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{"title"=>"Doxycycline Alters Metabolism and Proliferation of Human Cell Lines", "type"=>"journal", "authors"=>[{"first_name"=>"Ethan", "last_name"=>"Ahler", "scopus_author_id"=>"55535997100"}, {"first_name"=>"William J.", "last_name"=>"Sullivan", "scopus_author_id"=>"55992409300"}, {"first_name"=>"Ashley", "last_name"=>"Cass", "scopus_author_id"=>"55613785300"}, {"first_name"=>"Daniel", "last_name"=>"Braas", "scopus_author_id"=>"6508083580"}, {"first_name"=>"Autumn G.", "last_name"=>"York", "scopus_author_id"=>"55700461700"}, {"first_name"=>"Steven J.", "last_name"=>"Bensinger", "scopus_author_id"=>"6602800046"}, {"first_name"=>"Thomas G.", "last_name"=>"Graeber", "scopus_author_id"=>"6603539183"}, {"first_name"=>"Heather R.", "last_name"=>"Christofk", "scopus_author_id"=>"16549070800"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"369052268", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0064561", "scopus"=>"2-s2.0-84878525884", "pmid"=>"23741339", "sgr"=>"84878525884"}, "id"=>"07266099-50dc-3a3c-b0ee-f9667bb02003", "abstract"=>"The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of tetracyclines on mammalian cells-including inhibition of the mitochondrial ribosome-there have been few reports on potential off-target effects at concentrations commonly used in inducible systems. Here, we report that in human cell lines, commonly used concentrations of doxycycline change gene expression patterns and concomitantly shift metabolism towards a more glycolytic phenotype, evidenced by increased lactate secretion and reduced oxygen consumption. We also show that these concentrations are sufficient to slow proliferation. These findings suggest that researchers using doxycycline in inducible expression systems should design appropriate controls to account for potential confounding effects of the drug on cellular metabolism.", "link"=>"http://www.mendeley.com/research/doxycycline-alters-metabolism-proliferation-human-cell-lines", "reader_count"=>147, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Researcher"=>23, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>51, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>29, "Student > Bachelor"=>16, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Researcher"=>23, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>51, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>29, "Student > Bachelor"=>16, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>3, "Biochemistry, Genetics and Molecular Biology"=>29, "Agricultural and Biological Sciences"=>83, "Medicine and Dentistry"=>15, "Neuroscience"=>3, "Sports and Recreations"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Chemical Engineering"=>1, "Chemistry"=>3, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Neuroscience"=>{"Neuroscience"=>3}, "Chemistry"=>{"Chemistry"=>3}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>83}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>29}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "United Kingdom"=>1, "Mexico"=>1, "France"=>1, "Switzerland"=>1, "Russia"=>1}, "group_count"=>2}

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PMC Usage Stats | Further Information

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• {"unique-ip"=>"142", "full-text"=>"177", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
• {"unique-ip"=>"112", "full-text"=>"132", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[293, 503, 638, 755, 861, 960, 1056, 1146, 1239, 1323, 1403, 1491, 1568]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Pharmacology", "average_usage"=>[265, 471, 604, 723, 827, 926, 1022, 1113, 1210, 1290, 1377, 1454, 1532]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[258, 449, 572, 679, 775, 866, 956, 1041, 1124, 1211, 1291, 1371, 1437]}]}

F1000Prime