Iron-Ascorbate-Mediated Lipid Peroxidation Causes Epigenetic Changes in the Antioxidant Defense in Intestinal Epithelial Cells: Impact on Inflammation
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{"title"=>"Iron-Ascorbate-Mediated Lipid Peroxidation Causes Epigenetic Changes in the Antioxidant Defense in Intestinal Epithelial Cells: Impact on Inflammation", "type"=>"journal", "authors"=>[{"first_name"=>"Sabrina", "last_name"=>"Yara", "scopus_author_id"=>"55586588400"}, {"first_name"=>"Jean Claude", "last_name"=>"Lavoie", "scopus_author_id"=>"7103144615"}, {"first_name"=>"Jean François", "last_name"=>"Beaulieu", "scopus_author_id"=>"7102565163"}, {"first_name"=>"Edgard", "last_name"=>"Delvin", "scopus_author_id"=>"35464025700"}, {"first_name"=>"Devendra", "last_name"=>"Amre", "scopus_author_id"=>"6602750508"}, {"first_name"=>"Valerie", "last_name"=>"Marcil", "scopus_author_id"=>"6507754567"}, {"first_name"=>"Ernest", "last_name"=>"Seidman", "scopus_author_id"=>"7103309593"}, {"first_name"=>"Emile", "last_name"=>"Levy", "scopus_author_id"=>"35429629200"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84878097254", "sgr"=>"84878097254", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0063456", "pmid"=>"23717425", "pui"=>"368973471"}, "id"=>"b63a11d4-bf38-31fb-b4bd-d69e1394bfc8", "abstract"=>"INTRODUCTION: The gastrointestinal tract is frequently exposed to noxious stimuli that may cause oxidative stress, inflammation and injury. Intraluminal pro-oxidants from ingested nutrients especially iron salts and ascorbic acid frequently consumed together, can lead to catalytic formation of oxygen-derived free radicals that ultimately overwhelm the cellular antioxidant defense and lead to cell damage.\\n\\nHYPOTHESIS: Since the mechanisms remain sketchy, efforts have been exerted to evaluate the role of epigenetics in modulating components of endogenous enzymatic antioxidants in the intestine. To this end, Caco-2/15 cells were exposed to the iron-ascorbate oxygen radical-generating system.\\n\\nRESULTS: Fe/Asc induced a significant increase in lipid peroxidation as reflected by the elevated formation of malondialdehyde along with the alteration of antioxidant defense as evidenced by raised superoxide dismutase 2 (SOD2) and diminished glutathione peroxidase (GPx) activities and genes. Consequently, there was an up-regulation of inflammatory processes illustrated by the activation of NF-κB transcription factor, the higher production of interleukin-6 and cycloxygenase-2 as well as the decrease of IκB. Assessment of promoter's methylation revealed decreased levels for SOD2 and increased degree for GPx2. On the other hand, pre-incubation of Caco-2/15 cells with 5-Aza-2'-deoxycytidine, a demethylating agent, or Trolox antioxidant normalized the activities of SOD2 and GPx, reduced lipid peroxidation and prevented inflammation.\\n\\nCONCLUSION: Redox and inflammatory modifications in response to Fe/Asc -mediated lipid peroxidation may implicate epigenetic methylation.", "link"=>"http://www.mendeley.com/research/ironascorbatemediated-lipid-peroxidation-causes-epigenetic-changes-antioxidant-defense-intestinal-ep-4", "reader_count"=>3, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Ph. D. Student"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Ph. D. Student"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/1548001/Figure_1.tif"], "description"=>"<p>Caco-2/15 cells were incubated with Fe/Asc (200 µM/2 mM) and Trolox (0.25 mM) for 6 h at 37°C and/or with 5-AZA (10 µM) as described in Materials and Methods, Cellular viability was assessed by MTT. Results represent the means ± SEM of n = 3 independent experiments.</p>", "links"=>[], "tags"=>["Biochemistry", "genetics", "epigenetics", "immunology", "immunity", "inflammation", "Molecular cell biology", "gene expression", "DNA modification", "Cellular stress responses", "Metabolic disorders", "nutrition", "viability"], "article_id"=>1068439, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Sabrina Yara", "Jean-Claude Lavoie", "Jean-François Beaulieu", "Edgard Delvin", "Devendra Amre", "Valerie Marcil", "Ernest Seidman", "Emile Levy"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0063456.