miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines
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{"title"=>"miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines", "type"=>"journal", "authors"=>[{"first_name"=>"Himanshu", "last_name"=>"Arora"}, {"first_name"=>"Rehana", "last_name"=>"Qureshi"}, {"first_name"=>"Woong-Yang", "last_name"=>"Park"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0064273", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23717581"}, "id"=>"7b1c5dcc-6b8b-398f-9015-1dc24136c0b1", "abstract"=>"Epithelial-mesenchymal transition (EMT) is an important parameter related to breast cancer survival. Among several microRNAs predicted to target EMT-related genes, miR-506 is a novel miRNA found to be significantly related to breast cancer patient survival in a meta-analysis. miR-506 suppressed the expression of mesenchymal genes such as Vimentin, Snai2, and CD151 in MDA-MB-231 human breast cancer cell line. Moreover, NF-κB bound to the upstream promoter region of miR-506 to suppress transcription. Overexpression of miR-506 inhibited TGFβ-induced EMT and suppressed adhesion, invasion, and migration of MDA-MB-231 cells. From these results, we concluded that miR-506 plays a key role in the process of EMT through posttranslational control of EMT-related genes.", "link"=>"http://www.mendeley.com/research/mir506-regulates-epithelial-mesenchymal-transition-breast-cancer-cell-lines-3", "reader_count"=>24, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>1, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>1, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>4, "Arts and Humanities"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Finland"=>1, "Italy"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1066566"], "description"=>"<p>(A) miR-506 could induce TGFβ-induced morphological changes in MCF10A cells. (B) Expression of various EMT markers such as SNAI2, CD151, CDH1, and NF<b>-</b>κB were checked in miR-506 in TGFβ-treated MCF10A cells.</p>", "links"=>[], "tags"=>["biophysics", "Cell motility", "genetics", "gene expression", "DNA transcription", "epigenetics", "genomics", "Genome expression analysis", "Molecular cell biology", "cell adhesion", "Cell growth", "statistics", "Biostatistics", "Obstetrics and gynecology", "breast cancer", "oncology", "Basic cancer research", "metastasis", "Cancers and neoplasms", "Breast tumors", "epithelial", "mesenchymal"], "article_id"=>706261, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Himanshu Arora", "Rehana Qureshi", "Woong-Yang Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064273.g003", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regulation_of_epithelial_to_mesenchymal_transition_by_miR_506_/706261", "title"=>"Regulation of epithelial to mesenchymal transition by miR-506.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 01:44:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1066567"], "description"=>"<p>(A) Overexpression of miR-506 in MDA-MB-231 cells may alter the binding to the various matrix components responsible for cell adhesion (extracellular matrix array) such as fibronectin, collagen 1, collagen 4, lamin 1, fibrogen (bovine serum albumin was used as a negative control). (B) Invasive capacity of MDA-MB-231 cells was analyzed by Matrigen Invasion Assay. Overexpression of miR-506 on the regulation of overall migratory properties were observed by (C) wound healing assay or (D) Boyden Chamber Assay (3D migration assay). (E) Summary of miR-506-mediated control of EMT.</p>", "links"=>[], "tags"=>["biophysics", "Cell motility", "genetics", "gene expression", "DNA transcription", "epigenetics", "genomics", "Genome expression analysis", "Molecular cell biology", "cell adhesion", "Cell growth", "statistics", "Biostatistics", "Obstetrics and gynecology", "breast cancer", "oncology", "Basic cancer research", "metastasis", "Cancers and neoplasms", "Breast tumors", "mir-506"], "article_id"=>706262, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Himanshu Arora", "Rehana Qureshi", "Woong-Yang Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064273.g004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_miR_506_in_cell_adhesion_migration_and_invasion_/706262", "title"=>"Effects of miR-506 in cell adhesion, migration, and invasion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 01:44:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/1066556"], "description"=>"<p>(A) The clinical significance of miR-506 in patients with breast cancer. Tissue samples from patients with breast cancer were analyzed GEO dataset, and patients were divided into two sets based on miRNA expression (greater or less than the median, p<0.05). P values were computed by log rank and Wilcoxon tests of significance. (B) Expression of CD151, VIM, SNAI2, and CDH1 in the presence of overexpression of miR-506 was determined by qRT-PCR and (C) western blotting. (D) miR-506 targets the 3′UTRs of CD151, VIM, and SNAI2. The 3′ UTRs of CD151, VIM, and SNAI2 were cloned into psiCHECK2 vector. Mutations in the miR-506 target sites in these UTRs were generated. MDA-MB-231 cells were cotransfected with UTR (normal and mutant)-bearing psiCHECK2 vector and pcDNA3-cloned miR-506 for 48 hrs. Luciferase assays were performed. Renilla expression was normalized to the luciferase gene on the psiCHECK2 vector. All experiments were performed in triplicate and repeated at least twice.