Mucins as Diagnostic and Prognostic Biomarkers in a Fish-Parasite Model: Transcriptional and Functional Analysis
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{"title"=>"Mucins as Diagnostic and Prognostic Biomarkers in a Fish-Parasite Model: Transcriptional and Functional Analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Jaume", "last_name"=>"Pérez-Sánchez", "scopus_author_id"=>"7003402196"}, {"first_name"=>"Itziar", "last_name"=>"Estensoro", "scopus_author_id"=>"36542332300"}, {"first_name"=>"María José", "last_name"=>"Redondo", "scopus_author_id"=>"57197133209"}, {"first_name"=>"Josep Alvar", "last_name"=>"Calduch-Giner", "scopus_author_id"=>"6602688466"}, {"first_name"=>"Sadasivam", "last_name"=>"Kaushik", "scopus_author_id"=>"35565110300"}, {"first_name"=>"Ariadna", "last_name"=>"Sitjà-Bobadilla", "scopus_author_id"=>"7003289824"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"369102510", "doi"=>"10.1371/journal.pone.0065457", "sgr"=>"84878919234", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23776483", "scopus"=>"2-s2.0-84878919234"}, "id"=>"ca2f8703-2410-34a9-8a87-ad45f55edcf2", "abstract"=>"Mucins are O-glycosylated glycoproteins present on the apex of all wet-surfaced epithelia with a well-defined expression pattern, which is disrupted in response to a wide range of injuries or challenges. The aim of this study was to identify mucin gene sequences of gilthead sea bream (GSB), to determine its pattern of distribution in fish tissues and to analyse their transcriptional regulation by dietary and pathogenic factors. Exhaustive search of fish mucins was done in GSB after de novo assembly of next-generation sequencing data hosted in the IATS transcriptome database (www.nutrigroup-iats.org/seabreamdb). Six sequences, three categorized as putative membrane-bound mucins and three putative secreted-gel forming mucins, were identified. The transcriptional tissue screening revealed that Muc18 was the predominant mucin in skin, gills and stomach of GSB. In contrast, Muc19 was mostly found in the oesophagus and Muc13 was along the entire intestinal tract, although the posterior intestine exhibited a differential pattern with a high expression of an isoform that does not share a clear orthologous in mammals. This mucin was annotated as intestinal mucin (I-Muc). Its RNA expression was highly regulated by the nutritional background, whereas the other mucins, including Muc2 and Muc2-like, were expressed more constitutively and did not respond to high replacement of fish oil (FO) by vegetable oils (VO) in plant protein-based diets. After challenge with the intestinal parasite Enteromyxum leei, the expression of a number of mucins was decreased mainly in the posterior intestine of infected fish. But, interestingly, the highest down-regulation was observed for the I-Muc. Overall, the magnitude of the changes reflected the intensity and progression of the infection, making mucins and I-Muc, in particular, reliable markers of prognostic and diagnostic value of fish intestinal health.", "link"=>"http://www.mendeley.com/research/mucins-diagnostic-prognostic-biomarkers-fishparasite-model-transcriptional-functional-analysis", "reader_count"=>46, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>2, "Student > Master"=>9, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>2, "Student > Master"=>9, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>4, "Materials Science"=>1, "Agricultural and Biological Sciences"=>33, "Veterinary Science and Veterinary Medicine"=>2, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>33}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>5}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Hungary"=>1, "United States"=>1, "United Kingdom"=>1, "France"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1084392"], "description"=>"<p>Various functional domains are indicated in boxes: <i>O</i>-glycosylated region or PTS domain (yellow), extracellular proteolytic cleavage site SEA domain (orange), transmembrane domain (TM) (red), immunoglobulin domain (Ig) (grey), vW-D domain (dark blue), C8 domain (blue), and cystine knot domain (CK) (light blue). Discontinuous lines at NH<sub>2</sub> or COOH ends represent the predicted size of the lacking sequences in partial proteins according to homology comparisons.