Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans
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{"title"=>"Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans", "type"=>"journal", "authors"=>[{"first_name"=>"Mijke", "last_name"=>"Buitinga", "scopus_author_id"=>"55755185300"}, {"first_name"=>"Roman", "last_name"=>"Truckenmüller", "scopus_author_id"=>"6506092868"}, {"first_name"=>"Marten A.", "last_name"=>"Engelse", "scopus_author_id"=>"6506145687"}, {"first_name"=>"Lorenzo", "last_name"=>"Moroni", "scopus_author_id"=>"13908031800"}, {"first_name"=>"Hetty W M", "last_name"=>"Ten Hoopen", "scopus_author_id"=>"6603812084"}, {"first_name"=>"Clemens A.", "last_name"=>"van Blitterswijk", "scopus_author_id"=>"7006225712"}, {"first_name"=>"Eelco J P", "last_name"=>"de Koning", "scopus_author_id"=>"7004067963"}, {"first_name"=>"Aart A.", "last_name"=>"van Apeldoorn", "scopus_author_id"=>"6602270188"}, {"first_name"=>"Marcel", "last_name"=>"Karperien", "scopus_author_id"=>"7004301928"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"369039397", "sgr"=>"84878501317", "doi"=>"10.1371/journal.pone.0064772", "scopus"=>"2-s2.0-84878501317", "pmid"=>"23737999"}, "id"=>"cb9d3acc-4b20-396f-bc83-11512331020f", "abstract"=>"Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patients with type 1 diabetes. However, the suboptimal microenvironment for islets in the liver is likely to be involved in the progressive islet dysfunction that is often observed post-transplantation. This study validates a novel microwell scaffold platform to be used for the extrahepatic transplantation of islet of Langerhans. Scaffolds were fabricated from either a thin polymer film or an electrospun mesh of poly(ethylene oxide terephthalate)-poly(butylene terephthalate) (PEOT/PBT) block copolymer (composition: 4000PEOT30PBT70) and were imprinted with microwells, approximately 400 microm in diameter and approximately 350 microm in depth. The water contact angle and water uptake were 39+/-2 degrees and 52.1+/-4.0 wt%, respectively. The glucose flux through electrospun scaffolds was three times higher than for thin film scaffolds, indicating enhanced nutrient diffusion. Human islets cultured in microwell scaffolds for seven days showed insulin release and insulin content comparable to those of free-floating control islets. Islet morphology and insulin and glucagon expression were maintained during culture in the microwell scaffolds. Our results indicate that the microwell scaffold platform prevents islet aggregation by confinement of individual islets in separate microwells, preserves the islet's native rounded morphology, and provides a protective environment without impairing islet functionality, making it a promising platform for use in extrahepatic islet transplantation.", "link"=>"http://www.mendeley.com/research/microwell-scaffolds-extrahepatic-transplantation-islets-langerhans", "reader_count"=>55, "reader_count_by_academic_status"=>{"Researcher"=>12, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>7, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>12, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>7, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>8, "Business, Management and Accounting"=>1, "Chemistry"=>1, "Economics, Econometrics and Finance"=>1, "Engineering"=>15, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Materials Science"=>5, "Medicine and Dentistry"=>15, "Physics and Astronomy"=>1, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>5}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Engineering"=>{"Engineering"=>15}, "Chemistry"=>{"Chemistry"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "reader_count_by_country"=>{"United States"=>1, "Australia"=>2, "Switzerland"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1071210"], "description"=>"<p>(A) Contact angle measurements of non heat-treated and heat-treated 4000PEOT30PBT70 block copolymer films using the captive bubble method. Data represents mean ± SD of 20 measurements (<i>N</i> = 3 per condition). (B) Water uptake of non-treated and heat-treated 4000PEOT30PBT70 block copolymer films. Data represents mean ± SD, (<i>N</i> = 3 per condition), *<i>p</i><0.05, **<i>p</i><0.01.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Biomedical Engineering", "Medical devices", "biomaterials", "Tissue engineering", "genetics", "Human genetics", "Mitochondrial diseases", "Diabetes mellitus and deafness", "immunology", "Immunologic subspecialties", "transplantation", "wettability"], "article_id"=>709392, "categories"=>["Biological Sciences"], "users"=>["Mijke Buitinga", "Roman Truckenmüller", "Marten A. Engelse", "Lorenzo Moroni", "Hetty W. M. Ten Hoopen", "Clemens A. van Blitterswijk", "Eelco JP. de Koning", "Aart A. van Apeldoorn", "Marcel Karperien"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064772.g001", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PEOT_PBT_wettability_and_water_uptake_/709392", "title"=>"PEOT/PBT wettability and water uptake.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-30 02:36:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/1071211"], "description"=>"<p>Cytotoxicity test after 72 hours of incubation. Growth and morphology of MC3T3E-1 cells were analyzed in the presence of extracts of polypropylene films (negative control), natural rubber (positive control), polylactic acid and heated 4000PEOT30PBT70 films. (A) Light microscopy images of MC3T3E-1 cells cultured in standard and in the presence of the different material extracts, (B) Total amount of cells after 72 hours of incubation. Data represent mean ± SD, (n = 6), **<i>p</i><0.01, (C) The cytotoxic response index based on growth and morphological changes, scored in a single-blinded manner.