Gray Matter Is Targeted in First-Attack Multiple Sclerosis
Publication Date
September 10, 2013
Journal
PLOS ONE
Authors
Steven E. Schutzer, Thomas E. Angel, Tao Liu, Athena A. Schepmoes, et al
Volume
8
Issue
9
Pages
e66117
DOI
https://dx.plos.org/10.1371/journal.pone.0066117
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0066117
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24039694
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769274
Europe PMC
http://europepmc.org/abstract/MED/24039694
Web of Science
000327538600001
Scopus
84883772572
Mendeley
http://www.mendeley.com/research/gray-matter-targeted-firstattack-multiple-sclerosis
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Mendeley | Further Information

{"title"=>"Gray Matter Is Targeted in First-Attack Multiple Sclerosis", "type"=>"journal", "authors"=>[{"first_name"=>"Steven E.", "last_name"=>"Schutzer", "scopus_author_id"=>"7003390617"}, {"first_name"=>"Thomas E.", "last_name"=>"Angel", "scopus_author_id"=>"13409996600"}, {"first_name"=>"Tao", "last_name"=>"Liu", "scopus_author_id"=>"36071745600"}, {"first_name"=>"Athena A.", "last_name"=>"Schepmoes", "scopus_author_id"=>"14827175600"}, {"first_name"=>"Fang", "last_name"=>"Xie", "scopus_author_id"=>"37032272800"}, {"first_name"=>"Jonas", "last_name"=>"Bergquist", "scopus_author_id"=>"7004571643"}, {"first_name"=>"László", "last_name"=>"Vécsei", "scopus_author_id"=>"35452449900"}, {"first_name"=>"Denes", "last_name"=>"Zadori", "scopus_author_id"=>"8144520600"}, {"first_name"=>"David G.", "last_name"=>"Camp", "scopus_author_id"=>"7005585783"}, {"first_name"=>"Bart K.", "last_name"=>"Holland", "scopus_author_id"=>"7102232176"}, {"first_name"=>"Richard D.", "last_name"=>"Smith", "scopus_author_id"=>"55542871600"}, {"first_name"=>"Patricia K.", "last_name"=>"Coyle", "scopus_author_id"=>"23157884200"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84883772572", "pmid"=>"24039694", "sgr"=>"84883772572", "doi"=>"10.1371/journal.pone.0066117", "isbn"=>"1932-6203", "issn"=>"19326203", "pui"=>"369796091"}, "id"=>"bb7d14d1-9db7-3738-9dcf-dc23ff33da81", "abstract"=>"The cause of multiple sclerosis (MS), its driving pathogenesis at the earliest stages, and what factors allow the first clinical attack to manifest remain unknown. Some imaging studies suggest gray rather than white matter may be involved early, and some postulate this may be predictive of developing MS. Other imaging studies are in conflict. To determine if there was objective molecular evidence of gray matter involvement in early MS we used high-resolution mass spectrometry to identify proteins in the cerebrospinal fluid (CSF) of first-attack MS patients (two independent groups) compared to established relapsing remitting (RR) MS and controls. We found that the CSF proteins in first-attack patients were differentially enriched for gray matter components (axon, neuron, synapse). Myelin components did not distinguish these groups. The results support that gray matter dysfunction is involved early in MS, and also may be integral for the initial clinical presentation.", "link"=>"http://www.mendeley.com/research/gray-matter-targeted-firstattack-multiple-sclerosis", "reader_count"=>57, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Researcher"=>14, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>6, "Student > Bachelor"=>5, "Professor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Researcher"=>14, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>6, "Student > Bachelor"=>5, "Professor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>4, "Unspecified"=>8, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>20, "Neuroscience"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>2, "Psychology"=>2, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>20}, "Neuroscience"=>{"Neuroscience"=>6}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>8}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Korea (South)"=>1, "United States"=>1, "Italy"=>1, "Portugal"=>1, "Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1199753"], "description"=>"<p>In-depth off-line 2D-LC-<i>MS/MS</i> analysis of the CSF proteome of a pooled sample composed of CSF from all MS patients resulted in the identification of 2820 proteins, and the comparison to previous results obtained from analyses of healthy normals <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066117#pone.0066117-Schutzer1\" target=\"_blank\">[8]</a> and other neurologic disease (OND) <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066117#pone.0066117-Schutzer2\" target=\"_blank\">[9]</a>.</p>", "links"=>[], "tags"=>["off-line", "csf", "proteome", "pooled", "composed", "ms", "patients", "resulted", "2820", "normals", "neurologic"], "article_id"=>795933, "categories"=>["Biological Sciences"], "users"=>["Steven E. Schutzer", "Thomas E. Angel", "Tao Liu", "Athena A. Schepmoes", "Fang Xie", "Jonas Bergquist", "László Vécsei", "Denes Zadori", "David G. Camp II", "Bart K. Holland", "Richard D. Smith", "Patricia K. Coyle"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066117.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_depth_off_line_2D_LC_MS_MS_analysis_of_the_CSF_proteome_of_a_pooled_sample_composed_of_CSF_from_all_MS_patients_resulted_in_the_identification_of_2820_proteins_and_the_comparison_to_previous_results_obtained_from_analyses_of_healthy_normals_8_and_othe/795933", "title"=>"In-depth off-line 2D-LC-<i>MS/MS</i> analysis of the CSF proteome of a pooled sample composed of CSF from all MS patients resulted in the identification of 2820 proteins, and the comparison to previous results obtained from analyses of healthy normals [8] and other neurologic disease (OND) [9].", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-10 02:11:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1199754"], "description"=>"<p>A) Following the 1D LC-MS analysis of immunodepleted CSF samples we identified peptides referable to 86 proteins that show significant difference in abundance by ANOVA (p-value <0.05) (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066117#pone.0066117.s002\" target=\"_blank\">Table S2</a>). B) Partial least squares analysis of quantified proteins demonstrates that these three groups (control, first-attack CIS MS, RR-MS) can be distinguished from one another considering the CSF proteome.