The Observation of Highly Ordered Domains in Membranes with Cholesterol
Publication Date
June 18, 2013
Journal
PLOS ONE
Authors
Clare L. Armstrong, Drew Marquardt, Hannah Dies, Norbert Kučerka, et al
Volume
8
Issue
6
Pages
e66162
DOI
https://dx.plos.org/10.1371/journal.pone.0066162
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0066162
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23823623
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688844
Europe PMC
http://europepmc.org/abstract/MED/23823623
Web of Science
000320576400060
Scopus
84879173212
Mendeley
http://www.mendeley.com/research/observation-highly-ordered-domains-membranes-cholesterol
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Mendeley | Further Information

{"title"=>"The Observation of Highly Ordered Domains in Membranes with Cholesterol", "type"=>"journal", "authors"=>[{"first_name"=>"Clare L.", "last_name"=>"Armstrong", "scopus_author_id"=>"36624858500"}, {"first_name"=>"Drew", "last_name"=>"Marquardt", "scopus_author_id"=>"35573985600"}, {"first_name"=>"Hannah", "last_name"=>"Dies", "scopus_author_id"=>"55675255200"}, {"first_name"=>"Norbert", "last_name"=>"Kučerka", "scopus_author_id"=>"6603226169"}, {"first_name"=>"Zahra", "last_name"=>"Yamani", "scopus_author_id"=>"56211859900"}, {"first_name"=>"Thad A.", "last_name"=>"Harroun", "scopus_author_id"=>"6701589311"}, {"first_name"=>"John", "last_name"=>"Katsaras", "scopus_author_id"=>"7003585144"}, {"first_name"=>"An Chang", "last_name"=>"Shi", "scopus_author_id"=>"7004526101"}, {"first_name"=>"Maikel C.", "last_name"=>"Rheinstädter", "scopus_author_id"=>"6603439825"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"369142298", "sgr"=>"84879173212", "issn"=>"19326203", "pmid"=>"23823623", "scopus"=>"2-s2.0-84879173212", "doi"=>"10.1371/journal.pone.0066162", "isbn"=>"1932-6203"}, "id"=>"876f0619-3574-3fbc-baf0-b6c150063f78", "abstract"=>"Rafts, or functional domains, are transient nano- or mesoscopic structures in the exoplasmic leaflet of the plasma membrane, and are thought to be essential for many cellular processes. Using neutron diffraction and computer modelling, we present evidence for the existence of highly ordered lipid domains in the cholesterol-rich (32.5 mol%) liquid-ordered ([Formula: see text]) phase of dipalmitoylphosphatidylcholine membranes. The liquid ordered phase in one-component lipid membranes has previously been thought to be a homogeneous phase. The presence of highly ordered lipid domains embedded in a disordered lipid matrix implies non-uniform distribution of cholesterol between the two phases. The experimental results are in excellent agreement with recent computer simulations of DPPC/cholesterol complexes [Meinhardt, Vink and Schmid (2013). Proc Natl Acad Sci USA 110(12): 4476-4481], which reported the existence of nanometer size [Formula: see text] domains in a liquid disordered lipid environment.", "link"=>"http://www.mendeley.com/research/observation-highly-ordered-domains-membranes-cholesterol", "reader_count"=>72, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>9, "Researcher"=>21, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>21, "Other"=>3, "Student > Master"=>5, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>9, "Researcher"=>21, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>21, "Other"=>3, "Student > Master"=>5, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>1, "Physics and Astronomy"=>24, "Chemical Engineering"=>1, "Chemistry"=>22, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>22}, "Physics and Astronomy"=>{"Physics and Astronomy"=>24}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Czech Republic"=>1, "United States"=>1, "Japan"=>1}, "group_count"=>0}

CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1091444"], "description"=>"<p>The data are denoted by circles with the fit shown as a solid line. A disordered structure was observed in a), while the sharp features in b) are indicative of the presence of highly ordered lipid domains. A top view of the corresponding molecular structures are shown in the insets to the Figure using the same symbols as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066162#pone-0066162-g001\" target=\"_blank\">Figure 1</a> b); the quasi-Bragg reflections are indicated by vertical dashed lines and their associated Miller indices, [<i>hkl</i>]. Peaks resulting from the silicon substrates and the aluminum sample chamber (as described in the Materials and Methods Section) are highlighted in grey, but not accounted for in the fit.