Blood Dendritic Cell Frequency Declines in Idiopathic Parkinson’s Disease and Is Associated with Motor Symptom Severity
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{"title"=>"Blood Dendritic Cell Frequency Declines in Idiopathic Parkinson's Disease and Is Associated with Motor Symptom Severity", "type"=>"journal", "authors"=>[{"first_name"=>"Antonio", "last_name"=>"Ciaramella", "scopus_author_id"=>"7003470721"}, {"first_name"=>"Francesca", "last_name"=>"Salani", "scopus_author_id"=>"10140794900"}, {"first_name"=>"Federica", "last_name"=>"Bizzoni", "scopus_author_id"=>"9241715600"}, {"first_name"=>"Francesco E.", "last_name"=>"Pontieri", "scopus_author_id"=>"7003479146"}, {"first_name"=>"Alessandro", "last_name"=>"Stefani", "scopus_author_id"=>"7005314660"}, {"first_name"=>"Mariangela", "last_name"=>"Pierantozzi", "scopus_author_id"=>"7004208388"}, {"first_name"=>"Francesca", "last_name"=>"Assogna", "scopus_author_id"=>"24528556300"}, {"first_name"=>"Carlo", "last_name"=>"Caltagirone", "scopus_author_id"=>"35228717800"}, {"first_name"=>"Gianfranco", "last_name"=>"Spalletta", "scopus_author_id"=>"7004157010"}, {"first_name"=>"Paola", "last_name"=>"Bossù", "scopus_author_id"=>"7003656787"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84878937679", "doi"=>"10.1371/journal.pone.0065352", "pui"=>"369102091", "pmid"=>"23776473", "scopus"=>"2-s2.0-84878937679", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"4523172e-2aec-3c21-b86f-944d392f7687", "abstract"=>"The role of inflammation in Parkinson's Disease (PD) is well appreciated, but its underlying mechanisms are still unclear. Our objective was to determine whether dendritic cells (DC), a unique type of migratory immune cells that regulate immunological response and inflammation have an impact on PD. In a case-control study including 80 PD patients and 80 age- and gender-matched healthy control subjects, the two main blood subsets of plasmacytoid and myeloid DC were defined by flow cytometry analysis. Clinical evaluation of subjects consisting of cognition and depression assessment was performed using the Mini Mental State Examination and the Beck Depression Inventory. The severity of motor symptoms was measured using the Unified Parkinson's Disease Rating Scale-Part III. Comparison between patient and control DC measures and their relationships with clinical assessments were evaluated.The following main results were obtained: 1) the level of circulating DC (mainly the myeloid subset) was significantly reduced in PD patients in comparison with healthy controls; 2) after controlling for depressive and cognitive characteristics, the frequency of myeloid DC was confirmed as one of the independent determinants of PD; 3) the number of both myeloid and plasmacytoid DC was negatively associated with motor symptom severity. Overall, the decline of blood DC, perhaps due to the recruitment of immune cells to the site of disease-specific lesions, can be considered a clue of the immune alteration that characterizes PD, suggesting innovative exploitations of DC monitoring as a clinically significant tool for PD treatment. Indeed, this study suggests that reduced peripheral blood DC are a pathologically-relevant factor of PD and also displays the urgency to better understand DC role in PD for unraveling the immune system contribution to disease progression and thus favoring the development of innovative therapies ideally based on immunomodulation.", "link"=>"http://www.mendeley.com/research/blood-dendritic-cell-frequency-declines-idiopathic-parkinsons-disease-associated-motor-symptom-sever-3", "reader_count"=>20, "reader_count_by_academic_status"=>{"Researcher"=>8, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1}, "reader_count_by_user_role"=>{"Researcher"=>8, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>1, "Chemistry"=>2, "Psychology"=>3, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Psychology"=>{"Psychology"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1082173"], "description"=>"<p>The distribution of percentage values (upper panels) and total counts (lower panels) of pDC (left panels) and mDC (right panels) present in blood of HC (n = 80), dopaminergic drug-treated PD (T-PD, n = 73) and drug naïve PD (U-PD, n = 7) subjects is reported in the respective box-and-whisker plot, as indicated.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Antigen-presenting cells", "immunity", "inflammation", "Mental health", "psychiatry", "psychology", "neurology", "Cognitive neurology", "Neurodegenerative diseases", "Parkinson disease", "dc", "pd"], "article_id"=>716848, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Antonio Ciaramella", "Francesca Salani", "Federica Bizzoni", "Francesco E. Pontieri", "Alessandro Stefani", "Mariangela Pierantozzi", "Francesca Assogna", "Carlo Caltagirone", "Gianfranco Spalletta", "Paola Bossù"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065352.g003", "stats"=>{"downloads"=>2, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Blood_DC_decline_in_PD_subgroups_/716848", "title"=>"Blood DC decline in PD subgroups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-11 01:54:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1082174"], "description"=>"<p>The correlation of L-dopa equivalent dose with percentage values (upper panels) and total counts (lower panels) of pDC (left panels) and mDC (right panels) present in blood of PD (n = 80) subjects is reported in the respective scatter plot, as indicated. Lines represent linear regression.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Antigen-presenting cells", "immunity", "inflammation", "Mental health", "psychiatry", "psychology", "neurology", "Cognitive neurology", "Neurodegenerative diseases", "Parkinson disease", "dc", "led"], "article_id"=>716849, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Antonio Ciaramella", "Francesca Salani", "Federica Bizzoni", "Francesco E. Pontieri", "Alessandro Stefani", "Mariangela Pierantozzi", "Francesca Assogna", "Carlo Caltagirone", "Gianfranco Spalletta", "Paola Bossù"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065352.g004", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lack_of_association_between_blood_DC_levels_and_LED_in_PD_/716849", "title"=>"Lack of association between blood DC levels and LED in PD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-11 01:54:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1082175"], "description"=>"<p>The correlation of BDI SOM scores with percentage values (upper panel) and total counts (lower panel) of mDC present in blood of PD (n = 80) subjects is reported in the respective scatter plot, as indicated. Lines represent linear regression.