</p>", "links"=>[], "tags"=>["Biochemistry", "glycobiology", "glycoproteins", "Computational biology", "genomics", "Genome analysis tools", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "immunology", "immunity", "Immune defense", "microbiology", "Parasitology", "Molecular cell biology", "gene expression", "Zoology", "Ichthyology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Animal management", "Animal nutrition", "Veterinary anatomy and physiology", "Animal digestive anatomy", "Veterinary diseases", "Veterinary parasitology", "molecular", "gilthead", "bream"], "article_id"=>717877, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jaume Pérez-Sánchez", "Itziar Estensoro", "María José Redondo", "Josep Alvar Calduch-Giner", "Sadasivam Kaushik", "Ariadna Sitjà-Bobadilla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0065457.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_representation_of_the_molecular_structure_of_the_six_gilthead_sea_bream_mucins_/717877", "title"=>"Schematic representation of the molecular structure of the six gilthead sea bream mucins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-12 02:11:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1084393"], "description"=>"<p>Gilthead sea bream mucins are highlighted in yellow. GenBank accession numbers are provided for each sequence.</p>", "links"=>[], "tags"=>["Biochemistry", "glycobiology", "glycoproteins", "Computational biology", "genomics", "Genome analysis tools", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "immunology", "immunity", "Immune defense", "microbiology", "Parasitology", "Molecular cell biology", "gene expression", "Zoology", "Ichthyology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Animal management", "Animal nutrition", "Veterinary anatomy and physiology", "Animal digestive anatomy", "Veterinary diseases", "Veterinary parasitology", "membrane-bound", "secreted", "gel-forming"], "article_id"=>717878, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jaume Pérez-Sánchez", "Itziar Estensoro", "María José Redondo", "Josep Alvar Calduch-Giner", "Sadasivam Kaushik", "Ariadna Sitjà-Bobadilla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0065457.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phylogenetic_tree_of_membrane_bound_and_secreted_gel_forming_mucins_/717878", "title"=>"Phylogenetic tree of membrane-bound and secreted gel-forming mucins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-12 02:11:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1084395"], "description"=>"<p>For each tissue, the most abundant mucin is in bold face and different superscript letters stand for statistically significant differences (P<0.05) between mucins.</p>", "links"=>[], "tags"=>["Biochemistry", "glycobiology", "glycoproteins", "Computational biology", "genomics", "Genome analysis tools", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "immunology", "immunity", "Immune defense", "microbiology", "Parasitology", "Molecular cell biology", "gene expression", "Zoology", "Ichthyology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Animal management", "Animal nutrition", "Veterinary anatomy and physiology", "Animal digestive anatomy", "Veterinary diseases", "Veterinary parasitology", "mrna", "gilthead", "bream", "mucins"], "article_id"=>717880, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jaume Pérez-Sánchez", "Itziar Estensoro", "María José Redondo", "Josep Alvar Calduch-Giner", "Sadasivam Kaushik", "Ariadna Sitjà-Bobadilla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0065457.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_mRNA_expression_of_gilthead_sea_bream_mucins_in_different_tissues_/717880", "title"=>"Relative mRNA expression of gilthead sea bream mucins in different tissues.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-12 02:11:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1084396"], "description"=>"<p>Each bar represents the mean ± SEM of 7 infected animals. Asterisks indicate statistically significant differences (P<0.05) with control (CTRL) fish. Different letters stand for statistically significant differences (P<0.05) between mucins within each intestinal segment.</p>", "links"=>[], "tags"=>["Biochemistry", "glycobiology", "glycoproteins", "Computational biology", "genomics", "Genome analysis tools", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "immunology", "immunity", "Immune defense", "microbiology", "Parasitology", "Molecular cell biology", "gene expression", "Zoology", "Ichthyology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Animal management", "Animal nutrition", "Veterinary anatomy and physiology", "Animal digestive anatomy", "Veterinary diseases", "Veterinary parasitology", "mrna", "mucins", "anterior", "posterior", "intestinal", "segments", "gilthead", "bream", "infected"], "article_id"=>717881, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jaume Pérez-Sánchez", "Itziar Estensoro", "María José Redondo", "Josep Alvar Calduch-Giner", "Sadasivam Kaushik", "Ariadna Sitjà-Bobadilla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0065457.