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Effects_of_iron_ascorbate_and_5_Aza_2_8242_deoxycytidine_on_cell_viability_in_Caco_2_15_cells_/1068439", "title"=>"Effects of iron/ascorbate and 5-Aza-2′-deoxycytidine on cell viability in Caco-2/15 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 07:35:35"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/1548002/Figure_2.tif"], "description"=>"<p>Caco-2/15 cells were exposed to Fe/Asc (200 µM/2 mM) and Trolox (0.25 mM) for 6 h at 37°C and/or with 5-AZA (10 µM). Oxidative stress was assessed by measuring MDA as an index of lipid peroxidation. Values are means ± SEM for three independent experiments. ***P<0.001 vs. controls; <sup>###</sup>P<0.001 vs. Fe/Asc.</p>", "links"=>[], "tags"=>["Biochemistry", "genetics", "epigenetics", "immunology", "immunity", "inflammation", "Molecular cell biology", "gene expression", "DNA modification", "Cellular stress responses", "Metabolic disorders", "nutrition", "concentrations", "cells", "challenged"], "article_id"=>1068440, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Sabrina Yara", "Jean-Claude Lavoie", "Jean-François Beaulieu", "Edgard Delvin", "Devendra Amre", "Valerie Marcil", "Ernest Seidman", "Emile Levy"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0063456.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Malondialdehyde_concentrations_in_Caco_2_15_cells_challenged_with_iron_ascorbate_and_or_Trolox_/1068440", "title"=>"Malondialdehyde concentrations in Caco-2/15 cells challenged with iron/ascorbate and/or Trolox.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 07:35:35"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/1548005/Figure_3.tif"], "description"=>"<p>Caco-2/15 cells were incubated with Fe/Asc (200 µM/2 mM) and Trolox (0.25 mM) for 6 h at 37°C and/or with 5-AZA (10 µM). The protein expression of NF-κB (A, D) and IκB (B, E) were determined by western blot as described in Materials and Methods. Then the NF-κB/IκB was calculated (C, F). Results represent the means ± SEM of n = 3 independent experiments. *P<0.05, **P<0.01 vs. controls; <sup>#</sup>P<0.05, <sup>##</sup>P<0.01 vs. Fe/Asc.</p>", "links"=>[], "tags"=>["Biochemistry", "genetics", "epigenetics", "immunology", "immunity", "inflammation", "Molecular cell biology", "gene expression", "DNA modification", "Cellular stress responses", "Metabolic disorders", "nutrition", "oxidative", "transcription"], "article_id"=>1068443, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Sabrina Yara", "Jean-Claude Lavoie", "Jean-François Beaulieu", "Edgard Delvin", "Devendra Amre", "Valerie Marcil", "Ernest Seidman", "Emile Levy"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0063456.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Effects_of_oxidative_stress_on_transcription_factor_NF_954_B_in_Caco_2_15_cells_/1068443", "title"=>"Effects of oxidative stress on transcription factor NF-κB in Caco-2/15 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 07:35:35"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/1548008/Figure_4.tif"], "description"=>"<p>Cells were incubated with Fe/Asc (200 µM/2 mM) and Trolox (0.25 mM) for 6 h at 37°C and/or with 5-AZA (10 µM). The protein expression of Interleukin-6 (IL-6) (A, C) and cyclooxygenase 2 (COX2) (B, D) was determined by western blot as described in Materials and Methods. Results represent the means ± SEM of n = 3 independent experiments. *P<0.05, **P<0.01 vs. controls; <sup>#</sup>P<0.05, <sup>##</sup>P<0.01 vs. Fe/Asc.</p>", "links"=>[], "tags"=>["Biochemistry", "genetics", "epigenetics", "immunology", "immunity", "inflammation", "Molecular cell biology", "gene expression", "DNA modification", "Cellular stress responses", "Metabolic disorders", "nutrition", "oxidative", "inflammatory", "markers"], "article_id"=>1068446, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Sabrina Yara", "Jean-Claude Lavoie", "Jean-François Beaulieu", "Edgard Delvin", "Devendra Amre", "Valerie Marcil", "Ernest Seidman", "Emile Levy"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0063456.