The Chemokine CCL3 Promotes Experimental Liver Fibrosis in Mice
Publication Date
June 17, 2013
Journal
PLOS ONE
Authors
Daniel Heinrichs, Marie Luise Berres, Andreas Nellen, Petra Fischer, et al
Volume
8
Issue
6
Pages
e66106
DOI
https://dx.plos.org/10.1371/journal.pone.0066106
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0066106
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23799074
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684603
Europe PMC
http://europepmc.org/abstract/MED/23799074
Web of Science
000321397800023
Scopus
84879174817
Mendeley
http://www.mendeley.com/research/chemokine-ccl3-promotes-experimental-liver-fibrosis-mice
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"The Chemokine CCL3 Promotes Experimental Liver Fibrosis in Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Daniel", "last_name"=>"Heinrichs", "scopus_author_id"=>"37021448300"}, {"first_name"=>"Marie Luise", "last_name"=>"Berres", "scopus_author_id"=>"12809026200"}, {"first_name"=>"Andreas", "last_name"=>"Nellen", "scopus_author_id"=>"36497321800"}, {"first_name"=>"Petra", "last_name"=>"Fischer", "scopus_author_id"=>"55768283600"}, {"first_name"=>"David", "last_name"=>"Scholten", "scopus_author_id"=>"23036643200"}, {"first_name"=>"Christian", "last_name"=>"Trautwein", "scopus_author_id"=>"7005071218"}, {"first_name"=>"Hermann E.", "last_name"=>"Wasmuth", "scopus_author_id"=>"7003909487"}, {"first_name"=>"Hacer", "last_name"=>"Sahin", "scopus_author_id"=>"57192642917"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"369142041", "doi"=>"10.1371/journal.pone.0066106", "sgr"=>"84879174817", "scopus"=>"2-s2.0-84879174817", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23799074"}, "id"=>"1da01944-5f72-306f-bf54-0922595bf0eb", "abstract"=>"Liver fibrosis is associated with infiltrating immune cells and activation of hepatic stellate cells. We here aimed to investigate the effects of the CC chemokine CCL3, also known as macrophage inflammatory protein-1α, in two different fibrosis models. To this end, we treated mice either with carbon tetrachloride or with a methionine- and choline-deficient diet to induce fibrosis in CCL3 deficient and wild-type mice. The results show that the protein expression of CCL3 is increased in wild-type mice after chronic liver injury. Deletion of CCL3 exhibited reduced liver fibrosis compared to their wild-type counterparts. We could validate these results by treating the two mouse groups with either carbon tetrachloride or by feeding a methionine- and choline-deficient diet. In these models, lack of CCL3 is functionally associated with reduced stellate cell activation and liver immune cell infiltration. In vitro, we show that CCL3 leads to increased proliferation and migration of hepatic stellate cells. In conclusion, our results define the chemokine CCL3 as a mediator of experimental liver fibrosis. Thus, therapeutic modulation of CCL3 might be a promising target for chronic liver diseases.", "link"=>"http://www.mendeley.com/research/chemokine-ccl3-promotes-experimental-liver-fibrosis-mice", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>6, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84879174817"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84879174817?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879174817&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84879174817&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84879174817", "dc:identifier"=>"SCOPUS_ID:84879174817", "eid"=>"2-s2.0-84879174817", "dc:title"=>"The Chemokine CCL3 Promotes Experimental Liver Fibrosis in Mice", "dc:creator"=>"Heinrichs D.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"6", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-06-17", "prism:coverDisplayDate"=>"17 June 2013", "prism:doi"=>"10.1371/journal.pone.0066106", "citedby-count"=>"25", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Uniklinik RWTH Aachen", "affiliation-city"=>"Aachen", "affiliation-country"=>"Germany"}], "pubmed-id"=>"23799074", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e66106", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0066106", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"6", "html_views"=>"219"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"28", "xml_views"=>"3", "html_views"=>"99"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"75"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"50"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"50"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"41"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"5", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"3"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"6"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"7"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"11", "html_views"=>"10"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"12", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"5", "html_views"=>"13"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"6", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"6", "html_views"=>"8"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"12", "html_views"=>"8"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"12", "html_views"=>"10"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"10", "html_views"=>"3"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"8", "html_views"=>"7"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"14", "html_views"=>"7"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1090714"], "description"=>"<p>CCL3 