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_mRNA_expression_levels_of_mucins_in_the_anterior_AI_middle_MI_and_posterior_PI_intestinal_segments_of_gilthead_sea_bream_infected_by_Enteromyxum_leei_Trial_1_/717881", "title"=>"Relative mRNA expression levels of mucins in the anterior (AI), middle (MI) and posterior (PI) intestinal segments of gilthead sea bream infected by <i>Enteromyxum leei</i> (Trial 1).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-12 02:11:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1084397"], "description"=>"<p>Each bar represents the mean ± the SEM of 6–10 animals. Asterisk indicate statistically significant differences (P<0.05) between CTRL fish fed different diets. Significant differences were also found between each CTRL group and its corresponding RCPT group for the four mucins (not indicated to avoid confusion in symbol interpretations).</p>", "links"=>[], "tags"=>["Biochemistry", "glycobiology", "glycoproteins", "Computational biology", "genomics", "Genome analysis tools", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "immunology", "immunity", "Immune defense", "microbiology", "Parasitology", "Molecular cell biology", "gene expression", "Zoology", "Ichthyology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Animal management", "Animal nutrition", "Veterinary anatomy and physiology", "Animal digestive anatomy", "Veterinary diseases", "Veterinary parasitology", "mrna", "mucins", "posterior", "intestine", "gilthead", "bream", "fed", "oils", "diets", "infected", "kept", "unexposed", "parasite"], "article_id"=>717882, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jaume Pérez-Sánchez", "Itziar Estensoro", "María José Redondo", "Josep Alvar Calduch-Giner", "Sadasivam Kaushik", "Ariadna Sitjà-Bobadilla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0065457.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_mRNA_expression_levels_of_mucins_in_the_posterior_intestine_of_gilthead_sea_bream_fed_vegetable_oils_VO_or_fish_oil_FO_diets_and_infected_by_Enteromyxum_leei_RCPT_or_kept_unexposed_to_the_parasite_CTRL_Trial_2_/717882", "title"=>"Relative mRNA expression levels of mucins in the posterior intestine of gilthead sea bream fed vegetable oils (VO) or fish oil (FO) diets and infected by <i>Enteromyxum leei</i> (RCPT) or kept unexposed to the parasite (CTRL) (Trial 2).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-12 02:11:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/1084399"], "description"=>"a<p>Number of sequences.</p>b<p>Gene identity determined through BLAST searches.</p>c<p>Best BLAST-X protein sequence match.</p>d<p>Expectation value.</p>e<p>Codifying sequence.</p>", "links"=>[], "tags"=>["Biochemistry", "glycobiology", "glycoproteins", "Computational biology", "genomics", "Genome analysis tools", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "immunology", "immunity", "Immune defense", "microbiology", "Parasitology", "Molecular cell biology", "gene expression", "Zoology", "Ichthyology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Animal management", "Animal nutrition", "Veterinary anatomy and physiology", "Animal digestive anatomy", "Veterinary diseases", "Veterinary parasitology", "genes"], "article_id"=>717884, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jaume Pérez-Sánchez", "Itziar Estensoro", "María José Redondo", "Josep Alvar Calduch-Giner", "Sadasivam Kaushik", "Ariadna Sitjà-Bobadilla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0065457.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Classification_of_identified_genes_according_to_BLAST_searches_/717884", "title"=>"Classification of identified genes according to BLAST searches.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-12 02:11:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1084400"], "description"=>"<p>Forward and reverse primers for real-time PCR.