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Effects_of_oxidative_stress_on_inflammatory_markers_in_Caco_2_15_cells_/1068446", "title"=>"Effects of oxidative stress on inflammatory markers in Caco-2/15 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 07:35:35"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/1548012/Figure_5.tif"], "description"=>"<p>Cells were incubated with Fe/Asc (200 µM/2 mM) and Trolox (0.25 mM) for 6 h at 37°C and/or with 5-AZA (10 µM). The activities of SOD2 (A, D), GPx (B, E) and G-Red (C) were then measured as described in Materials and Methods. Results represent the means ± SEM of n = 3 independent experiments. *P<0.05 vs. controls; <sup>#</sup>P<0.05, <sup>##</sup>P<0.01 vs. Fe/Asc.</p>", "links"=>[], "tags"=>["Biochemistry", "genetics", "epigenetics", "immunology", "immunity", "inflammation", "Molecular cell biology", "gene expression", "DNA modification", "Cellular stress responses", "Metabolic disorders", "nutrition", "oxidative", "endogenous", "antioxidant", "activities"], "article_id"=>1068450, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Sabrina Yara", "Jean-Claude Lavoie", "Jean-François Beaulieu", "Edgard Delvin", "Devendra Amre", "Valerie Marcil", "Ernest Seidman", "Emile Levy"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0063456.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Effects_of_oxidative_stress_on_regulatory_endogenous_antioxidant_activities_in_Caco_2_15_cells_/1068450", "title"=>"Effects of oxidative stress on regulatory endogenous antioxidant activities in Caco-2/15 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 07:35:35"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/1548016/Figure_6.tif"], "description"=>"<p>Cells were incubated with Fe/Asc (200 µM/2 mM) and Trolox (0.25 mM) for 6 h at 37°C and/or with 5-AZA (10 µM). Gene expression of SOD2 (A, C) and GPx (B, D) were then measured as described in Materials and Methods. Results represent the means ± SEM of n = 3 independent experiments. *P<0.05, ***P<0.001 vs. controls; <sup>##</sup>P<0.01, <sup>###</sup>P<0.001 vs. Fe/Asc.</p>", "links"=>[], "tags"=>["Biochemistry", "genetics", "epigenetics", "immunology", "immunity", "inflammation", "Molecular cell biology", "gene expression", "DNA modification", "Cellular stress responses", "Metabolic disorders", "nutrition", "oxidative", "antioxidant", "genes"], "article_id"=>1068454, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Sabrina Yara", "Jean-Claude Lavoie", "Jean-François Beaulieu", "Edgard Delvin", "Devendra Amre", "Valerie Marcil", "Ernest Seidman", "Emile Levy"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0063456.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Effects_of_oxidative_stress_on_antioxidant_genes_in_Caco_2_15_cells_/1068454", "title"=>"Effects of oxidative stress on antioxidant genes in Caco-2/15 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 07:35:35"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/1548019/Figure_7.tif"], "description"=>"<p>Cells were incubated with Fe/Asc (200 µM/2 mM) and Trolox (0.25 mM) for 6 h at 37°C and/or with 5-AZA (10 µM). DNA methylation of SOD2 (A, C) and GPx2 (B, D) was then determined as described in Materials and Methods. Results represent the means ± SEM of n = 3 independent experiments. **P<0.01, ***P<0.001 vs. controls; <sup>#</sup>P<0.05, <sup>##</sup>P<0.01 vs. Fe/Asc.</p>", "links"=>[], "tags"=>["Biochemistry", "genetics", "epigenetics", "immunology", "immunity", "inflammation", "Molecular cell biology", "gene expression", "DNA modification", "Cellular stress responses", "Metabolic disorders", "nutrition", "gpx2", "promoter", "methylation"], "article_id"=>1068456, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Sabrina Yara", "Jean-Claude Lavoie", "Jean-François Beaulieu", "Edgard Delvin", "Devendra Amre", "Valerie Marcil", "Ernest Seidman", "Emile Levy"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0063456.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_SOD2_and_GPX2_promoter_methylation_following_Fe_Asc_exposition_/1068456", "title"=>"SOD2 and GPX2 promoter methylation following Fe/Asc exposition.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 07:35:35"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"7", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[272, 466, 589, 702, 806, 903, 995, 1086, 1176, 1258, 1347, 1422, 1493]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[262, 463, 587, 693, 790, 882, 965, 1051, 1135, 1218, 1300, 1376, 1438]}]}
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