</p>", "links"=>[], "tags"=>["biophysics", "Cell motility", "genetics", "gene expression", "DNA transcription", "epigenetics", "genomics", "Genome expression analysis", "Molecular cell biology", "cell adhesion", "Cell growth", "statistics", "Biostatistics", "Obstetrics and gynecology", "breast cancer", "oncology", "Basic cancer research", "metastasis", "Cancers and neoplasms", "Breast tumors", "mir-506", "emt-regulating", "mirna", "suppression", "emt-related", "genes"], "article_id"=>706259, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Himanshu Arora", "Rehana Qureshi", "Woong-Yang Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064273.g001", "stats"=>{"downloads"=>0, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selection_of_miR_506_as_a_candidate_EMT_regulating_miRNA_and_suppression_of_EMT_related_genes_by_miR_506_/706259", "title"=>"Selection of miR-506 as a candidate EMT-regulating miRNA and suppression of EMT-related genes by miR-506.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 01:44:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1066562"], "description"=>"<p>(A) Chromatin immunoprecipitation showing the interaction between NF-κB and miR-506. (B) miR-506 and NF-κB correlation in different breast cancer cell lines. (C) Expression of miR-506 in MDA-MB-231 cells transfected with siNF-κB. (D) NF-κB expression in MDA-MB-231 cells transfected with miR-506.</p>", "links"=>[], "tags"=>["biophysics", "Cell motility", "genetics", "gene expression", "DNA transcription", "epigenetics", "genomics", "Genome expression analysis", "Molecular cell biology", "cell adhesion", "Cell growth", "statistics", "Biostatistics", "Obstetrics and gynecology", "breast cancer", "oncology", "Basic cancer research", "metastasis", "Cancers and neoplasms", "Breast tumors", "upstream", "sequences", "mir-506", "suppress"], "article_id"=>706260, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Himanshu Arora", "Rehana Qureshi", "Woong-Yang Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064273.g002", "stats"=>{"downloads"=>4, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Binding_of_NF_954_B_to_upstream_sequences_of_miR_506_to_suppress_transcription_/706260", "title"=>"Binding of NF-κB to upstream sequences of miR-506 to suppress transcription.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-22 01:44:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1066569", "https://ndownloader.figshare.com/files/1066572", "https://ndownloader.figshare.com/files/1066573", "https://ndownloader.figshare.com/files/1066576", "https://ndownloader.figshare.com/files/1066577"], "description"=>"<div><p>Epithelial-mesenchymal transition (EMT) is an important parameter related to breast cancer survival. Among several microRNAs predicted to target EMT-related genes, miR-506 is a novel miRNA found to be significantly related to breast cancer patient survival in a meta-analysis. miR-506 suppressed the expression of mesenchymal genes such as Vimentin, Snai2, and CD151 in MDA-MB-231 human breast cancer cell line. Moreover, NF<b>-</b>κB bound to the upstream promoter region of miR-506 to suppress transcription. Overexpression of miR-506 inhibited TGFβ-induced EMT and suppressed adhesion, invasion, and migration of MDA-MB-231 cells. From these results, we concluded that miR-506 plays a key role in the process of EMT through posttranslational control of EMT-related genes.</p></div>", "links"=>[], "tags"=>["biophysics", "Cell motility", "genetics", "gene expression", "DNA transcription", "epigenetics", "genomics", "Genome expression analysis", "Molecular cell biology", "cell adhesion", "Cell growth", "statistics", "Biostatistics", "Obstetrics and gynecology", "breast cancer", "oncology", "Basic cancer research", "metastasis", "Cancers and neoplasms", "Breast tumors", "regulates", "epithelial", "mesenchymal", "cancer"], "article_id"=>706263, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Himanshu Arora", "Rehana Qureshi", "Woong-Yang Park"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0064273.s001", "https://dx.doi.org/10.1371/journal.pone.0064273.s002", "https://dx.doi.org/10.1371/journal.pone.0064273.s003", "https://dx.doi.org/10.1371/journal.pone.0064273.s004", "https://dx.doi.org/10.1371/journal.pone.0064273.s005"], "stats"=>{"downloads"=>25, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miR_506_Regulates_Epithelial_Mesenchymal_Transition_in_Breast_Cancer_Cell_Lines_/706263", "title"=>"miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-05-22 01:44:23"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"1", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"20", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"4"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[275, 472, 605, 720, 822, 921, 1013, 1106, 1200, 1289, 1378, 1459, 1531]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[284, 491, 620, 738, 843, 945, 1043, 1137, 1225, 1315, 1400, 1479, 1555]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Oncology", "average_usage"=>[249, 468, 599, 718, 820, 920, 1008, 1093, 1181, 1281, 1357, 1444, 1517]}]}
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