Deciphering the Unique MicroRNA Signature in Human Esophageal Adenocarcinoma
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{"title"=>"Deciphering the Unique MicroRNA Signature in Human Esophageal Adenocarcinoma", "type"=>"journal", "authors"=>[{"first_name"=>"Rama", "last_name"=>"Saad", "scopus_author_id"=>"36968729100"}, {"first_name"=>"Zheng", "last_name"=>"Chen", "scopus_author_id"=>"55605762692"}, {"first_name"=>"Shoumin", "last_name"=>"Zhu", "scopus_author_id"=>"37091795900"}, {"first_name"=>"Peilin", "last_name"=>"Jia", "scopus_author_id"=>"14030192100"}, {"first_name"=>"Zhongming", "last_name"=>"Zhao", "scopus_author_id"=>"7404147874"}, {"first_name"=>"M. Kay", "last_name"=>"Washington", "scopus_author_id"=>"7007171283"}, {"first_name"=>"Abbes", "last_name"=>"Belkhiri", "scopus_author_id"=>"6603100270"}, {"first_name"=>"Wael", "last_name"=>"El-Rifai", "scopus_author_id"=>"55354403700"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84878407662", "pui"=>"369024956", "doi"=>"10.1371/journal.pone.0064463", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "sgr"=>"84878407662", "pmid"=>"23724052"}, "id"=>"d8437f48-d28b-385a-9f12-634b2fc89673", "abstract"=>"BACKGROUND AND METHODS: Esophageal adenocarcinoma (EAC) is characterized by a steep rise in incidence rates in the Western population. The unique miRNA signature that distinguishes EAC from other upper gastrointestinal cancers remains unclear. Herein, we performed a comprehensive microarray profiling for the specific miRNA signature associated with EAC. We validated this signature by qRT-PCR. RESULTS: Microarray analysis showed that 21 miRNAs were consistently deregulated in EAC. miR-194, miR-192, miR-200a, miR-21, miR-203, miR-205, miR-133b, and miR-31 were selected for validation using 46 normal squamous (NS), 23 Barrett's esophagus (BE), 17 Barrett's high grade dysplasia (HGD), 34 EAC, 33 gastric adenocarcinoma (GC), and 45 normal gastric (NG) tissues. The qRT-PCR analysis indicated that 2 miRNAs (miR-21 and miR-133b) were deregulated in both EAC and GC, and 6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC, as compared to BE but not in GC, indicating their potential unique role in EAC. Our data showed that miR-194, miR-192, miR-21, and miR-31 were up-regulated in BE adjacent to HGD lesions relative to isolated BE samples. Analysis of clinicopathological features indicated that down-regulation of miR-203 is significantly associated with progression and tumor stages in EAC. Interestingly, the overexpression levels of miR-194, miR-200a, and miR-192 were significantly higher in early EAC stages, suggesting that these miRNAs may be involved in EAC tumor development rather than progression. CONCLUSION: Our findings demonstrate the presence of a unique miRNA signature for EAC. This may provide some clues for the distinct molecular features of EAC to be considered in future studies of the role of miRNAs in EAC and their utility as disease biomarkers.", "link"=>"http://www.mendeley.com/research/deciphering-unique-microrna-signature-human-esophageal-adenocarcinoma", "reader_count"=>27, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>3, "Student > Bachelor"=>6, "Lecturer"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>3, "Student > Bachelor"=>6, "Lecturer"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>14, "Agricultural and Biological Sciences"=>7}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1068585"], "description"=>"#<p>The median values of FC are shown relative to reference miR-191.</p>*<p>P value is shown for the comparison to NS.</p>**<p>P value is shown for the comparison to BE.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "mirna"], "article_id"=>707547, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.t003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_levels_of_miRNA_expression_in_NS_BE_HGD_and_EAC_/707547", "title"=>"Median levels of miRNA expression in NS, BE, HGD, and EAC.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-28 02:05:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068584"], "description"=>"<p>Sequence of qRT-PCR primers from the miRbase database (<a href=\"http://www.miRbase.org\" target=\"_blank\">www.miRbase.org</a>).</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "qrt-pcr", "primers", "mirbase"], "article_id"=>707546, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.t001", "stats"=>{"downloads"=>3, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sequence_of_qRT_PCR_primers_from_the_miRbase_database_www_miRbase_org_/707546", "title"=>"Sequence of qRT-PCR primers from the miRbase database (www.miRbase.org).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-28 02:05:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068577"], "description"=>"<p>The expression levels of the 2 miRNAs (miR-21, and miR-133b) were measured by means of qRT-PCR in 13 BE, 34 EAC, 45 NG, and 33 GC tissue samples. The FC of expression relative to miR-191 is shown using box-and-whisker plots. The horizontal line represents the median value. Data were graphed as a range from 5<sup>th</sup> to 95<sup>th</sup> percentile. Student’s t-test was used for statistical analysis. A p value ≤0.05 was considered statistically significant.