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Antigen-presenting cells", "immunity", "inflammation", "Mental health", "psychiatry", "psychology", "neurology", "Cognitive neurology", "Neurodegenerative diseases", "Parkinson disease", "dc", "somatic", "severity"], "article_id"=>716851, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Antonio Ciaramella", "Francesca Salani", "Federica Bizzoni", "Francesco E. Pontieri", "Alessandro Stefani", "Mariangela Pierantozzi", "Francesca Assogna", "Carlo Caltagirone", "Gianfranco Spalletta", "Paola Bossù"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065352.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Blood_DC_association_with_somatic_depression_severity_in_PD_/716851", "title"=>"Blood DC association with somatic depression severity in PD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-11 01:54:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1082177"], "description"=>"<p>The correlation of UPDRS III score with percentage values (upper panels) and total counts (lower panels) of pDC (left panels) and mDC (right panels) present in blood of PD patients (n = 80) is reported in the respective scatter plot, as indicated. Lines represent linear regression.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Antigen-presenting cells", "immunity", "inflammation", "Mental health", "psychiatry", "psychology", "neurology", "Cognitive neurology", "Neurodegenerative diseases", "Parkinson disease", "dc", "severity"], "article_id"=>716852, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Antonio Ciaramella", "Francesca Salani", "Federica Bizzoni", "Francesco E. Pontieri", "Alessandro Stefani", "Mariangela Pierantozzi", "Francesca Assogna", "Carlo Caltagirone", "Gianfranco Spalletta", "Paola Bossù"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065352.g006", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Blood_DC_association_with_motor_symptom_severity_in_PD_/716852", "title"=>"Blood DC association with motor symptom severity in PD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-11 01:54:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/1082178"], "description"=>"<p>Values are expressed as mean ± SD or percentage of subjects (%).</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Antigen-presenting cells", "immunity", "inflammation", "Mental health", "psychiatry", "psychology", "neurology", "Cognitive neurology", "Neurodegenerative diseases", "Parkinson disease", "hc", "pd"], "article_id"=>716853, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Antonio Ciaramella", "Francesca Salani", "Federica Bizzoni", "Francesco E. Pontieri", "Alessandro Stefani", "Mariangela Pierantozzi", "Francesca Assogna", "Carlo Caltagirone", "Gianfranco Spalletta", "Paola Bossù"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065352.t001", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Socio_demographic_and_clinical_characteristics_of_HC_and_PD_subjects_/716853", "title"=>"Socio-demographic and clinical characteristics of HC and PD subjects.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-11 01:54:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1082169"], "description"=>"<p>Representative immunophenotype plots of the whole blood sample from one HC subject are reported to show the gating strategy. Total cells were identified in a forward scatter (FSC)/side scatter (SSC) plot and gated (R1, left panel A). Then DC were identified by gating lineage negative (Lin<sup>−</sup>) cells (R2, middle panel B). Finally, myeloid DC (R3) were identified by CD11c and HLA-DR expression, while plasmacytoid DC (R4) were identified by CD123 and HLA-DR expression (right panel C).</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Antigen-presenting cells", "immunity", "inflammation", "Mental health", "psychiatry", "psychology", "neurology", "Cognitive neurology", "Neurodegenerative diseases", "Parkinson disease"], "article_id"=>716844, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Antonio Ciaramella", "Francesca Salani", "Federica Bizzoni", "Francesco E. Pontieri", "Alessandro Stefani", "Mariangela Pierantozzi", "Francesca Assogna", "Carlo Caltagirone", "Gianfranco Spalletta", "Paola Bossù"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065352.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gating_strategy_/716844", "title"=>"Gating strategy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-11 01:54:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1082171"], "description"=>"<p>The distribution of percentage values (upper panels) and total counts (lower panels) of pDC (left panels) and mDC (right panels) present in blood of HC (n = 80) and PD (n = 80) subjects is reported in the respective box-and-whisker plot, as indicated.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Antigen-presenting cells", "immunity", "inflammation", "Mental health", "psychiatry", "psychology", "neurology", "Cognitive neurology", "Neurodegenerative diseases", "Parkinson disease", "dc"], "article_id"=>716846, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Antonio Ciaramella", "Francesca Salani", "Federica Bizzoni", "Francesco E. Pontieri", "Alessandro Stefani", "Mariangela Pierantozzi", "Francesca Assogna", "Carlo Caltagirone", "Gianfranco Spalletta", "Paola Bossù"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0065352.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Blood_DC_decline_in_PD_/716846", "title"=>"Blood DC decline in PD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-11 01:54:06"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
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  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[253, 430]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[238, 424, 545, 650, 749, 839, 926, 1006, 1090, 1167, 1243, 1316, 1380]}, {"subject_area"=>"/Medicine and health sciences/Neurology", "average_usage"=>[271, 485, 617, 733, 835, 933, 1026, 1115, 1207, 1294, 1386, 1475, 1543]}, {"subject_area"=>"/Medicine and health sciences/Pharmaceutics", "average_usage"=>[254, 457, 591, 700, 808, 906, 1001, 1093, 1185, 1276, 1373, 1457, 1535]}]}
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