Vincristine Chemotherapy Trials and Pharmacokinetics in Tasmanian Devils with Tasmanian Devil Facial Tumor Disease
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{"title"=>"Vincristine Chemotherapy Trials and Pharmacokinetics in Tasmanian Devils with Tasmanian Devil Facial Tumor Disease", "type"=>"journal", "authors"=>[{"first_name"=>"David N.", "last_name"=>"Phalen", "scopus_author_id"=>"7004605094"}, {"first_name"=>"Angela", "last_name"=>"Frimberger", "scopus_author_id"=>"56123710900"}, {"first_name"=>"Stephen", "last_name"=>"Pyecroft", "scopus_author_id"=>"22981020400"}, {"first_name"=>"Sarah", "last_name"=>"Peck", "scopus_author_id"=>"55496108400"}, {"first_name"=>"Colette", "last_name"=>"Harmsen", "scopus_author_id"=>"55495956300"}, {"first_name"=>"Suzanneth", "last_name"=>"Lola", "scopus_author_id"=>"55759586700"}, {"first_name"=>"Beatriz", "last_name"=>"de Mello Mattos", "scopus_author_id"=>"55760336500"}, {"first_name"=>"Kong M.", "last_name"=>"Li", "scopus_author_id"=>"7404989900"}, {"first_name"=>"Andrew J.", "last_name"=>"McLachlan", "scopus_author_id"=>"55316633600"}, {"first_name"=>"Antony", "last_name"=>"Moore", "scopus_author_id"=>"7402762969"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84878802103", "doi"=>"10.1371/journal.pone.0065133", "isbn"=>"1932-6203", "pmid"=>"23762298", "issn"=>"19326203", "scopus"=>"2-s2.0-84878802103", "pui"=>"369081942"}, "id"=>"72255dff-106a-3616-b387-de6b4b93c18a", "abstract"=>"Tasmanian Devil Facial Tumor Disease (DFTD) is a transmissible cancer threatening to cause the extinction of Tasmanian Devils in the wild. The aim of this study was to determine the susceptibility of the DFTD to vincristine. Escalating dosage rates of vincristine (0.05 to 0.136 mg/kg) were given to Tasmanian devils in the early stages of DFTD (n = 8). None of these dosage rates impacted the outcome of the disease. A dosage rate of 0.105 mg/kg, a rate significantly higher than that given in humans or domestic animals, was found to the highest dosage rate that could be administered safely. Signs of toxicity included anorexia, vomiting, diarrhea and neutropenia. Pharmacokinetic studies showed that, as with other species, there was a rapid drop in blood concentration following a rapid intravenous infusion with a high volume of distribution (1.96 L/kg) and a relatively long elimination half life (11 h). Plasma clearance (1.8 ml/min/kg) was slower in the Tasmanian devil than in humans, suggesting that pharmacodynamics and not pharmacokinetics explain the Tasmanian devil's ability to tolerate high dosage rates of vincristine. While providing base-line data for the use of vincristine in Tasmanian devils and possibly other marsupials with vincristine susceptible cancers, these findings strongly suggest that vincristine will not be effective in the treatment of DFTD.", "link"=>"http://www.mendeley.com/research/vincristine-chemotherapy-trials-pharmacokinetics-tasmanian-devils-tasmanian-devil-facial-tumor-disea", "reader_count"=>28, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>4, "Student > Master"=>5, "Other"=>4, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>4, "Student > Master"=>5, "Other"=>4, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Veterinary Science and Veterinary Medicine"=>7, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>7}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1077322"], "description"=>"<p>Median plasma vincristine concentration versus time for Tasmanian devils (n = 6) corrected for a dose of vincristine 0.05 mg/kg.</p>", "links"=>[], "tags"=>["ecology", "Drugs and devices", "Pharmacodynamics", "pharmacokinetics", "oncology", "Cancer treatment", "Chemotherapy and drug treatment", "Animal types", "wildlife", "Veterinary diseases", "Veterinary medicine", "Veterinary oncology", "Veterinary pharmacology", "Veterinary toxicology", "plasma", "vincristine", "tasmanian", "devils", "corrected"], "article_id"=>713870, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David N. Phalen", "Angela Frimberger", "Stephen Pyecroft", "Sarah Peck", "Colette Harmsen", "Suzanneth Lola", "Beatriz de Mello Mattos", "Kong M. Li", "Andrew J. McLachlan", "Antony Moore"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065133.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_plasma_vincristine_concentration_versus_time_for_Tasmanian_devils_n_8202_8202_6_corrected_for_a_dose_of_vincristine_0_05_mg_kg_/713870", "title"=>"Median plasma vincristine concentration versus time for Tasmanian devils (n = 6) corrected for a dose of vincristine 0.05 mg/kg.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-06 01:04:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/1077323"], "description"=>"<p>Criteria for toxic effects in Tasmanian devils receiving vincristine.</p>", "links"=>[], "tags"=>["ecology", "Drugs and devices", "Pharmacodynamics", "pharmacokinetics", "oncology", "Cancer treatment", "Chemotherapy and drug treatment", "Animal types", "wildlife", "Veterinary diseases", "Veterinary medicine", "Veterinary oncology", "Veterinary pharmacology", "Veterinary toxicology", "tasmanian", "devils"], "article_id"=>713871, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David N. Phalen", "Angela Frimberger", "Stephen Pyecroft", "Sarah Peck", "Colette Harmsen", "Suzanneth Lola", "Beatriz de Mello Mattos", "Kong M. Li", "Andrew J. McLachlan", "Antony Moore"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065133.t002", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Criteria_for_toxic_effects_in_Tasmanian_devils_receiving_vincristine_/713871", "title"=>"Criteria for toxic effects in Tasmanian devils receiving vincristine.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-06 01:04:31"}

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Relative Metric

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