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Biomedical Engineering", "Medical devices", "biomaterials", "Tissue engineering", "genetics", "Human genetics", "Mitochondrial diseases", "Diabetes mellitus and deafness", "immunology", "Immunologic subspecialties", "transplantation"], "article_id"=>709393, "categories"=>["Biological Sciences"], "users"=>["Mijke Buitinga", "Roman Truckenmüller", "Marten A. Engelse", "Lorenzo Moroni", "Hetty W. M. Ten Hoopen", "Clemens A. van Blitterswijk", "Eelco JP. de Koning", "Aart A. van Apeldoorn", "Marcel Karperien"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064772.g002", "stats"=>{"downloads"=>3, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PEOT_PBT_cytotoxicity_/709393", "title"=>"PEOT/PBT cytotoxicity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-30 02:36:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/1071213"], "description"=>"<p>SEM images of (A) the stainless steel mould, (B) the scaffold area, (C) thin film microwell scaffold, (D) electrospun microwell scaffold, (E) cross-section of a thin film microwell showing the tapered shape and the smooth polymer surface, (F) cross-section of a electrospun microwell showing the fibrous network.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Biomedical Engineering", "Medical devices", "biomaterials", "Tissue engineering", "genetics", "Human genetics", "Mitochondrial diseases", "Diabetes mellitus and deafness", "immunology", "Immunologic subspecialties", "transplantation", "scaffold"], "article_id"=>709394, "categories"=>["Biological Sciences"], "users"=>["Mijke Buitinga", "Roman Truckenmüller", "Marten A. Engelse", "Lorenzo Moroni", "Hetty W. M. Ten Hoopen", "Clemens A. van Blitterswijk", "Eelco JP. de Koning", "Aart A. van Apeldoorn", "Marcel Karperien"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064772.g003", "stats"=>{"downloads"=>2, "page_views"=>110, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microwell_scaffold_morphology_/709394", "title"=>"Microwell scaffold morphology.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-30 02:36:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1071214"], "description"=>"<p>(A)Typical glucose diffusion graphs for thin film and electrospun microwell scaffolds. For the thin film microwell scaffold, the concentration of glucose in the acceptor compartment is represented as a dashed line, because only the last time-point was within analytical range of the Vitros DT60 II chemistry system. (B) Maximum glucose flux through dense and electrospun microwell scaffolds. Data represents mean ± SD (n = 3), **<i>p</i><0.01.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Biomedical Engineering", "Medical devices", "biomaterials", "Tissue engineering", "genetics", "Human genetics", "Mitochondrial diseases", "Diabetes mellitus and deafness", "immunology", "Immunologic subspecialties", "transplantation", "diffusion", "microwell"], "article_id"=>709395, "categories"=>["Biological Sciences"], "users"=>["Mijke Buitinga", "Roman Truckenmüller", "Marten A. Engelse", "Lorenzo Moroni", "Hetty W. M. Ten Hoopen", "Clemens A. van Blitterswijk", "Eelco JP. de Koning", "Aart A. van Apeldoorn", "Marcel Karperien"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064772.g004", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glucose_diffusion_through_microwell_scaffolds_/709395", "title"=>"Glucose diffusion through microwell scaffolds.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-30 02:36:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1071217"], "description"=>"<p>(A, B) Confocal fluorescence microscopy images of Phalloidin-TRITC stained human islets that were cultured in thin film (A) and electrospun (B) microwell scaffolds. (C–H) High resolution SEM images of islets in the thin film (C,E) and electrospun (D,FD) microwell scaffolds, and tissue culture plastic (G,H).</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Biomedical Engineering", "Medical devices", "biomaterials", "Tissue engineering", "genetics", "Human genetics", "Mitochondrial diseases", "Diabetes mellitus and deafness", "immunology", "Immunologic subspecialties", "transplantation"], "article_id"=>709398, "categories"=>["Biological Sciences"], "users"=>["Mijke Buitinga", "Roman Truckenmüller", "Marten A. Engelse", "Lorenzo Moroni", "Hetty W. M. Ten Hoopen", "Clemens A. van Blitterswijk", "Eelco JP. de Koning", "Aart A. van Apeldoorn", "Marcel Karperien"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064772.g005", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Islet_morphology_/709398", "title"=>"Islet morphology.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-30 02:36:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1071218"], "description"=>"<p>(A) Insulin secretory response to glucose stimulation of human islets cultured for 7 days in thin film and electrospun microwell scaffolds. Free-floating islets served as a control. Data represent mean ± SD (n = 3 per condition). (B) Insulin content of human islets cultured in thin film and electrospun microwell scaffold or under free-floating conditions. Data represent mean ± SD (n = 3 per condition).</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Biomedical Engineering", "Medical devices", "biomaterials", "Tissue engineering", "genetics", "Human genetics", "Mitochondrial diseases", "Diabetes mellitus and deafness", "immunology", "Immunologic subspecialties", "transplantation", "microwell"], "article_id"=>709399, "categories"=>["Biological Sciences"], "users"=>["Mijke Buitinga", "Roman Truckenmüller", "Marten A. Engelse", "Lorenzo Moroni", "Hetty W. M. Ten Hoopen", "Clemens A. van Blitterswijk", "Eelco JP. de Koning", "Aart A. van Apeldoorn", "Marcel Karperien"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064772.g006", "stats"=>{"downloads"=>4, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Islet_function_in_microwell_scaffolds_/709399", "title"=>"Islet function in microwell scaffolds.