expression is increased in MCD-fed wild-type mice compared to untreated control (<b>A</b>). Representative Sirius red staining of <i>CCL3<sup>−/−</sup></i> and wild-type (<i>CCL3<sup>+/+</sup></i>) mice after MCD diet (x100 magnification). Quantitative analysis of the Sirius red-positive area showed a significantly decrease in <i>CCL3<sup>−/−</sup></i> mice compared to wild-type mice (<b>B</b>). Hydroxyproline concentration in the liver (<b>C</b>) and serum level of ALT (<b>D</b>) were also significantly decreased in <i>CCL3<sup>−/−</sup></i> mice. Data are expressed as means ± SEM of eight mice per group. *<i>P</i><0.05, ***<i>P</i><0.001.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Immune physiology", "cytokines", "genetics", "Animal genetics", "histology", "immunology", "Immune system", "Molecular cell biology", "cytometry", "flow cytometry", "Extracellular matrix", "Extracellular matrix composition", "gene expression", "Gastroenterology and hepatology", "Liver diseases", "Nonalcoholic steatohepatitis", "fibrosis", "mice", "weeks", "mcd"], "article_id"=>723270, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Daniel Heinrichs", "Marie-Luise Berres", "Andreas Nellen", "Petra Fischer", "David Scholten", "Christian Trautwein", "Hermann E. Wasmuth", "Hacer Sahin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066106.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Liver_fibrosis_in_CCL3_8722_8722_mice_after_eight_weeks_of_MCD_diet_/723270", "title"=>"Liver fibrosis in <i>CCL3<sup>−/−</sup></i> mice after eight weeks of MCD diet.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-17 00:54:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/1090716"], "description"=>"<p>MCD-fed <i>CCL3<sup>−/−</sup></i> mice show a significantly altered expression of the fibrosis-related genes <i>Col1a1</i>, <i>TIMP1</i> and <i>MMP9</i> compared to wild-type mice. However, mRNA expression of <i>TGF-β1</i> does not vary in <i>CCL3<sup>−/−</sup></i> mice (<b>A</b>). <i>α-SMA</i> expression is significantly decreased in <i>CCL3<sup>−/−</sup></i> mice after MCD diet. Representative α-SMA staining is shown in the left panel (x100 magnification, <b>B</b>). Data are expressed as means ± SEM of eight mice per group. *<i>P</i><0.05.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Immune physiology", "cytokines", "genetics", "Animal genetics", "histology", "immunology", "Immune system", "Molecular cell biology", "cytometry", "flow cytometry", "Extracellular matrix", "Extracellular matrix composition", "gene expression", "Gastroenterology and hepatology", "Liver diseases", "Nonalcoholic steatohepatitis", "genes", "weeks", "mcd"], "article_id"=>723272, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Daniel Heinrichs", "Marie-Luise Berres", "Andreas Nellen", "Petra Fischer", "David Scholten", "Christian Trautwein", "Hermann E. Wasmuth", "Hacer Sahin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066106.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fibrosis_related_genes_after_eight_weeks_of_MCD_diet_/723272", "title"=>"Fibrosis-related genes after eight weeks of MCD diet.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-17 00:54:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/1090718"], "description"=>"<p>Acute liver injury after CCl<sub>4</sub> challenge is associated with augmented hepatic expression of CCL3, while CCL3 after chronic CCl<sub>4</sub> treatment has a tendency toward higher expression (<b>A</b>). Sirius red staining after the CCl<sub>4</sub> treatment (x100 magnification) shows reduced liver fibrosis in <i>CCL3</i> deficient mice (<b>B</b>). Hydroxyproline contents in the liver (<b>C</b>) and serum level of ALT (<b>D</b>) were significantly decreased in <i>CCL3<sup>−/−</sup></i> mice. Data are expressed as means ± SEM of eight mice per group. *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Immune physiology", "cytokines", "genetics", "Animal genetics", "histology", "immunology", "Immune system", "Molecular cell biology", "cytometry", "flow cytometry", "Extracellular matrix", "Extracellular matrix composition", "gene expression", "Gastroenterology and hepatology", "Liver diseases", "Nonalcoholic steatohepatitis", "fibrosis", "mice"], "article_id"=>723274, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Daniel Heinrichs", "Marie-Luise Berres", "Andreas Nellen", "Petra Fischer", "David Scholten", "Christian Trautwein", "Hermann E. Wasmuth", "Hacer Sahin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066106.