</p>", "links"=>[], "tags"=>["Biochemistry", "glycobiology", "glycoproteins", "Computational biology", "genomics", "Genome analysis tools", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "immunology", "immunity", "Immune defense", "microbiology", "Parasitology", "Molecular cell biology", "gene expression", "Zoology", "Ichthyology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Animal management", "Animal nutrition", "Veterinary anatomy and physiology", "Animal digestive anatomy", "Veterinary diseases", "Veterinary parasitology", "primers", "Real-time"], "article_id"=>717885, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jaume Pérez-Sánchez", "Itziar Estensoro", "María José Redondo", "Josep Alvar Calduch-Giner", "Sadasivam Kaushik", "Ariadna Sitjà-Bobadilla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0065457.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forward_and_reverse_primers_for_real_time_PCR_/717885", "title"=>"Forward and reverse primers for real-time PCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-12 02:11:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1084401", "https://ndownloader.figshare.com/files/1084420", "https://ndownloader.figshare.com/files/1084422"], "description"=>"<div><p>Mucins are <i>O</i>-glycosylated glycoproteins present on the apex of all wet-surfaced epithelia with a well-defined expression pattern, which is disrupted in response to a wide range of injuries or challenges. The aim of this study was to identify mucin gene sequences of gilthead sea bream (GSB), to determine its pattern of distribution in fish tissues and to analyse their transcriptional regulation by dietary and pathogenic factors. Exhaustive search of fish mucins was done in GSB after <i>de novo</i> assembly of next-generation sequencing data hosted in the IATS transcriptome database (<a href=\"http://www.nutrigroup-iats.org/seabreamdb\" target=\"_blank\">www.nutrigroup-iats.org/seabreamdb</a>). Six sequences, three categorized as putative membrane-bound mucins and three putative secreted-gel forming mucins, were identified. The transcriptional tissue screening revealed that Muc18 was the predominant mucin in skin, gills and stomach of GSB. In contrast, Muc19 was mostly found in the oesophagus and Muc13 was along the entire intestinal tract, although the posterior intestine exhibited a differential pattern with a high expression of an isoform that does not share a clear orthologous in mammals. This mucin was annotated as intestinal mucin (I-Muc). Its RNA expression was highly regulated by the nutritional background, whereas the other mucins, including Muc2 and Muc2-like, were expressed more constitutively and did not respond to high replacement of fish oil (FO) by vegetable oils (VO) in plant protein-based diets. After challenge with the intestinal parasite <i>Enteromyxum leei</i>, the expression of a number of mucins was decreased mainly in the posterior intestine of infected fish. But, interestingly, the highest down-regulation was observed for the I-Muc. Overall, the magnitude of the changes reflected the intensity and progression of the infection, making mucins and I-Muc, in particular, reliable markers of prognostic and diagnostic value of fish intestinal health.</p></div>", "links"=>[], "tags"=>["Biochemistry", "glycobiology", "glycoproteins", "Computational biology", "genomics", "Genome analysis tools", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "immunology", "immunity", "Immune defense", "microbiology", "Parasitology", "Molecular cell biology", "gene expression", "Zoology", "Ichthyology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Animal management", "Animal nutrition", "Veterinary anatomy and physiology", "Animal digestive anatomy", "Veterinary diseases", "Veterinary parasitology", "diagnostic", "prognostic", "fish-parasite", "transcriptional"], "article_id"=>717886, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jaume Pérez-Sánchez", "Itziar Estensoro", "María José Redondo", "Josep Alvar Calduch-Giner", "Sadasivam Kaushik", "Ariadna Sitjà-Bobadilla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0065457.s001", "https://dx.doi.org/10.1371/journal.pone.0065457.s002", "https://dx.doi.org/10.1371/journal.pone.0065457.s003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mucins_as_Diagnostic_and_Prognostic_Biomarkers_in_a_Fish_Parasite_Model_Transcriptional_and_Functional_Analysis_/717886", "title"=>"Mucins as Diagnostic and Prognostic Biomarkers in a Fish-Parasite Model: Transcriptional and Functional Analysis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-06-12 02:11:26"}

PMC Usage Stats | Further Information

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Relative Metric

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