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-30 02:36:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1071219"], "description"=>"<p>(A) Insulin secretory response and, (B) insulin content of islets cultured in thin film scaffolds or under free-floating conditions of three different human donors. Data represent mean ± SD (n = 3 per condition).</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Biomedical Engineering", "Medical devices", "biomaterials", "Tissue engineering", "genetics", "Human genetics", "Mitochondrial diseases", "Diabetes mellitus and deafness", "immunology", "Immunologic subspecialties", "transplantation", "donors", "microwell"], "article_id"=>709400, "categories"=>["Biological Sciences"], "users"=>["Mijke Buitinga", "Roman Truckenmüller", "Marten A. Engelse", "Lorenzo Moroni", "Hetty W. M. Ten Hoopen", "Clemens A. van Blitterswijk", "Eelco JP. de Koning", "Aart A. van Apeldoorn", "Marcel Karperien"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064772.g007", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Islet_function_of_multiple_donors_in_thin_film_microwell_scaffolds_/709400", "title"=>"Islet function of multiple donors in thin film microwell scaffolds.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-30 02:36:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1071221"], "description"=>"<p>Insulin (red) and glucagon (green) positive cells can be observed throughout the islets. The microwell scaffold is indicated by the white arrows. All data were obtained after 7 days of culturing.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Biomedical Engineering", "Medical devices", "biomaterials", "Tissue engineering", "genetics", "Human genetics", "Mitochondrial diseases", "Diabetes mellitus and deafness", "immunology", "Immunologic subspecialties", "transplantation", "free-floating", "islets", "cultured", "microwell"], "article_id"=>709401, "categories"=>["Biological Sciences"], "users"=>["Mijke Buitinga", "Roman Truckenmüller", "Marten A. Engelse", "Lorenzo Moroni", "Hetty W. M. Ten Hoopen", "Clemens A. van Blitterswijk", "Eelco JP. de Koning", "Aart A. van Apeldoorn", "Marcel Karperien"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0064772.g008", "stats"=>{"downloads"=>7, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histology_of_free_floating_control_islets_and_of_islets_cultured_in_thin_film_microwell_scaffolds_/709401", "title"=>"Histology of free-floating control islets and of islets cultured in thin film microwell scaffolds.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-05-30 02:36:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1071222", "https://ndownloader.figshare.com/files/1071223"], "description"=>"<div><p>Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patients with type 1 diabetes. However, the suboptimal microenvironment for islets in the liver is likely to be involved in the progressive islet dysfunction that is often observed post-transplantation. This study validates a novel microwell scaffold platform to be used for the extrahepatic transplantation of islet of Langerhans. Scaffolds were fabricated from either a thin polymer film or an electrospun mesh of poly(ethylene oxide terephthalate)-poly(butylene terephthalate) (PEOT/PBT) block copolymer (composition: 4000PEOT30PBT70) and were imprinted with microwells, ∼400 µm in diameter and ∼350 µm in depth. The water contact angle and water uptake were 39±2° and 52.1±4.0 wt%, respectively. The glucose flux through electrospun scaffolds was three times higher than for thin film scaffolds, indicating enhanced nutrient diffusion. Human islets cultured in microwell scaffolds for seven days showed insulin release and insulin content comparable to those of free-floating control islets. Islet morphology and insulin and glucagon expression were maintained during culture in the microwell scaffolds. Our results indicate that the microwell scaffold platform prevents islet aggregation by confinement of individual islets in separate microwells, preserves the islet’s native rounded morphology, and provides a protective environment without impairing islet functionality, making it a promising platform for use in extrahepatic islet transplantation.</p></div>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Biomedical Engineering", "Medical devices", "biomaterials", "Tissue engineering", "genetics", "Human genetics", "Mitochondrial diseases", "Diabetes mellitus and deafness", "immunology", "Immunologic subspecialties", "transplantation", "scaffolds", "extrahepatic", "islets"], "article_id"=>709402, "categories"=>["Biological Sciences"], "users"=>["Mijke Buitinga", "Roman Truckenmüller", "Marten A. Engelse", "Lorenzo Moroni", "Hetty W. M. Ten Hoopen", "Clemens A. van Blitterswijk", "Eelco JP. de Koning", "Aart A. van Apeldoorn", "Marcel Karperien"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0064772.s001", "https://dx.doi.org/10.1371/journal.pone.0064772.s002"], "stats"=>{"downloads"=>5, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microwell_Scaffolds_for_the_Extrahepatic_Transplantation_of_Islets_of_Langerhans_/709402", "title"=>"Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-05-30 02:36:42"}

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Relative Metric

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