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "mirnas", "dysregulated", "eac"], "article_id"=>707541, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.g006", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Identification_of_miRNAs_commonly_dysregulated_in_both_EAC_and_GC_/707541", "title"=>"Identification of miRNAs commonly dysregulated in both EAC and GC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-28 02:05:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068576"], "description"=>"<p>The expression levels of the 6 miRNAs (miR-194, miR-192, miR-203, miR-205, miR-200a, and miR-31) were measured by means of qRT-PCR in 13 BE, 34 EAC, 45 NG, and 33 GC tissue samples. The FC of expression relative to miR-191 is shown using box-and-whisker plots. The plot groups the data into five categories: the lowest observation, the first quartile (Q1), the median (Q2), the third quartile (Q3), and the largest observation. The horizontal line represents the median value. Data were graphed as a range from 5<sup>th</sup> to 95<sup>th</sup> percentile. Student’s t-test was used for statistical analysis. A p value ≤0.05 was considered statistically significant.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "mirnas"], "article_id"=>707540, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Identification_of_unique_miRNAs_for_EAC_/707540", "title"=>"Identification of unique miRNAs for EAC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-28 02:05:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068573"], "description"=>"<p>The expression of 4 miRNAs (miR-205, miR-133b, miR-203, and miR-31) was evaluated using qRT-PCR in 46 NS, 13 BE, 17 HGD, and 34 EAC tissues. The data are plotted as the FC of expression relative to miR-191 expression. Each data point represents a different patient tissue sample. The horizontal bars indicate the median. Student’s t-test was used for statistical analysis. A value of p≤0.05 was considered statistically significant.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "validation", "down-regulated", "mirnas"], "article_id"=>707537, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.g003", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_qRT_PCR_validation_of_down_regulated_miRNAs_in_EAC_/707537", "title"=>"qRT-PCR validation of down-regulated miRNAs in EAC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-28 02:05:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068571"], "description"=>"<p>The Venn diagram was used to identify overlapping and non-overlapping miRNAs in the analysis of Exiqon and Agilent microarrays. 3 EAC tissue samples were used for microarray. 3 pooled NS tissue samples were used as a tissue comparator. miRNAs with ≥2 FC difference (up or down) were included. Exi, Exiqon; Agi, Agilent; D, down-regulated; U, up-regulated.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "diagram", "mirna"], "article_id"=>707535, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.g001", "stats"=>{"downloads"=>4, "page_views"=>43, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Venn_diagram_of_miRNA_analysis_in_EAC_/707535", "title"=>"Venn diagram of miRNA analysis in EAC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-28 02:05:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068572"], "description"=>"<p>The expression of 4 miRNAs (miR-192, miR-194, miR-21, and miR-200a) was evaluated using qRT-PCR in 46 NS, 13 BE, 17 HGD, and 34 EAC tissues. The data are plotted as the FC of expression relative to miR-191 expression. Each data point represents a different sample. The horizontal bars indicate the median. Student’s t-test was used for statistical analysis. A value of p≤0.05 was considered statistically significant.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "validation", "up-regulated", "mirnas"], "article_id"=>707536, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.g002", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_qRT_PCR_validation_of_up_regulated_miRNAs_in_EAC_/707536", "title"=>"qRT-PCR validation of up-regulated miRNAs in EAC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-28 02:05:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068586"], "description"=>"<p>miRNAs that displayed at least 2-FC between EAC and NS in both Agilent and Exiqon microarray platforms.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "displayed", "2-fc", "eac", "ns", "agilent", "exiqon", "microarray"], "article_id"=>707548, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.t002", "stats"=>{"downloads"=>7, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miRNAs_that_displayed_at_least_2_FC_between_EAC_and_NS_in_both_Agilent_and_Exiqon_microarray_platforms_/707548", "title"=>"miRNAs that displayed at least 2-FC between EAC and NS in both Agilent and Exiqon microarray platforms.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-28 02:05:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068583"], "description"=>"<p>Profile of differentially expressed miRNAs in EAC as opposed to GC.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "differentially", "mirnas", "eac"], "article_id"=>707545, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.t004", "stats"=>{"downloads"=>9, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Profile_of_differentially_expressed_miRNAs_in_EAC_as_opposed_to_GC_/707545", "title"=>"Profile of differentially expressed miRNAs in EAC as opposed to GC.