</p>", "links"=>[], "tags"=>["quantification", "csf", "proteins"], "article_id"=>795934, "categories"=>["Biological Sciences"], "users"=>["Steven E. Schutzer", "Thomas E. Angel", "Tao Liu", "Athena A. Schepmoes", "Fang Xie", "Jonas Bergquist", "László Vécsei", "Denes Zadori", "David G. Camp II", "Bart K. Holland", "Richard D. Smith", "Patricia K. Coyle"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066117.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Label_free_quantification_of_CSF_proteins_identified_in_patient_and_control_samples_/795934", "title"=>"Label-free quantification of CSF proteins identified in patient and control samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-10 02:11:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1199755"], "description"=>"<p>Increased in first-attack CIS-MS vs established RR-MS, but Decreased in first-attack CIS-MS vs Controls.</p>", "links"=>[], "tags"=>["first-attack", "cis-ms", "established"], "article_id"=>795935, "categories"=>["Biological Sciences"], "users"=>["Steven E. Schutzer", "Thomas E. Angel", "Tao Liu", "Athena A. Schepmoes", "Fang Xie", "Jonas Bergquist", "László Vécsei", "Denes Zadori", "David G. Camp II", "Bart K. Holland", "Richard D. Smith", "Patricia K. Coyle"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066117.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_in_first_attack_CIS_MS_vs_established_RR_MS_but_Decreased_in_first_attack_CIS_MS_vs_Controls_/795935", "title"=>"Increased in first-attack CIS-MS vs established RR-MS, but Decreased in first-attack CIS-MS vs Controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-10 02:11:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1199756"], "description"=>"<p>Decreased in first-attack CIS-MS vs established RR-MS and controls.</p>", "links"=>[], "tags"=>["first-attack", "cis-ms", "established", "rr-ms"], "article_id"=>795936, "categories"=>["Biological Sciences"], "users"=>["Steven E. Schutzer", "Thomas E. Angel", "Tao Liu", "Athena A. Schepmoes", "Fang Xie", "Jonas Bergquist", "László Vécsei", "Denes Zadori", "David G. Camp II", "Bart K. Holland", "Richard D. Smith", "Patricia K. Coyle"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066117.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Decreased_in_first_attack_CIS_MS_vs_established_RR_MS_and_controls_/795936", "title"=>"Decreased in first-attack CIS-MS vs established RR-MS and controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-10 02:11:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1199757"], "description"=>"<p>Significant CSF Brain Protein Changes in first-attack CIS-MS vs. established RR-MS and Controls Increased in first attack CIS-MS vs. established RR-MS, Controls.</p>", "links"=>[], "tags"=>["csf", "first-attack", "cis-ms", "established", "rr-ms", "controls"], "article_id"=>795937, "categories"=>["Biological Sciences"], "users"=>["Steven E. Schutzer", "Thomas E. Angel", "Tao Liu", "Athena A. Schepmoes", "Fang Xie", "Jonas Bergquist", "László Vécsei", "Denes Zadori", "David G. Camp II", "Bart K. Holland", "Richard D. Smith", "Patricia K. Coyle"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066117.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Significant_CSF_Brain_Protein_Changes_in_first_attack_CIS_MS_vs_established_RR_MS_and_Controls_Increased_in_first_attack_CIS_MS_vs_established_RR_MS_Controls_/795937", "title"=>"Significant CSF Brain Protein Changes in first-attack CIS-MS vs. established RR-MS and Controls Increased in first attack CIS-MS vs. established RR-MS, Controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-10 02:11:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1199758", "https://ndownloader.figshare.com/files/1199759"], "description"=>"<div><p>The cause of multiple sclerosis (MS), its driving pathogenesis at the earliest stages, and what factors allow the first clinical attack to manifest remain unknown. Some imaging studies suggest gray rather than white matter may be involved early, and some postulate this may be predictive of developing MS. Other imaging studies are in conflict. To determine if there was objective molecular evidence of gray matter involvement in early MS we used high-resolution mass spectrometry to identify proteins in the cerebrospinal fluid (CSF) of first-attack MS patients (two independent groups) compared to established relapsing remitting (RR) MS and controls. We found that the CSF proteins in first-attack patients were differentially enriched for gray matter components (axon, neuron, synapse). Myelin components did not distinguish these groups. The results support that gray matter dysfunction is involved early in MS, and also may be integral for the initial clinical presentation.</p></div>", "links"=>[], "tags"=>["targeted", "first-attack"], "article_id"=>795938, "categories"=>["Biological Sciences"], "users"=>["Steven E. Schutzer", "Thomas E. Angel", "Tao Liu", "Athena A. Schepmoes", "Fang Xie", "Jonas Bergquist", "László Vécsei", "Denes Zadori", "David G. Camp II", "Bart K. Holland", "Richard D. Smith", "Patricia K. Coyle"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066117.s001", "https://dx.doi.org/10.1371/journal.pone.0066117.s002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gray_Matter_Is_Targeted_in_First_Attack_Multiple_Sclerosis_/795938", "title"=>"Gray Matter Is Targeted in First-Attack Multiple Sclerosis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-09-10 02:11:49"}

PMC Usage Stats | Further Information

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Relative Metric

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