</p>", "links"=>[], "tags"=>["Biochemistry", "cytochemistry", "cell membrane", "Membrane structures", "lipids", "Lipid structure", "biophysics", "Biophysics simulations", "Computational biology", "Macromolecular structure analysis", "in-plane", "scans", "dppc-d62", "bilayers", "setup"], "article_id"=>723904, "categories"=>["Physics", "Biological Sciences"], "users"=>["Clare L. Armstrong", "Drew Marquardt", "Hannah Dies", "Norbert Kučerka", "Zahra Yamani", "Thad A. Harroun", "John Katsaras", "An-Chang Shi", "Maikel C. Rheinstädter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066162.g003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_the_in_plane_scans_of_DPPC_d62_bilayers_with_32_5_mol_cholesterol_using_a_the_conventional_high_energy_resolution_small_E_setup_and_b_the_low_energy_resolution_large_E_setup_/723904", "title"=>"Comparison between the in-plane scans of DPPC-d62 bilayers with 32.5 mol% cholesterol using a) the conventional high energy resolution (small Δ<i>E</i>) setup and b) the low energy resolution (large Δ<i>E</i>) setup.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-18 01:05:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1091427"], "description"=>"<p>a) Schematic of a lipid bilayer containing a lipid domain as studied by neutron scattering techniques using a low (top) and high (bottom) spatial resolution setup. b) In-plane representation of saturated hydrocarbon-chain lipid-cholesterol interactions in accordance with the umbrella model, whereby each lipid is associated with 2 cholesterol molecules. This structural arrangement results when the cholesterol content is 66 mol%. The blue squares represent lipid head groups, the yellow circles correspond to lipid tails, and the red circle are cholesterol molecules. c) Schematic molecular structures of DPPC and cholesterol molecules.</p>", "links"=>[], "tags"=>["Biochemistry", "cytochemistry", "cell membrane", "Membrane structures", "lipids", "Lipid structure", "biophysics", "Biophysics simulations", "Computational biology", "Macromolecular structure analysis", "studied"], "article_id"=>723899, "categories"=>["Physics", "Biological Sciences"], "users"=>["Clare L. Armstrong", "Drew Marquardt", "Hannah Dies", "Norbert Kučerka", "Zahra Yamani", "Thad A. Harroun", "John Katsaras", "An-Chang Shi", "Maikel C. Rheinstädter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066162.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematics_of_the_studied_systems_/723899", "title"=>"Schematics of the studied systems.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-18 01:04:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1091453"], "description"=>"<p>The collimation was set to (c1–c2–c3–c4): 30-18-28-60 (in minutes). Energy and <i>Q</i>-resolution (given as FWHM) were calculated using the ResLib software package by A. Zheludev <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066162#pone.0066162-Zheludev1\" target=\"_blank\">[80]</a> adapted to the N5 spectrometer. For comparison, typical values for energy, , , and coherence length for (cold) neutron diffraction and X-ray diffraction experiments are also included.</p>", "links"=>[], "tags"=>["Biochemistry", "cytochemistry", "cell membrane", "Membrane structures", "lipids", "Lipid structure", "biophysics", "Biophysics simulations", "Computational biology", "Macromolecular structure analysis", "setups", "crystals", "monochromater"], "article_id"=>723913, "categories"=>["Physics", "Biological Sciences"], "users"=>["Clare L. Armstrong", "Drew Marquardt", "Hannah Dies", "Norbert Kučerka", "Zahra Yamani", "Thad A. Harroun", "John Katsaras", "An-Chang Shi", "Maikel C. Rheinstädter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066162.t001", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Instrumental_parameters_for_the_low_and_high_energy_resolution_setups_used_PG_002_crystals_were_used_for_both_the_monochromater_and_analyzer_/723913", "title"=>"Instrumental parameters for the low () and high () energy resolution setups used. PG(002) crystals were used for both the monochromater and analyzer.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-18 01:05:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1091451"], "description"=>"<p>Data were taken with and without a PG filter, which was used to suppress higher order reflections.