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-28 02:05:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068581"], "description"=>"<p>The expression of miRNAs in 13 isolated BE, 10 BE adjacent to HGD, and 17 HGD tissue samples were evaluated by qRT-PCR. The data are plotted as the FC of expression relative to miR-191 expression. Each data point represents a different patient tissue sample. The horizontal bars indicate the median. Student’s t-test was used for statistical analysis. A value of p≤0.05 was considered statistically significant.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "lesions", "adjacent"], "article_id"=>707543, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.g008", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miRNA_expression_in_isolated_BE_and_BE_lesions_adjacent_to_HGD_/707543", "title"=>"miRNA expression in isolated BE and BE lesions adjacent to HGD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-28 02:05:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068582"], "description"=>"#<p>The median values of FC are shown relative to reference miR-191.</p>*<p>P value is shown for the comparison to BE.</p>**<p>P value is shown for the comparison to BE adjacent to HGD.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "mirna", "adjacent"], "article_id"=>707544, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.t005", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_levels_of_miRNA_expression_in_isolated_BE_and_BE_adjacent_to_HGD_/707544", "title"=>"Median levels of miRNA expression in isolated BE and BE adjacent to HGD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-05-28 02:05:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068578"], "description"=>"<p>The expression levels of the 4 miRNAs (miR-203, miR-194, miR-192, and miR-200a) were evaluated in EAC tissue samples of stages I, II and III by means of qRT-PCR. The data is expressed as the log10 FC relative to miR-191. Each data point represents a different patient tissue sample. ANOVA was used for statistical analysis of the difference in miRNA expression across the 3 stages. Student t-test was used for statistical analysis between stages I&II, stages II&III, and stages I&III. A p value ≤0.05 was considered statistically significant.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "mirna", "eac"], "article_id"=>707542, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.g007", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_the_miRNA_expression_level_and_EAC_tumor_stage_/707542", "title"=>"Correlation between the miRNA expression level and EAC tumor stage.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-28 02:05:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1068575"], "description"=>"<p>The heatmap was generated using the Treeview® software <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0064463#pone.0064463-Page1\" target=\"_blank\">[18]</a>. The log10 values of fold expression of the 8 miRNAs (miR-192, miR-200a, miR-194, miR-21, miR-203, miR-205, miR-31, and miR-133b) were used for hierarchical clustering. miR-191 was used as a reference gene. The heatmap indicates the four histological groups of NS, BE (isolated BE or BE adjacent to HGD), HGD, and EAC.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Gastroenterology and hepatology", "esophagus", "Gastrointestinal cancers", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "mirna"], "article_id"=>707539, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rama Saad", "Zheng Chen", "Shoumin Zhu", "Peilin Jia", "Zhongming Zhao", "M. Kay Washington", "Abbes Belkhiri", "Wael El-Rifai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064463.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heatmap_of_the_miRNA_signature_in_EAC_/707539", "title"=>"Heatmap of the miRNA signature in EAC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-28 02:05:39"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"2", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"27", "full-text"=>"27", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"28", "full-text"=>"38", "pdf"=>"15", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"26", "full-text"=>"21", "pdf"=>"35", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"43", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"31", "full-text"=>"25", "pdf"=>"17", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"76", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"39", "full-text"=>"29", "pdf"=>"23", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"31", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
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  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"31", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"27", "full-text"=>"17", "pdf"=>"13", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"24", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
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Relative Metric

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