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reduced_liver_fibrosis_in_CCL3_8722_8722_mice_after_CCl_4_challenge_/723274", "title"=>"Reduced liver fibrosis in <i>CCL3<sup>−/−</sup></i> mice after CCl<sub>4</sub> challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-17 00:54:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1090719"], "description"=>"<p>CCl<sub>4</sub> treatment of <i>CCL3<sup>−/−</sup></i> mice lead to significantly altered expression of the fibrosis-related genes <i>Col1a1, TGF-β1, TIMP1</i> and <i>MMP9</i> in <i>CCL3<sup>−/−</sup></i> mice (<b>A</b>)<b>.</b> α-SMA expression is significantly decreased in <i>CCL3<sup>−/−</sup></i> mice (x100 magnification, <b>B</b>). Data are expressed as means ± SEM of eight mice per group. *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Immune physiology", "cytokines", "genetics", "Animal genetics", "histology", "immunology", "Immune system", "Molecular cell biology", "cytometry", "flow cytometry", "Extracellular matrix", "Extracellular matrix composition", "gene expression", "Gastroenterology and hepatology", "Liver diseases", "Nonalcoholic steatohepatitis", "fibrosis-related", "genes"], "article_id"=>723275, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Daniel Heinrichs", "Marie-Luise Berres", "Andreas Nellen", "Petra Fischer", "David Scholten", "Christian Trautwein", "Hermann E. Wasmuth", "Hacer Sahin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066106.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Altered_expression_of_fibrosis_related_genes_in_CCL3_8722_8722_mice_/723275", "title"=>"Altered expression of fibrosis-related genes in <i>CCL3<sup>−/−</sup></i> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-17 00:54:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1090720"], "description"=>"<p><i>CCL3<sup>−/−</sup></i> mice treated with CCl<sub>4</sub> show altered expression of the inflammation-related genes <i>TNF-α, IL-1β, IL-2 and MCP-1</i> compared to wild-type mice (<b>A</b>). CD8<sup>+</sup> T cell infiltration is significantly decreased in <i>CCL3<sup>−/−</sup></i> mice (<b>B</b>). Data are expressed as means ± SEM of eight mice per group. *<i>P</i><0.05.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Immune physiology", "cytokines", "genetics", "Animal genetics", "histology", "immunology", "Immune system", "Molecular cell biology", "cytometry", "flow cytometry", "Extracellular matrix", "Extracellular matrix composition", "gene expression", "Gastroenterology and hepatology", "Liver diseases", "Nonalcoholic steatohepatitis", "reduced", "mice", "treated"], "article_id"=>723276, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Daniel Heinrichs", "Marie-Luise Berres", "Andreas Nellen", "Petra Fischer", "David Scholten", "Christian Trautwein", "Hermann E. Wasmuth", "Hacer Sahin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066106.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inflammation_is_reduced_in_CCL3_8722_8722_mice_treated_with_CCl_4_/723276", "title"=>"Inflammation is reduced in <i>CCL3<sup>−/−</sup></i> mice treated with CCl<sub>4</sub>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-17 00:54:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1090722"], "description"=>"<p>CD45<sup>+</sup> and CD3<sup>+</sup>cell infiltration is markedly reduced in <i>CCL3<sup>−/−</sup></i> mice (x100 magnification, <b>A,</b> x200 magnification, <b>B</b>). Data are expressed as means ± SEM of eight mice per group. *<i>P</i><0.05, ***<i>P</i><0.001.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Immune physiology", "cytokines", "genetics", "Animal genetics", "histology", "immunology", "Immune system", "Molecular cell biology", "cytometry", "flow cytometry", "Extracellular matrix", "Extracellular matrix composition", "gene expression", "Gastroenterology and hepatology", "Liver diseases", "Nonalcoholic steatohepatitis", "leads", "reduced", "influx"], "article_id"=>723278, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Daniel Heinrichs", "Marie-Luise Berres", "Andreas Nellen", "Petra Fischer", "David Scholten", "Christian Trautwein", "Hermann E. Wasmuth", "Hacer Sahin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066106.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_lack_of_CCL3_leads_to_reduced_influx_of_CD45_and_CD3_cells_/723278", "title"=>"The lack of <i>CCL3</i> leads to reduced influx of CD45<sup>+</sup> and CD3<sup>+</sup> cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-17 00:54:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1090723"], "description"=>"<p>Stimulation of hepatic stellate cell line (GRX) with recombinant CCL3 led to significantly increased proliferation compared to untreated cells (<b>A</b>). Stimulation of GRX cells with recombinant CCL3 showed significantly increased wound healing after 32 hours, while there is no difference after 24 hours between the groups (<b>B</b>). Data are expressed as means ± SEM of three independent experiments. ***<i>P</i><0.001.