</p>", "links"=>[], "tags"=>["Biochemistry", "cytochemistry", "cell membrane", "Membrane structures", "lipids", "Lipid structure", "biophysics", "Biophysics simulations", "Computational biology", "Macromolecular structure analysis", "diffraction"], "article_id"=>723911, "categories"=>["Physics", "Biological Sciences"], "users"=>["Clare L. Armstrong", "Drew Marquardt", "Hannah Dies", "Norbert Kučerka", "Zahra Yamani", "Thad A. Harroun", "John Katsaras", "An-Chang Shi", "Maikel C. Rheinstädter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066162.g007", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_plane_diffraction_data_and_peak_assignments_/723911", "title"=>"In-plane diffraction data and peak assignments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-18 01:05:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1091450"], "description"=>"<p>Orientation of the sample for in-plane scans, such that the scattering vector, <i>Q</i>, lies in the plane of the membrane (<i>q<sub>||</sub></i>). <i>k<sub>i</sub></i> and <i>k<sub>f</sub></i> are the incident and final neutron wave vectors (<i>k = </i>2<i>π = λ</i>) and the c’s denote the location of collimators along the beam line.</p>", "links"=>[], "tags"=>["Biochemistry", "cytochemistry", "cell membrane", "Membrane structures", "lipids", "Lipid structure", "biophysics", "Biophysics simulations", "Computational biology", "Macromolecular structure analysis", "triple", "axis"], "article_id"=>723910, "categories"=>["Physics", "Biological Sciences"], "users"=>["Clare L. Armstrong", "Drew Marquardt", "Hannah Dies", "Norbert Kučerka", "Zahra Yamani", "Thad A. Harroun", "John Katsaras", "An-Chang Shi", "Maikel C. Rheinstädter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066162.g006", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Geometry_of_the_triple_axis_spectrometer_/723910", "title"=>"Geometry of the triple axis spectrometer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-18 01:05:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1091447"], "description"=>"<p>a) The scattering function <i>S</i>(<i>q||</i>) integrated over an area of 250<i>×</i>250 Å<sup>2</sup>, resulting in a diffraction pattern indicative of fluid, disordered bilayers. b) <i>S</i>(<i>q||</i>) for an ordered lipid domain of size 70<i>×</i>70 Å<sup>2</sup>. Three sharp correlation peaks are observed. The dots represent data obtained from the computer model, while the solid lines correspond to the fits obtained from the neutron scattering experiment in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066162#pone-0066162-g003\" target=\"_blank\">Figure 3</a> a) and b). Areas of integration are indicated by the blue and red rectangles shown in c). c) Snapshot of a typical configuration in the computer model. The blue region corresponds to the disordered lipid matrix, and the red regions to ordered lipid domains. The total system size was 300<i>×</i>300 Å<sup>2</sup> and contained <i>∼</i>2000 lipid molecules, or <i>∼</i>4000 lipid tails. The ordered domains were <i>∼</i>70<i>×</i>70 Å<sup>2</sup> in size and included <i>∼</i>110 lipid molecules. d) A close up view of the computer model system, where the blue circles represent lipid tails in the fluid disordered state and the red diamonds are tails in the <i>l<sub>o</sub></i> phase.</p>", "links"=>[], "tags"=>["Biochemistry", "cytochemistry", "cell membrane", "Membrane structures", "lipids", "Lipid structure", "biophysics", "Biophysics simulations", "Computational biology", "Macromolecular structure analysis"], "article_id"=>723907, "categories"=>["Physics", "Biological Sciences"], "users"=>["Clare L. Armstrong", "Drew Marquardt", "Hannah Dies", "Norbert Kučerka", "Zahra Yamani", "Thad A. Harroun", "John Katsaras", "An-Chang Shi", "Maikel C. Rheinstädter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066162.g005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_the_computer_modelling_/723907", "title"=>"Results of the computer modelling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-18 01:05:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1091430"], "description"=>"<p><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066162#pone.0066162-Vist1\" target=\"_blank\">[35]</a>–<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066162#pone.0066162-Marsh1\" target=\"_blank\">[40]</a>. Besides the well known gel and fluid phases, the so-called liquid-order phase is observed at high cholesterol concentrations. The 32.5 mol% sample, as depicted by the ⊛, was determined to be in the <i>l<sub>o</sub></i> phase.