghe", "Vera Nelen", "Bianca Cox", "Ann Cuypers", "Peter Hoet", "Greet Schoeters", "Tim S. Nawrot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0063208.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_study_population_/697302", "title"=>"Characteristics of the study population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-03 02:01:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052973"], "description"=>"<p>Mean mitochondrial DNA (mtDNA) content of human TK6 cells exposed to 0; 0.05; 0.5; 5; 50 and 500 µM benzo<i>(a)</i>pyrene (BAP). Data are presented as mean ± SD; n = 3. *p<0.05 vs control (0 µM BAP); **p<0.01 vs. control (Analysis of variance: Kruskall-Wallis). Jonckheere-Terpstra test showed a significant (p = 0.0011) decrease over the exposure range.</p>", "links"=>[], "tags"=>["Biochemistry", "Bioenergetics", "Energy-producing organelles", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Stress signaling cascade", "Cellular stress responses", "Population biology", "epidemiology", "Environmental epidemiology", "Environmental sciences", "Environmental engineering", "pollution", "Clinical research design", "hematology", "White cells", "mitochondrial", "dna"], "article_id"=>697299, "categories"=>["Medicine", "Engineering", "Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Nicky Pieters", "Gudrun Koppen", "Karen Smeets", "Dorota Napierska", "Michelle Plusquin", "Sofie De Prins", "Hendrik Van De Weghe", "Vera Nelen", "Bianca Cox", "Ann Cuypers", "Peter Hoet", "Greet Schoeters", "Tim S. Nawrot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0063208.g003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_mitochondrial_DNA_content_in_response_to_benzo_a_pyrene_/697299", "title"=>"Mean mitochondrial DNA content in response to benzo<i>(a)</i>pyrene.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 02:01:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1052971"], "description"=>"<p>Four correlation plots are given, each indicating different PAH exposure, volatile PAHs in house dust in winter (A), non-volatile PAHs in house dust in winter (B), volatile PAHs in house dust in summer in (C) and non-volatile PAHs in house dust in summer in (D). Values of mitochondrial DNA content (mtDNAcn) are log transformed.</p>", "links"=>[], "tags"=>["Biochemistry", "Bioenergetics", "Energy-producing organelles", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Stress signaling cascade", "Cellular stress responses", "Population biology", "epidemiology", "Environmental epidemiology", "Environmental sciences", "Environmental engineering", "pollution", "Clinical research design", "hematology", "White cells", "mitochondrial", "dna", "pah"], "article_id"=>697298, "categories"=>["Medicine", "Engineering", "Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Nicky Pieters", "Gudrun Koppen", "Karen Smeets", "Dorota Napierska", "Michelle Plusquin", "Sofie De Prins", "Hendrik Van De Weghe", "Vera Nelen", "Bianca Cox", "Ann Cuypers", "Peter Hoet", "Greet Schoeters", "Tim S. Nawrot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0063208.g002", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_mitochondrial_DNA_content_and_PAH_exposure_in_winter_and_in_summer_/697298", "title"=>"Association between mitochondrial DNA content and PAH exposure in winter and in summer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-03 02:01:38"}

PMC Usage Stats | Further Information

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Relative Metric

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