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Immune physiology", "cytokines", "genetics", "Animal genetics", "histology", "immunology", "Immune system", "Molecular cell biology", "cytometry", "flow cytometry", "Extracellular matrix", "Extracellular matrix composition", "gene expression", "Gastroenterology and hepatology", "Liver diseases", "Nonalcoholic steatohepatitis", "ccl3"], "article_id"=>723279, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Daniel Heinrichs", "Marie-Luise Berres", "Andreas Nellen", "Petra Fischer", "David Scholten", "Christian Trautwein", "Hermann E. Wasmuth", "Hacer Sahin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066106.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_vitro_evidence_for_a_role_of_CCL3_in_liver_fibrosis_/723279", "title"=>"<i>In vitro</i> evidence for a role of CCL3 in liver fibrosis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-17 00:54:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1090726", "https://ndownloader.figshare.com/files/1090728", "https://ndownloader.figshare.com/files/1090729", "https://ndownloader.figshare.com/files/1090731"], "description"=>"<div><p>Liver fibrosis is associated with infiltrating immune cells and activation of hepatic stellate cells. We here aimed to investigate the effects of the CC chemokine CCL3, also known as macrophage inflammatory protein-1α, in two different fibrosis models. To this end, we treated mice either with carbon tetrachloride or with a methionine- and choline-deficient diet to induce fibrosis in <i>CCL3</i> deficient and wild-type mice. The results show that the protein expression of CCL3 is increased in wild-type mice after chronic liver injury. Deletion of <i>CCL3</i> exhibited reduced liver fibrosis compared to their wild-type counterparts. We could validate these results by treating the two mouse groups with either carbon tetrachloride or by feeding a methionine- and choline-deficient diet. In these models, lack of <i>CCL3</i> is functionally associated with reduced stellate cell activation and liver immune cell infiltration. <i>In vitro</i>, we show that CCL3 leads to increased proliferation and migration of hepatic stellate cells. In conclusion, our results define the chemokine CCL3 as a mediator of experimental liver fibrosis. Thus, therapeutic modulation of CCL3 might be a promising target for chronic liver diseases.</p></div>", "links"=>[], "tags"=>["Anatomy and physiology", "Immune physiology", "cytokines", "genetics", "Animal genetics", "histology", "immunology", "Immune system", "Molecular cell biology", "cytometry", "flow cytometry", "Extracellular matrix", "Extracellular matrix composition", "gene expression", "Gastroenterology and hepatology", "Liver diseases", "Nonalcoholic steatohepatitis", "chemokine", "ccl3", "fibrosis"], "article_id"=>723280, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Daniel Heinrichs", "Marie-Luise Berres", "Andreas Nellen", "Petra Fischer", "David Scholten", "Christian Trautwein", "Hermann E. Wasmuth", "Hacer Sahin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066106.s001", "https://dx.doi.org/10.1371/journal.pone.0066106.s002", "https://dx.doi.org/10.1371/journal.pone.0066106.s003", "https://dx.doi.org/10.1371/journal.pone.0066106.s004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Chemokine_CCL3_Promotes_Experimental_Liver_Fibrosis_in_Mice_/723280", "title"=>"The Chemokine CCL3 Promotes Experimental Liver Fibrosis in Mice", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-06-17 00:54:40"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"7", "abstract"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"37", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"13", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"27", "full-text"=>"27", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"23", "full-text"=>"28", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"31", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Ecology", "average_usage"=>[290, 478, 601, 716, 816, 914, 1016, 1112, 1203, 1285, 1373, 1451, 1516]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 466, 591, 701, 799, 887, 982, 1067, 1155, 1237, 1317, 1395, 1458]}, {"subject_area"=>"/Ecology and environmental sciences/Community ecology", "average_usage"=>[285, 478]}, {"subject_area"=>"/Ecology and environmental sciences/Ecology", "average_usage"=>[298, 487, 610, 722, 827, 929, 1029, 1125, 1217, 1306, 1388, 1464, 1535]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[262, 463, 587, 693, 790, 882, 965, 1051, 1135, 1218, 1300, 1376, 1438]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[267, 466, 592, 709, 806, 901, 989, 1075, 1162, 1254, 1342, 1424, 1486]}]}
Loading … Spinner
There are currently no alerts