</p>", "links"=>[], "tags"=>["Biochemistry", "cytochemistry", "cell membrane", "Membrane structures", "lipids", "Lipid structure", "biophysics", "Biophysics simulations", "Computational biology", "Macromolecular structure analysis", "diagram"], "article_id"=>723901, "categories"=>["Physics", "Biological Sciences"], "users"=>["Clare L. Armstrong", "Drew Marquardt", "Hannah Dies", "Norbert Kučerka", "Zahra Yamani", "Thad A. Harroun", "John Katsaras", "An-Chang Shi", "Maikel C. Rheinstädter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066162.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phase_diagram_of_phospholipid_cholesterol_complexes_such_as_DMPC_cholesterol_and_DPPC_cholesterol_as_reported_by_for_example_/723901", "title"=>"Phase diagram of phospholipid/cholesterol complexes, such as DMPC/cholesterol and DPPC/cholesterol, as reported by, for example,", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-18 01:05:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1091454"], "description"=>"<div><p>Rafts, or functional domains, are transient nano- or mesoscopic structures in the exoplasmic leaflet of the plasma membrane, and are thought to be essential for many cellular processes. Using neutron diffraction and computer modelling, we present evidence for the existence of highly ordered lipid domains in the cholesterol-rich (32.5 mol%) liquid-ordered () phase of dipalmitoylphosphatidylcholine membranes. The liquid ordered phase in one-component lipid membranes has previously been thought to be a homogeneous phase. The presence of highly ordered lipid domains embedded in a disordered lipid matrix implies non-uniform distribution of cholesterol between the two phases. The experimental results are in excellent agreement with recent computer simulations of DPPC/cholesterol complexes [Meinhardt, Vink and Schmid (2013). Proc Natl Acad Sci USA 110(12): 4476–4481], which reported the existence of nanometer size domains in a liquid disordered lipid environment.</p></div>", "links"=>[], "tags"=>["Biochemistry", "cytochemistry", "cell membrane", "Membrane structures", "lipids", "Lipid structure", "biophysics", "Biophysics simulations", "Computational biology", "Macromolecular structure analysis", "ordered", "domains", "membranes"], "article_id"=>723914, "categories"=>["Physics", "Biological Sciences"], "users"=>["Clare L. Armstrong", "Drew Marquardt", "Hannah Dies", "Norbert Kučerka", "Zahra Yamani", "Thad A. Harroun", "John Katsaras", "An-Chang Shi", "Maikel C. Rheinstädter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066162", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Observation_of_Highly_Ordered_Domains_in_Membranes_with_Cholesterol_/723914", "title"=>"The Observation of Highly Ordered Domains in Membranes with Cholesterol", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-18 01:05:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1091445"], "description"=>"<p>Curves were calculated using Eq. (1) from <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066162#pone.0066162-Edholm1\" target=\"_blank\">[60]</a>.</p>", "links"=>[], "tags"=>["Biochemistry", "cytochemistry", "cell membrane", "Membrane structures", "lipids", "Lipid structure", "biophysics", "Biophysics simulations", "Computational biology", "Macromolecular structure analysis", "areas", "dppc", "molecules"], "article_id"=>723905, "categories"=>["Physics", "Biological Sciences"], "users"=>["Clare L. Armstrong", "Drew Marquardt", "Hannah Dies", "Norbert Kučerka", "Zahra Yamani", "Thad A. Harroun", "John Katsaras", "An-Chang Shi", "Maikel C. Rheinstädter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066162.g004", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Area_per_molecule_and_partial_areas_for_DPPC_and_cholesterol_molecules_as_function_of_cholesterol_concentration_/723905", "title"=>"Area per molecule and partial areas for DPPC and cholesterol molecules as function of cholesterol concentration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-18 01:05:05"}

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Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Computer and information sciences", "average_usage"=>[297, 488, 616, 724, 828, 939, 1038, 1127, 1223, 1311, 1393, 1479, 1556]}, {"subject_area"=>"/Computer and information sciences/Computer modeling", "average_usage"=>[175, 339, 394, 458, 498]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[254, 431, 547, 651, 748, 842, 932, 1017, 1098, 1178, 1259, 1336, 1404]}, {"subject_area"=>"/Physical sciences/Physics", "average_usage"=>[254, 421, 527, 626, 720, 813, 900, 983, 1063, 1136, 1210, 1283, 1342]}]}
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