Impact of a Better Persistence with Antihypertensive Agents on Ischemic Stroke Outcomes for Secondary Prevention
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{"title"=>"Impact of a Better Persistence with Antihypertensive Agents on Ischemic Stroke Outcomes for Secondary Prevention", "type"=>"journal", "authors"=>[{"first_name"=>"Jie", "last_name"=>"Xu", "scopus_author_id"=>"57005795500"}, {"first_name"=>"Xingquan", "last_name"=>"Zhao", "scopus_author_id"=>"7407574974"}, {"first_name"=>"Yilong", "last_name"=>"Wang", "scopus_author_id"=>"36553742800"}, {"first_name"=>"Chunxue", "last_name"=>"Wang", "scopus_author_id"=>"24069476500"}, {"first_name"=>"Liping", "last_name"=>"Liu", "scopus_author_id"=>"55644001192"}, {"first_name"=>"Baoying", "last_name"=>"Sun", "scopus_author_id"=>"55750195900"}, {"first_name"=>"Anxin", "last_name"=>"Wang", "scopus_author_id"=>"42162115700"}, {"first_name"=>"Yongjun", "last_name"=>"Wang", "scopus_author_id"=>"8320879700"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84878955283", "doi"=>"10.1371/journal.pone.0065233", "pui"=>"369102101", "pmid"=>"23776454", "scopus"=>"2-s2.0-84878955283", "issn"=>"19326203", "isbn"=>"1932-6203"}, "id"=>"d8495270-967d-3085-ba79-9505c666673d", "abstract"=>"BACKGROUND: The efficacy of antihypertensive (AH) treatment after stroke has been investigated in several randomized clinical trials. However, non-adherence to AH medication is common for stroke patients in \"real world\" setting. The purpose of this study was to assess the impact of persistence with AH agents on ischemic stroke (IS) outcomes.\\n\\nMETHODS AND RESULTS: Using the China National Stroke Registry, we analyzed data from 8409 IS patients with hypertension. Persistence with AH therapy (high persistence ≥75%, low persistence <75%) was measured by patient self-report at 3, 6, and 12 months after stroke. Multivariate logistic regression model was used to assess the relationship between persistence and IS outcomes (stroke recurrence, combined vascular events and death) at 12 months. Of the 8409 patients in this study, 40.0% were female and the mean age at study entry was 66.7 years. 31.6% of patients had high persistence with AH drugs, and 68.4% had low persistence during 1 year after stroke onset. High persistence with AH drugs significantly decreased the risk of stroke recurrence (odds ratio, 0.78; 95% CI, 0.68 to 0.89), combined vascular events (0.71; 0.63-0.81) and death (0.44; 0.36-0.53) compared with low persistence.\\n\\nCONCLUSIONS: Our study reinforces the benefits of AH medications in routine clinical practice and highlights the importance of persistence with AH therapy among IS patients known to be hypertensive within the first year of an event.", "link"=>"http://www.mendeley.com/research/impact-better-persistence-antihypertensive-agents-ischemic-stroke-outcomes-secondary-prevention", "reader_count"=>18, "reader_count_by_academic_status"=>{"Researcher"=>9, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>9, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>1, "Psychology"=>2, "Chemistry"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1082231"], "description"=>"<p>Abbreviations: OR, odds ratio; CI, confidence interval.</p>*<p>Adjusted for age, level of education, monthly household income, marital status, history of stroke, myocardial infarction, atrial fibrillation, diabetes mellitus, antihypertensive medication history, class of prescribed antihypertensive drug at discharge, severity of stroke on admission, dysphagia, co-medication at discharge (antiplatelet agents, anticoagulants, lipid-lowering agents and anti-diabetic medications).</p>", "links"=>[], "tags"=>["Clinical research design", "Cohort studies", "Longitudinal studies", "Drugs and devices", "Pharmacoepidemiology", "epidemiology", "neurology", "Cerebrovascular diseases", "Ischemic stroke", "Non-clinical medicine", "Health care quality", "Public health", "Behavioral and social aspects of health", "rates", "ratios", "outcomes", "patients"], "article_id"=>716901, "categories"=>["Medicine"], "users"=>["Jie Xu", "Xingquan Zhao", "Yilong Wang", "Chunxue Wang", "Liping Liu", "Baoying Sun", "Anxin Wang", "Yongjun Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065233.t003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Event_rates_and_odds_ratios_of_stroke_outcomes_at_1_year_for_IS_patients_with_hypertension_/716901", "title"=>"Event rates and odds ratios of stroke outcomes at 1 year for IS patients with hypertension.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-11 01:55:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1082232"], "description"=>"<p>Abbreviations: CVE, Combined vascular events; CI, confidence interval; OR, odds ratio.</p>", "links"=>[], "tags"=>["Clinical research design", "Cohort studies", "Longitudinal studies", "Drugs and devices", "Pharmacoepidemiology", "epidemiology", "neurology", "Cerebrovascular diseases", "Ischemic stroke", "Non-clinical medicine", "Health care quality", "Public health", "Behavioral and social aspects of health"], "article_id"=>716902, "categories"=>["Medicine"], "users"=>["Jie Xu", "Xingquan Zhao", "Yilong Wang", "Chunxue Wang", "Liping Liu", "Baoying Sun", "Anxin Wang", "Yongjun Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065233.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Risk_factors_for_poor_outcomes_/716902", "title"=>"Risk factors for poor outcomes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-11 01:55:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1082229"], "description"=>"<p>Abbreviations: ICH, Intracerebral Hemorrhage; SAH, Subarachnoid Hemorrhage; TIA, Transient ischemic attack.</p>", "links"=>[], "tags"=>["Clinical research design", "Cohort studies", "Longitudinal studies", "Drugs and devices", "Pharmacoepidemiology", "epidemiology", "neurology", "Cerebrovascular diseases", "Ischemic stroke", "Non-clinical medicine", "Health care quality", "Public health", "Behavioral and social aspects of health"], "article_id"=>716899, "categories"=>["Medicine"], "users"=>["Jie Xu", "Xingquan Zhao", "Yilong Wang", "Chunxue Wang", "Liping Liu", "Baoying Sun", "Anxin Wang", "Yongjun Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065233.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_flow_diagram_/716899", "title"=>"Patient flow diagram.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-11 01:54:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1082233"], "description"=>"<p>Abbreviations: ACEI, angiotensin-converting enzyme inhibitors; AH, antihypertensive; ARB, angiotensin receptor blockers; CCB, calcium channel blockers; SBP, Systolic blood pressure; SD, standard deviation.</p>*<p>missing 39.</p>#<p>missing 72.</p>†<p>based on 6806 patients who were prescribed with AH medication.</p>‡<p>based on 875 patients with atrial fibrillation.</p>§<p>based on 2787 patients with diabetes mellitus.</p>", "links"=>[], "tags"=>["Clinical research design", "Cohort studies", "Longitudinal studies", "Drugs and devices", "Pharmacoepidemiology", "epidemiology", "neurology", "Cerebrovascular diseases", "Ischemic stroke", "Non-clinical medicine", "Health care quality", "Public health", "Behavioral and social aspects of health", "persistence", "predictors"], "article_id"=>716903, "categories"=>["Medicine"], "users"=>["Jie Xu", "Xingquan Zhao", "Yilong Wang", "Chunxue Wang", "Liping Liu", "Baoying Sun", "Anxin Wang", "Yongjun Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065233.t001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_in_relation_to_persistence_for_identification_of_predictors_of_persistence_/716903", "title"=>"Baseline characteristics in relation to persistence for identification of predictors of persistence.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-11 01:55:03"}

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Relative Metric

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